TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 348.418 | Formula: C20H16N2O2S
H donors: 0 H acceptors: 1 LogP: 4.42 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)n1cnc2c(c1=O)scc2c1cccc(c1)C
InChi: 1S/C20H16N2O2S/c1-13-4-3-5-14(10-13)17-11-25-19-18(17)21-12-22(20(19)23)15-6-8-16(24-2)9-7-15/h3-12H,1-2H3
InChiKey: CZBUORLZFLNTGZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutamate receptor, metabotropic 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04606 glutamate receptor, metabotropic 3, putative	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	Metabotropic glutamate receptor precursor.	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	Metabotropic glutamate receptor precursor, putative	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0041	0.0196	0.0204
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0041	0.0196	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0235	0.0061
Schistosoma mansoni	oxysterol-binding protein 1	0.0046	0.0235	0.0348
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0396	0.3215	0.4771
Plasmodium falciparum	PH domain-containing protein, putative	0.0046	0.0235	0.037
Loa Loa (eye worm)	rho-GTPase-activating	0.0046	0.0235	0.0235
Trichomonas vaginalis	AGC family protein kinase	0.1193	1	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Brugia malayi	Hr1 repeat family protein	0.0396	0.3215	0.3215
Echinococcus granulosus	calcium dependent secretion activator 1	0.0046	0.0235	0.0348
Brugia malayi	intracellular kinase	0.0468	0.3833	0.3833
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0396	0.3215	0.3215
Echinococcus multilocularis	serine threonine protein kinase	0.0396	0.3215	0.4771
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0046	0.0235	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Schistosoma mansoni	metabotropic glutamate receptor	0.0041	0.0192	0.0286
Giardia lamblia	Kinase, AGC PKA	0.0764	0.6347	1
Schistosoma mansoni	hypothetical protein	0.0046	0.0235	0.0348
Schistosoma mansoni	hypothetical protein	0.0046	0.0235	0.0348
Trypanosoma cruzi	PH domain containing protein, putative	0.0046	0.0235	0.0059
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0468	0.3833	1
Echinococcus granulosus	cytochrome P450 2K1	0.0041	0.0196	0.0291
Schistosoma mansoni	myotubularin-related protein	0.0046	0.0235	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Brugia malayi	PH domain containing protein	0.0046	0.0235	0.0235
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0042	0.0198	0.0294
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0059	0.0344	0.0227
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0059	0.0344	0.0227
Trypanosoma cruzi	hypothetical protein	0.0046	0.0235	0.0059
Schistosoma mansoni	serine/threonine protein kinase	0.0396	0.3215	0.4771
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0059	0.0344	0.0151
Trichomonas vaginalis	AGC family protein kinase	0.0396	0.3215	0.3094
Entamoeba histolytica	hypothetical protein	0.0059	0.0344	0.0112
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.0231	0.0342
Echinococcus granulosus	beta 1 syntrophin	0.0046	0.0235	0.0348
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0396	0.3215	0.4771
Trichomonas vaginalis	AGC family protein kinase	0.0396	0.3215	0.3094
Brugia malayi	cytochrome P450	0.0041	0.0196	0.0196
Trypanosoma brucei	protein kinase, putative	0.0059	0.0344	0.0151
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0046	0.0235	0.0348
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0046	0.0235	0.0235
Schistosoma mansoni	hypothetical protein	0.0046	0.0235	0.0348
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0046	0.0235	0.0061
Entamoeba histolytica	protein kinase, putative	0.0059	0.0344	0.0112
Trichomonas vaginalis	CMGC family protein kinase	0.0468	0.3833	0.3723
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0751	0.6238	0.9257
Loa Loa (eye worm)	cytochrome P450 family protein	0.0041	0.0196	0.0196
Trichomonas vaginalis	centaurin alpha, putative	0.0046	0.0235	0.0061
Brugia malayi	probable spectrin beta chain	0.0046	0.0235	0.0235
Brugia malayi	Protein kinase domain containing protein	0.0396	0.3215	0.3215
Echinococcus multilocularis	Pleckstrin y	0.0046	0.0235	0.0348
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0046	0.0235	0.0348
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0059	0.0344	0.0898
Schistosoma mansoni	goodpasture antigen-binding protein	0.0046	0.0235	0.0348
Echinococcus granulosus	protein kinase shaggy	0.0468	0.3833	0.5688
Entamoeba histolytica	protein kinase, putative	0.0059	0.0344	0.0112
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0468	0.3833	0.5886
Brugia malayi	Syntrophin-1	0.0046	0.0235	0.0235
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0041	0.0196	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.081	0.6738	0.666
