TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 437.922 | Formula: C23H24ClN5O2
H donors: 0 H acceptors: 3 LogP: 4.02 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(c(c1)c1nnc2n1c1cc(ccc1nc2C)CN1CCOCC1)Cl
InChi: 1S/C23H24ClN5O2/c1-3-31-17-5-6-19(24)18(13-17)23-27-26-22-15(2)25-20-7-4-16(12-21(20)29(22)23)14-28-8-10-30-11-9-28/h4-7,12-13H,3,8-11,14H2,1-2H3
InChiKey: PQYOTCFMIISAPG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Starlite/ChEMBL	References
Homo sapiens	phosphodiesterase 2A, cGMP-stimulated	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	Get druggable targets OG5_135549	All targets in OG5_135549
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135549	All targets in OG5_135549
Schistosoma japonicum	cGMP-dependent 3',5'-cyclic phosphodiesterase, putative	Get druggable targets OG5_135549	All targets in OG5_135549
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135363	All targets in OG5_135363
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	Get druggable targets OG5_135363	All targets in OG5_135363
Schistosoma japonicum	ko:K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC3.1.4.17], putative	Get druggable targets OG5_135549	All targets in OG5_135549
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	Get druggable targets OG5_135363	All targets in OG5_135363
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135363	All targets in OG5_135363
Schistosoma japonicum	cGMP-dependent 3',5'-cyclic phosphodiesterase, putative	Get druggable targets OG5_135549	All targets in OG5_135549
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	Get druggable targets OG5_135549	All targets in OG5_135549
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	Get druggable targets OG5_135363	All targets in OG5_135363

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	668 aa	25.7 %
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	693 aa	25.3 %
Leishmania infantum	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.6 %
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	712 aa	25.0 %
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	656 aa	30.9 %
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	716 aa	26.0 %
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	26.5 %
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	668 aa	24.7 %
Trypanosoma brucei	cAMP-specific phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	666 aa	30.5 %
Leishmania infantum	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.4 %
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	686 aa	29.0 %
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	668 aa	30.5 %
Drosophila melanogaster	Phosphodiesterase 6	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	684 aa	32.2 %
Leishmania mexicana	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	672 aa	30.2 %
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	655 aa	24.1 %
Leishmania donovani	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.6 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	689 aa	22.8 %
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	674 aa	29.2 %
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	683 aa	27.5 %
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	666 aa	29.1 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	711 aa	26.2 %
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	665 aa	23.5 %
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	666 aa	30.5 %
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	689 aa	22.8 %
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	674 aa	29.1 %
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	661 aa	30.3 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	699 aa	25.5 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	653 aa	23.0 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	686 aa	24.1 %
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	665 aa	30.5 %
Trypanosoma brucei	cAMP-specific phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	661 aa	30.3 %
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	679 aa	26.7 %
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	682 aa	23.5 %
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	688 aa	29.1 %
Leishmania mexicana	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.8 %
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	682 aa	28.9 %
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	661 aa	22.7 %
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	phosphodiesterase 2A, cGMP-stimulated	934 aa	748 aa	27.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0041	0.071	0.2157
Entamoeba histolytica	hypothetical protein	0.0037	0.0628	0.0848
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0038	0.0638	0.0661
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0638	0.0716
Trypanosoma brucei	hypothetical protein, conserved	0.0016	0.0155	0.0419
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0363	0.0436
Schistosoma mansoni	amine GPCR	0.0038	0.0638	0.0661
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0313	0.6704	0.756
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0155	0.0152
Schistosoma mansoni	myosin xvIII	0.0038	0.0638	0.0661
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0057	0.1059	0.1516
Schistosoma mansoni	opsin-like receptor	0.0038	0.0638	0.0661
Echinococcus granulosus	hypothetical protein	0.0038	0.0638	0.0716
Toxoplasma gondii	GAF domain-containing protein	0.0041	0.071	0.2753
Loa Loa (eye worm)	TAR-binding protein	0.0131	0.2697	0.2695
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Echinococcus multilocularis	g-protein coupled receptor	0.0038	0.0638	0.0716
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0087	0.1724	0.5497
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.1059	0.1516
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0638	0.0716
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.2697	0.2998
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0638	0.0716
