Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | 0.1845 | 0.6981 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0819 | 0.1819 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0673 | 0.1081 | 0.1549 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.1492 | 0.5202 | 0.7452 |
Loa Loa (eye worm) | hypothetical protein | 0.0673 | 0.1081 | 0.1549 |
Onchocerca volvulus | Matrilysin homolog | 0.1492 | 0.5202 | 0.7452 |
Brugia malayi | Matrixin family protein | 0.0673 | 0.1081 | 0.1549 |
Brugia malayi | Matrixin family protein | 0.0673 | 0.1081 | 0.1549 |
Mycobacterium ulcerans | hydrolase | 0.0819 | 0.1819 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0458 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0673 | 0.1081 | 0.1549 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0819 | 0.1819 | 0.2605 |
Brugia malayi | Hemopexin family protein | 0.0954 | 0.2495 | 0.3574 |
Brugia malayi | Matrixin family protein | 0.0673 | 0.1081 | 0.1549 |
Loa Loa (eye worm) | hypothetical protein | 0.0819 | 0.1819 | 0.2605 |
Loa Loa (eye worm) | matrixin family protein | 0.1492 | 0.5202 | 0.7452 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0819 | 0.1819 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0673 | 0.1081 | 0.1549 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0458 | 0 | 0.5 |
Brugia malayi | Matrixin family protein | 0.1626 | 0.5879 | 0.8421 |
Loa Loa (eye worm) | hypothetical protein | 0.1845 | 0.6981 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0954 | 0.2495 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.1626 | 0.5879 | 0.8421 |
Onchocerca volvulus | 0.0673 | 0.1081 | 0.1549 | |
Onchocerca volvulus | 0.0954 | 0.2495 | 0.3574 | |
Onchocerca volvulus | Matrilysin homolog | 0.0673 | 0.1081 | 0.1549 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0673 | 0.1081 | 0.1549 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.2445 | 1 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0673 | 0.1081 | 0.4333 |
Brugia malayi | ecdysteroid receptor | 0.1845 | 0.6981 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 100 uM | Antiproliferative activity against HEK293 cells assessed as inhibition of cell proliferation incubated for 18 hrs followed by MTT addition for 4 hrs by MTT assay | ChEMBL. | 25128666 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.