Detailed information for compound 927862

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 314.462 | Formula: C21H30O2
  • H donors: 1 H acceptors: 1 LogP: 5.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCc1cc(O)c2c(c1)OC(C1=C2C[C@@H](C)CC1)(C)C
  • InChi: 1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h12-14,22H,5-11H2,1-4H3/t14-/m0/s1
  • InChiKey: NEBZNJDFIPBXCS-AWEZNQCLSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cannabinoid receptor 2 (macrophage) Starlite/ChEMBL References
Homo sapiens cannabinoid receptor 1 (brain) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0066 0.0117 0.0116
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0212 0.0537 0.0537
Echinococcus granulosus proteasome prosome macropain 0.1282 0.3614 0.3614
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Plasmodium vivax proteasome subunit beta type-4, putative 0.0252 0.0651 0.1799
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.004 0.004
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0996 0.2792 0.7723
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0085 0.017 0.017
Echinococcus granulosus g-protein coupled receptor 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0002 0.0001
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.004 0.004
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0252 0.0651 0.0651
Brugia malayi sulfakinin receptor protein 0.004 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0053 0.008 0.0079
Echinococcus granulosus sodium channel protein 0.0212 0.0537 0.0537
Schistosoma mansoni cellular tumor antigen P53 0.0163 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Mycobacterium ulcerans beta-lactamase 0.0066 0.0117 0.032
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0212 0.0537 0.0537
Echinococcus multilocularis neuropeptide FF receptor 2 0.004 0.004 0.004
Echinococcus multilocularis orexin receptor type 2 0.004 0.004 0.004
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0252 0.0651 0.1799
Echinococcus multilocularis muscleblind protein 1 0.0165 0.0401 0.0401
Echinococcus multilocularis beta LACTamase domain containing family member 0.0066 0.0117 0.0117
Toxoplasma gondii proteasome subunit 0.0252 0.0651 0.1799
Leishmania major proteasome beta 2 subunit, putative 0.0252 0.0651 0.18
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0252 0.0651 0.176
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0052 0.0052
Trypanosoma brucei proteasome beta 6 subunit 0.0996 0.2792 0.7712
Loa Loa (eye worm) hypothetical protein 0.0057 0.009 0.0089
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0429 0.1186
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0252 0.0651 0.0651
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.004 0.004
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0252 0.0651 0.18
Brugia malayi Cytochrome P450 family protein 0.0055 0.0085 0.0084
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.004 0.004 0.004
Mycobacterium tuberculosis Probable lipase LipE 0.0066 0.0117 0.032
Schistosoma mansoni biogenic amine receptor 0.004 0.004 0.004
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0252 0.0651 0.18
Echinococcus multilocularis calcium activated potassium channel 0.0212 0.0537 0.0537
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Mycobacterium ulcerans hypothetical protein 0.0066 0.0117 0.032
Echinococcus granulosus peregrin 0.0026 0.0001 0.0001
Schistosoma mansoni amine GPCR 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0212 0.0537 0.0536
Onchocerca volvulus 0.004 0.004 0.0318
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0996 0.2792 0.7723
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0252 0.0651 0.18
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0212 0.0537 0.0537
Echinococcus granulosus jumonji domain containing protein 0.0036 0.003 0.003
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0617 0.1702 0.4707
Toxoplasma gondii LsmAD domain-containing protein 0.0057 0.009 0.0247
Trichomonas vaginalis D-aminoacylase, putative 0.0066 0.0117 0.0323
Schistosoma mansoni ryanodine receptor related 0.0212 0.0537 0.0537
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0252 0.0651 0.18
Toxoplasma gondii hypothetical protein 0.0212 0.0537 0.1483
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.3502 1 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0035 0.0028 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0034 0.0092
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0002 0.0003
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0252 0.0651 0.18
Leishmania major proteasome alpha 1 subunit, putative 0.0252 0.0651 0.18
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0212 0.0537 0.0537
Echinococcus multilocularis g protein coupled receptor 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0031 0.003
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.004 0.004
Echinococcus multilocularis neuropeptide s receptor 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Trichomonas vaginalis set domain proteins, putative 0.0456 0.1239 0.3426
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0252 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Echinococcus multilocularis tachykinin peptides receptor 99D 0.004 0.004 0.004
Trichomonas vaginalis D-aminoacylase, putative 0.0066 0.0117 0.0323
Entamoeba histolytica hypothetical protein 0.0075 0.0141 0.0389
Echinococcus granulosus neuropeptides capa receptor 0.004 0.004 0.004
Brugia malayi G-protein coupled receptor 0.004 0.004 0.0039
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.004 0.004
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0002 0.0003
Echinococcus multilocularis potassium voltage gated channel protein 0.0212 0.0537 0.0537
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.004 0.004
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0252 0.0651 0.0651
Echinococcus multilocularis biogenic amine (5HT) receptor 0.004 0.004 0.004
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0212 0.0537 0.0537
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0252 0.0651 0.18
Toxoplasma gondii proteasome subunit beta type, putative 0.1282 0.3614 1
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.034 0.0903 0.0903
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0252 0.0651 0.18
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0996 0.2792 0.2792
Entamoeba histolytica hypothetical protein 0.0075 0.0141 0.0389
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0252 0.0651 0.176
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.0344 0.0344
Giardia lamblia Proteasome subunit beta type 3 0.0252 0.0651 0.1799
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.004 0.004 0.004
Mycobacterium tuberculosis Probable lipase LipD 0.0066 0.0117 0.032
Brugia malayi Pre-SET motif family protein 0.0401 0.1079 0.1079
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0212 0.0537 0.0537
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0252 0.0651 0.1799
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0035 0.0028 0.0028
Brugia malayi 20S proteasome alpha5 subunit 0.0252 0.0651 0.065
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0212 0.0537 0.1483
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Echinococcus multilocularis conserved hypothetical protein 0.0728 0.2021 0.2021
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0031 0.0031
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0252 0.0651 0.18
Echinococcus multilocularis dro:myosuppressin receptor 0.004 0.004 0.004
Onchocerca volvulus Neuropeptide F receptor homolog 0.004 0.004 0.0318
Brugia malayi CHE-14 protein 0.0044 0.0052 0.0051
Echinococcus multilocularis sodium channel protein 0.0212 0.0537 0.0537
Brugia malayi Cyclic-nucleotide gated cation channel 0.0212 0.0537 0.0536
Brugia malayi Serotonin receptor 0.0525 0.1437 0.1436
Brugia malayi larval opioid receptor 0.004 0.004 0.0039
Schistosoma mansoni hypothetical protein 0.0212 0.0537 0.0537
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0252 0.0651 0.065
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0212 0.0537 0.1483
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0252 0.0651 0.1799
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0212 0.0537 0.0537
