Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | DNA gyrase (type II topoisomerase), subunit A | References | |
Escherichia coli | DNA gyrase, subunit B | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.043 | 0.1514 | 0.1459 |
Echinococcus multilocularis | neuroligin | 0.043 | 0.1514 | 0.1459 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0121 | 0.0276 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.0276 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.043 | 0.1514 | 0.1459 |
Giardia lamblia | DNA topoisomerase II | 0.0064 | 0.0045 | 0.5 |
Onchocerca volvulus | 0.043 | 0.1514 | 1 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2545 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2545 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.043 | 0.1514 | 0.1459 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.043 | 0.1514 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.043 | 0.1514 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2545 | 1 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0153 | 0.0402 | 0.3378 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0152 | 0.0397 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.043 | 0.1514 | 0.1459 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.1514 | 0.1459 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.043 | 0.1514 | 0.1459 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0153 | 0.0402 | 0.3378 |
Echinococcus granulosus | BC026374 protein S09 family | 0.043 | 0.1514 | 0.1459 |
Brugia malayi | Carboxylesterase family protein | 0.043 | 0.1514 | 0.1459 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.043 | 0.1514 | 0.1459 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0318 | 0.1064 | 1 |
Schistosoma mansoni | gliotactin | 0.043 | 0.1514 | 0.1459 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0318 | 0.1064 | 0.5954 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.1514 | 0.1459 |
Echinococcus granulosus | acetylcholinesterase | 0.2545 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.043 | 0.1514 | 0.1459 |
Echinococcus granulosus | carboxylesterase 5A | 0.2545 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.043 | 0.1514 | 0.1459 |
Echinococcus multilocularis | acetylcholinesterase | 0.2545 | 1 | 1 |
Onchocerca volvulus | 0.043 | 0.1514 | 1 | |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0318 | 0.1064 | 1 |
Onchocerca volvulus | 0.043 | 0.1514 | 1 | |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.043 | 0.1514 | 0.1459 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0318 | 0.1064 | 0.5954 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.043 | 0.1514 | 0.1459 |
Loa Loa (eye worm) | hypothetical protein | 0.2545 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.043 | 0.1514 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2545 | 1 | 1 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0318 | 0.1064 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.1514 | 0.1459 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.043 | 0.1514 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0121 | 0.0276 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.1514 | 0.1459 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.043 | 0.1514 | 1 |
Onchocerca volvulus | 0.043 | 0.1514 | 1 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.043 | 0.1514 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.043 | 0.1514 | 0.1459 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.043 | 0.1514 | 0.1459 |
Brugia malayi | Carboxylesterase family protein | 0.2545 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.1514 | 0.1459 |
Echinococcus granulosus | acetylcholinesterase | 0.2545 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.043 | 0.1514 | 0.1459 |
Echinococcus granulosus | neuroligin | 0.043 | 0.1514 | 0.1459 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.043 | 0.1514 | 0.1459 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0153 | 0.0402 | 0.2419 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.043 | 0.1514 | 0.1459 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0318 | 0.1064 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.1514 | 0.1459 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.1514 | 0.1459 |
Brugia malayi | Carboxylesterase family protein | 0.043 | 0.1514 | 0.1459 |
Onchocerca volvulus | 0.043 | 0.1514 | 1 | |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0088 | 0.0143 | 0.0788 |
Loa Loa (eye worm) | carboxylesterase | 0.2545 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2545 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.0276 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0069 | 0.0065 | 0.5 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0318 | 0.1064 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.043 | 0.1514 | 0.1459 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0318 | 0.1064 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 18 uM | Inhibition of Escherichia coli GyrB A2B2 subunits assessed reduction in DNA supercoiling activity by malachite green dye based by spectrophotometry | ChEMBL. | 25137573 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.