Entamoeba histolytica	protein kinase, putative	0.1193	1	1
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0041	0.0196	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0235	0.0061
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0059	0.0344	0.0227
Mycobacterium leprae	putative cytochrome p450	0.0041	0.0196	0.5
Entamoeba histolytica	protein kinase, putative	0.0396	0.3215	0.3052
Brugia malayi	Plekhf2 protein	0.0046	0.0235	0.0235
Trichomonas vaginalis	kinesin light chain, putative	0.0046	0.0235	0.0061
Schistosoma mansoni	hypothetical protein	0.0046	0.0235	0.0348
Schistosoma mansoni	goodpasture antigen-binding protein	0.0046	0.0235	0.0348
Entamoeba histolytica	p21-activated kinase	0.0059	0.0344	0.0112
Entamoeba histolytica	protein kinase, putative	0.0059	0.0344	0.0112
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0396	0.3215	0.4771
Entamoeba histolytica	protein kinase, putative	0.1147	0.9609	0.96
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0046	0.0235	0.0348
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0046	0.0235	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Trypanosoma brucei	protein kinase, putative	0.0468	0.3833	0.3709
Echinococcus multilocularis	Oxysterol binding protein 11	0.0046	0.0235	0.0348
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0235	0.0061
Echinococcus granulosus	pdz domain containing protein	0.0046	0.0235	0.0348
Entamoeba histolytica	protein kinase domain containing protein	0.0468	0.3833	0.3684
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.006	0.0356	0.0529
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0059	0.0344	0.0227
Echinococcus granulosus	myotubularin protein 13	0.0046	0.0235	0.0348
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0764	0.6347	0.9402
Brugia malayi	PH domain containing protein	0.0046	0.0235	0.0235
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0235	0.0061
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0046	0.0235	0.0348
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0041	0.0196	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0041	0.0196	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0442	0.3606	0.3492
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0396	0.3215	0.4771
Trichomonas vaginalis	AGC family protein kinase	0.1193	1	1
Trichomonas vaginalis	centaurin/arf, putative	0.0046	0.0235	0.0061
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0046	0.0235	0.0348
Echinococcus multilocularis	myotubularin protein 13	0.0046	0.0235	0.0348
Echinococcus granulosus	serine:threonine protein kinase N2	0.0396	0.3215	0.4771
Leishmania major	folate/biopterin transporter, putative	0.0059	0.0344	0.0898
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0041	0.0196	0.5
Trypanosoma cruzi	cytochrome P450, putative	0.0144	0.1068	0.1333
Echinococcus multilocularis	nervana 2	0.0751	0.6238	0.9257
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0059	0.0344	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Schistosoma mansoni	dynamin	0.0046	0.0235	0.0348
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0046	0.0235	0.0059
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0041	0.0196	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Echinococcus multilocularis	oxysterol binding protein 1	0.0046	0.0235	0.0348
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0764	0.6347	0.942
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0049	0.026	0.026
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0041	0.0196	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0396	0.3215	0.4771
Brugia malayi	Pleckstrin Homology Domain	0.0046	0.0235	0.0235
Schistosoma mansoni	serine/threonine protein kinase	0.0396	0.3215	0.4771
Schistosoma mansoni	syntrophin	0.0046	0.0235	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Trypanosoma cruzi	cytochrome P450, putative	0.0144	0.1068	0.1333
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0059	0.0344	0.0227
Trypanosoma cruzi	hypothetical protein	0.0046	0.0235	0.0059
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0235	0.0061
Trichomonas vaginalis	hypothetical protein	0.0046	0.0235	0.0061
Schistosoma mansoni	growth factor receptor-bound protein	0.0046	0.0235	0.0348
Echinococcus granulosus	oxysterol binding protein 3	0.0046	0.0235	0.0348
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0764	0.6347	1
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Loa Loa (eye worm)	cytochrome P450 family protein	0.0144	0.1068	0.1068
Entamoeba histolytica	PH domain containing protein kinase, putative	0.081	0.6738	0.666
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0041	0.0196	0.5
Echinococcus multilocularis		0.0041	0.0196	0.0291
Brugia malayi	PH domain containing protein	0.0046	0.0235	0.0235
