Detailed information for compound 928029

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 589.614 | Formula: C31H32FN5O6
  • H donors: 4 H acceptors: 4 LogP: 2.87 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(c(c1)F)C(=O)NC(=O)Nc1ccc2c(c1)NC(=O)/C/2=C\c1[nH]c(c(c1C)CCC(=O)N1CCOCC1)C
  • InChi: 1S/C31H32FN5O6/c1-17-21(8-9-28(38)37-10-12-43-13-11-37)18(2)33-26(17)16-24-22-6-4-19(14-27(22)35-30(24)40)34-31(41)36-29(39)23-7-5-20(42-3)15-25(23)32/h4-7,14-16,33H,8-13H2,1-3H3,(H,35,40)(H2,34,36,39,41)/b24-16-
  • InChiKey: JWFVSAJXAAUKIH-JLPGSUDCSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fms-related tyrosine kinase 3 Starlite/ChEMBL References
Homo sapiens aurora kinase B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis glycoprotein Antigen 5 0.0022 0.0042 0.0049
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0169 0.1563 0.2165
Loa Loa (eye worm) hypothetical protein 0.0169 0.1563 0.1557
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.1689 0.5884
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0005
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0058 0.0417 0.041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0116 0.0191
Echinococcus granulosus carbonic anhydrase 0.0374 0.3679 0.511
Echinococcus granulosus smad 0.0024 0.0072 0.009
Echinococcus granulosus multidrug resistance protein 1 0.0067 0.0515 0.0707
Schistosoma mansoni hypothetical protein 0.0034 0.0172 0.0229
Schistosoma mansoni agrin 0.0058 0.0417 0.0571
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.018 0.0304
Brugia malayi SPARC precursor 0.0058 0.0417 0.0722
Entamoeba histolytica P-glycoprotein 6, putative 0.003 0.0131 0.0034
Trypanosoma brucei unspecified product 0.0024 0.0068 0.0074
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0227 0.0306
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.003 0.0131 0.0352
Trypanosoma brucei DNA polymerase eta, putative 0.0035 0.018 0.0272
Brugia malayi hypothetical protein 0.0169 0.1563 0.2737
Echinococcus granulosus transcription factor Dp 1 0.004 0.0227 0.0306
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.1061 1
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0097 0.0816 0.1434
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.0999 0.138
Leishmania major hypothetical protein, conserved 0.0018 0.0007 0.0012
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0097 0.0816 0.2215
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0005
Trichomonas vaginalis ABC transporter, putative 0.0097 0.0816 0.2188
Plasmodium vivax ABC transporter B family member 7, putative 0.003 0.0131 0.0376
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0464 0.0773
Echinococcus granulosus roundabout 2 0.0019 0.0012 0.0007
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0569 0.569 1
Echinococcus granulosus agrin 0.0058 0.0417 0.0571
Leishmania major protein kinase, putative 0.0068 0.0522 0.0918
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0215 0.0377
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0189 0.032
Echinococcus granulosus multidrug resistance protein 1 0.0097 0.0816 0.1126
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0342 0.3345 0.4646
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0468 0.0641
Brugia malayi Trypsin family protein 0.0022 0.0042 0.0061
Onchocerca volvulus 0.0169 0.1563 0.5441
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0468 0.0641
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0468 0.0641
Leishmania major ABC-thiol transporter 0.003 0.0131 0.023
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0072 0.009
Leishmania major p-glycoprotein e 0.003 0.0131 0.023
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0097 0.0816 0.1126
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0035 0.018 0.0173
Leishmania major cytochrome p450-like protein 0.002 0.0026 0.0045
Echinococcus granulosus ATP binding cassette sub family B 0.003 0.0131 0.0172
Loa Loa (eye worm) TK/ROR protein kinase 0.002 0.0025 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0116 0.0109
Entamoeba histolytica P-glycoprotein-1 0.0097 0.0816 0.2188
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0116 0.038
Loa Loa (eye worm) hypothetical protein 0.0058 0.0417 0.041
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.003 0.004
Echinococcus granulosus multidrug resistance protein 1 0.0097 0.0816 0.1126
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0097 0.0816 0.2188
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0019 0.0012 0.0007
Brugia malayi ABC transporter family protein 0.0097 0.0816 0.1423
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0215 0.0289
Schistosoma mansoni rab6-interacting 0.0041 0.024 0.0324
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.003 0.0131 0.0352
Onchocerca volvulus 0.0041 0.024 0.0815
Brugia malayi N-terminal motif family protein 0.0181 0.1689 0.296
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0215 0.0365
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.003 0.0131 0.0376
Echinococcus multilocularis thyroid hormone receptor alpha 0.0029 0.0116 0.0151
Mycobacterium ulcerans hypothetical protein 0.0028 0.0104 0.082
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0012 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0116 0.0191
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0116 0.0151
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0342 0.3345 0.3341
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0097 0.0816 0.2188
Echinococcus granulosus ATP binding cassette sub family B 0.003 0.0131 0.0172
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 0.0233
Brugia malayi Trypsin family protein 0.0022 0.0042 0.0061
Trypanosoma brucei unspecified product 0.0024 0.0068 0.0074
Trypanosoma brucei carbonic anhydrase-like protein 0.0569 0.569 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0097 0.0816 0.1126
Echinococcus granulosus microtubule associated protein 2 0.0714 0.7193 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.1563 0.1557
Echinococcus multilocularis arginase 2, mitochondrial 0.0337 0.3301 0.4583
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0524 0.1271
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0097 0.0816 0.2188
Loa Loa (eye worm) Smad1 0.0024 0.0072 0.0065
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0032 0.0154 0.0251
