Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | epsilon tubulin, putative | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0017 | 0.0165 | 0.0395 |
Echinococcus granulosus | neural cadherin | 0.0017 | 0.0165 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Brugia malayi | EGF-like domain containing protein | 0.0017 | 0.0165 | 0.0395 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | notch | 0.0017 | 0.0165 | 0.0165 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.4164 | 1 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Brugia malayi | EGF-like domain containing protein | 0.0017 | 0.0165 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Brugia malayi | hypothetical protein | 0.0051 | 0.4164 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0017 | 0.0165 | 0.0395 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0017 | 0.0165 | 0.0395 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0015 | 0 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.4164 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0015 | 0 | 0.5 |
Entamoeba histolytica | tubulin gamma chain | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0165 | 0.0165 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0017 | 0.0165 | 0.0395 |
Echinococcus granulosus | protein jagged 1 | 0.0017 | 0.0165 | 0.0395 |
Echinococcus granulosus | peroxidasin | 0.0051 | 0.4164 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0051 | 0.4164 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 0.4164 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | notch protein | 0.0017 | 0.0165 | 0.0395 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0051 | 0.4164 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0051 | 0.4164 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 0.4164 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0017 | 0.0165 | 0.0395 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Plasmodium falciparum | tubulin epsilon chain, putative | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | notch | 0.0017 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Plasmodium vivax | tubulin beta chain, putative | 0.0015 | 0 | 0.5 |
Brugia malayi | EGF-like domain containing protein | 0.0017 | 0.0165 | 0.0395 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0015 | 0 | 0.5 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.4164 | 1 |
Onchocerca volvulus | 0.0051 | 0.4164 | 1 | |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | slit 2 protein | 0.0017 | 0.0165 | 0.0395 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0017 | 0.0165 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.4164 | 1 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | 0.0051 | 0.4164 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 0.4164 | 1 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0017 | 0.0165 | 0.0395 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0165 | 0.0165 |
Trypanosoma cruzi | tubulin gamma chain | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0102 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0015 | 0 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | Notch2 | 0.0017 | 0.0165 | 0.0395 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0017 | 0.0165 | 0.0395 |
Plasmodium falciparum | alpha tubulin 1 | 0.0015 | 0 | 0.5 |
Leishmania major | epsilon tubulin, putative | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | notch | 0.0017 | 0.0165 | 0.0395 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Plasmodium vivax | tubulin gamma chain, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Brugia malayi | EGF-like domain containing protein | 0.0017 | 0.0165 | 0.0395 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0051 | 0.4164 | 1 |
Echinococcus multilocularis | fibropellin Ia | 0.0017 | 0.0165 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.4164 | 1 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0017 | 0.0165 | 0.0395 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | gamma-tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Brugia malayi | Peroxidasin | 0.0051 | 0.4164 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0051 | 0.4164 | 1 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0017 | 0.0165 | 0.0165 |
Echinococcus granulosus | fibropellin Ia | 0.0017 | 0.0165 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.4164 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0051 | 0.4164 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0165 | 0.0165 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.4164 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 0.4164 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.4164 | 1 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | slit | 0.0017 | 0.0165 | 0.0165 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | notch | 0.0017 | 0.0165 | 0.0165 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0017 | 0.0165 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0017 | 0.0165 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.4164 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Echinococcus granulosus | slit 2 protein | 0.0017 | 0.0165 | 0.0395 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0051 | 0.4164 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.4164 | 1 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0017 | 0.0165 | 0.0395 |
Brugia malayi | Blistered cuticle protein 3 | 0.0051 | 0.4164 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | protein jagged 1 | 0.0017 | 0.0165 | 0.0395 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | beta tubulin, putative | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0015 | 0 | 0.5 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0015 | 0 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | notch | 0.0017 | 0.0165 | 0.0165 |
Echinococcus multilocularis | neural cadherin | 0.0017 | 0.0165 | 0.0395 |
Schistosoma mansoni | peroxidasin | 0.0051 | 0.4164 | 0.4164 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Plasmodium falciparum | tubulin gamma chain | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | protein jagged 2 | 0.0017 | 0.0165 | 0.0395 |
Schistosoma mansoni | septate junction protein | 0.0017 | 0.0165 | 0.0165 |
Brugia malayi | Delta serrate ligand family protein | 0.0017 | 0.0165 | 0.0395 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0165 | 0.0165 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0051 | 0.4164 | 1 |
Schistosoma mansoni | peroxidasin | 0.0051 | 0.4164 | 0.4164 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.4164 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Onchocerca volvulus | Peroxidasin homolog | 0.0051 | 0.4164 | 1 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0051 | 0.4164 | 1 |
Brugia malayi | Cadherin domain containing protein | 0.0017 | 0.0165 | 0.0395 |
Brugia malayi | Cadherin domain containing protein | 0.0017 | 0.0165 | 0.0395 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | cell polarity protein | 0.0017 | 0.0165 | 0.0165 |
Echinococcus multilocularis | notch | 0.0017 | 0.0165 | 0.0395 |
Brugia malayi | notch-like transmembrane receptor | 0.0017 | 0.0165 | 0.0395 |
Echinococcus multilocularis | protein jagged 1 | 0.0017 | 0.0165 | 0.0395 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0017 | 0.0165 | 0.0395 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.4164 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | notch | 0.0017 | 0.0165 | 0.0165 |
Onchocerca volvulus | Peroxidase homolog | 0.0051 | 0.4164 | 1 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | protein jagged 2 | 0.0017 | 0.0165 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0017 | 0.0165 | 0.0395 |
Brugia malayi | EGF-like domain containing protein | 0.0017 | 0.0165 | 0.0395 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0017 | 0.0165 | 0.0395 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0165 | 0.0165 |
Brugia malayi | EGF-like domain containing protein | 0.0017 | 0.0165 | 0.0395 |
Echinococcus granulosus | protein jagged 1 | 0.0017 | 0.0165 | 0.0395 |
Schistosoma mansoni | notch | 0.0017 | 0.0165 | 0.0165 |
Echinococcus multilocularis | protein jagged 2 | 0.0017 | 0.0165 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.4164 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Plasmodium vivax | tubulin epsilon chain, putative | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | 0.0051 | 0.4164 | 1 | |
Brugia malayi | Muscle positioning protein 4 | 0.0017 | 0.0165 | 0.0395 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0017 | 0.0165 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.4164 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | delta-like protein 1 | 0.0017 | 0.0165 | 0.0395 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0165 | 0.0165 |
Giardia lamblia | High cysteine protein | 0.0017 | 0.0165 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0017 | 0.0165 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Echinococcus multilocularis | peroxidasin | 0.0051 | 0.4164 | 1 |
Plasmodium falciparum | alpha tubulin 2 | 0.0015 | 0 | 0.5 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0017 | 0.0165 | 0.0165 |
Plasmodium falciparum | tubulin beta chain | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0165 | 0.0395 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 0.4164 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC80 (functional) | = 125 ug ml-1 | Antifungal activity against Candida albicans ATCC 10231 by NCCLS method | ChEMBL. | 25127462 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.