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0518	0.0516
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0119	0.2435	0.7836
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0016	0.0155	0.0419
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0222	0.0549
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0016	0.0155	0.0419
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0518	0.0582
Brugia malayi	hypothetical protein	0.0038	0.0638	0.0638
Brugia malayi	Inositol monophosphatase family protein	0.0013	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0518	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0046	0.082	0.2519
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0057	0.1059	0.4219
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0638	0.0661
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0638	0.0716
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0016	0.0155	0.0172
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0638	0.0661
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0638	0.0716
Echinococcus granulosus	neuropeptide s receptor	0.0038	0.0638	0.0716
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0155	0.0114
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.071	0.2157
Echinococcus multilocularis	sex peptide receptor	0.0038	0.0638	0.0716
Onchocerca volvulus		0.0038	0.0638	0.0581
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0016	0.0155	0.0419
Mycobacterium leprae	POSSIBLE MONOPHOSPHATASE CYSQ	0.0013	0.0081	0.0086
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0119	0.2435	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0038	0.0638	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0363	0.036
Echinococcus granulosus	fmrfamide receptor	0.0038	0.0638	0.0716
Schistosoma mansoni	hypothetical protein	0.0038	0.0638	0.0661
Echinococcus multilocularis	inositol monophosphatase	0.0013	0.0081	0.0089
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0363	0.1013
Brugia malayi	TAR-binding protein	0.0131	0.2697	0.2697
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0638	0.0661
Trypanosoma brucei	GAF domain/TIP41-like family, putative	0.0046	0.082	0.3215
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0628	0.065
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0306	0.6533	1
Loa Loa (eye worm)	cytochrome P450	0.0011	0.0055	0.0053
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0038	0.0638	0.0661
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0016	0.0155	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0222	0.0219
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0363	0.1013
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0057	0.1059	0.1516
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0638	0.0635
Brugia malayi	Dopamine receptor protein 1	0.0038	0.0638	0.0638
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.071	0.0975
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0638	0.0716
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0016	0.0155	0.0172
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0161	0.3352	0.3742
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0638	0.0716
Brugia malayi	hypothetical protein	0.0038	0.0638	0.0638
Schistosoma mansoni	cpg binding protein	0.0031	0.0478	0.048
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.088	0.088
Trypanosoma cruzi	GAF domain/TIP41-like family, putative	0.0046	0.082	0.3215
Schistosoma mansoni	opsin-like receptor	0.0038	0.0638	0.0661
Leishmania major	myo-inositol-1 phosphatase, putative	0.0013	0.0081	0.011
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0038	0.0638	0.0716
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0638	0.0716
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0638	0.0661
Brugia malayi	AKH receptor	0.0038	0.0638	0.0638
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0038	0.0638	0.0716
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.1059	0.1516
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0038	0.0638	0.0661
Brugia malayi	putative neuropeptide receptor	0.0038	0.0638	0.0638
Echinococcus multilocularis	dro:myosuppressin receptor	0.0038	0.0638	0.0716
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.1011	0.4018
Entamoeba histolytica	hypothetical protein	0.0037	0.0628	0.0848
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0057	0.1059	0.4219
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0638	0.0716
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0131	0.2697	0.2695
Brugia malayi	cytochrome P450	0.0011	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0155	0.0152
Echinococcus multilocularis	3'(2'),5' bisphosphate nucleotidase 1	0.0013	0.0081	0.0089
Mycobacterium ulcerans	monophosphatase CysQ	0.0013	0.0081	0.0086
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0638	0.0661
Echinococcus multilocularis		0.0011	0.0055	0.0059
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0038	0.0638	0.0635
Echinococcus granulosus	cytochrome P450 2K1	0.0011	0.0055	0.0059
Echinococcus granulosus	muscleblind protein	0.0155	0.3221	0.3631
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0638	0.0635
Onchocerca volvulus		0.0038	0.0638	0.0581
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0638	0.0716
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0363	0.1013
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0638	0.0661
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0638	0.0661
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0119	0.2435	0.3648
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0016	0.0155	0.0113
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0016	0.0155	0.0419
Echinococcus multilocularis	somatostatin receptor	0.0038	0.0638	0.0716
Mycobacterium ulcerans	putative regulatory protein	0.0041	0.071	0.2157
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.1059	0.1516
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0016	0.0155	0.0152
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0038	0.0638	0.0661