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0034 0.0092
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.3502 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0057 0.0092 0.0092
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0212 0.0537 0.0537
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0252 0.0651 0.18
Brugia malayi proteasome subunit alpha type 4 0.0252 0.0651 0.065
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0212 0.0537 0.0536
Loa Loa (eye worm) hypothetical protein 0.0115 0.0256 0.0255
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0212 0.0537 0.0537
Echinococcus granulosus hypothetical protein 0.0212 0.0537 0.0537
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.004 0.0039
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.004 0.004 0.0039
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0212 0.0537 0.0537
Echinococcus multilocularis potassium voltage gated channel protein 0.0212 0.0537 0.0537
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0212 0.0537 0.0537
Schistosoma mansoni voltage-gated cation channel 0.3502 1 1
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0212 0.0537 0.0537
Echinococcus multilocularis voltage dependent calcium channel 0.3502 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0024 0.0064
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0252 0.0651 0.176
Brugia malayi hypothetical protein 0.0057 0.009 0.0089
Echinococcus granulosus lysine specific demethylase 5A 0.0031 0.0017 0.0017
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0252 0.0651 0.1799
Echinococcus granulosus g protein coupled receptor 0.004 0.004 0.004
Trypanosoma cruzi 20S proteasome subunit 0.0617 0.1702 0.4707
Plasmodium vivax SET domain protein, putative 0.0057 0.0092 0.0252
Toxoplasma gondii proteasome subunit alpha1, putative 0.0252 0.0651 0.1799
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0617 0.1702 0.4707
Brugia malayi gonadotropin-releasing hormone receptor 2 0.004 0.004 0.0039
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0996 0.2792 0.7723
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.004 0.004
Brugia malayi beta-lactamase 0.0066 0.0117 0.0116
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.004 0.004
Schistosoma mansoni amine GPCR 0.004 0.004 0.004
Giardia lamblia Proteasome subunit beta type 2 0.0617 0.1702 0.4707
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.004 0.004
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0052 0.0052
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0429 0.1186
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0035 0.0028 0.0028
Brugia malayi hypothetical protein 0.0037 0.0032 0.0031
Echinococcus granulosus muscleblind protein 0.0165 0.0401 0.0401
Giardia lamblia 20S proteasome alpha subunit 6 0.0252 0.0651 0.1799
Brugia malayi Calcitonin receptor-like protein seb-1 0.0115 0.0256 0.0255
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0034 0.0033
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0252 0.0651 0.1799
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0617 0.1702 0.4682
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0212 0.0537 0.1442
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0052 0.0052
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Echinococcus granulosus hyperpolarization activated cyclic 0.0212 0.0537 0.0537
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0252 0.0651 0.0651
Echinococcus multilocularis transient receptor potential cation channel 0.0212 0.0537 0.0537
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0252 0.0651 0.1799
Echinococcus multilocularis proteasome subunit alpha type 6 0.0252 0.0651 0.0651
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0252 0.0651 0.0651
Mycobacterium ulcerans esterase/lipase LipP 0.0066 0.0117 0.032
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.004 0.004
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0252 0.0651 0.18
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0252 0.0651 0.18
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0252 0.0651 0.176
Onchocerca volvulus 0.004 0.004 0.0318
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0035 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0036 0.0031 0.0031
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.004 0.004
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.004 0.004 0.004
Echinococcus multilocularis nmda type glutamate receptor 0.0083 0.0167 0.0167
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.004 0.004 0.0039
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0252 0.0651 0.18
Toxoplasma gondii hypothetical protein 0.0212 0.0537 0.1483
Schistosoma mansoni survival motor neuron protein 0.005 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Leishmania major hypothetical protein, conserved 0.0212 0.0537 0.1483
Echinococcus multilocularis microtubule associated protein 2 0.1335 0.3768 0.3768
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus granulosus neuropeptide Y receptor 0.004 0.004 0.004
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0252 0.0651 0.18
Brugia malayi ion channel NompC 0.0212 0.0537 0.0536
Brugia malayi proteasome subunit alpha type 6 0.0252 0.0651 0.065
Entamoeba histolytica hypothetical protein 0.0075 0.0141 0.0389
Leishmania major hypothetical protein, unknown function 0.0212 0.0537 0.1483
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.004 0.004 0.004
Brugia malayi proteasome subunit beta type 3 0.0252 0.0651 0.065
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0052 0.0142
Loa Loa (eye worm) hypothetical protein 0.0066 0.0117 0.0116
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0034 0.0092
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus granulosus expressed protein 0.0387 0.1041 0.1041
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0252 0.0651 0.0651
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.1282 0.3614 1
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0429 0.1186
Onchocerca volvulus 0.0057 0.0092 0.0734
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.004 0.004
Giardia lamblia 20S proteasome alpha subunit 1 0.0252 0.0651 0.1799
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0252 0.0651 0.18
Onchocerca volvulus 0.0066 0.0117 0.094
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0024 0.0064
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0002 0.0003
Leishmania major proteasome beta-1 subunit, putative 0.0252 0.0651 0.18
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0212 0.0537 0.0537
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0031 0.003
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0057 0.0092 0.0252
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.004 0.004 0.0318
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.004 0.004
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Entamoeba histolytica hypothetical protein 0.0075 0.0141 0.0389
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.004 0.004 0.0039
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0066 0.0117 0.032
Echinococcus multilocularis snurportin 1 0.034 0.0903 0.0903
Brugia malayi Proteasome subunit alpha type 7-1 0.0252 0.0651 0.065
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0996 0.2792 0.7723
Giardia lamblia 20S proteasome alpha subunit 7 0.0252 0.0651 0.1799
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0617 0.1702 0.4707
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0117 0.0323
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0002 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0456 0.1261
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0212 0.0537 0.0537
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.3502 1 1
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0252 0.0651 0.1799
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0117 0.0323
Loa Loa (eye worm) hypothetical protein 0.0078 0.0152 0.0151
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0252 0.0651 0.18
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0252 0.0651 0.5
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0252 0.0651 0.18
Echinococcus multilocularis conserved hypothetical protein 0.0212 0.0537 0.0537
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0252 0.0651 0.065
