Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | DNA gyrase, subunit B | References | |
Escherichia coli | DNA gyrase (type II topoisomerase), subunit A | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0321 | 0.0889 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0069 | 0.1248 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.0434 | 0.0969 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0076 | 0.1488 | 0.4113 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.3097 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0121 | 0.3097 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0076 | 0.1488 | 0.0593 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0318 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.2191 | 0.6057 |
Echinococcus granulosus | carboxylesterase 5A | 0.0136 | 0.3617 | 0.5862 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0153 | 0.4204 | 0.3378 |
Schistosoma mansoni | eyes absent homolog | 0.0096 | 0.2191 | 0.2332 |
Schistosoma mansoni | chromobox protein | 0.0076 | 0.1488 | 0.0593 |
Brugia malayi | Carboxylesterase family protein | 0.0136 | 0.3617 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.3617 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0136 | 0.3617 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0069 | 0.1248 | 0.2812 |
Echinococcus multilocularis | chromobox protein 1 | 0.0076 | 0.1488 | 0.0593 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0318 | 1 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0046 | 0.0434 | 0.348 |
Giardia lamblia | DNA topoisomerase II | 0.0064 | 0.108 | 0.5 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0088 | 0.1938 | 0.0788 |
Echinococcus multilocularis | geminin | 0.0184 | 0.5289 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0318 | 1 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0069 | 0.1248 | 0.3451 |
Echinococcus granulosus | acetylcholinesterase | 0.0136 | 0.3617 | 0.5862 |
Schistosoma mansoni | chromobox protein | 0.0076 | 0.1488 | 0.0593 |
Loa Loa (eye worm) | carboxylesterase | 0.0136 | 0.3617 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0076 | 0.1488 | 0.0593 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0069 | 0.1248 | 0.2812 |
Echinococcus granulosus | acetylcholinesterase | 0.0136 | 0.3617 | 0.5862 |
Brugia malayi | hypothetical protein | 0.0096 | 0.2191 | 0.5672 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0153 | 0.4204 | 0.3378 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0153 | 0.4204 | 0.2419 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0318 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.0434 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.2191 | 0.6057 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0069 | 0.1248 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0069 | 0.1248 | 0.7946 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.5289 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0069 | 0.1248 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0318 | 1 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0076 | 0.1488 | 0.3539 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0318 | 1 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0069 | 0.1248 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0136 | 0.3617 | 0.5862 |
Echinococcus granulosus | chromobox protein 1 | 0.0076 | 0.1488 | 0.0593 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.3617 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0136 | 0.3617 | 0.5862 |
Trichomonas vaginalis | chromobox protein, putative | 0.0076 | 0.1488 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0136 | 0.3617 | 0.5862 |
Echinococcus granulosus | geminin | 0.0184 | 0.5289 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0136 | 0.3617 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0318 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0136 | 0.3617 | 0.5862 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.0321 | 0.2575 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.3097 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0121 | 0.3097 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0076 | 0.1488 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.5289 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0069 | 0.1248 | 0.2812 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0152 | 0.4156 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 uM | Inhibition of Escherichia coli GyrB A2B2 subunits assessed reduction in DNA supercoiling activity by malachite green dye based by spectrophotometry | ChEMBL. | 25137573 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.