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0518	0.0582
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0161	0.3352	0.3352
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0038	0.0638	0.0716
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0638	0.0661
Brugia malayi	Serotonin receptor	0.0038	0.0638	0.0638
Echinococcus granulosus	inositol monophosphatase 1	0.0119	0.2435	0.2744
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0638	0.0716
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0016	0.0155	0.0113
Leishmania major	inositol polyphosphate 1-phosphatase, putative	0.0013	0.0081	0.011
Loa Loa (eye worm)	cytochrome P450 family protein	0.0011	0.0055	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0016	0.0155	0.0419
Trypanosoma cruzi	inositol polyphosphate 1-phosphatase, putative	0.0013	0.0081	0.011
Schistosoma mansoni	myo inositol monophosphatase	0.0013	0.0081	0.003
Giardia lamblia	Hypothetical protein	0.0016	0.0155	0.0114
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.088	0.0936
Trichomonas vaginalis	inositol monophosphatase, putative	0.0119	0.2435	0.3648
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0638	0.0635
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0016	0.0155	0.0113
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0638	0.0661
Echinococcus multilocularis	neuropeptide receptor A26	0.0038	0.0638	0.0716
Brugia malayi	hypothetical protein	0.0038	0.0638	0.0638
Echinococcus multilocularis	serotonin receptor	0.0038	0.0638	0.0716
Echinococcus multilocularis	tar DNA binding protein	0.0131	0.2697	0.304
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0638	0.0716
Schistosoma mansoni	hypothetical protein	0.0412	0.8867	1
Leishmania major	hypothetical protein, conserved	0.0016	0.0155	0.0419
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0016	0.0155	0.0419
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0638	0.0635
Schistosoma mansoni	inositol monophosphatase	0.0119	0.2435	0.27
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0363	0.1013
Brugia malayi	Muscleblind-like protein	0.0155	0.3221	0.3221
Echinococcus granulosus	neuropeptide FF receptor 2	0.0038	0.0638	0.0716
Echinococcus multilocularis	dnaJ subfamily B	0.0412	0.8867	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0038	0.0638	0.0716
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0155	0.0419
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0016	0.0155	0.0172
Mycobacterium ulcerans	monophosphatase CysQ	0.0013	0.0081	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Schistosoma mansoni	hypothetical protein	0.0032	0.0518	0.0526
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0016	0.0155	0.0114
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0628	0.0706
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0016	0.0155	0.0114
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.1059	0.1516
Brugia malayi	GnHR receptor homolog	0.0038	0.0638	0.0638
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0149	0.3092	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Echinococcus granulosus	tar DNA binding protein	0.0131	0.2697	0.304
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.071	0.0975
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0038	0.0638	0.0716
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0038	0.0638	0.0716
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0363	0.1292
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0222	0.0219
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0638	0.0716
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0222	0.1209
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.071	0.0975
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0016	0.0155	0.0172
Onchocerca volvulus		0.0038	0.0638	0.0581
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0016	0.0155	0.0419
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0016	0.0155	0.0155
Mycobacterium tuberculosis	Probable monophosphatase	0.0013	0.0081	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0638	0.0716
Brugia malayi	Cytochrome P450 family protein	0.0011	0.0055	0.0055
Onchocerca volvulus		0.0038	0.0638	0.0581
Mycobacterium ulcerans	putative regulatory protein	0.0041	0.071	0.2157
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0038	0.0638	0.0635
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0638	0.0716
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0638	0.0661
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0199	0.0474
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0306	0.6533	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0016	0.0155	0.0419
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0638	0.0716
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0016	0.0155	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0222	0.0219
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0016	0.0155	0.0155
Loa Loa (eye worm)	inositol-1	0.0119	0.2435	0.2433
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0016	0.0155	0.0114
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0313	0.6704	0.756
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0119	0.2435	1
Brugia malayi	hypothetical protein	0.0037	0.0628	0.0628
Schistosoma mansoni	amine GPCR	0.0038	0.0638	0.0661
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0016	0.0155	0.0155
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0638	0.0716
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0638	0.0661
Mycobacterium leprae	Probable monophosphatase	0.0013	0.0081	0.0086
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0119	0.2435	0.3648
Schistosoma mansoni	pap-inositol-14-phosphatase	0.0013	0.0081	0.003
Brugia malayi	Dopamine receptor protein 2	0.0038	0.0638	0.0638
Brugia malayi	larval opioid receptor	0.0038	0.0638	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0038	0.0638	0.0716
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0155	0.0419
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0016	0.0155	0.0172