Schistosoma mansoni	oxysterol-binding protein 1	0.0046	0.0235	0.0348
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0041	0.0196	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0235	0.0061
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0046	0.0235	0.0235
Trichomonas vaginalis	AGC family protein kinase	0.1193	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0046	0.0235	0.0235
Echinococcus granulosus	metabotropic glutamate receptor 5	0.006	0.0356	0.0529
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0046	0.0235	0.0348
Brugia malayi	PH domain containing protein	0.0046	0.0235	0.0235
Trichomonas vaginalis	centaurin gamma, putative	0.0046	0.0235	0.0061
Trypanosoma cruzi	Protein kinase B	0.081	0.6738	1
Toxoplasma gondii	hypothetical protein	0.0046	0.0235	0.0244
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Brugia malayi	Dynamin	0.0046	0.0235	0.0235
Brugia malayi	Cytochrome P450 family protein	0.0144	0.1068	0.1068
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0046	0.0235	0.0348
Brugia malayi	Oxysterol-binding protein	0.0046	0.0235	0.0235
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0046	0.0235	0.0348
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Echinococcus multilocularis	oxysterol binding protein 9	0.0046	0.0235	0.0348
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0041	0.0196	0.5
Brugia malayi	PH domain containing protein	0.0046	0.0235	0.0235
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.1147	0.9609	0.9609
Brugia malayi	hypothetical protein	0.0046	0.0235	0.0235
Onchocerca volvulus		0.0468	0.3833	1
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0046	0.0235	0.0348
Echinococcus granulosus	protein kinase c epsilon type	0.0396	0.3215	0.4771
Trichomonas vaginalis	AGC family protein kinase	0.1193	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0235	0.0061
Echinococcus multilocularis	Pleckstrin y	0.0046	0.0235	0.0348
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0059	0.0344	0.0172
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0041	0.0196	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Echinococcus multilocularis	rac serine:threonine kinase	0.081	0.6738	1
Leishmania major	protein kinase, putative	0.0059	0.0344	0.0898
Loa Loa (eye worm)	cytochrome P450	0.0041	0.0196	0.0196
Echinococcus granulosus	serine threonine protein kinase nrc	0.0764	0.6347	0.942
Trichomonas vaginalis	AGC family protein kinase	0.1193	1	1
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0059	0.0344	0.0151
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0046	0.0235	0.0348
Echinococcus granulosus	Protein kinase C brain isozyme	0.0396	0.3215	0.4771
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0059	0.0344	0.0151
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0059	0.0344	0.0112
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0235	0.0061
Trypanosoma cruzi	hypothetical protein	0.0046	0.0235	0.0059
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0396	0.3215	0.4771
Echinococcus granulosus	NDR protein kinase	0.0396	0.3215	0.4771
Loa Loa (eye worm)	CYP4Cod1	0.0144	0.1068	0.1068
Schistosoma mansoni	rho gtpase activating protein	0.0046	0.0235	0.0348
Brugia malayi	Dynamin	0.0046	0.0235	0.0235
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0396	0.3215	0.3215
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0396	0.3215	0.3215
Schistosoma mansoni	atypical protein kinase C	0.0396	0.3215	0.4771
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0046	0.0235	0.0235
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0059	0.0344	0.0172
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0046	0.0235	0.0348
Trypanosoma cruzi	hypothetical protein	0.0046	0.0235	0.0059
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0764	0.6347	0.942
Trypanosoma brucei	cytochrome P450, putative	0.0144	0.1068	0.0889
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Loa Loa (eye worm)	oxysterol binding protein	0.0046	0.0235	0.0235
Schistosoma mansoni	hypothetical protein	0.0041	0.0196	0.0291
Echinococcus multilocularis	Glutaredoxin protein 5	0.0751	0.6238	0.9257
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Echinococcus multilocularis	nervana 2	0.0751	0.6238	0.9257
Brugia malayi	Oxysterol binding protein	0.0046	0.0235	0.0235
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0235	0.0061
Schistosoma mansoni	serine/threonine protein kinase	0.0396	0.3215	0.4771
Echinococcus granulosus	pleckstrin y domain containing family A	0.0046	0.0235	0.0348
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0396	0.3215	0.4771
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0041	0.0196	0.5
Echinococcus granulosus	DCC interacting protein 13 beta	0.0046	0.0235	0.0348
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Trypanosoma brucei	rac serine-threonine kinase, putative	0.1193	1	1
