Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.8591 | 0.7411 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.8591 | 0.8591 |
Loa Loa (eye worm) | carboxylesterase | 0.0067 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.7627 | 0.7373 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0067 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0049 | 0.6221 | 0.6221 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.4556 | 0.3976 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.6221 | 0.5818 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.5257 | 0.4751 |
Echinococcus granulosus | carboxylesterase 5A | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.8591 | 0.7411 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 58 nM | Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ion level after 18 hrs by fluorescence-based FDSS6000 assay | ChEMBL. | 25127154 |
Inhibition (binding) | = 90.57 % | Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ion level at 1 uM after 18 hrs by fluorescence-based FDSS6000 assay | ChEMBL. | 25127154 |
Inhibition (binding) | = 91.33 % | Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ion level at 10 uM after 18 hrs by fluorescence-based FDSS6000 assay | ChEMBL. | 25127154 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.