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0119	0.2435	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0038	0.0638	0.0638
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0016	0.0155	0.0114
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0155	0.0419
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0363	0.1013
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0638	0.0661
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0016	0.0155	0.0172
Onchocerca volvulus		0.0038	0.0638	0.0581
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0363	0.1013
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0363	0.036
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0038	0.0638	0.0716
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0016	0.0155	0.0155
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0638	0.0661
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0306	0.6533	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0016	0.0155	0.0419
Brugia malayi	G-protein coupled receptor	0.0038	0.0638	0.0638
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0016	0.0155	0.0172
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0363	0.1013
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0057	0.1059	0.1516
Onchocerca volvulus		0.0025	0.0363	0.0304
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.088	0.099
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0038	0.0638	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0222	0.0219
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0638	0.0716
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0038	0.0638	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0363	0.036
Trypanosoma cruzi	myo-inositol-1 phosphatase, putative	0.0013	0.0081	0.011
Giardia lamblia	Fructose-bisphosphate aldolase	0.0306	0.6533	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0638	0.0716
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0155	0.0114
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0016	0.0155	0.0113
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.088	0.0936
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0016	0.0155	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Toxoplasma gondii	hypothetical protein	0.0041	0.071	0.2753
Loa Loa (eye worm)	CYP4Cod1	0.0011	0.0055	0.0053
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0363	0.1292
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0518	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.1059	0.1516
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.1059	0.1516
Brugia malayi	follicle stimulating hormone receptor	0.0038	0.0638	0.0638
Toxoplasma gondii	hypothetical protein	0.0041	0.071	0.2753
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0638	0.0716
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0638	0.0716
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0638	0.0661
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0081	0.0079
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0638	0.0661
Brugia malayi	RE15519p	0.0038	0.0638	0.0638
Echinococcus multilocularis	allatostatin A receptor	0.0038	0.0638	0.0716
Mycobacterium ulcerans	monophosphatase	0.0013	0.0081	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3221	0.3219
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0518	0.0582
Echinococcus multilocularis	serotonin receptor	0.0038	0.0638	0.0716
Brugia malayi	hypothetical protein	0.0038	0.0638	0.0638
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0638	0.0661
Onchocerca volvulus		0.0038	0.0638	0.0581
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0103	0.2073	0.3088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.088	0.099
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0363	0.1292
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0442	0.0439
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0638	0.0716
Onchocerca volvulus		0.0038	0.0638	0.0581
Onchocerca volvulus		0.0038	0.0638	0.0581
Brugia malayi	sulfakinin receptor protein	0.0038	0.0638	0.0638
Echinococcus multilocularis	muscleblind protein 1	0.0155	0.3221	0.3631
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0038	0.0638	0.0638
Onchocerca volvulus	Inositol monophosphatase 3 homolog	0.0013	0.0081	0.0021
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0057	0.1059	0.4219
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.088	0.0878
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0638	0.0716
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0638	0.0661
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.1345	0.1345
Schistosoma mansoni	neuropeptide f receptor 76f	0.0038	0.0638	0.0661
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Brugia malayi	Cytochrome P450 family protein	0.0052	0.0951	0.0951
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0149	0.3092	1
Brugia malayi	RNA recognition motif domain containing protein	0.0131	0.2697	0.2697
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0638	0.0716
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0057	0.1059	0.1516
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Echinococcus granulosus	neuropeptide receptor A26	0.0038	0.0638	0.0716
Echinococcus granulosus	cpg binding protein	0.0031	0.0478	0.0537
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0638	0.0661
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0638	0.0716
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0363	0.1013
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0016	0.0155	0.0419
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0306	0.6533	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0038	0.0638	0.0716
Echinococcus granulosus	allatostatin A receptor	0.0038	0.0638	0.0716
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0016	0.0155	0.0114
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0638	0.0716
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0107	0.2159	0.6929
Echinococcus multilocularis	inositol monophosphatase 1	0.0119	0.2435	0.2744