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0059	0.0344	0.0179
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0059	0.0344	0.0151
Schistosoma mansoni	serine/threonine protein kinase	0.0396	0.3215	0.4771
Trypanosoma cruzi	NIMA-related kinase, putative	0.0059	0.0344	0.0227
Schistosoma mansoni	vav2	0.0046	0.0235	0.0348
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0235	0.0061
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0041	0.0196	0.5
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0059	0.0344	0.0227
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0056	0.0317	0.0471
Toxoplasma gondii	hypothetical protein	0.0046	0.0235	0.0244
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0059	0.0344	0.0227
Brugia malayi	Cytohesin 3	0.0046	0.0235	0.0235
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0041	0.0196	0.5
Brugia malayi	PH domain containing protein	0.0046	0.0235	0.0235
Trichomonas vaginalis	AGC family protein kinase	0.1193	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0468	0.3833	0.3684
Loa Loa (eye worm)	Plekhf2 protein	0.0046	0.0235	0.0235
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0468	0.3833	0.5688
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0396	0.3215	0.3215
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0046	0.0235	0.0348
Schistosoma mansoni	dynamin	0.0046	0.0235	0.0348
Brugia malayi	Protein kinase domain containing protein	0.0396	0.3215	0.3215
Trichomonas vaginalis	AGC family protein kinase	0.0396	0.3215	0.3094
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0235	0.0061
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0042	0.0198	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0046	0.0235	0.0244
Echinococcus multilocularis	pdz domain containing protein	0.0046	0.0235	0.0348
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0046	0.0235	0.037
Leishmania major	cytochrome p450-like protein	0.0041	0.0196	0.0511
Entamoeba histolytica	protein kinase, putative	0.0059	0.0344	0.0112
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0046	0.0235	0.0348
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0046	0.0235	0.0348
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0059	0.0344	0.0898
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0059	0.0344	0.0112
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0046	0.0235	0.0348
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0396	0.3215	0.4771
Trichomonas vaginalis	AGC family protein kinase	0.1193	1	1
Echinococcus granulosus	Rho GTPase activating protein 24	0.0046	0.0235	0.0348
Brugia malayi	Uncoordinated protein 104	0.0046	0.0235	0.0235
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0046	0.0235	0.0348
Echinococcus multilocularis	oxysterol binding protein 3	0.0046	0.0235	0.0348
Brugia malayi	metabotropic glutamate receptor type 2	0.0024	0.0047	0.0047
Brugia malayi	Cytochrome P450 family protein	0.0144	0.1068	0.1068
Echinococcus multilocularis	protein kinase c epsilon type	0.0396	0.3215	0.4771
Echinococcus granulosus	GRB2 associated binding protein 3	0.0046	0.0235	0.0348
Schistosoma mansoni	metabotropic glutamate receptor	0.0024	0.0047	0.0069
Brugia malayi	PH domain containing protein	0.0046	0.0235	0.0235
Loa Loa (eye worm)	syntrophin-1	0.0046	0.0235	0.0235
Schistosoma mansoni	zinc finger protein	0.0046	0.0235	0.0348
Schistosoma mansoni	serine/threonine protein kinase	0.0396	0.3215	0.4771
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Trypanosoma cruzi	PH domain containing protein, putative	0.0046	0.0235	0.0059
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0046	0.0235	0.0061
Echinococcus multilocularis	protein kinase c iota type	0.0396	0.3215	0.4771
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0059	0.0344	0.0112
Plasmodium falciparum	glycogen synthase kinase 3	0.0468	0.3833	0.6038
Leishmania major	protein kinase, putative	0.0059	0.0344	0.0898
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0151	0.0151
Entamoeba histolytica	protein kinase, putative	0.0468	0.3833	0.3684
Toxoplasma gondii	Oxysterol-binding protein	0.0046	0.0235	0.0244
Brugia malayi	protein kinase C II.	0.0396	0.3215	0.3215
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Leishmania major	cytochrome p450-like protein	0.0041	0.0196	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Echinococcus multilocularis	protein kinase shaggy	0.0468	0.3833	0.5688
Entamoeba histolytica	protein kinase, putative	0.1193	1	1
Echinococcus multilocularis	beta 1 syntrophin	0.0046	0.0235	0.0348
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0396	0.3215	0.4771
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0041	0.0196	0.5
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0046	0.0235	0.0348
Schistosoma mansoni	hypothetical protein	0.0046	0.0235	0.0348
