Detailed information for compound 927936

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 327.321 | Formula: C15H12F3NO2S
  • H donors: 0 H acceptors: 0 LogP: 4.75 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC(Oc1ccc2c(c1)C[C@H]1ON2[C@@H](C1)c1cccs1)(F)F
  • InChi: 1S/C15H12F3NO2S/c16-15(17,18)20-10-3-4-12-9(6-10)7-11-8-13(19(12)21-11)14-2-1-5-22-14/h1-6,11,13H,7-8H2/t11-,13+/m1/s1
  • InChiKey: YEJVABOLZHNQJU-YPMHNXCESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0301
Schistosoma mansoni hypothetical protein 0.0123 0.1348 0.726
Schistosoma mansoni hypothetical protein 0.005 0.0482 0.2594
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0084 0.0403
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.029 0.1517
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2309 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0084 0.0357
Onchocerca volvulus Protein cycle homolog 0.0018 0.0093 0.0033
Schistosoma mansoni lamin 0.0026 0.0193 0.1037
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0084 0.0403
Echinococcus multilocularis musashi 0.0026 0.0193 0.099
Brugia malayi jmjC domain containing protein 0.0093 0.0993 0.4297
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0581 0.2437
Echinococcus multilocularis thyroid hormone receptor alpha 0.014 0.1555 0.8364
Echinococcus multilocularis lamin dm0 0.0026 0.0193 0.099
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0301
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.029 0.1517
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0026 0.0185 0.0705
Onchocerca volvulus 0.0026 0.0185 0.0393
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0067 0.2968
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0268 0.0918
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0226 0.1173
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0272 0.1086
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0311 0.5331
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0268 0.1067
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.003 0.0108
Loa Loa (eye worm) hypothetical protein 0.0033 0.0272 0.1086
Brugia malayi Bromodomain containing protein 0.0028 0.0218 0.0938
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0218 0.085
Brugia malayi Pre-SET motif family protein 0.0029 0.0226 0.0973
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0583 1
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0084 0.0357
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0226 0.1218
Schistosoma mansoni coup transcription factor 0.0017 0.0084 0.0453
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0583 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0218 0.085
Echinococcus granulosus dna polymerase kappa 0.0059 0.0583 0.3102
Schistosoma mansoni DNA polymerase eta 0.0033 0.0272 0.1465
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0272 0.1421
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0218 0.1129
Brugia malayi hypothetical protein 0.0025 0.0172 0.0738
Onchocerca volvulus 0.0231 0.2645 1
Echinococcus granulosus bloom syndrome protein 0.0023 0.0158 0.0803
Schistosoma mansoni hypothetical protein 0.0035 0.0298 0.1604
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0172 0.2952
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0018 0.0093 0.0499
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0158 0.0803
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0172 0.7886
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0158 0.0677
Onchocerca volvulus 0.0029 0.0226 0.0555
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0583 0.0583
Trypanosoma brucei unspecified product 0.0023 0.015 0.2568
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0084 0.0357
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0046 0.0098
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0583 0.0583
Brugia malayi nuclear hormone receptor 0.0017 0.0084 0.0357
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0018 0.0093 0.0394
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0158 0.0499
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0218 0.964
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0298 0.1604
Entamoeba histolytica hypothetical protein 0.0035 0.0298 1
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0084 0.0403
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0226 0.1218
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0172 0.2952
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0264
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0084 0.0453
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0218 0.1129
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.0583 0.2122
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0227 0.389
Plasmodium vivax SET domain protein, putative 0.0029 0.0226 1
Brugia malayi hypothetical protein 0.012 0.1309 0.5665
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0099 0.0533
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0264
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0084 0.0403
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0845 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0264
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0226 0.1218
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0084 0.0264
Loa Loa (eye worm) hypothetical protein 0.012 0.1309 0.5623
Brugia malayi PHD-finger family protein 0.0028 0.0218 0.0938
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0259 0.4437
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0018 0.0093 0.0301
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0084 0.0357
Plasmodium falciparum phd finger protein, putative 0.0028 0.0218 1
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0084 0.0403
Echinococcus multilocularis lamin 0.0026 0.0193 0.099
Trypanosoma brucei DNA polymerase IV, putative 0.0052 0.0506 0.8677
Loa Loa (eye worm) hypothetical protein 0.0026 0.0187 0.0713