Onchocerca volvulus		0.0038	0.0638	0.0581
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.088	0.099
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0016	0.0155	0.0419
Schistosoma mansoni	cpg binding protein	0.0029	0.0442	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0016	0.0155	0.0172
Schistosoma mansoni	hypothetical protein	0.007	0.1345	0.1464
Echinococcus granulosus	GPCR family 2	0.0032	0.0518	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.1059	0.1516
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.1059	0.1516
Brugia malayi	Inositol monophosphatase family protein	0.0013	0.0081	0.0081
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0638	0.0716
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0057	0.1059	0.1192
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0057	0.1059	0.1516
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0016	0.0155	0.0113
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0638	0.0716
Loa Loa (eye worm)	hypothetical protein	0.007	0.1345	0.1343
Brugia malayi	hypothetical protein	0.0038	0.0638	0.0638
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0306	0.6533	1
Echinococcus granulosus	orexin receptor type 2	0.0038	0.0638	0.0716
Trypanosoma brucei	inositol-1(or 4)-monophosphatase, putative	0.0013	0.0081	0.011
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0107	0.2159	0.6929
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0638	0.0716
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.2697	0.2998
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0222	0.1209
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0038	0.0638	0.0635
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0057	0.1059	0.1516
Onchocerca volvulus		0.0463	1	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0518	0.0526
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0518	0.0518
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0016	0.0155	0.0419
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0038	0.0638	0.0716
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0363	0.0363
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0016	0.0155	0.0172
Brugia malayi	Cytochrome P450 family protein	0.0011	0.0055	0.0055
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0038	0.0638	0.0638
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0038	0.0638	0.0661
Entamoeba histolytica	hypothetical protein	0.0037	0.0628	0.0848
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.2073	0.3088
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0638	0.0716
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.1059	0.1516
Loa Loa (eye worm)	hypothetical protein	0.0297	0.6355	0.6354
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0016	0.0155	0.0419
Schistosoma mansoni	hypothetical protein	0.0013	0.0081	0.003
Schistosoma mansoni	amine GPCR	0.0038	0.0638	0.0661
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0638	0.0716
Echinococcus granulosus	7TM GPCR rhodopsin	0.0038	0.0638	0.0716
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0638	0.0661
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0155	0.0419
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0038	0.0638	0.0661
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0016	0.0155	0.0419
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0016	0.0155	0.0113
Schistosoma mansoni	hypothetical protein	0.0038	0.0638	0.0661
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0016	0.0155	0.0419
Toxoplasma gondii	hypothetical protein	0.0013	0.0081	0.011
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Schistosoma mansoni	inositol monophosphatase	0.0119	0.2435	0.27
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0016	0.0155	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Brugia malayi	ORL1-like opioid receptor	0.0038	0.0638	0.0638
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0363	0.0363
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0638	0.0716
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.071	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0057	0.1059	0.1516
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0016	0.0155	0.0419
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0038	0.0638	0.0661
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0363	0.0436
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0038	0.0638	0.0661
Leishmania major	hypothetical protein, conserved	0.0016	0.0155	0.0419
Brugia malayi	Melatonin receptor type 1A	0.0038	0.0638	0.0638
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0057	0.1059	0.1516
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0016	0.0155	0.0419
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0103	0.2073	0.3088
Brugia malayi	neuropeptide F receptor	0.0038	0.0638	0.0638
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0016	0.0155	0.0113
Schistosoma mansoni	hypothetical protein	0.0038	0.0638	0.0661
Loa Loa (eye worm)	RNA binding protein	0.0131	0.2697	0.2695
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0638	0.0661
Brugia malayi	G protein-coupled receptor	0.0038	0.0638	0.0638
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0638	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0155	0.0152
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0057	0.1059	0.1192
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0016	0.0155	0.0114
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0222	1
Brugia malayi	hypothetical protein	0.0038	0.0638	0.0638
Schistosoma mansoni	hypothetical protein	0.0013	0.0081	0.003
Echinococcus multilocularis	G protein coupled receptor 139	0.0038	0.0638	0.0716
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.2697	0.2998
Onchocerca volvulus		0.0038	0.0638	0.0581
Brugia malayi	neuropeptide F receptor	0.0038	0.0638	0.0638
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0016	0.0155	0.0114
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0155	0.0419
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0016	0.0155	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0038	0.0638	0.0716