Loa Loa (eye worm) proteasome subunit beta type 2 0.0617 0.1702 0.1701
Brugia malayi MH2 domain containing protein 0.0227 0.0579 0.0578
Echinococcus granulosus neuropeptides capa receptor 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0244 0.0628 0.0627
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.0092 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0276 0.0719 0.0719
Loa Loa (eye worm) hypothetical protein 0.0165 0.0401 0.04
Loa Loa (eye worm) melatonin receptor type 1A 0.004 0.004 0.0039
Toxoplasma gondii peptidase, T1 family protein 0.0252 0.0651 0.1799
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) PAS-3 protein 0.0252 0.0651 0.065
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0035 0.0028 0.0028
Brugia malayi neuropeptide F receptor 0.004 0.004 0.0039
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0252 0.0651 0.1799
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.009 0.0248
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0212 0.0537 0.0536
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0617 0.1702 0.1702
Brugia malayi olfactory channel protein osm-9 0.0212 0.0537 0.0536
Echinococcus multilocularis two pore calcium channel protein 1 0.0212 0.0537 0.0537
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0252 0.0651 0.18
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.004 0.004
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0212 0.0537 0.0536
Loa Loa (eye worm) voltage-dependent calcium channel 0.0212 0.0537 0.0536
Echinococcus granulosus two pore calcium channel protein 1 0.0212 0.0537 0.0537
Leishmania major C-8 sterol isomerase-like protein 0.0578 0.159 0.4399
Echinococcus granulosus short transient receptor potential channel 6 0.0212 0.0537 0.0537
Schistosoma mansoni calcium-activated potassium channel 0.0212 0.0537 0.0537
Schistosoma mansoni importin beta-1 0.0032 0.0018 0.0018
Plasmodium vivax proteasome subunit beta type-2, putative 0.0617 0.1702 0.4707
Echinococcus granulosus transient receptor potential gamma protein 0.0212 0.0537 0.0537
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0996 0.2792 0.2792
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0212 0.0537 0.1483
Echinococcus granulosus potassium voltage gated channel protein 0.0212 0.0537 0.0537
Loa Loa (eye worm) voltage-gated potassium channel 0.0212 0.0537 0.0536
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.3502 1 1
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0252 0.0651 0.0651
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0252 0.0651 0.18
Echinococcus granulosus two pore calcium channel protein 2 0.0212 0.0537 0.0537
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0034 0.0092
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0252 0.0651 0.18
Schistosoma mansoni adenoreceptor 0.004 0.004 0.004
Brugia malayi Proteasome A-type and B-type family protein 0.0252 0.0651 0.065
Echinococcus granulosus orexin receptor type 2 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0578 0.159 0.159
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.003
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0252 0.0651 0.065
Echinococcus granulosus tar DNA binding protein 0.0276 0.0719 0.0719
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0252 0.0651 0.1799
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.004 0.004
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0017 0.0016
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Onchocerca volvulus 0.004 0.004 0.0318
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0223 0.0223
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1282 0.3614 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.004 0.004
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Mycobacterium leprae Probable lipase LipE 0.0066 0.0117 0.032
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.009 0.0247
Echinococcus multilocularis transient receptor potential cation channel 0.0212 0.0537 0.0537
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.3502 1 1
Trypanosoma brucei proteasome beta 7 subunit 0.0252 0.0651 0.176
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0252 0.0651 0.0651
Brugia malayi Dopamine receptor 0.004 0.004 0.0039
Echinococcus multilocularis tar DNA binding protein 0.0276 0.0719 0.0719
Brugia malayi Dopamine receptor protein 2 0.004 0.004 0.0039
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0034 0.0092
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0252 0.0651 0.1799
Loa Loa (eye worm) voltage-gated calcium channel 0.0212 0.0537 0.0536
Echinococcus granulosus voltage gated hydrogen channel 1 0.0212 0.0537 0.0537
Echinococcus granulosus neuropeptide receptor 0.004 0.004 0.004
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0034 0.0034
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.1282 0.3614 0.3614
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0066 0.0117 0.0116
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.004 0.004 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.004 0.004
Trypanosoma brucei proteasome subunit beta type-5, putative 0.1282 0.3614 1
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0252 0.0651 0.18
Echinococcus multilocularis hyperpolarization activated cyclic 0.0212 0.0537 0.0537
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0024 0.0064
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0034 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.004 0.004
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0026 0.0001 0.0001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.004 0.004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.004 0.004
Onchocerca volvulus 0.0456 0.1239 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0034 0.0034
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0276 0.0719 0.0718
Echinococcus granulosus G protein coupled receptor 139 0.004 0.004 0.004
Schistosoma mansoni microtubule-associated protein tau 0.1335 0.3768 0.3768
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0252 0.0651 0.18
Leishmania major proteasome beta 2 subunit, putative 0.0617 0.1702 0.4707
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0252 0.0651 0.18
Schistosoma mansoni glutamate receptor NMDA 0.0035 0.0028 0.0028
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0252 0.0651 0.18
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0212 0.0537 0.0537
Echinococcus granulosus proteasome subunit alpha type 6 0.0252 0.0651 0.0651
Echinococcus granulosus alpha 1A adrenergic receptor 0.004 0.004 0.004
Echinococcus multilocularis g protein coupled receptor 0.004 0.004 0.004
Echinococcus multilocularis two pore calcium channel protein 2 0.0212 0.0537 0.0537
Echinococcus granulosus 7TM GPCR rhodopsin 0.004 0.004 0.004
Echinococcus granulosus proteasome subunit alpha type 2 0.0252 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Loa Loa (eye worm) ion channel NompC 0.0212 0.0537 0.0536
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0092 0.0092
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.004 0.004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.004 0.004
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0252 0.0651 0.1799
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.004 0.004
Brugia malayi Tachykinin-like peptides receptor 99D 0.004 0.004 0.0039
Echinococcus multilocularis G protein coupled receptor 139 0.004 0.004 0.004
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0212 0.0537 0.1442
Giardia lamblia 20S proteasome alpha subunit 5 0.0252 0.0651 0.1799
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0252 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Echinococcus granulosus transient receptor potential cation channel 0.0212 0.0537 0.0537
Echinococcus multilocularis proteasome subunit beta type 7 0.0252 0.0651 0.0651
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Onchocerca volvulus 0.0212 0.0537 0.4328
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Echinococcus granulosus neuropeptide receptor 0.004 0.004 0.004
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0212 0.0537 0.0536
Plasmodium falciparum proteasome subunit beta type-4 0.0252 0.0651 0.1799
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0212 0.0537 0.0537
Mycobacterium ulcerans proteasome PrcB 0.1282 0.3614 1
