Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | checkpoint kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Serine/threonine-protein kinase Chk1, putative | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.108 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0413 | 0.2404 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0413 | 0.2404 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.108 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.108 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.108 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.108 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.108 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0413 | 0.2404 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.108 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.108 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.108 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0958 | 0.8602 | 0.8159 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.108 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.108 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0544 | 0.3896 | 0.3896 |
Brugia malayi | FAD binding domain containing protein | 0.108 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.0413 | 0.2404 | 0.2404 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0536 | 0.3803 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.108 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0667 | 0.5295 | 0.5295 |
Schistosoma mansoni | cytochrome P450 reductase | 0.108 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0958 | 0.8602 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.108 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0667 | 0.5295 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.108 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.108 | 1 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0536 | 0.3803 | 0.3803 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.108 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.108 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0413 | 0.2404 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0958 | 0.8602 | 0.8159 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0413 | 0.2404 | 0.2404 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0413 | 0.2404 | 0.5 |
Leishmania major | p450 reductase, putative | 0.108 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.108 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0667 | 0.5295 | 0.5295 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0667 | 0.5295 | 0.5295 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.108 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0958 | 0.8602 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0536 | 0.3803 | 0.5 |
Treponema pallidum | flavodoxin | 0.0413 | 0.2404 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0958 | 0.8602 | 0.8159 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10 uM | Inhibition of Chk1 (unknown origin) by luminescent ADP-Glo assay | ChEMBL. | 25042558 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.