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0638	0.0716
Schistosoma mansoni	lozenge	0.0058	0.1084	0.1168
Schistosoma mansoni	amine GPCR	0.0038	0.0638	0.0661
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0638	0.0661
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0638	0.0661
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0038	0.0638	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Onchocerca volvulus		0.0038	0.0638	0.0581
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0103	0.2073	0.3088
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0016	0.0155	0.0114
Brugia malayi	Cytochrome P450 family protein	0.0011	0.0055	0.0055
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0518	0.0582
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0057	0.1059	0.1516
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0638	0.0716
Treponema pallidum	fructose-bisphosphate aldolase	0.0306	0.6533	0.5
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0016	0.0155	0.0113
Schistosoma mansoni	opsin-like receptor	0.0038	0.0638	0.0661
Brugia malayi	RNA binding protein	0.0131	0.2697	0.2697
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0363	0.1013
Plasmodium falciparum	GAF domain-related protein, putative	0.0041	0.071	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0038	0.0638	0.0661
Schistosoma mansoni	cpg binding protein	0.0031	0.0478	0.048
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0306	0.6533	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0306	0.6533	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0016	0.0155	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0016	0.0155	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Echinococcus granulosus	3'2'5' bisphosphate nucleotidase 1	0.0013	0.0081	0.0089
Echinococcus multilocularis	cpg binding protein	0.0031	0.0478	0.0537
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0638	0.0716
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0038	0.0638	0.0638
Schistosoma mansoni	growth hormone secretagogue receptor	0.0038	0.0638	0.0661
Echinococcus granulosus	serotonin receptor	0.0038	0.0638	0.0716
Loa Loa (eye worm)	cytochrome P450 family protein	0.0052	0.0951	0.0949
Loa Loa (eye worm)	cytochrome P450 family protein	0.0011	0.0055	0.0053
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0638	0.0716
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0057	0.1059	0.4219
Schistosoma mansoni	adenoreceptor	0.0038	0.0638	0.0661
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0038	0.0638	0.0716
Entamoeba histolytica	hypothetical protein	0.0037	0.0628	0.0848
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0628	0.0706
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0038	0.0638	0.0635
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.1059	0.1516
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0119	0.2435	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0038	0.0638	0.0638
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.2697	0.2998
Loa Loa (eye worm)	runx1	0.0058	0.1084	0.1082
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0638	0.0716
Toxoplasma gondii	hypothetical protein	0.0041	0.071	0.2753
Echinococcus multilocularis	Protein lozenge	0.0058	0.1084	0.1221
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0057	0.1059	0.1516
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0016	0.0155	0.0172
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0638	0.0661
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0638	0.0716
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0038	0.0638	0.0716
Giardia lamblia	hypothetical protein	0.0016	0.0155	0.0114
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0119	0.2435	1
Brugia malayi	hypothetical protein	0.0038	0.0638	0.0638
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0016	0.0155	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0016	0.0155	0.0419
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0638	0.0716
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0087	0.1724	0.5497
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Onchocerca volvulus		0.0029	0.0442	0.0384
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0638	0.0716
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0057	0.1059	0.4219
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0038	0.0638	0.0635
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0057	0.1059	0.1139
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0306	0.6533	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0363	0.1013
Trypanosoma cruzi	GAF domain/TIP41-like family, putative	0.0046	0.082	0.3215
Echinococcus granulosus	somatostatin receptor	0.0038	0.0638	0.0716
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0199	0.0474
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.071	0.0975
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0119	0.2435	0.3648
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0638	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0313	0.6704	0.6704
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0518	0.0518
Loa Loa (eye worm)	TYRA-2 protein	0.0038	0.0638	0.0635
Echinococcus granulosus	G protein coupled receptor 139	0.0038	0.0638	0.0716
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0016	0.0155	0.0419
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0155	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0102	0.2057	0.2055
Brugia malayi	hypothetical protein	0.0038	0.0638	0.0638
Mycobacterium tuberculosis	Monophosphatase CysQ	0.0013	0.0081	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0016	0.0155	0.0419
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.1155	0.1248
Brugia malayi	hypothetical protein	0.0038	0.0638	0.0638
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0057	0.1059	0.1516
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.2697	0.2998
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0363	0.1013