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0252 0.0651 0.1799
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0026 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0026 0.0071
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0035 0.0028 0.0028
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0252 0.0651 0.1799
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0212 0.0537 0.0537
Onchocerca volvulus 0.004 0.004 0.0318
Schistosoma mansoni transient receptor potential channel 0.0212 0.0537 0.0537
Mycobacterium ulcerans lipase LipD 0.0066 0.0117 0.032
Echinococcus granulosus g protein coupled receptor 0.004 0.004 0.004
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0024 0.0016
Loa Loa (eye worm) hypothetical protein 0.0476 0.1297 0.1296
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.004 0.004
Echinococcus granulosus hypothetical protein 0.0768 0.2135 0.2135
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni hypothetical protein 0.034 0.0903 0.0903
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0252 0.0651 0.18
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0117 0.0322
Echinococcus multilocularis ryanodine receptor 44f 0.0212 0.0537 0.0537
Echinococcus granulosus microtubule associated protein 2 0.1335 0.3768 0.3768
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0401 0.1079 0.1079
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1282 0.3614 1
Loa Loa (eye worm) transcription factor SMAD2 0.0227 0.0579 0.0578
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Leishmania major hypothetical protein, conserved 0.0066 0.0117 0.0323
Echinococcus multilocularis serotonin receptor 0.004 0.004 0.004
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0212 0.0537 0.1483
Echinococcus multilocularis proteasome subunit beta type 6 0.0252 0.0651 0.0651
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.041 0.041
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0252 0.0651 0.1799
Echinococcus granulosus serotonin receptor 0.004 0.004 0.004
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0252 0.0651 0.1799
Schistosoma mansoni jumonji/arid domain-containing protein 0.0031 0.0017 0.0017
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0212 0.0537 0.0537
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Onchocerca volvulus 0.004 0.004 0.0318
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0252 0.0651 0.18
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus granulosus voltage gated potassium channel 0.0212 0.0537 0.0537
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0252 0.0651 0.18
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.004 0.004 0.0039
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.004 0.0039
Echinococcus granulosus PHD finger protein rhinoceros 0.0026 0.0001 0.0001
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.004 0.004 0.004
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Onchocerca volvulus 0.0066 0.0117 0.094
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.004 0.004
Echinococcus multilocularis potassium large conductance calcium activated 0.0212 0.0537 0.0537
Brugia malayi Serotonin/octopamine receptor family protein 7 0.004 0.004 0.0039
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0252 0.0651 0.0651
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.004 0.004 0.004
Onchocerca volvulus 0.004 0.004 0.0318
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0895 0.25 0.25
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0252 0.0651 0.176
Loa Loa (eye worm) hypothetical protein 0.0066 0.0117 0.0116
Trichomonas vaginalis D-aminoacylase, putative 0.0066 0.0117 0.0323
Onchocerca volvulus 0.0097 0.0206 0.1657
Echinococcus granulosus neuropeptide receptor A26 0.004 0.004 0.004
Brugia malayi Transient-receptor-potential like protein 0.0212 0.0537 0.0536
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0212 0.0537 0.0536
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.041 0.041
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.004 0.004 0.004
Brugia malayi Muscleblind-like protein 0.0165 0.0401 0.04
Brugia malayi G protein-coupled receptor 0.004 0.004 0.0039
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0212 0.0537 0.1483
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.004 0.004 0.0039
Loa Loa (eye worm) MH2 domain-containing protein 0.0227 0.0579 0.0578
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0034 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.004 0.004 0.004
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0252 0.0651 0.176
Brugia malayi Melatonin receptor type 1A 0.004 0.004 0.0039
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.004 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0429 0.1186
Mycobacterium tuberculosis Probable hydrolase 0.0066 0.0117 0.032
Echinococcus multilocularis g protein coupled receptor 0.004 0.004 0.004
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.004 0.004
Onchocerca volvulus 0.004 0.004 0.0318
Brugia malayi Proteasome A-type and B-type family protein 0.0252 0.0651 0.065
Loa Loa (eye worm) hypothetical protein 0.0026 0.0002 0.0001
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.004 0.004
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0252 0.0651 0.1799
Echinococcus granulosus sodium leak channel non selective protein 0.0212 0.0537 0.0537
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0252 0.0651 0.18
Onchocerca volvulus 0.0163 0.0396 0.3191
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0034 0.0033
Brugia malayi Proteasome A-type and B-type family protein 0.1282 0.3614 0.3614
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0252 0.0651 0.1799
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.0092 0.0092
Brugia malayi proteasome subunit beta type 1 0.0996 0.2792 0.2791
Echinococcus granulosus expressed conserved protein 0.0095 0.0201 0.0201
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0252 0.0651 0.18
Loa Loa (eye worm) voltage-gated potassium channel 0.0212 0.0537 0.0536
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0252 0.0651 0.1799
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.004 0.004
Schistosoma mansoni opsin-like receptor 0.004 0.004 0.004
Echinococcus granulosus transient receptor potential cation channel 0.0212 0.0537 0.0537
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0212 0.0537 0.0537
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0212 0.0537 0.0537
Echinococcus multilocularis voltage gated potassium channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni amine GPCR 0.0214 0.0543 0.0543
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0252 0.0651 0.18
Echinococcus multilocularis proteasome (prosome, macropain) 0.1282 0.3614 0.3614
Brugia malayi Pre-SET motif family protein 0.0057 0.0092 0.0091
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0212 0.0537 0.0536
Brugia malayi putative neuropeptide receptor 0.004 0.004 0.0039
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0057 0.0092 0.0092
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0066 0.0117 0.0116
Echinococcus multilocularis glutamate receptor 2 0.0035 0.0028 0.0028
Echinococcus multilocularis potassium voltage gated channel protein 0.0212 0.0537 0.0537
Echinococcus granulosus sex peptide receptor 0.004 0.004 0.004
Toxoplasma gondii transporter, cation channel family protein 0.0212 0.0537 0.1483
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0252 0.0651 0.065
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Trichomonas vaginalis penicillin-binding protein, putative 0.0066 0.0117 0.0323
Loa Loa (eye worm) hypothetical protein 0.0026 0.0002 0.0001
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0252 0.0651 0.18
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Loa Loa (eye worm) RNA binding protein 0.0276 0.0719 0.0718
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.3502 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.004 0.004
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0212 0.0537 0.0537
Echinococcus granulosus voltage gated potassium channel 0.0212 0.0537 0.0537
Trichomonas vaginalis esterase, putative 0.0066 0.0117 0.0323
Echinococcus multilocularis transient receptor potential cation channel 0.0212 0.0537 0.0537