Echinococcus multilocularis aurora kinase A 0.0068 0.0522 0.0717
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0524 0.0518
Schistosoma mansoni multidrug resistance protein 0.003 0.0131 0.0172
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0022 0.0042 0.0049
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0189 0.032
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0468 0.462
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.003 0.0131 0.0352
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.003 0.0131 0.0218
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0464 0.458
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0335 0.0578
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0116 0.0151
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0049
Onchocerca volvulus 0.0169 0.1563 0.5441
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0936 0.8659
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0026 0.0033
Loa Loa (eye worm) hypothetical protein 0.0169 0.1563 0.1557
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0215 0.0208
Toxoplasma gondii transporter, major facilitator family protein 0.0169 0.1563 0.4246
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0116 0.0191
Loa Loa (eye worm) hypothetical protein 0.0169 0.1563 0.1557
Echinococcus multilocularis enteropeptidase 0.0022 0.0042 0.0049
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0097 0.0816 0.1126
Entamoeba histolytica P-glyco protein 6, putative 0.0097 0.0816 0.2188
Schistosoma mansoni intermediate filament proteins 0.0028 0.0107 0.0139
Brugia malayi Cytochrome P450 family protein 0.002 0.0026 0.0033
Brugia malayi ABC transporter 0.003 0.0131 0.0218
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0005
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0062 0.0464 0.1081
Brugia malayi secreted modular calcium-binding protein 1 0.0058 0.0417 0.0722
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0116 0.0151
Loa Loa (eye worm) AUR protein kinase 0.0068 0.0522 0.0515
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0058 0.0417 0.0722
Echinococcus granulosus aurora kinase A 0.0068 0.0522 0.0717
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0116 0.0191
Loa Loa (eye worm) hypothetical protein 0.0169 0.1563 0.1557
Echinococcus granulosus defective proboscis extension response 0.0019 0.0012 0.0007
Brugia malayi polk-prov protein 0.0038 0.0215 0.0366
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0097 0.0816 0.2188
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.018 0.0304
Trypanosoma brucei p-glycoprotein 0.003 0.0131 0.0185
Brugia malayi multidrug resistance protein 3 0.0097 0.0816 0.1423
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0116 0.0151
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0335 0.0328
Onchocerca volvulus 0.0022 0.0042 0.0122
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0058 0.0417 0.1131
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0097 0.0816 0.2188
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0204 0.0346
Schistosoma mansoni lipoxygenase 0.0114 0.0999 0.138
Trichomonas vaginalis abcb9, putative 0.0097 0.0816 0.2188
Echinococcus granulosus multidrug resistance associated protein 7 0.003 0.0131 0.0172
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0464 0.0773
Plasmodium falciparum ABC transporter B family member 4, putative 0.003 0.0131 0.0337
Echinococcus multilocularis tumor protein p63 0.035 0.343 0.4763
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0464 0.458
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.018 0.0304
Entamoeba histolytica deoxycytidyl transferase, putative 0.0035 0.018 0.0188
Echinococcus granulosus twitchin 0.0019 0.0018 0.0015
Brugia malayi sodium-independent organic anion transporter family protein 0.0169 0.1563 0.2737
Loa Loa (eye worm) hypothetical protein 0.0027 0.0102 0.0095
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0072 0.009
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0468 0.1268
Trichomonas vaginalis DNA polymerase eta, putative 0.0062 0.0464 0.1081
Trichomonas vaginalis abcb9, putative 0.0097 0.0816 0.2188
Loa Loa (eye worm) hypothetical protein 0.0028 0.0107 0.01
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0116 0.0109
Echinococcus multilocularis Immunoglobulin 0.0019 0.0012 0.0007
Echinococcus multilocularis lamin dm0 0.0028 0.0107 0.0139
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0049
Echinococcus granulosus single minded 2 0.0037 0.0204 0.0273
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0097 0.0816 0.2188
Loa Loa (eye worm) hypothetical protein 0.0295 0.2866 0.2861
Echinococcus granulosus Mastin 0.0022 0.0042 0.0049
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0374 0.3679 0.6461
Brugia malayi ABC transporter family protein 0.003 0.0131 0.0218
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0107 0.01
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0204 0.0273
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0295 0.2866 0.3979
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0522 0.1264
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0189 0.1708
Echinococcus multilocularis RUN 0.0041 0.024 0.0324
Brugia malayi P-glycoprotein-like protein 0.003 0.0131 0.0218
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0116 0.038
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.003 0.0131 0.0352
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.003 0.0131 0.023
Toxoplasma gondii ABC transporter, putative 0.003 0.0131 0.0352
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0342 0.3345 0.5874
Onchocerca volvulus 0.0037 0.0204 0.0687
Toxoplasma gondii protease inhibitor PI2 0.0058 0.0417 0.1131
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.003 0.0131 0.0034
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0936 0.8659
Echinococcus multilocularis roundabout 2 0.0019 0.0012 0.0007
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.003 0.0131 0.0218
Entamoeba histolytica protein kinase, putative 0.0068 0.0522 0.1264
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0097 0.0816 0.2188
Echinococcus granulosus arginase 2 mitochondrial 0.0337 0.3301 0.4583
Schistosoma mansoni loxhd1 0.0041 0.024 0.0324
Echinococcus granulosus geminin 0.0175 0.163 0.2258
Echinococcus granulosus 3'partial|arginase 2 mitochondrial 0.0337 0.3301 0.4583
