TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 302.223 | Formula: C12H13Cl2N3S
H donors: 1 H acceptors: 0 LogP: 4.14 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCCCn1c(n[nH]c1=S)c1cccc(c1Cl)Cl
InChi: 1S/C12H13Cl2N3S/c1-2-3-7-17-11(15-16-12(17)18)8-5-4-6-9(13)10(8)14/h4-6H,2-3,7H2,1H3,(H,16,18)
InChiKey: NYQVQAVYPSFABC-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	helicase	0.0012	0.0052	0.0049
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0487	0.289
Schistosoma mansoni	acetylcholinesterase	0.0096	0.1559	0.1516
Onchocerca volvulus		0.0096	0.1559	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0015	0.0114	0.0414
Brugia malayi	Cytochrome P450 family protein	0.0045	0.0653	0.0653
Echinococcus multilocularis	musashi	0.0027	0.0326	0.0324
Loa Loa (eye worm)	acetylcholinesterase 1	0.0566	1	1
Onchocerca volvulus		0.0012	0.0063	0.0074
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0791	0.0789
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1559	0.1558
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.1117	0.7065
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.004	0.0557	0.3353
Brugia malayi	Associated with TFs and helicases family protein	0.0012	0.0052	0.0052
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0791	0.0789
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0038	0.0518	0.5
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0487	1
Schistosoma mansoni	cpg binding protein	0.003	0.0386	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0052	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0065
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0482	0.2857
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0096	0.1559	0.1558
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0096	0.1559	0.1516
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0326	0.0276
Loa Loa (eye worm)	hypothetical protein	0.004	0.0557	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0052	0.0049
Entamoeba histolytica	hypothetical protein	0.0036	0.0487	0.9326
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0487	0.0113
Onchocerca volvulus		0.0096	0.1559	1
Entamoeba histolytica	transcription factor BTF3, putative	0.0036	0.0482	0.9228
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1076	0.1074
Brugia malayi	beta-lactamase	0.0036	0.0487	0.0487
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0487	0.0113
Brugia malayi	intermediate filament protein	0.0027	0.0326	0.0326
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.0611	0.3713
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0013	0.0081	0.0029
Brugia malayi	beta-NAC-like protein	0.0036	0.0482	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0487	0.0485
Schistosoma mansoni	hypothetical protein	0.0408	0.7162	0.7147
Schistosoma mansoni	hypothetical protein	0.0032	0.0414	0.0364
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0518	0.3096
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0349	0.197
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0487	0.1403
Onchocerca volvulus		0.0096	0.1559	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0487	0.0487
Brugia malayi	hypothetical protein	0.0096	0.1559	0.1559
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0012	0.0052	0.0052
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.1646	0.1646
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0566	1	1
Echinococcus multilocularis	lamin	0.0027	0.0326	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1559	0.1558
Echinococcus multilocularis	chromobox protein 1	0.0071	0.1117	0.1115
Brugia malayi	Carboxylesterase family protein	0.0566	1	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0414	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0052	0.0049
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0791	0.0743
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0487	0.0485
Echinococcus granulosus	BC026374 protein S09 family	0.0096	0.1559	0.1558
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0326	0.0324
Echinococcus granulosus	intermediate filament protein	0.0027	0.0326	0.0324
Brugia malayi	M-phase phosphoprotein, mpp8	0.0012	0.0052	0.0052
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0096	0.1559	0.3166
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0487	0.0485
Entamoeba histolytica	hypothetical protein	0.0036	0.0487	0.9326
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0052	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1559	0.1558
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0487	0.0485
Brugia malayi	Heterochromatin protein 1	0.0071	0.1117	0.1117
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0096	0.1559	0.3166
Brugia malayi	hypothetical protein	0.0012	0.0052	0.0052
Loa Loa (eye worm)	inositol-1	0.0038	0.0518	0.0516
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0487	0.0113
Echinococcus granulosus	inositol monophosphatase 1	0.0038	0.0518	0.0516
Brugia malayi	Carboxylesterase family protein	0.0096	0.1559	0.1559
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0487	0.1403
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0326	0.0324
Echinococcus multilocularis	chromobox protein 2	0.0012	0.0052	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0052	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1559	0.1558
Schistosoma mansoni	hypothetical protein	0.0032	0.0414	0.0364
Entamoeba histolytica	hypothetical protein	0.0036	0.0487	0.9326
Brugia malayi	CHD4 protein	0.0013	0.0081	0.0081
Schistosoma mansoni	cpg binding protein	0.0029	0.0357	0.0307
Loa Loa (eye worm)	carboxylesterase	0.0566	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0052	0.0049
Onchocerca volvulus		0.0036	0.0487	0.289
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0013	0.0081	0.0079
Schistosoma mansoni	hypothetical protein	0.0169	0.2875	0.2838
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0487	0.0113
