Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.0679 | 0.8159 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0766 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0679 | 0.8159 | 0.8159 |
Echinococcus granulosus | methionine synthase reductase | 0.0473 | 0.3805 | 0.1096 |
Onchocerca volvulus | 0.0437 | 0.3043 | 0.5 | |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0766 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0437 | 0.3043 | 0.3043 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0766 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0473 | 0.3805 | 0.2407 |
Leishmania major | p450 reductase, putative | 0.0766 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0437 | 0.3043 | 0.3043 |
Plasmodium falciparum | hexokinase | 0.0437 | 0.3043 | 0.3043 |
Brugia malayi | FAD binding domain containing protein | 0.0473 | 0.3805 | 0.3805 |
Trypanosoma brucei | hexokinase | 0.0437 | 0.3043 | 0.3043 |
Onchocerca volvulus | 0.0437 | 0.3043 | 0.5 | |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0766 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0766 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0437 | 0.3043 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0437 | 0.3043 | 0.3043 |
Brugia malayi | hexokinase | 0.0437 | 0.3043 | 0.3043 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0766 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0437 | 0.3043 | 0.3043 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.0106 | 0.0106 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0766 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0766 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0766 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.0437 | 0.3043 | 0.1473 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0386 | 0.1964 | 0.0151 |
Onchocerca volvulus | 0.0437 | 0.3043 | 0.5 | |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0766 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0437 | 0.3043 | 0.3043 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0473 | 0.3805 | 0.3805 |
Brugia malayi | FAD binding domain containing protein | 0.0766 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0679 | 0.8159 | 0.8159 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0766 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0766 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0437 | 0.3043 | 0.3043 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0679 | 0.8159 | 0.8159 |
Entamoeba histolytica | hexokinase 2 | 0.0437 | 0.3043 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0679 | 0.8159 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.0437 | 0.3043 | 0.3043 |
Loa Loa (eye worm) | hexokinase | 0.0437 | 0.3043 | 0.3043 |
Treponema pallidum | hexokinase (hxk) | 0.0437 | 0.3043 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0766 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0437 | 0.3043 | 0.3043 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0766 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0766 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0437 | 0.3043 | 0.3043 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0766 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0766 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0437 | 0.3043 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0766 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0473 | 0.3805 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0437 | 0.3043 | 0.3043 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0766 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0473 | 0.3805 | 0.1096 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0766 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of human carbonic anhydrase 2 assessed as conversion of 4-nitrophenyl acetate to 4-nitrophnolate after 5 mins | ChEMBL. | 20036446 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.