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0309 0.042
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0295 0.2866 0.3979
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0468 0.0822
Echinococcus multilocularis dna polymerase kappa 0.0062 0.0464 0.0636
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0072 0.009
Brugia malayi Smad1 0.0024 0.0072 0.0113
Leishmania major trypanothione reductase 0.0047 0.0309 0.0543
Echinococcus multilocularis carbonic anhydrase 0.0374 0.3679 0.511
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0035 0.018 0.024
Loa Loa (eye worm) ABC transporter 0.003 0.0131 0.0124
Brugia malayi Inositol-1 0.0036 0.0189 0.032
Trypanosoma cruzi agmatinase, putative 0.0123 0.1086 0.1898
Onchocerca volvulus 0.0058 0.0417 0.1434
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.003 0.0131 0.0218
Entamoeba histolytica P-glycoprotein-2 0.0097 0.0816 0.2188
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0116 0.0191
Plasmodium falciparum multidrug resistance-associated protein 2 0.003 0.0131 0.0337
Echinococcus multilocularis expressed protein 0.0058 0.0417 0.0571
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0097 0.0816 0.2188
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0068 0.0522 0.1264
Trypanosoma cruzi MFS transporter, putative 0.0169 0.1563 0.2737
Onchocerca volvulus 0.0028 0.0107 0.0349
Schistosoma mansoni smdr1 0.003 0.0131 0.0172
Echinococcus multilocularis Mastin 0.0022 0.0042 0.0049
Schistosoma mansoni coup transcription factor 0.0029 0.0116 0.0151
Entamoeba histolytica P-glycoprotein 6, putative 0.003 0.0131 0.0034
Loa Loa (eye worm) ABC transporter 0.003 0.0131 0.0124
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0215 0.0289
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0005
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0049
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0035 0.018 0.024
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0096 0.0805 0.111
Loa Loa (eye worm) hypothetical protein 0.0058 0.0417 0.041
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0068 0.0522 0.0717
Echinococcus multilocularis carbonic anhydrase 0.0374 0.3679 0.511
Loa Loa (eye worm) hypothetical protein 0.0034 0.0172 0.0165
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0072 0.009
Echinococcus multilocularis neuroglian 0.0019 0.0012 0.0007
Brugia malayi ABC transporter transmembrane region family protein 0.0029 0.012 0.0199
Loa Loa (eye worm) glutathione reductase 0.0047 0.0309 0.0302
Brugia malayi ABC transporter 0.0029 0.012 0.0199
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0058 0.0417 0.1131
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0173
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0058 0.0417 0.0722
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0215 0.0298
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0277 0.0376
Plasmodium vivax ABC transporter B family member 4, putative 0.003 0.0131 0.0376
Brugia malayi serine/threonine kinase 12 0.0068 0.0522 0.0906
Brugia malayi multidrug resistance related protein 1 0.003 0.0131 0.0218
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0189 0.0218
Echinococcus granulosus multidrug resistance protein 1 0.0097 0.0816 0.1126
Giardia lamblia Aurora kinase 0.0068 0.0522 1
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0169 0.1563 0.2165
Echinococcus granulosus carbonic anhydrase 0.0374 0.3679 0.511
Plasmodium vivax arginase, putative 0.0337 0.3301 1
Onchocerca volvulus 0.0051 0.0347 0.119
Brugia malayi ABC transporter family protein 0.003 0.0131 0.0218
Schistosoma mansoni rab6-interacting 0.0041 0.024 0.0324
Echinococcus multilocularis multidrug resistance protein 1 0.0067 0.0515 0.0707
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0522 0.1264
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.008 0.0647 0.6494
Schistosoma mansoni multidrug resistance protein 0.003 0.0131 0.0172
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.024 0.0324
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0464 0.0773
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0169 0.1563 0.2165
Trichomonas vaginalis ABC transporter, putative 0.0097 0.0816 0.2188
Echinococcus multilocularis microtubule associated protein 2 0.0714 0.7193 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0189 0.0218
Brugia malayi sodium-independent organic anion transporter family protein 0.0169 0.1563 0.2737
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0116 0.0151
Brugia malayi sodium-independent organic anion transporter family protein 0.0169 0.1563 0.2737
Trichomonas vaginalis xanthine dehydrogenase, putative 0.017 0.1575 0.4575
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0189 0.6966
Onchocerca volvulus 0.0274 0.2643 0.9219
Brugia malayi MH2 domain containing protein 0.0024 0.0072 0.0113
Giardia lamblia ABC transporter, putative 0.003 0.0131 0.027
Loa Loa (eye worm) hypothetical protein 0.0169 0.1563 0.1557
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0335 0.0578
Trypanosoma cruzi arginase, putative 0.0123 0.1086 0.1898
Echinococcus multilocularis transmembrane protease serine 3 0.0022 0.0042 0.0049
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.003 0.0131 0.0352
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0067 0.0515 0.1242
Toxoplasma gondii kringle domain-containing protein 0.0018 0.0007 0.0016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0215 0.0365
Trypanosoma brucei trypanothione reductase 0.0047 0.0309 0.0499
Loa Loa (eye worm) hypothetical protein 0.0029 0.0116 0.0109
Schistosoma mansoni inositol monophosphatase 0.0036 0.0189 0.0253
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 0.0233
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0189 0.0218
Entamoeba histolytica ATP-binding cassette protein, putative 0.003 0.0131 0.0034
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0524 0.091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0116 0.0109
Trypanosoma brucei DNA polymerase IV, putative 0.0056 0.0393 0.0649
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0374 0.3679 0.6461
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.003 0.0131 0.0352
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0097 0.0816 0.2188
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0058 0.0417 0.1131