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0041	0.0192	0.0286
Loa Loa (eye worm)	glutamate receptor	0.0019	0.0008	0.0008
Echinococcus granulosus	serine/threonine protein kinase	0.081	0.6738	1
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0046	0.0235	0.0348
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0046	0.0235	0.0061
Trichomonas vaginalis	centaurin beta, putative	0.0046	0.0235	0.0061
Schistosoma mansoni	serine/threonine kinase	0.0396	0.3215	0.4771
Leishmania major	hypothetical protein, conserved	0.0046	0.0235	0.0612
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0046	0.0235	0.0348
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0235	0.0061
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0468	0.3833	0.5688
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0041	0.0196	0.5
Schistosoma mansoni	zinc finger protein	0.0046	0.0235	0.0348
Echinococcus granulosus	protein kinase C gamma type	0.0396	0.3215	0.4771
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0041	0.0196	0.5
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0046	0.0235	0.0235
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0059	0.0344	0.0227
Schistosoma mansoni	cytochrome P450	0.0041	0.0196	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Echinococcus granulosus	oxysterol binding protein 1	0.0046	0.0235	0.0348
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0235	0.0061
Trypanosoma brucei	PH domain containing protein, putative	0.0046	0.0235	0.004
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0046	0.0235	0.0348
Echinococcus granulosus	Pleckstrin y	0.0046	0.0235	0.0348
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0044	0.0221	0.0221
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0041	0.0196	0.5
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0764	0.6347	1
Trichomonas vaginalis	centaurin/arf, putative	0.0046	0.0235	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0396	0.3215	0.3215
Trypanosoma cruzi	hypothetical protein	0.0046	0.0235	0.0059
Echinococcus granulosus	nervana 2	0.0751	0.6238	0.9257
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0046	0.0235	0.0059
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0046	0.0235	0.0059
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0041	0.0192	0.0286
Loa Loa (eye worm)	cytochrome P450 family protein	0.0144	0.1068	0.1068
Schistosoma mansoni	serine/threonine-protein kinase	0.081	0.6738	1
Brugia malayi	PH domain containing protein	0.0046	0.0235	0.0235
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Toxoplasma gondii	AGC kinase	0.1147	0.9609	1
Echinococcus multilocularis	Pleckstrin y	0.0046	0.0235	0.0348
Mycobacterium leprae	Conserved hypothetical protein	0.0041	0.0196	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Echinococcus granulosus	dynamin 1	0.0046	0.0235	0.0348
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0046	0.0235	0.037
Trypanosoma cruzi	hypothetical protein	0.0046	0.0235	0.0059
Trypanosoma cruzi	PH domain containing protein, putative	0.0046	0.0235	0.0059
Schistosoma mansoni	serine/threonine protein kinase	0.0396	0.3215	0.4771
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0396	0.3215	0.3215
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0046	0.0235	0.0348
Toxoplasma gondii	AtPH1 family protein	0.0046	0.0235	0.0244
Echinococcus granulosus	protein kinase c iota type	0.0396	0.3215	0.4771
Loa Loa (eye worm)	cytohesin 3	0.0046	0.0235	0.0235
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Schistosoma mansoni	centaurin alpha	0.0046	0.0235	0.0348
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0396	0.3215	0.4771
Echinococcus multilocularis	dynamin 1	0.0046	0.0235	0.0348
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0046	0.0235	0.037
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.0231	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Brugia malayi	Cadps2 protein	0.0046	0.0235	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0716	0.0716
Entamoeba histolytica	protein kinase, putative	0.0059	0.0344	0.0112
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0046	0.0235	0.0348
Brugia malayi	PH domain containing protein	0.0046	0.0235	0.0235
Brugia malayi	MAX-1A	0.0046	0.0235	0.0235
Leishmania major	serine/threonine-protein kinase a, putative	0.0059	0.0344	0.0898
Echinococcus granulosus	Glutaredoxin protein 5	0.0751	0.6238	0.9257
Loa Loa (eye worm)	glutamate receptor	0.0049	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0046	0.0235	0.0235
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0046	0.0235	0.037
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Echinococcus granulosus	nervana 2	0.0751	0.6238	0.9257
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0235	0.0061
Echinococcus granulosus	cytohesin 1	0.0046	0.0235	0.0348
