Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.1052 | 1 | 1 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0052 | 0.0243 | 0.0126 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0052 | 0.0243 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0459 | 0.4216 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0082 | 0.0535 | 0.0535 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.1052 | 1 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0059 | 0.0314 | 0.0199 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.0243 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0144 | 0.0026 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0059 | 0.0314 | 0.0314 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0206 | 0.1742 | 0.1643 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0489 | 0.0375 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.1052 | 1 | 0.5 |
Onchocerca volvulus | 0.0052 | 0.0243 | 1 | |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.1052 | 1 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0118 | 0.0118 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0459 | 0.4216 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0065 | 0.0372 | 0.0257 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0118 | 0.0118 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.1052 | 1 | 1 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0059 | 0.0314 | 0.0199 |
Mycobacterium leprae | conserved hypothetical protein | 0.0039 | 0.0118 | 0.5 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.1052 | 1 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.0118 | 0.0118 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0252 | 0.2191 | 0.5058 |
Schistosoma mansoni | bromodomain containing protein | 0.0069 | 0.041 | 0.0295 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0052 | 0.0243 | 0.0127 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0052 | 0.0243 | 0.0127 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.1052 | 1 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.0143 | 0.0143 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.0118 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0189 | 0.0072 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.0118 | 0.0001 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.1052 | 1 | 0.5 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.1052 | 1 | 1 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0052 | 0.0243 | 0.0126 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.0243 | 0.0243 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.1052 | 1 | 1 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.1052 | 1 | 1 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.0243 | 0.0243 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0169 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0243 | 0.0126 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.1052 | 1 | 1 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0059 | 0.0314 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0314 | 0.0198 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0065 | 0.0372 | 0.0257 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0059 | 0.0314 | 0.0199 |
Brugia malayi | beta-lactamase | 0.0039 | 0.0118 | 0.0118 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0059 | 0.0314 | 0.0199 |
Schistosoma mansoni | hypothetical protein | 0.0317 | 0.2831 | 0.2745 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.1052 | 1 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0206 | 0.1742 | 0.1643 |
Mycobacterium leprae | Probable lipase LipE | 0.0039 | 0.0118 | 0.5 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.1052 | 1 | 1 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0052 | 0.0243 | 0.0127 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.1052 | 1 | 1 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0052 | 0.0243 | 0.0127 |
Loa Loa (eye worm) | MBCTL1 | 0.0059 | 0.0314 | 0.0198 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.1052 | 1 | 1 |
Echinococcus multilocularis | 0.1052 | 1 | 1 | |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.0243 | 0.0126 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 40 % | Inhibition of amyloid beta (1 to 42) (unknown origin) oligomerization assessed as reduction in intensity of experimental fluorescence plateau at 1:5 Abeta:compound ratio by thioflavin T assay based fluorescence microscopy | ChEMBL. | 25238173 |
Activity (binding) | = 56 % | Inhibition of amyloid beta (1 to 42) (unknown origin) oligomerization assessed as reduction in intensity of experimental fluorescence plateau at 1:10 Abeta:compound ratio by thioflavin T assay based fluorescence microscopy | ChEMBL. | 25238173 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.