Schistosoma mansoni ap endonuclease 0.0038 0.0215 0.0289
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0169 0.1563 0.1557
Toxoplasma gondii exonuclease III APE 0.0038 0.0215 0.058
Onchocerca volvulus 0.0169 0.1563 0.5441
Echinococcus multilocularis Smad4 0.0024 0.0072 0.009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0005
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0058 0.0417 0.1131
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0097 0.0816 0.2215
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0215 0.0298
Loa Loa (eye worm) hypoxia-induced factor 1 0.0156 0.1428 0.1422
Echinococcus multilocularis dna polymerase eta 0.0035 0.018 0.024
Onchocerca volvulus 0.0169 0.1563 0.5441
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.1061 1
Echinococcus multilocularis ATP binding cassette sub family B 0.003 0.0131 0.0172
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0116 0.0151
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0215 0.1974
Leishmania major agmatinase-like protein 0.0123 0.1086 0.1908
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0116 0.0191
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0097 0.0816 0.2188
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0097 0.0816 0.1126
Onchocerca volvulus 0.0022 0.0042 0.0122
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0097 0.0816 0.2188
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0058 0.0417 0.0722
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0522 0.1264
Schistosoma mansoni ap endonuclease 0.0038 0.0215 0.0289
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0019 0.0012 0.0007
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0107 0.0176
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0524 0.072
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0035
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0116 0.038
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.0999 0.138
Brugia malayi hypothetical protein 0.0019 0.0012 0.0009
Plasmodium vivax glutathione reductase, putative 0.0047 0.0309 0.0916
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0113 0.0982 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0215 0.0565
Schistosoma mansoni lamin 0.0028 0.0107 0.0139
Giardia lamblia MRP-like ABC transporter 0.003 0.0131 0.027
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0464 0.0773
Loa Loa (eye worm) hypothetical protein 0.0169 0.1563 0.1557
Plasmodium vivax multidrug resistance protein 1, putative 0.0097 0.0816 0.2456
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0116 0.0191
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0524 0.088
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0522 0.0717
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0569 0.569 1
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0464 0.0773
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.024 0.0635
Trypanosoma brucei multidrug resistance-associated protein, putative 0.003 0.0131 0.0185
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0569 0.569 0.5687
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.003 0.0131 0.1097
Plasmodium falciparum multidrug resistance protein 1 0.0097 0.0816 0.2203
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0097 0.0816 0.2188
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0116 0.0151
Brugia malayi MH2 domain containing protein 0.0359 0.3529 0.6197
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0116 0.0151
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.2294 0.2288
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.025 0.1284
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0068 0.0522 0.1264
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0277 0.0376
Onchocerca volvulus 0.0097 0.0816 0.2829
Brugia malayi serine/threonine protein kinase 6 0.0068 0.0522 0.0906
Brugia malayi Trypsin-like protease protein 5 0.0022 0.0042 0.0061
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0097 0.0816 0.7365
Echinococcus granulosus intermediate filament protein 0.0028 0.0107 0.0139
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0042 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.025 0.0396
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.003 0.0131 0.0172
Loa Loa (eye worm) hypothetical protein 0.0374 0.3679 0.3675
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0035
Entamoeba histolytica protein kinase , putative 0.0068 0.0522 0.1264
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0277 0.0376
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0215 0.0298
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0215 0.063
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0464 0.0773
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0524 0.072
Plasmodium falciparum arginase 0.0337 0.3301 0.8969
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0029 0.012 0.0157
Toxoplasma gondii aurora kinase 0.0068 0.0522 0.1416
Echinococcus granulosus multidrug resistance associated protein 1 0.003 0.0131 0.0172
Toxoplasma gondii thioredoxin reductase 0.0047 0.0309 0.0836
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0097 0.0816 0.2188
Loa Loa (eye worm) hypothetical protein 0.003 0.0131 0.0124
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0464 0.0804
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0204 0.1858
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0005
Schistosoma mansoni microtubule-associated protein tau 0.0714 0.7193 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0116 0.0109
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0189 0.0288
Leishmania major DNA polymerase eta, putative 0.0035 0.018 0.0316
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0097 0.0816 0.2188
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0464 0.0773
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0049
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.003 0.0131 0.0376
Toxoplasma gondii ABC transporter family protein 0.003 0.0131 0.0352
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0215 0.0901
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0172 0.029
Schistosoma mansoni follistatin 0.0058 0.0417 0.0571
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0277 0.0376
Brugia malayi intermediate filament protein 0.0028 0.0107 0.0176