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0235	0.0061
Loa Loa (eye worm)	hypothetical protein	0.006	0.0356	0.0356
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0468	0.3833	0.5688
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0235	0.0061
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0042	0.0198	0.0294
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0144	0.1068	1
Brugia malayi	Cytochrome P450 family protein	0.0041	0.0196	0.0196
Echinococcus granulosus	Oxysterol binding protein 11	0.0046	0.0235	0.0348
Leishmania major	hypothetical protein, conserved	0.0046	0.0235	0.0612
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0059	0.0344	0.0112
Trichomonas vaginalis	protein transport protein sec7, putative	0.0046	0.0235	0.0061
Trichomonas vaginalis	alpha chimerin, putative	0.0046	0.0235	0.0061
Trichomonas vaginalis	CMGC family protein kinase	0.0468	0.3833	0.3723
Trichomonas vaginalis	protein transport protein sec7, putative	0.0046	0.0235	0.0061
Brugia malayi	Cytochrome P450 family protein	0.0041	0.0196	0.0196
Echinococcus granulosus	Pleckstrin y	0.0046	0.0235	0.0348
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0396	0.3215	0.4771
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0046	0.0235	0.0061
Entamoeba histolytica	protein kinase 2, putative	0.0764	0.6347	0.626
Echinococcus granulosus	oxysterol binding protein 9	0.0046	0.0235	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Leishmania major	cytochrome p450-like protein	0.0144	0.1068	0.2786
Plasmodium falciparum	oxysterol-binding protein, putative	0.0046	0.0235	0.037
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0046	0.0235	0.0061
Echinococcus granulosus	Pleckstrin y	0.0046	0.0235	0.0348
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0046	0.0235	0.0348
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0751	0.6238	0.9257
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0046	0.0235	0.0348
Brugia malayi	Variant SH3 domain containing protein	0.0046	0.0235	0.0235
Loa Loa (eye worm)	uncoordinated protein 104	0.0046	0.0235	0.0235
Trypanosoma cruzi	NIMA-related kinase, putative	0.0059	0.0344	0.0227
Echinococcus multilocularis	cytohesin 1	0.0046	0.0235	0.0348
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0468	0.3833	0.3833
Entamoeba histolytica	hypothetical protein	0.0059	0.0344	0.0112
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Echinococcus multilocularis	actin binding protein anillin	0.0046	0.0235	0.0348
Loa Loa (eye worm)	AGC/AKT protein kinase	0.1193	1	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.081	0.6738	1
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0235	0.0061
Brugia malayi	p70 ribosomal S6 kinase beta	0.1147	0.9609	0.9609
Toxoplasma gondii	protein kinase domain-containing protein	0.0059	0.0344	0.0358
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0468	0.3833	0.3989
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0042	0.0198	0.0198
Loa Loa (eye worm)	PH domain-containing protein	0.0046	0.0235	0.0235
Trypanosoma cruzi	PH domain containing protein, putative	0.0046	0.0235	0.0059
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0046	0.0235	0.0061
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0383	0.3105	0.2983
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0468	0.3833	0.3833
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0046	0.0235	0.0348
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0041	0.0196	0.0511
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0396	0.3215	0.3215
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0059	0.0344	0.0358
Trypanosoma cruzi	hypothetical protein	0.0046	0.0235	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0235	0.0235
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0468	0.3833	0.5559
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0041	0.0196	0.5
Schistosoma mansoni	serine/threonine-protein kinase	0.081	0.6738	1
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0344	0.0172
Brugia malayi	TBC domain containing protein	0.0046	0.0235	0.0235
Brugia malayi	Variant SH3 domain containing protein	0.0046	0.0235	0.0235

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 221 nM	Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ion level after 18 hrs by fluorescence-based FDSS6000 assay	ChEMBL.	25127154
Inhibition (binding)	= 78.05 %	Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ion level at 1 uM after 18 hrs by fluorescence-based FDSS6000 assay	ChEMBL.	25127154
Inhibition (binding)	= 89.05 %	Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ion level at 10 uM after 18 hrs by fluorescence-based FDSS6000 assay	ChEMBL.	25127154

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3330824

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 928672