Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0335 | 0.1253 | 0.0742 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0038 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0039 | 0.0031 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1366 | 0.5582 | 0.5 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0335 | 0.1253 | 0.1246 |
Brugia malayi | thymidylate synthase | 0.0353 | 0.1327 | 0.0821 |
Echinococcus multilocularis | roundabout 2 | 0.0046 | 0.0039 | 0.0039 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1366 | 0.5582 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.2419 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0353 | 0.1327 | 0.0821 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0304 | 0.1123 | 0.1704 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0039 | 0.0031 |
Onchocerca volvulus | 0.0353 | 0.1327 | 1 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0353 | 0.1327 | 0.1327 |
Loa Loa (eye worm) | thymidylate synthase | 0.0353 | 0.1327 | 0.132 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1366 | 0.5582 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1366 | 0.5582 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.0046 | 0.0039 | 0.0039 |
Brugia malayi | Dihydrofolate reductase | 0.2419 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1366 | 0.5582 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1366 | 0.5582 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0168 | 0.0552 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0038 | 0.0009 | 0.0009 |
Echinococcus multilocularis | thymidylate synthase | 0.0353 | 0.1327 | 0.1327 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2419 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2419 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2419 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.2419 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2419 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2419 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0353 | 0.1327 | 0.1327 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2419 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 13 uM | Antiproliferative activity against human HeLa cells after 48 hrs by MTT/quantitative colorimetric method | ChEMBL. | 25176193 |
IC50 (functional) | = 21 uM | Antiproliferative activity against human DU145 cells after 48 hrs by MTT/quantitative colorimetric method | ChEMBL. | 25176193 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 25176193 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.