Giardia lamblia DINP protein human, muc B family 0.0039 0.0349 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0027 0.0784
Loa Loa (eye worm) hypothetical protein 0.012 0.1309 0.5623
Schistosoma mansoni hypothetical protein 0.0165 0.1857 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0172 0.7602
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0084 0.0264
Trichomonas vaginalis rotamase, putative 0.0033 0.0268 0.0918
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0264
Loa Loa (eye worm) hypothetical protein 0.0026 0.0193 0.0739
Onchocerca volvulus Alhambra homolog 0.0028 0.0218 0.0523
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.1348 0.7246
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0272 0.4669
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0124 0.5681
Loa Loa (eye worm) hypothetical protein 0.0049 0.0462 0.1915
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0084 0.0403
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0084 0.0357
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0084 0.0264
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0583 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0226 0.0886
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0172 0.7886
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0764 0.4113
Schistosoma mansoni hypothetical protein 0.0011 0.001 0.0052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0084 0.0403
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0311 0.5331
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.029 0.156
Echinococcus granulosus geminin 0.0165 0.1857 1
Brugia malayi hypothetical protein 0.0018 0.0093 0.0394
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0084 0.0264
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0272 0.1465
Echinococcus granulosus lamin 0.0026 0.0193 0.099
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0084 0.0453
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0272 0.1172
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0084 0.0403
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2645 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0084 0.0357
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0272 0.1465
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0583 1
Brugia malayi hypothetical protein 0.0035 0.0298 0.1284
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0268 0.1153
Brugia malayi hypothetical protein 0.0016 0.0068 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0084 0.0357
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0218 0.8436
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0583 1
Trypanosoma brucei unspecified product 0.0052 0.0506 0.8677
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0084 0.0357
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0172 0.6653
Loa Loa (eye worm) hypothetical protein 0.0025 0.0172 0.0649
Brugia malayi polk-prov protein 0.0036 0.0311 0.1339
Loa Loa (eye worm) RecQ helicase 0.0023 0.0158 0.0587
Brugia malayi jmjC domain containing protein 0.0034 0.029 0.1249
Onchocerca volvulus 0.0026 0.0193 0.0423
Echinococcus multilocularis dna polymerase eta 0.0033 0.0272 0.1421
Trichomonas vaginalis rotamase, putative 0.0032 0.0259 0.0883
Loa Loa (eye worm) hypothetical protein 0.0026 0.0185 0.0705
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0084 0.0403
Brugia malayi nuclear receptor NHR-88 0.0017 0.0084 0.0357
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0583 1
Schistosoma mansoni intermediate filament proteins 0.0026 0.0193 0.1037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0084 0.0264
Echinococcus multilocularis dna polymerase kappa 0.0059 0.0583 0.3102
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0084 0.0357
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0272 0.4669
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0193 0.0739
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0084 0.0403
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0352 0.1851
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0084 0.0264
Schistosoma mansoni rotamase 0.0033 0.0268 0.1442
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0993 0.5323
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0264
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0259 0.4437
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0084 0.0453
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0018 0.0093 0.0394
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0018 0.0093 0.0394
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.0583 0.2122
Brugia malayi steroid hormone receptor 0.0017 0.0084 0.0357
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0027 0.047
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0065 0.2511
Leishmania major hypothetical protein, conserved 0.0025 0.0172 0.4927
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0349 1
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0046 0.0193
Echinococcus granulosus peregrin 0.0028 0.0218 0.1129
Schistosoma mansoni lamin 0.0026 0.0193 0.1037
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0084 0.0357
Brugia malayi Pre-SET motif family protein 0.0203 0.2309 1
Onchocerca volvulus Huntingtin homolog 0.012 0.1309 0.4782
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0583 1
Schistosoma mansoni thyroid hormone receptor 0.014 0.1555 0.8372
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0084 0.0403
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0193 0.0827
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0084 0.0403
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0259 1
Leishmania major DNA polymerase kappa, putative 0.0039 0.0349 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0298 0.156
Echinococcus multilocularis aryl hydrocarbon receptor 0.0026 0.0185 0.0949
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0084 0.0357
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0583 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.1348 0.7246