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0219 0.0218
Echinococcus granulosus beta LACTamase domain containing family member 0.0066 0.0117 0.0117
Schistosoma mansoni amine GPCR 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0085 0.0084
Echinococcus multilocularis protein dispatched 1 0.005 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0102 0.0219 0.0218
Echinococcus granulosus glutamate NMDA receptor subunit 0.0082 0.0161 0.0161
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0252 0.0651 0.176
Loa Loa (eye worm) hypothetical protein 0.0066 0.0117 0.0116
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0212 0.0537 0.0537
Brugia malayi jmjC domain containing protein 0.0085 0.017 0.0169
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0693 0.1915
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0252 0.0651 0.1799
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Echinococcus multilocularis expressed conserved protein 0.0095 0.0201 0.0201
Echinococcus multilocularis serotonin receptor 0.004 0.004 0.004
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.009 0.0248
Mycobacterium tuberculosis Conserved protein 0.0066 0.0117 0.032
Echinococcus multilocularis hyperpolarization activated cyclic 0.0212 0.0537 0.0537
Echinococcus multilocularis shaker cognate 0.0212 0.0537 0.0537
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0252 0.0651 0.18
Plasmodium vivax proteasome subunit beta type-6, putative 0.0252 0.0651 0.1799
Mycobacterium leprae conserved hypothetical protein 0.0066 0.0117 0.032
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.004 0.004
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0212 0.0537 0.4328
Schistosoma mansoni alpha-glucosidase 0.0145 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.0066 0.0117 0.0116
Brugia malayi RNA binding protein 0.0276 0.0719 0.0718
Loa Loa (eye worm) hypothetical protein 0.0044 0.0052 0.0051
Loa Loa (eye worm) calcium channel 0.3502 1 1
Brugia malayi beta-lactamase family protein 0.0066 0.0117 0.0116
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0252 0.0651 0.18
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.004 0.004
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0252 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Schistosoma mansoni tar DNA-binding protein 0.0276 0.0719 0.0719
Schistosoma mansoni two-pore calcium channel 0.0212 0.0537 0.0537
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.1282 0.3614 1
Toxoplasma gondii proteasome beta subunit 0.0252 0.0651 0.1799
Trypanosoma brucei glucosidase, putative 0.0037 0.0034 0.0044
Echinococcus multilocularis somatostatin receptor 0.004 0.004 0.004
Loa Loa (eye worm) follicle stimulating hormone receptor 0.004 0.004 0.0039
Echinococcus granulosus proteasome subunit beta type 6 0.0252 0.0651 0.0651
Brugia malayi TAR-binding protein 0.0276 0.0719 0.0718
Onchocerca volvulus 0.004 0.004 0.0318
Brugia malayi RNA, U transporter 1 0.009 0.0187 0.0186
Echinococcus granulosus importin subunit beta 1 0.0032 0.0018 0.0018
Schistosoma mansoni opsin-like receptor 0.004 0.004 0.004
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.1282 0.3614 1
Echinococcus granulosus proteasome subunit beta t family 0.0252 0.0651 0.0651
Echinococcus multilocularis voltage gated potassium channel 0.0212 0.0537 0.0537
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0083 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Giardia lamblia Deoxynucleoside kinase 0.0723 0.2006 0.5548
Brugia malayi AKH receptor 0.004 0.004 0.0039
Schistosoma mansoni growth hormone secretagogue receptor 0.004 0.004 0.004
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.004 0.004
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0212 0.0537 0.0537
Brugia malayi jmjC domain containing protein 0.0031 0.0017 0.0016
Schistosoma mansoni amine GPCR 0.004 0.004 0.004
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0212 0.0537 0.0537
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0252 0.0651 0.176
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Brugia malayi proteasome subunit alpha type 3 0.0252 0.0651 0.065
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0219 0.0219
Schistosoma mansoni hypothetical protein 0.004 0.004 0.004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0115 0.0256 0.0255
Schistosoma mansoni hypothetical protein 0.0036 0.0031 0.0031
Brugia malayi Proteasome subunit alpha type 1 0.0252 0.0651 0.065
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.004 0.0039
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0026 0.0025
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0115 0.0256 0.0255
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0996 0.2792 0.7723
Brugia malayi beta-lactamase family protein 0.0066 0.0117 0.0116
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0578 0.159 0.4399
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.004 0.004 0.004
Echinococcus granulosus neuropeptide FF receptor 2 0.004 0.004 0.004
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0252 0.0651 0.1799
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0212 0.0537 0.0537
Echinococcus multilocularis fmrfamide receptor 0.004 0.004 0.004
Echinococcus multilocularis G-protein coupled receptor, putative 0.004 0.004 0.004
Toxoplasma gondii ABC1 family protein 0.0066 0.0117 0.0322
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0252 0.0651 0.18
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.004 0.004
Onchocerca volvulus 0.004 0.004 0.0318
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0252 0.0651 0.1799
Echinococcus granulosus hyperpolarization activated cyclic 0.0212 0.0537 0.0537
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.004 0.004
Echinococcus multilocularis neuropeptide receptor A26 0.004 0.004 0.004
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.0628 0.0628
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0018 0.0018
Echinococcus granulosus g protein coupled receptor 0.004 0.004 0.004
Echinococcus granulosus Proteasome subunit alpha beta 0.0252 0.0651 0.0651
Toxoplasma gondii proteasome subunit alpha type, putative 0.0252 0.0651 0.1799
Echinococcus multilocularis sodium leak channel non selective protein 0.0212 0.0537 0.0537
Echinococcus multilocularis peregrin 0.0026 0.0001 0.0001
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0252 0.0651 0.0651
Schistosoma mansoni hypothetical protein 0.0036 0.0031 0.0031
Schistosoma mansoni alpha-1 adrenergic receptor 0.004 0.004 0.004
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.004 0.004 0.0039
Schistosoma mansoni transient receptor potential channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) STAT protein 0.0174 0.0427 0.0426
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.004 0.004
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0031 0.0031
Trypanosoma brucei C-8 sterol isomerase, putative 0.0578 0.159 0.4372
Schistosoma mansoni hypothetical protein 0.004 0.004 0.004
Echinococcus multilocularis transient receptor potential cation channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.0057 0.0092 0.0091
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0252 0.0651 0.18
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0002 0.0003
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0066 0.0117 0.032
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0252 0.0651 0.0651
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.004 0.004
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0035 0.0028 0.0028
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0693 0.1915
Brugia malayi proteasome subunit alpha type 1 0.0252 0.0651 0.065
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Onchocerca volvulus 0.004 0.004 0.0318
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0066 0.0117 0.032
Loa Loa (eye worm) TYRA-2 protein 0.004 0.004 0.0039
Schistosoma mansoni peptide (allatostatin)-like receptor 0.004 0.004 0.004
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.0429 0.3461
Schistosoma mansoni neuropeptide receptor 0.004 0.004 0.004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0066 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Loa Loa (eye worm) hypothetical protein 0.0476 0.1297 0.1296