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0038	0.0518	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0414	0.0414
Echinococcus granulosus	Chromobox protein 3	0.0012	0.0052	0.0049
Trichomonas vaginalis	esterase, putative	0.0036	0.0487	0.289
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0076	0.0074
Echinococcus multilocularis	lamin dm0	0.0027	0.0326	0.0324
Echinococcus multilocularis	para nitrobenzyl esterase	0.0096	0.1559	0.1558
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0487	0.0485
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0487	0.289
Echinococcus multilocularis	inositol monophosphatase 1	0.0038	0.0518	0.0516
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0414	0.0412
Echinococcus multilocularis	geminin	0.0169	0.2875	0.2874
Brugia malayi	hypothetical protein	0.0036	0.0487	0.0487
Brugia malayi	beta-lactamase family protein	0.0036	0.0487	0.0487
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0012	0.0052	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0557	0.3353
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0518	0.0469
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0611	0.3713
Echinococcus granulosus	GPCR family 2	0.0032	0.0414	0.0412
Echinococcus granulosus	dnaJ subfamily B	0.0408	0.7162	0.7162
Schistosoma mansoni	gliotactin	0.0096	0.1559	0.1516
Schistosoma mansoni	cpg binding protein	0.003	0.0386	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0566	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0317	0.0315
Echinococcus multilocularis	chromobox protein 1	0.0071	0.1117	0.1115
Echinococcus multilocularis	transcription factor btf3	0.0036	0.0482	0.048
Schistosoma mansoni	hypothetical protein	0.0032	0.0414	0.0364
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0168	0.0772
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.1646	0.1645
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0487	0.0438
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0096	0.1559	0.1558
Loa Loa (eye worm)	hypothetical protein	0.0566	1	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0487	0.0438
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0414	0.0412
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.1076	0.1076
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0557	0.3353
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0487	0.0485
Entamoeba histolytica	hypothetical protein	0.0036	0.0482	0.9228
Echinococcus multilocularis	carboxylesterase 5A	0.0566	1	1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0487	0.0113
Schistosoma mansoni	chromobox protein	0.0071	0.1117	0.1071
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0487	0.0113
Schistosoma mansoni	hypothetical protein	0.0032	0.0414	0.0364
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0487	0.1403
Entamoeba histolytica	hypothetical protein	0.0036	0.0487	0.9326
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0482	0.2857
Brugia malayi	SET domain containing protein	0.0012	0.0063	0.0063
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0791	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1559	0.1558
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.0791	0.0791
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0487	0.0485
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0487	0.0485
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0487	0.289
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1559	0.1558
Schistosoma mansoni	lamin	0.0027	0.0326	0.0276
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0038	0.0518	0.0289
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1559	0.1558
Mycobacterium ulcerans	carboxylesterase, LipT	0.0096	0.1559	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0487	0.289
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0791	0.0789
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0414	0.0412
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0487	0.0438
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0414	0.0412
Toxoplasma gondii	ABC1 family protein	0.0036	0.0487	0.5696
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0487	1
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0611	0.3713
Echinococcus multilocularis	acetylcholinesterase	0.0566	1	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0357	0.0355
Brugia malayi	Valyl-tRNA synthetase	0.0012	0.0052	0.0052
Echinococcus granulosus	acetylcholinesterase	0.0566	1	1
Onchocerca volvulus		0.0096	0.1559	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0168	0.0772
Loa Loa (eye worm)	heterochromatin protein 1	0.0071	0.1117	0.1115
Loa Loa (eye worm)	carboxylesterase	0.0096	0.1559	0.1558
Brugia malayi	chromobox protein homolog 3	0.004	0.0557	0.0557
Schistosoma mansoni	hypothetical protein	0.0069	0.1076	0.103
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0168	0.0772
Loa Loa (eye worm)	CHromoDomain protein family member	0.0013	0.0081	0.0079
Brugia malayi	Carboxylesterase family protein	0.0096	0.1559	0.1559
Toxoplasma gondii	NAC domain-containing protein	0.0036	0.0482	0.5629
Brugia malayi	Carboxylesterase family protein	0.0096	0.1559	0.1559
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0933	0.0886
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0482	0.2857
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0012	0.0063	0.0011
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0038	0.0518	0.6101
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.0791	0.0789
Echinococcus granulosus	lamin	0.0027	0.0326	0.0324
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0518	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0487	0.0485
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0518	1
Echinococcus granulosus	lamin dm0	0.0027	0.0326	0.0324
Onchocerca volvulus		0.0036	0.0487	0.289
Echinococcus granulosus	geminin	0.0169	0.2875	0.2874
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0076	0.0074
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.0817	1
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0414	0.0414
