Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.3245 | 0.536 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.1355 | 0.0687 | 0.0767 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3245 | 0.536 | 0.536 |
Brugia malayi | Carboxylesterase family protein | 0.3245 | 0.536 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.3245 | 0.536 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3245 | 0.536 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3245 | 0.536 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3245 | 0.536 | 1 |
Schistosoma mansoni | integrin alpha | 0.1198 | 0.0299 | 0.0299 |
Echinococcus multilocularis | acetylcholinesterase | 0.3245 | 0.536 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.1198 | 0.0299 | 0.0299 |
Echinococcus multilocularis | integrin beta 2 | 0.1355 | 0.0687 | 0.0767 |
Echinococcus granulosus | carboxylesterase 5A | 0.3245 | 0.536 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.1829 | 0.1859 | 0.3083 |
Loa Loa (eye worm) | carboxylesterase | 0.3245 | 0.536 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.3245 | 0.536 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.3245 | 0.536 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.3245 | 0.536 | 1 |
Brugia malayi | Integrin beta pat-3 precursor | 0.1829 | 0.1859 | 0.3083 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of amyloid beta (1 to 42) (unknown origin) oligomerization assessed as reduction in intensity of experimental fluorescence plateau at 1:10 Abeta:compound ratio by thioflavin T assay based fluorescence microscopy | ChEMBL. | 25238173 | |
FC (binding) | Inhibition of amyloid beta (1 to 42) (unknown origin) oligomerization assessed as fold change in half-life of aggregation extension/reduction at 1:10 Abeta:compound ratio by thioflavin T assay based fluorescence microscopy | ChEMBL. | 25238173 | |
Inhibition (binding) | Inhibition of amyloid beta (1 to 42) (unknown origin) oligomerization assessed as fold change in half-life of aggregation extension/reduction at 1:1 Abeta:compound ratio by thioflavin T assay based fluorescence microscopy | ChEMBL. | 25238173 | |
Inhibition (binding) | Inhibition of amyloid beta (1 to 42) (unknown origin) oligomerization assessed as reduction in intensity of experimental fluorescence plateau at 1:1 Abeta:compound ratio by thioflavin T assay based fluorescence microscopy | ChEMBL. | 25238173 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.