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Echinococcus granulosus thyrotropin releasing hormone receptor 0.004 0.004 0.004
Echinococcus granulosus transient receptor potential cation channel 0.0212 0.0537 0.0537
Schistosoma mansoni hypothetical protein 0.0042 0.0047 0.0047
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.006 0.0099 0.5
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0252 0.0651 0.18
Schistosoma mansoni tar DNA-binding protein 0.0276 0.0719 0.0719
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0031 0.003
Schistosoma mansoni hypothetical protein 0.0036 0.0031 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.004 0.004
Onchocerca volvulus 0.004 0.004 0.0318
Echinococcus granulosus nmda type glutamate receptor 0.0083 0.0167 0.0167
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Echinococcus granulosus ryanodine receptor 44f 0.0212 0.0537 0.0537
Echinococcus granulosus 7tm_1 domain containing protein 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni hypothetical protein 0.004 0.004 0.004
Leishmania major proteasome alpha 7 subunit, putative 0.0252 0.0651 0.18
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0212 0.0537 0.1483
Schistosoma mansoni hypothetical protein 0.0042 0.0047 0.0047
Echinococcus multilocularis alpha 1A adrenergic receptor 0.004 0.004 0.004
Schistosoma mansoni biogenic amine receptor 0.004 0.004 0.004
Brugia malayi hypothetical protein 0.0212 0.0537 0.0536
Echinococcus granulosus transient receptor potential cation channel 0.0212 0.0537 0.0537
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0212 0.0537 0.1483
Echinococcus multilocularis fmrfamide receptor 0.004 0.004 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Echinococcus granulosus voltage dependent calcium channel 0.3502 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0693 0.1915
Echinococcus granulosus potassium large conductance calcium activated 0.0212 0.0537 0.0537
Schistosoma mansoni hypothetical protein 0.0042 0.0047 0.0047
Plasmodium vivax ataxin-2 like protein, putative 0.0057 0.009 0.0247
Schistosoma mansoni biogenic amine receptor 0.004 0.004 0.004
Schistosoma mansoni transient receptor potential channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0252 0.0651 0.18
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Onchocerca volvulus 0.0066 0.0117 0.094
Schistosoma mansoni hypothetical protein 0.0078 0.0152 0.0152
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0252 0.0651 0.065
Echinococcus multilocularis transfer RNA-Gly 0.0212 0.0537 0.0537
Loa Loa (eye worm) beta-lactamase 0.0066 0.0117 0.0116
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0034 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0276 0.0719 0.0719
Plasmodium vivax proteasome subunit beta type-5, putative 0.1282 0.3614 1
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0617 0.1702 0.4707
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0252 0.0651 0.1798
Echinococcus multilocularis sex peptide receptor 0.004 0.004 0.004
Brugia malayi ORL1-like opioid receptor 0.004 0.004 0.0039
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0252 0.0651 0.1799
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0252 0.0651 0.1799
Plasmodium vivax importin-beta 2, putative 0.0032 0.0018 0.0047
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.006 0.0099 0.027
Schistosoma mansoni alpha glucosidase 0.0037 0.0034 0.0034
Plasmodium falciparum importin beta, putative 0.0032 0.0018 0.0047
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0252 0.0651 0.18
Trypanosoma brucei PAB1-binding protein , putative 0.0057 0.009 0.0201
Loa Loa (eye worm) hypothetical protein 0.0165 0.0401 0.04
Leishmania major hypothetical protein, conserved 0.0057 0.009 0.0248
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0017
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0617 0.1702 0.1702
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0212 0.0537 0.0537
Echinococcus granulosus voltage dependent calcium channel 0.0212 0.0537 0.0537
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0996 0.2792 0.7723
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0034 0.0091
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0252 0.0651 0.0651
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0252 0.0651 0.0651
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0034 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0693 0.1915
Schistosoma mansoni jumonji domain containing protein 0.0067 0.012 0.012
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0266 0.0693 0.0692
Echinococcus multilocularis voltage dependent calcium channel 0.3502 1 1
Brugia malayi G-protein coupled receptor 0.004 0.004 0.0039
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0252 0.0651 0.18
Schistosoma mansoni myosin xvIII 0.004 0.004 0.004
Trichomonas vaginalis rotamase, putative 0.0035 0.0026 0.0071
Echinococcus multilocularis short transient receptor potential channel 6 0.0212 0.0537 0.0537
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.007 0.0069
Onchocerca volvulus Notchless protein homolog 0.0252 0.0651 0.5253
Echinococcus multilocularis PHD finger protein rhinoceros 0.0026 0.0001 0.0001
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0024 0.0064
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0252 0.0651 0.18
Toxoplasma gondii transporter, cation channel family protein 0.0212 0.0537 0.1483
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0252 0.0651 0.18
Loa Loa (eye worm) hypothetical protein 0.0044 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0085 0.017 0.017
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.004 0.004
Plasmodium vivax proteasome subunit beta type-7, putative 0.0252 0.0651 0.1799
Schistosoma mansoni opsin-like receptor 0.004 0.004 0.004
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.004 0.004 0.004
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0252 0.0651 0.0651
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0252 0.0651 0.0651
Leishmania major proteasome beta 3 subunit, putative 0.0252 0.0651 0.18
Echinococcus multilocularis lysine specific demethylase 5A 0.0031 0.0017 0.0017
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0212 0.0537 0.0536
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0034 0.0092
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0034 0.0092
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0031 0.0031
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0212 0.0537 0.0536
Echinococcus granulosus tachykinin peptides receptor 99D 0.004 0.004 0.004
Schistosoma mansoni hypothetical protein 0.005 0.007 0.007
Echinococcus granulosus transient receptor potential cation channel 0.0212 0.0537 0.0537
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Echinococcus multilocularis allatostatin A receptor 0.004 0.004 0.004
Echinococcus granulosus allatostatin A receptor 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0212 0.0537 0.0537
Echinococcus multilocularis short transient receptor potential channel 6 0.0212 0.0537 0.0537
Schistosoma mansoni histamine h1 receptor 0.004 0.004 0.004
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0252 0.0651 0.18
Leishmania major proteasome beta 5 subunit, putative 0.1282 0.3614 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0424 0.1146 0.3167
Onchocerca volvulus 0.004 0.004 0.0318
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0252 0.0651 0.18
Schistosoma mansoni voltage-gated ion channel 0.0212 0.0537 0.0537
Schistosoma mansoni hypothetical protein 0.0026 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0252 0.0651 0.1799
Mycobacterium ulcerans proteasome PrcA 0.0252 0.0651 0.1798
Onchocerca volvulus 0.004 0.004 0.0318
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.004 0.004 0.004
Leishmania major proteasome alpha 2 subunit, putative 0.0252 0.0651 0.18
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.004 0.004 0.004
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0252 0.0651 0.0651
Schistosoma mansoni vesicular amine transporter 0.0212 0.0537 0.0537
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0252 0.0651 0.0651
Leishmania major proteasome beta 7 subunit, putative 0.0252 0.0651 0.18
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0212 0.0537 0.0537