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0172 0.2952
Entamoeba histolytica hypothetical protein 0.0035 0.0298 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0272 0.9048
Leishmania major DNA polymerase eta, putative 0.0033 0.0272 0.7793
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0084 0.0453
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0218 0.1175
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0264
Echinococcus multilocularis peregrin 0.0028 0.0218 0.1129
Loa Loa (eye worm) hypothetical protein 0.0036 0.0311 0.1255
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0084 0.0357
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0084 0.0453
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0226 0.1173
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0193 0.0739
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0084 0.0403
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0027 0.047
Echinococcus granulosus aryl hydrocarbon receptor 0.0026 0.0185 0.0949
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0158 0.0499
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0583 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0084 0.0403
Giardia lamblia PHD finger protein 15 0.0028 0.0218 0.6247
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0583 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0084 0.0453
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0226 0.1218
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0583 1
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0084 0.0453
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0226 0.1173
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0349 0.0079
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0084 0.0403
Mycobacterium ulcerans proteasome PrcA 0.0845 1 1
Echinococcus multilocularis expressed protein 0.0033 0.0268 0.1397
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0264
Onchocerca volvulus Huntingtin homolog 0.012 0.1309 0.4782
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0084 0.0357
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0272 0.1421
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0301
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0084 0.0357
Onchocerca volvulus 0.0026 0.0193 0.0423
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0583 1
Entamoeba histolytica hypothetical protein 0.0035 0.0298 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.003 0.0108
Echinococcus granulosus intermediate filament protein 0.0026 0.0193 0.099
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0084 0.0357
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0084 0.0453
Brugia malayi ecdysteroid receptor 0.0017 0.0084 0.0357
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0993 0.5323
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0084 0.0453
Entamoeba histolytica hypothetical protein 0.0035 0.0298 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0583 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0259 0.7405
Loa Loa (eye worm) hypothetical protein 0.0118 0.1289 0.5538
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0227 0.389
Schistosoma mansoni thyroid hormone receptor 0.014 0.1555 0.8372
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0084 0.0403
Schistosoma mansoni hypothetical protein 0.0028 0.0218 0.1175
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.0025
Schistosoma mansoni hypothetical protein 0.0165 0.1857 1
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0583 1
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0017 0.0077 0.2981
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0298 0.156
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0583 1
Echinococcus granulosus dna polymerase eta 0.0033 0.0272 0.1421
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.029 0.1164
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0084 0.0453
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0084 0.0264
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0301
Brugia malayi intermediate filament protein 0.0026 0.0193 0.0827
Brugia malayi hypothetical protein 0.0018 0.0093 0.0394
Echinococcus granulosus lamin dm0 0.0026 0.0193 0.099
Brugia malayi hypothetical protein 0.0026 0.0185 0.0794
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0272 0.1172
Echinococcus multilocularis geminin 0.0165 0.1857 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0264
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0084 0.0264
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0226 0.8752
Echinococcus granulosus expressed protein 0.0033 0.0268 0.1397
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0084 0.0357
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0259 0.4437
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0227 0.389
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0259 0.8548
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0084 0.0403
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0218 0.8436
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0349 0.5992
Trypanosoma brucei unspecified product 0.0023 0.015 0.2568
Echinococcus granulosus jumonji domain containing protein 0.004 0.0352 0.1851
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.029 0.156
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0213 0.1103

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) > 305.8 uM Cytotoxicity against human THP1 cells ChEMBL. 25173828
IC50 (functional) = 142.7 uM Antiparasitic activity against epimastigote stage of Trypanosoma cruzi infected in Vero cells assessed as parasite growth inhibition after 24 hrs by hemocytometery ChEMBL. 25173828
IC50 (functional) = 256.4 uM Antiparasitic activity against promastigote stage of Leishmania infantum infected in THP1 cells assessed as parasite growth inhibition after 24 hrs by hemocytometery ChEMBL. 25173828

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.