Loa Loa (eye worm) hypothetical protein 0.0029 0.0116 0.0109
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.003 0.0131 0.023
Mycobacterium tuberculosis Probable reductase 0.0108 0.0936 0.8659
Giardia lamblia Multidrug resistance-associated protein 1 0.003 0.0131 0.027
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0464 0.0804
Brugia malayi ecdysteroid receptor 0.0029 0.0116 0.0191
Trypanosoma cruzi agmatinase, putative 0.0123 0.1086 0.1898
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0022 0.0042 0.0049
Schistosoma mansoni multidrug resistance protein 0.0029 0.012 0.0157
Onchocerca volvulus 0.0022 0.0042 0.0122
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0116 0.0191
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0116 0.0151
Trypanosoma brucei aurora B kinase 0.0068 0.0522 0.0876
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0524 0.091
Loa Loa (eye worm) hypothetical protein 0.0058 0.0417 0.041
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.003 0.0131 0.023
Loa Loa (eye worm) ABC transporter 0.003 0.0131 0.0124
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.003 0.0131 0.1097
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0049
Trypanosoma cruzi multidrug resistance protein E, putative 0.003 0.0131 0.0218
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0026 0.0019
Schistosoma mansoni hypothetical protein 0.0374 0.3679 0.511
Schistosoma mansoni vesicular amine transporter 0.0019 0.0012 0.0007
Schistosoma mansoni smad1 5 8 and 0.0024 0.0072 0.009
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0309 0.0302
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0107 0.01
Plasmodium falciparum ABC transporter B family member 7, putative 0.003 0.0131 0.0337
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0097 0.0816 0.1126
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0522 0.1264
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.018 0.0526
Leishmania major DNA polymerase kappa, putative 0.0042 0.025 0.044
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0042 0.0049
Echinococcus multilocularis follistatin 0.0058 0.0417 0.0571
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.015 0.0211
Schistosoma mansoni nephrin 0.0019 0.0012 0.0007
Entamoeba histolytica hypothetical protein 0.003 0.0131 0.0034
Entamoeba histolytica P-glycoprotein-2, putative 0.0097 0.0816 0.2188
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0058 0.0417 0.0722
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0097 0.0816 0.2188
Entamoeba histolytica P-glycoprotein 5, putative 0.0097 0.0816 0.2188
Schistosoma mansoni lamin 0.0028 0.0107 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0116 0.0191
Echinococcus multilocularis multidrug resistance associated protein 1 0.003 0.0131 0.0172
Echinococcus granulosus Solute carrier organic anion transporter family 0.0169 0.1563 0.2165
Entamoeba histolytica protein kinase, putative 0.0068 0.0522 0.1264
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0026 0.0033
Echinococcus multilocularis Immunoglobulin 0.0019 0.0012 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0359 0.3529 0.3524
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0189 0.0253
Entamoeba histolytica P-glycoprotein-5 0.0097 0.0816 0.2188
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0138 0.0198
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0468 0.462
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0277 0.0271
Loa Loa (eye worm) doublecortin family protein 0.0041 0.024 0.0233
Schistosoma mansoni lipoxygenase 0.0041 0.024 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0116 0.0191
Plasmodium vivax ABC transporter B family member 6, putative 0.003 0.0131 0.0376
Schistosoma mansoni multidrug resistance protein 0.003 0.0131 0.0172
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0032 0.0154 0.1341
Schistosoma mansoni inositol monophosphatase 0.0036 0.0189 0.0253
Loa Loa (eye worm) hypothetical protein 0.0181 0.1689 0.1683
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0116 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0116 0.0191
Plasmodium falciparum serine/threonine protein kinase, putative 0.0068 0.0522 0.1403
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0342 0.3345 0.4646
Trichomonas vaginalis xanthine dehydrogenase, putative 0.017 0.1575 0.4575
Brugia malayi Fibronectin type III domain containing protein 0.0019 0.0012 0.0009
Echinococcus granulosus multidrug resistance protein 1 0.0067 0.0515 0.0707
Schistosoma mansoni carbonic anhydrase-related 0.0374 0.3679 0.511
Trypanosoma brucei unspecified product 0.0056 0.0393 0.0649
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0374 0.3679 0.6461
Schistosoma mansoni hypothetical protein 0.0022 0.0042 0.0049
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0005
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.034 0.0333
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.003 0.0131 0.0218
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0936 0.8659
Brugia malayi Trypsin family protein 0.0022 0.0042 0.0061
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0026 0.0019
Echinococcus multilocularis multidrug resistance associated protein 7 0.003 0.0131 0.0172
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0464 0.0773
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0277 0.0376
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0215 0.0334
Leishmania major arginase 0.0337 0.3301 0.5801
Loa Loa (eye worm) hypothetical protein 0.0058 0.0417 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0337 0.3301 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0097 0.0816 0.2188
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0116 0.0191
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.005 0.0339 0.3278
Loa Loa (eye worm) inositol-1 0.0036 0.0189 0.0182
Brugia malayi steroid hormone receptor 0.0029 0.0116 0.0191
Loa Loa (eye worm) agrin synaptic family protein 0.0058 0.0417 0.041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0116 0.0191
Entamoeba histolytica ATP-binding cassette protein, putative 0.003 0.0131 0.0034
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0035 0.018 0.024
Trypanosoma cruzi aurora B kinase, putative 0.0068 0.0522 0.0906
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0189 0.0218
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0116 0.0151