Loa Loa (eye worm) TAR-binding protein 0.0276 0.0719 0.0718
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.041 0.0409
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.004 0.004
Leishmania major proteasome alpha 1 subunit, putative 0.0252 0.0651 0.18
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0693 0.1915
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Toxoplasma gondii heat shock protein hslv, putative 0.0252 0.0651 0.1799
Mycobacterium leprae proteasome (beta subunit) PrcB 0.1282 0.3614 1
Brugia malayi G protein-coupled receptor F59B2.13 0.004 0.004 0.0039
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0219 0.0603
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.009 0.0247
Schistosoma mansoni voltage-dependent calcium channel 0.0212 0.0537 0.0537
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0252 0.0651 0.176
Schistosoma mansoni rotamase 0.0035 0.0026 0.0026
Onchocerca volvulus 0.0026 0.0002 0.0006
Trypanosoma brucei proteasome alpha 7 subunit 0.0252 0.0651 0.176
Schistosoma mansoni patched 1 0.0044 0.0052 0.0052
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0212 0.0537 0.0537
Brugia malayi RNA recognition motif domain containing protein 0.0276 0.0719 0.0718
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0252 0.0651 0.065
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0212 0.0537 0.0536
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0252 0.0651 0.18
Echinococcus granulosus expressed protein 0.0035 0.0026 0.0026
Echinococcus multilocularis transient receptor potential cation channel 0.0212 0.0537 0.0537
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0617 0.1702 0.4707
Echinococcus granulosus TRP transient receptor potential channel 0.0212 0.0537 0.0537
Giardia lamblia Proteasome subunit beta type 5 precursor 0.1282 0.3614 1
Onchocerca volvulus 0.004 0.004 0.0318
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.004 0.004
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0252 0.0651 0.18
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.041 0.0409
Echinococcus multilocularis g-protein coupled receptor 0.004 0.004 0.004
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.3502 1 1
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0252 0.0651 0.18
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0212 0.0537 0.0537
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0252 0.0651 0.18
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0252 0.0651 0.1799
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0212 0.0537 0.0536
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0693 0.1915
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0212 0.0537 0.0536
Echinococcus multilocularis muscleblind protein 0.0165 0.0401 0.0401
Onchocerca volvulus 0.004 0.004 0.0318
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0617 0.1702 0.1702
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0212 0.0537 0.0536
Echinococcus granulosus transient receptor potential cation channel 0.0212 0.0537 0.0537
Echinococcus granulosus subfamily T1A non peptidase ue 0.0252 0.0651 0.0651
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0252 0.0651 0.18
Onchocerca volvulus 0.004 0.004 0.0318
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0212 0.0537 0.0537
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0252 0.0651 0.18
Schistosoma mansoni neuropeptide receptor 0.004 0.004 0.004
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0252 0.0651 0.0651
Echinococcus granulosus shaker cognate 0.0212 0.0537 0.0537
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.041 0.041
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.004 0.004
Onchocerca volvulus 0.004 0.004 0.0318
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.0344 0.0344
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.004 0.004 0.004
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0082 0.0161 0.0161
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0252 0.0651 0.0651
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0018 0.0047
Trichomonas vaginalis rotamase, putative 0.0034 0.0024 0.0064
Echinococcus granulosus dro:myosuppressin receptor 0.004 0.004 0.004
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0996 0.2792 0.7723
Loa Loa (eye worm) hypothetical protein 0.0066 0.0117 0.0116
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0212 0.0537 0.0537
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0252 0.0651 0.0651
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0578 0.159 0.159
Schistosoma mansoni transient receptor potential channel 4 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.0163 0.0396 0.0395
Echinococcus multilocularis tumor protein p63 0.1115 0.3134 0.3134
Loa Loa (eye worm) proteasome subunit beta type 1 0.0996 0.2792 0.2791
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0212 0.0537 0.0536
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0252 0.0651 0.1798
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.004 0.004
Schistosoma mansoni 60S ribosomal protein L21 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.004 0.004
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0252 0.0651 0.176
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0252 0.0651 0.065
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0252 0.0651 0.1799
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0252 0.0651 0.18
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.3502 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0212 0.0537 0.0537
Echinococcus multilocularis neuropeptide receptor 0.004 0.004 0.004
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0212 0.0537 0.4328
Schistosoma mansoni hypothetical protein 0.0075 0.0141 0.0141
Echinococcus multilocularis proteasome subunit alpha type 2 0.0252 0.0651 0.0651
Echinococcus granulosus potassium voltage gated channel protein 0.0212 0.0537 0.0537
Trypanosoma brucei hypothetical protein, conserved 0.0066 0.0117 0.0276
Leishmania major proteasome alpha 3 subunit, putative 0.0252 0.0651 0.18
Echinococcus granulosus proteasome subunit beta type 7 0.0252 0.0651 0.0651
Onchocerca volvulus 0.005 0.007 0.0555
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0429 0.1186
Brugia malayi hypothetical protein 0.0075 0.0141 0.014
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.006 0.0099 0.5
Schistosoma mansoni alpha-glucosidase 0.0145 0.0343 0.0343
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0252 0.0651 0.18
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Plasmodium falciparum proteasome subunit beta type-5 0.1282 0.3614 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.004 0.004 0.004
Schistosoma mansoni neuropeptide receptor 0.004 0.004 0.004
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0617 0.1702 0.4707
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0429 0.1186
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0152 0.0151
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0092 0.0092
Brugia malayi GnHR receptor homolog 0.004 0.004 0.0039
Echinococcus granulosus short transient receptor potential channel 6 0.0212 0.0537 0.0537
Echinococcus granulosus glutamate receptor 2 0.0035 0.0028 0.0028
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0052 0.0051
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.3502 1 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0034 0.0092
Echinococcus granulosus tumor protein p63 0.1115 0.3134 0.3134
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0252 0.0651 0.065
Echinococcus multilocularis potassium voltage gated channel protein 0.0212 0.0537 0.0537
Schistosoma mansoni tar DNA-binding protein 0.0276 0.0719 0.0719
Brugia malayi STAT protein, DNA binding domain containing protein 0.0174 0.0427 0.0426
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0212 0.0537 0.0536
Mycobacterium tuberculosis Conserved protein 0.0066 0.0117 0.032
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0024 0.0063
Giardia lamblia 20S proteasome alpha subunit 2 0.0252 0.0651 0.1799
Trichomonas vaginalis penicillin-binding protein, putative 0.0066 0.0117 0.0323
Brugia malayi Proteasome A-type and B-type family protein 0.0252 0.0651 0.065
Brugia malayi Serotonin receptor 0.004 0.004 0.0039
Brugia malayi neuropeptide F receptor 0.004 0.004 0.0039
