Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | checkpoint kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Serine/threonine-protein kinase Chk1, putative | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | FAD binding domain containing protein | 0.0661 | 0.5285 | 0.5285 |
Schistosoma mansoni | cytochrome P450 reductase | 0.1071 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.1071 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0531 | 0.3791 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.1071 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.041 | 0.2389 | 0.2389 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1071 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.054 | 0.3884 | 0.3884 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.1071 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0949 | 0.8599 | 0.8159 |
Trypanosoma cruzi | p450 reductase, putative | 0.1071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1071 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.1071 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.1071 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.1071 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.1071 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.041 | 0.2389 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.1071 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.1071 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.041 | 0.2389 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.1071 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.041 | 0.2389 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0949 | 0.8599 | 0.8159 |
Treponema pallidum | flavodoxin | 0.041 | 0.2389 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.1071 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0949 | 0.8599 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0531 | 0.3791 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0661 | 0.5285 | 0.5285 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0661 | 0.5285 | 0.5285 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.1071 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.1071 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0949 | 0.8599 | 0.8159 |
Loa Loa (eye worm) | flavodoxin family protein | 0.041 | 0.2389 | 0.2389 |
Entamoeba histolytica | type A flavoprotein, putative | 0.041 | 0.2389 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.1071 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.041 | 0.2389 | 0.5 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0531 | 0.3791 | 0.3791 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1071 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1071 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.1071 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0661 | 0.5285 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1071 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0949 | 0.8599 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10 uM | Inhibition of Chk1 (unknown origin) by luminescent ADP-Glo assay | ChEMBL. | 25042558 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.