Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1362 | 0.1362 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0419 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0071 | 0.1362 | 0.1362 |
Onchocerca volvulus | 0.0071 | 0.1362 | 0.5 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0071 | 0.1362 | 0.1362 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0071 | 0.1362 | 0.1362 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0071 | 0.1362 | 0.1362 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0071 | 0.1362 | 0.1362 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0071 | 0.1362 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0071 | 0.1362 | 0.1362 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0071 | 0.1362 | 0.1362 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1362 | 0.1362 |
Onchocerca volvulus | 0.0071 | 0.1362 | 0.5 | |
Onchocerca volvulus | 0.0071 | 0.1362 | 0.5 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0071 | 0.1362 | 0.1362 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0071 | 0.1362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1362 | 0.1362 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0071 | 0.1362 | 0.1362 |
Onchocerca volvulus | 0.0071 | 0.1362 | 0.5 | |
Schistosoma mansoni | acetylcholinesterase | 0.0071 | 0.1362 | 0.1362 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0071 | 0.1362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1362 | 0.1362 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1362 | 0.1362 |
Loa Loa (eye worm) | carboxylesterase | 0.0071 | 0.1362 | 0.1362 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0071 | 0.1362 | 0.1362 |
Onchocerca volvulus | 0.0071 | 0.1362 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0419 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0419 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0419 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0419 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0071 | 0.1362 | 0.1362 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0419 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0419 | 1 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0071 | 0.1362 | 0.1362 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0419 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0071 | 0.1362 | 0.1362 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1362 | 0.1362 |
Brugia malayi | Carboxylesterase family protein | 0.0071 | 0.1362 | 0.1362 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0071 | 0.1362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0071 | 0.1362 | 0.1362 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0071 | 0.1362 | 0.1362 |
Echinococcus granulosus | acetylcholinesterase | 0.0419 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0071 | 0.1362 | 0.1362 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0071 | 0.1362 | 0.1362 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0071 | 0.1362 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0071 | 0.1362 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1362 | 0.1362 |
Echinococcus granulosus | carboxylesterase 5A | 0.0419 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0071 | 0.1362 | 0.1362 |
Echinococcus multilocularis | neuroligin | 0.0071 | 0.1362 | 0.1362 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0 % | Displacement of [3H]muscimol form GABAA receptor in rat cerebral cortex assessed as specific radio-ligand binding level at 1 uM incubated for 10 mins by liquid scintillation counting method | ChEMBL. | 25226229 |
Activity (functional) | = 62.5 % | Anticonvulsant activity in Swiss mouse assessed as protection against seizures at 300 mg/kg, ip administered 60 mins before test by maximal electroshock seizure test | ChEMBL. | 25226229 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.