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0035 0.0028 0.0028
Echinococcus granulosus potassium voltage gated channel protein 0.0212 0.0537 0.0537
Echinococcus granulosus somatostatin receptor 0.004 0.004 0.004
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0252 0.0651 0.0651
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0141 0.0141
Echinococcus multilocularis jumonji domain containing protein 0.0036 0.003 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.004 0.004
Echinococcus multilocularis transient receptor potential cation channel 0.0212 0.0537 0.0537
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0996 0.2792 0.2792
Loa Loa (eye worm) jmjC domain-containing protein 0.0053 0.008 0.0079
Echinococcus granulosus snurportin 1 0.034 0.0903 0.0903
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0141 0.0141
Schistosoma mansoni jumonji/arid domain-containing protein 0.0031 0.0017 0.0017
Echinococcus multilocularis GPCR, family 2 0.0036 0.0031 0.0031
Brugia malayi RE15519p 0.004 0.004 0.0039
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0266 0.0693 0.0692
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0066 0.0117 0.0117
Brugia malayi proteasome subunit beta type 2 0.0617 0.1702 0.1701
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0141 0.0141
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0212 0.0537 0.0537
Mycobacterium tuberculosis Conserved protein 0.0066 0.0117 0.032
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0252 0.0651 0.18
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.3502 1 1
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0252 0.0651 0.0651
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0212 0.0537 0.0536
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0252 0.0651 0.18
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0212 0.0537 0.0537
Schistosoma mansoni glutamate receptor NMDA 0.0082 0.0161 0.0161
Brugia malayi cation channel family protein 0.0212 0.0537 0.0536
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0031 0.0031
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.006 0.0099 0.027
Loa Loa (eye worm) ryanodine receptor 0.0212 0.0537 0.0536
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.004 0.004 0.004
Leishmania major proteasome alpha 7 subunit, putative 0.0252 0.0651 0.18
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0212 0.0537 0.0537
Giardia lamblia 20S proteasome alpha subunit 3 0.0252 0.0651 0.1799
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0252 0.0651 0.065
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0252 0.0651 0.18
Echinococcus multilocularis protein patched 0.0044 0.0052 0.0052
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0252 0.0651 0.18
Plasmodium vivax proteasome subunit beta type-1, putative 0.0996 0.2792 0.7723
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Brugia malayi Importin beta-1 subunit 0.0032 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus granulosus peptide allatostatin:somatostatin 0.004 0.004 0.004
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0617 0.1702 0.1702
Echinococcus multilocularis neuropeptide receptor 0.004 0.004 0.004
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0034 0.0092
Chlamydia trachomatis glutamine binding protein 0.006 0.0099 0.5
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0252 0.0651 0.18
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0456 0.1261
Echinococcus granulosus neuropeptide Y receptor 0.004 0.004 0.004
Giardia lamblia Proteasome subunit beta type 1 0.0996 0.2792 0.7723
Loa Loa (eye worm) hypothetical protein 0.0199 0.0498 0.0497
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0252 0.0651 0.1799
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Toxoplasma gondii transporter, cation channel family protein 0.0212 0.0537 0.1483
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0212 0.0537 0.0537
Brugia malayi proteasome subunit alpha type 2 0.0252 0.0651 0.065
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Echinococcus multilocularis expressed protein 0.0035 0.0026 0.0026
Echinococcus multilocularis expressed protein 0.0387 0.1041 0.1041
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0252 0.0651 0.18
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni neuropeptide f receptor 76f 0.004 0.004 0.004
Echinococcus granulosus neuropeptide s receptor 0.004 0.004 0.004
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0002 0.0001
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.1282 0.3614 0.3614
Brugia malayi voltage-dependent calcium channel 0.0212 0.0537 0.0536
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0212 0.0537 0.0536
Echinococcus granulosus potassium voltage gated channel protein 0.0212 0.0537 0.0537
Loa Loa (eye worm) proteasome subunit beta type 3 0.0252 0.0651 0.065
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Echinococcus granulosus potassium voltage gated channel protein 0.0212 0.0537 0.0537
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0252 0.0651 0.0651
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0429 0.1186
Plasmodium vivax proteasome subunit beta type-3, putative 0.0252 0.0651 0.1799
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.004 0.004
Brugia malayi hypothetical protein 0.0244 0.0628 0.0627
Brugia malayi cation channel family protein 0.0212 0.0537 0.0536
Echinococcus granulosus calcium activated potassium channel 0.0212 0.0537 0.0537
Schistosoma mansoni hypothetical protein 0.0042 0.0047 0.0047
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0212 0.0537 0.0537
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0066 0.0117 0.032
Brugia malayi Dopamine receptor protein 1 0.004 0.004 0.0039
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0219 0.0219
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0252 0.0651 0.18
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0212 0.0537 0.0537
Mycobacterium tuberculosis Probable esterase LipL 0.0066 0.0117 0.032
Brugia malayi follicle stimulating hormone receptor 0.004 0.004 0.0039
Brugia malayi putative neuropeptide receptor NPR1 0.004 0.004 0.0039
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0002 0.0001
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.006 0.0099 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.004 0.004
Echinococcus granulosus fmrfamide receptor 0.004 0.004 0.004
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0252 0.0651 0.0651
Giardia lamblia 20S proteasome alpha subunit 4 0.0252 0.0651 0.1799
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0034 0.0092
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0055 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.004 0.004 0.0039
Echinococcus multilocularis transient receptor potential gamma protein 0.0212 0.0537 0.0537
Echinococcus granulosus GPCR family 2 0.0036 0.0031 0.0031
Echinococcus granulosus Proteasome subunit alpha type 7 0.0252 0.0651 0.0651
Schistosoma mansoni neuropeptide receptor 0.004 0.004 0.004

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 10.9 nM Partial agonist activity at human cannabinoid CB2 receptor expressed in CHO-K1 cells assessed as [S35]GTPgammaS binding by scintillation counting ChEMBL. 25072877
EC50 (binding) = 87.5 nM Partial agonist activity at human cannabinoid CB1 receptor expressed in CHO-K1 cells assessed as [S35]GTPgammaS binding by scintillation counting ChEMBL. 25072877
Emax (binding) = 146 % Partial agonist activity at human cannabinoid CB2 receptor expressed in CHO-K1 cells assessed as [S35]GTPgammaS binding by scintillation counting relative to vehicle treated control ChEMBL. 25072877
Emax (binding) = 240 % Partial agonist activity at human cannabinoid CB1 receptor expressed in CHO-K1 cells assessed as [S35]GTPgammaS binding by scintillation counting relative to vehicle treated control ChEMBL. 25072877
Ki (binding) = 5 nM Displacement of [3H]CP55940 from human cannabinoid CB1 receptor expressed in CHO-K1 cells by liquid scintillation counting ChEMBL. 25072877
Ki (binding) = 17 nM Displacement of [3H]CP55940 from human cannabinoid CB2 receptor expressed in CHO-K1 cells by liquid scintillation counting ChEMBL. 25072877

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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