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0487	0.289
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0357	0.0357
Onchocerca volvulus		0.0096	0.1559	1
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.1117	0.7065
Echinococcus granulosus	acetylcholinesterase	0.0566	1	1
Echinococcus granulosus	neuroligin	0.0096	0.1559	0.1558
Onchocerca volvulus		0.0027	0.0326	0.1818
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0349	0.197
Loa Loa (eye worm)	cytochrome P450 family protein	0.0045	0.0653	0.0651
Echinococcus granulosus	chromobox protein 1	0.0071	0.1117	0.1115
Loa Loa (eye worm)	carboxylesterase	0.0096	0.1559	0.1558
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0518	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.1646	0.1646
Onchocerca volvulus		0.0036	0.0487	0.289
Echinococcus multilocularis	cpg binding protein	0.003	0.0386	0.0384
Echinococcus multilocularis	dnaJ subfamily B	0.0408	0.7162	0.7162
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0487	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0065
Plasmodium vivax	basic transcription factor 3b, putative	0.0036	0.0482	0.9884
Echinococcus granulosus	chromobox protein 2	0.0012	0.0052	0.0049
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0168	0.0772
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0326	0.0326
Loa Loa (eye worm)	hypothetical protein	0.01	0.1646	0.1645
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0168	0.0772
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0487	0.0113
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0487	0.0113
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0013	0.0081	0.0079
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0096	0.1559	0.3166
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0326	0.0324
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0114	0.0414
Brugia malayi	Inositol-1	0.0038	0.0518	0.0518
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0487	0.0485
Onchocerca volvulus		0.0031	0.0403	0.233
Schistosoma mansoni	chromobox protein	0.0071	0.1117	0.1071
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0791	0.0789
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0518	0.3096
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0015	0.0105	0.0358
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0487	0.0485
Schistosoma mansoni	BC026374 protein (S09 family)	0.0096	0.1559	0.1516
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0168	0.0772
Loa Loa (eye worm)	ICD-1 protein	0.0036	0.0482	0.048
Trichomonas vaginalis	spcc417.12 protein, putative	0.0096	0.1559	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0168	0.0772
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0518	0.0469
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0012	0.0052	0.0049
Echinococcus granulosus	transcription factor btf3	0.0036	0.0482	0.048
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0096	0.1559	0.1516
Leishmania major	hypothetical protein, conserved	0.0036	0.0487	0.1403
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0168	0.0772
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0414	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0414	0.0412
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0096	0.1559	0.1558
Echinococcus granulosus	Chromo domain	0.0012	0.0052	0.0049
Echinococcus multilocularis	Chromo domain	0.0012	0.0052	0.0049
Brugia malayi	Protein cec-1.	0.0012	0.0052	0.0052
Plasmodium falciparum	basic transcription factor 3b, putative	0.0036	0.0482	1
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0487	1
Onchocerca volvulus		0.0027	0.0326	0.1818
Echinococcus granulosus	para nitrobenzyl esterase	0.0096	0.1559	0.1558
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0791	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0052	0.0049
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0096	0.1559	0.1516
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0403	0.0401
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0518	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0102	0.01
Trichomonas vaginalis	inositol monophosphatase, putative	0.0038	0.0518	0.3096
Echinococcus multilocularis	neuroligin	0.0096	0.1559	0.1558
Echinococcus granulosus	chromobox protein 1	0.0071	0.1117	0.1115
Schistosoma mansoni	transcription factor btf3	0.0036	0.0482	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0076	0.0074
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0096	0.1559	0.1516
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0229	0.3959	1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0487	0.0113
Brugia malayi	Carboxylesterase family protein	0.0096	0.1559	0.1559
Echinococcus multilocularis	Chromobox protein 3	0.0012	0.0052	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0487	0.0485
Brugia malayi	beta-lactamase family protein	0.0036	0.0487	0.0487
Onchocerca volvulus		0.0029	0.0357	0.2026
Echinococcus granulosus	carboxylesterase 5A	0.0566	1	1
Schistosoma mansoni	hypothetical protein	0.0169	0.2875	0.2838
Schistosoma mansoni	hypothetical protein	0.0036	0.0487	0.0438
Echinococcus granulosus	cpg binding protein	0.003	0.0386	0.0384
Echinococcus multilocularis	acetylcholinesterase	0.0566	1	1
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0096	0.1559	1
Schistosoma mansoni	lamin	0.0027	0.0326	0.0276

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 16 %	Displacement of [3H]muscimol form GABAA receptor in rat cerebral cortex assessed as specific radio-ligand binding level at 1 uM incubated for 10 mins by liquid scintillation counting method	ChEMBL.	25226229
Activity (functional)	= 25 %	Anticonvulsant activity in Swiss mouse assessed as protection against seizures at 300 mg/kg, ip administered 60 mins before test by maximal electroshock seizure test	ChEMBL.	25226229

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3329362

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 927602