Schistosoma mansoni carbonic anhydrase 0.0374 0.3679 0.511
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0097 0.0816 0.2188
Onchocerca volvulus Putative organic anion transporter 0.0169 0.1563 0.5441
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.003 0.0131 0.1097
Entamoeba histolytica Arginase, putative 0.0337 0.3301 1
Loa Loa (eye worm) AUR protein kinase 0.0068 0.0522 0.0515
Brugia malayi prostaglandin transporter 0.0169 0.1563 0.2737
Loa Loa (eye worm) hypothetical protein 0.0097 0.0816 0.0809
Leishmania major p-glycoprotein 0.0097 0.0816 0.1434
Echinococcus granulosus dna polymerase eta 0.0035 0.018 0.024
Schistosoma mansoni hypothetical protein 0.0022 0.0042 0.0049
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0022 0.0042 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0337 0.3301 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.003 0.0131 0.0034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0035
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0215 0.0333
Schistosoma mansoni multidrug resistance protein 0.0097 0.0816 0.1126
Echinococcus multilocularis musashi 0.0028 0.0107 0.0139
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0097 0.0816 0.2188
Brugia malayi nuclear hormone receptor 0.0029 0.0116 0.0191
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0068 0.0522 0.1564
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0042 0.0049
Trichomonas vaginalis aldehyde oxidase, putative 0.017 0.1575 0.4575
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.024 0.0324
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0116 0.0151
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0097 0.0816 0.0809
Loa Loa (eye worm) AUR protein kinase 0.0068 0.0522 0.0515
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.003 0.0131 0.0218
Onchocerca volvulus 0.0029 0.0116 0.038
Schistosoma mansoni smdr2 0.0097 0.0816 0.1126
Onchocerca volvulus 0.0022 0.0042 0.0122
Schistosoma mansoni single-minded 0.005 0.0339 0.0461
Brugia malayi hypothetical protein 0.0041 0.024 0.041
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0097 0.0816 0.2188
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0374 0.3679 0.6461
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0116 0.0191
Echinococcus granulosus follistatin 0.0058 0.0417 0.0571
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0019 0.0012 0.0007
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.025 0.044
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0116 0.0151
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0936 0.8659
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.1061 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.024 0.0324
Echinococcus multilocularis 0.0337 0.3301 0.4583
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.024 0.0324
Trypanosoma cruzi arginase, putative 0.0123 0.1086 0.1898
Loa Loa (eye worm) multidrug resistance protein 3 0.0097 0.0816 0.0809
Brugia malayi serine/threonine-protein kinase 6 0.0068 0.0522 0.0906
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0215 0.0365
Brugia malayi nuclear receptor NHR-88 0.0029 0.0116 0.0191
Brugia malayi hypothetical protein 0.0041 0.024 0.041
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.008 0.0647 0.6494
Onchocerca volvulus 0.0022 0.0042 0.0122
Echinococcus multilocularis smad 0.0024 0.0072 0.009
Brugia malayi Doublecortin family protein 0.0041 0.024 0.041
Entamoeba histolytica multidrug resistance protein, putative 0.003 0.0131 0.0034
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0097 0.0816 0.1126
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0116 0.0151
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0057 0.0412 0.4035
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0936 0.8659
Schistosoma mansoni multidrug resistance protein 0.0097 0.0816 0.1126
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0035
Plasmodium falciparum glutathione reductase 0.0047 0.0309 0.0821
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0215 0.2355
Echinococcus multilocularis ATP binding cassette sub family B 0.003 0.0131 0.0172
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0116 0.0151
Schistosoma mansoni terminal deoxycytidyl transferase 0.0035 0.018 0.024
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0116 0.0191
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0116 0.0151
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0569 0.569 0.7909
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0097 0.0816 0.1126
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0468 0.462
Schistosoma mansoni multidrug resistance protein 0.0097 0.0816 0.1126
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0049
Entamoeba histolytica P-glycoprotein-2 0.0097 0.0816 0.2188
Trypanosoma brucei agmatinase, putative 0.0123 0.1086 0.1871
Schistosoma mansoni multidrug resistance protein 0.003 0.0131 0.0172
Echinococcus multilocularis ATP binding cassette sub family B 0.0096 0.0805 0.111
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0097 0.0816 0.5
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0116 0.0151
Plasmodium falciparum ABC transporter B family member 3, putative 0.003 0.0131 0.0337
Loa Loa (eye worm) hypothetical protein 0.003 0.0131 0.0124
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0022 0.0042 0.0049
Brugia malayi glutathione reductase 0.0047 0.0309 0.0531
Echinococcus granulosus glycoprotein Antigen 5 0.0022 0.0042 0.0049
Echinococcus granulosus neuroglian 0.0019 0.0012 0.0007
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0116 0.0151
Echinococcus granulosus carbonic anhydrase 0.0374 0.3679 0.511
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0342 0.3345 0.4646
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.024 0.0324
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.003 0.0131 0.1097
Onchocerca volvulus Putative organic anion transporter 0.0169 0.1563 0.5441
Schistosoma mansoni hypothetical protein 0.0041 0.024 0.0324
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0524 0.091
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0097 0.0816 0.2188
Onchocerca volvulus Putative organic anion transporter 0.0169 0.1563 0.5441
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0374 0.3679 0.6461
Brugia malayi hypothetical protein 0.0022 0.0042 0.0061
Echinococcus multilocularis ATP binding cassette sub family B 0.003 0.0131 0.0172
Echinococcus granulosus dna polymerase kappa 0.0062 0.0464 0.0636
Mycobacterium ulcerans hypothetical protein 0.0022 0.0042 0.0169
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0309 0.0916
Brugia malayi Trypsin family protein 0.0295 0.2866 0.5031
Trichomonas vaginalis Arginase, putative 0.0337 0.3301 1
Plasmodium falciparum ABC transporter B family member 5, putative 0.003 0.0131 0.0337
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0277 0.0376
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0019 0.0012 0.0007
Schistosoma mansoni smad1 5 8 and 0.0024 0.0072 0.009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0116 0.0109
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.024 0.0708
Schistosoma mansoni smad 0.0024 0.0072 0.009
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0116 0.0151
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0215 1
Plasmodium falciparum carbonic anhydrase 0.0374 0.3679 1
Echinococcus granulosus ATP binding cassette sub family B 0.0029 0.012 0.0157
Brugia malayi hypothetical protein 0.0169 0.1563 0.2737
Brugia malayi hypothetical protein 0.003 0.0131 0.0218
Echinococcus multilocularis multidrug resistance protein 1 0.0097 0.0816 0.1126
Brugia malayi MH1 domain containing protein 0.0024 0.0072 0.0113
Loa Loa (eye worm) hypothetical protein 0.0029 0.0116 0.0109
Plasmodium falciparum multidrug resistance protein 2 0.003 0.0131 0.0337
Loa Loa (eye worm) trypsin family protein 0.0022 0.0042 0.0035
Loa Loa (eye worm) carbonic anhydrase 3 0.0569 0.569 0.5687
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0113
Brugia malayi Protein kinase domain containing protein 0.002 0.0025 0.0031
Loa Loa (eye worm) hypothetical protein 0.003 0.0131 0.0124
Brugia malayi ABC transporter transmembrane region family protein 0.003 0.0131 0.0218
Plasmodium vivax ABC transporter B family member 5, putative 0.003 0.0131 0.0376
Echinococcus granulosus enteropeptidase 0.0022 0.0042 0.0049
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0309 0.0531
Loa Loa (eye worm) CYP4Cod1 0.002 0.0026 0.0019
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0032 0.0154 0.1341
Loa Loa (eye worm) transcription factor SMAD2 0.0359 0.3529 0.3524
Trypanosoma brucei multidrug resistance protein E 0.003 0.0131 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0138 0.0198
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0072 0.009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0277 0.0376
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.003 0.0131 0.023
Brugia malayi Cytochrome P450 family protein 0.005 0.034 0.0586
Onchocerca volvulus 0.0169 0.1563 0.5441
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.003 0.0131 0.0352
Loa Loa (eye worm) hypothetical protein 0.0374 0.3679 0.3675
Echinococcus granulosus carbonic anhydrase II 0.0569 0.569 0.7909
Loa Loa (eye worm) hypothetical protein 0.0029 0.0116 0.0109
Echinococcus granulosus transmembrane protease serine 3 0.0022 0.0042 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0464 0.0773
Plasmodium vivax ABC transporter B family member 3, putative 0.003 0.0131 0.0376
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0569 0.569 1
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.003 0.0131 0.023
Trichomonas vaginalis ABC transporter, putative 0.0097 0.0816 0.2188
Plasmodium falciparum thioredoxin reductase 0.0047 0.0309 0.0821
Schistosoma mansoni carbonic anhydrase-related 0.0374 0.3679 0.511
Schistosoma mansoni Smad4 0.0024 0.0072 0.009
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0057 0.0412 0.302
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.003 0.0131 0.023
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0116 0.0151
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0116 0.0151
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0097 0.0816 0.1126
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0464 0.0773
Entamoeba histolytica ABC transporter, putative 0.003 0.0131 0.0034
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0277 0.0476
Brugia malayi MH2 domain containing protein 0.0024 0.0072 0.0113
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0215 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0309 0.1913
Schistosoma mansoni hypothetical protein 0.0175 0.163 0.2258
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0116 0.0191
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.003 0.0131 0.0124
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0116 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0116 0.0109
Schistosoma mansoni DNA polymerase eta 0.0035 0.018 0.024
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.003 0.0131 0.0185
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0569 0.569 0.7909
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0468 0.0641
Schistosoma mansoni smad1 5 8 and 0.0024 0.0072 0.009
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0042 0.0049
Entamoeba histolytica ATP-binding cassette protein, putative 0.003 0.0131 0.0034
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.024 0.0324
Plasmodium vivax multidrug resistance protein 2, putative 0.003 0.0131 0.0376
Loa Loa (eye worm) hypothetical protein 0.0051 0.0347 0.034
Trichomonas vaginalis ABC transporter, putative 0.0097 0.0816 0.2188
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0189 0.0511
Brugia malayi ABC transporter family protein 0.003 0.0131 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0215 0.0334
Leishmania major carbonic anhydrase-like protein 0.0569 0.569 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0116 0.0151
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0936 0.8659
Echinococcus multilocularis multidrug resistance protein 1 0.0097 0.0816 0.1126
Brugia malayi Cytochrome P450 family protein 0.002 0.0026 0.0033
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0097 0.0816 0.2188
Brugia malayi hypothetical protein 0.0169 0.1563 0.2737
Schistosoma mansoni protein kinase 0.0068 0.0522 0.0717
Plasmodium falciparum ABC transporter B family member 6, putative 0.003 0.0131 0.0337
Loa Loa (eye worm) hypothetical protein 0.0295 0.2866 0.2861
Treponema pallidum hypothetical protein 0.0028 0.0104 0.3134
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0005
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0097 0.0816 0.2188
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0524 0.072
Echinococcus multilocularis lamin 0.0028 0.0107 0.0139
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0309 0.042
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0468 0.3621
Schistosoma mansoni carbonic anhydrase-related 0.0374 0.3679 0.511
Brugia malayi PAS domain containing protein 0.005 0.0339 0.0583
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0464 0.0773
Echinococcus multilocularis carbonic anhydrase 0.0374 0.3679 0.511
Schistosoma mansoni hypothetical protein 0.0175 0.163 0.2258
Echinococcus granulosus lamin dm0 0.0028 0.0107 0.0139
Schistosoma mansoni cell adhesion molecule 0.0019 0.0012 0.0007
Leishmania major pentamidine resistance protein 1 0.003 0.0131 0.023
Trypanosoma brucei multidrug resistance-associated protein, putative 0.003 0.0131 0.0185
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0138 0.0198
Loa Loa (eye worm) hypothetical protein 0.0096 0.0805 0.0799
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0189 0.0253
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.008 0.0647 0.5547
Toxoplasma gondii hypothetical protein 0.0374 0.3679 1
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0022 0.0042 0.0061
Echinococcus granulosus Smad4 0.0024 0.0072 0.009
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.015 0.0211
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0042 0.0049
Echinococcus multilocularis agrin 0.0058 0.0417 0.0571
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0049
Schistosoma mansoni organic anion transporter 0.0169 0.1563 0.2165
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0116 0.0151
Trichomonas vaginalis taga, putative 0.0097 0.0816 0.2188
Giardia lamblia Multidrug resistance-associated protein 1 0.003 0.0131 0.027
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0569 0.569 1
Onchocerca volvulus 0.0041 0.024 0.0815
Loa Loa (eye worm) hypothetical protein 0.0029 0.0116 0.0109
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0068 0.0522 0.0717
Schistosoma mansoni polycystin 1-related 0.0041 0.024 0.0324
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0072 0.0065
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0189 0.0332
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0339 0.0461
Giardia lamblia DINP protein human, muc B family 0.0042 0.025 0.3239
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0116 0.0151
Brugia malayi ABC transporter transmembrane region family protein 0.003 0.0131 0.0218
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0057 0.0412 0.4035
Schistosoma mansoni organic anion transporter 0.0169 0.1563 0.2165
Loa Loa (eye worm) hypothetical protein 0.0029 0.0116 0.0109
Echinococcus multilocularis ATP binding cassette sub family B 0.003 0.0131 0.0172
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.003 0.0131 0.0185
Brugia malayi hypoxia-induced factor 1 0.0156 0.1428 0.25
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0005
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0116 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0116 0.0109
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0042 0.0049
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.1061 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0116 0.0109
Schistosoma mansoni multidrug resistance protein 0.003 0.0131 0.0172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0116 0.0109
Loa Loa (eye worm) hypothetical protein 0.0097 0.0816 0.0809
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0116 0.0109
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0464 0.0804
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0374 0.3679 0.3675
Echinococcus granulosus tumor protein p63 0.035 0.343 0.4763
Brugia malayi follicle stimulating hormone receptor 0.024 0.2294 0.4024
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0116 0.0151
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0113
Loa Loa (eye worm) hypothetical protein 0.0038 0.0215 0.0208
Echinococcus multilocularis carbonic anhydrase II 0.0569 0.569 0.7909
Brugia malayi MH1 domain containing protein 0.0024 0.0072 0.0113
Echinococcus multilocularis geminin 0.0175 0.163 0.2258
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0116 0.0151
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0072 0.0065
Schistosoma mansoni arginase 0.0337 0.3301 0.4583
Loa Loa (eye worm) TK/KIN16 protein kinase 0.002 0.003 0.0023
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0097 0.0816 0.1126
Onchocerca volvulus 0.0295 0.2866 1
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0068 0.0522 0.1264
Echinococcus multilocularis 0.003 0.0131 0.0172
Brugia malayi Thioredoxin reductase 0.0047 0.0309 0.0531
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0347 0.0473
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.003 0.0131 0.1097
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0116 0.0151
Trichomonas vaginalis abcb9, putative 0.0097 0.0816 0.2188
Plasmodium falciparum multidrug resistance-associated protein 1 0.003 0.0131 0.0337
Onchocerca volvulus 0.0028 0.0107 0.0349
Loa Loa (eye worm) hypothetical protein 0.0169 0.1563 0.1557
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0049
Treponema pallidum quinoline 2-oxidoreductase 0.0027 0.0098 0.2721
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0464 0.0804
Echinococcus granulosus lamin 0.0028 0.0107 0.0139
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0524 0.0921
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.003 0.0131 0.023
Loa Loa (eye worm) hypothetical protein 0.005 0.0335 0.0328
Echinococcus granulosus Immunoglobulin 0.0019 0.0012 0.0007
Echinococcus granulosus RUN 0.0041 0.024 0.0324
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.0522 0.1264

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 16.4 nM Inhibition of Aurora B (unknown origin) using HLRRASLG substrate ChEMBL. 25089810
IC50 (functional) = 17.9 nM Cytotoxicity against human MV4-11 cells assessed as cell viability after 48 hrs by MTT assay ChEMBL. 25089810
IC50 (binding) = 106 nM Inhibition of FLT3 (unknown origin) using EAIYAAPFAKKK substrate ChEMBL. 25089810

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 25089810

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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