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0081	0.0079
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0638	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0161	0.3352	0.335
Brugia malayi	Serotonin receptor	0.0038	0.0638	0.0638
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0638	0.0716
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0102	0.2057	0.2057
Echinococcus granulosus	g-protein coupled receptor	0.0038	0.0638	0.0716
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.088	0.0936
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0442	0.0442
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.1059	0.1516
Echinococcus granulosus	inositol monophosphatase	0.0013	0.0081	0.0089
Onchocerca volvulus		0.0038	0.0638	0.0581
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0149	0.3092	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0363	0.0436
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0057	0.1059	0.1516
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0016	0.0155	0.0419
Onchocerca volvulus		0.0038	0.0638	0.0581
Brugia malayi	G-protein coupled receptor	0.0038	0.0638	0.0638
Echinococcus multilocularis	muscleblind protein	0.0155	0.3221	0.3631
Loa Loa (eye worm)	melatonin receptor type 1A	0.0038	0.0638	0.0635
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0199	0.0474
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0222	0.0549
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0038	0.0638	0.0581
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0038	0.0638	0.0716
Trypanosoma brucei	inositol polyphosphate 1-phosphatase, putative	0.0013	0.0081	0.011
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Schistosoma mansoni	hypothetical protein	0.0038	0.0638	0.0661
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.1059	0.1516
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0638	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0463	1	1
Brugia malayi	Dopamine receptor	0.0038	0.0638	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Loa Loa (eye worm)	PDE1B protein	0.0016	0.0155	0.0152
Echinococcus granulosus	sex peptide receptor	0.0038	0.0638	0.0716
Leishmania major	hypothetical protein, conserved	0.0046	0.082	0.3215
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Brugia malayi	G protein-coupled receptor F59B2.13	0.0038	0.0638	0.0638
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0638	0.0716
Schistosoma mansoni	amine GPCR	0.0038	0.0638	0.0661
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0638	0.0716
Brugia malayi	putative neuropeptide receptor NPR1	0.0038	0.0638	0.0638
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0638	0.0716
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0638	0.0661
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.1059	0.1516
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0057	0.1059	0.1516
Schistosoma mansoni	hypothetical protein	0.0032	0.0518	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0222	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3221	0.3219
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0363	0.1013
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Schistosoma mansoni	hypothetical protein	0.0032	0.0518	0.0526
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.1059	0.1516
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0638	0.0716
Echinococcus granulosus	dnaJ subfamily B	0.0412	0.8867	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0102	0.2057	0.2055
Brugia malayi	Inositol-1	0.0119	0.2435	0.2435
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0306	0.6533	1
Onchocerca volvulus		0.0038	0.0638	0.0581
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0102	0.2057	0.2057
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0038	0.0638	0.0716
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0363	0.0363
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0306	0.6533	1
Loa Loa (eye worm)	hypothetical protein	0.0256	0.545	0.5449
Onchocerca volvulus		0.0038	0.0638	0.0581
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0016	0.0155	0.0113
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0199	0.0474
Onchocerca volvulus		0.0038	0.0638	0.0581
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0016	0.0155	0.0114
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0016	0.0155	0.0114
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0038	0.0638	0.0581
Loa Loa (eye worm)	hypothetical protein	0.0463	1	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0016	0.0155	0.0114
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0638	0.0661
Brugia malayi	hypothetical protein	0.0038	0.0638	0.0638
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0057	0.1059	0.1516
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0016	0.0155	0.0419
Onchocerca volvulus		0.0038	0.0638	0.0581
Echinococcus multilocularis	orexin receptor type 2	0.0038	0.0638	0.0716
Schistosoma mansoni	histamine h1 receptor	0.0038	0.0638	0.0661
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.088	0.099
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0062	0.1169	0.1686
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0638	0.0635
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0062	0.1169	0.1686
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0119	0.2435	1
Mycobacterium ulcerans	inositol-monophosphatase ImpA	0.0013	0.0081	0.0086
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0016	0.0155	0.0419
Schistosoma mansoni	hypothetical protein	0.0037	0.0628	0.065
Echinococcus multilocularis	neuropeptide s receptor	0.0038	0.0638	0.0716

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6.1 nM	Inhibition of human PDE2A expressed in Sf9 cells incubated for 40 mins using [3H]-cGMP substrate by scintillation counting method	ChEMBL.	25221665
IC50 (binding)	= 266 nM	Inhibition of rat PDE10A expressed in Sf9 cells incubated for 60 mins using [3H]-cAMP substrate by scintillation counting method	ChEMBL.	25221665

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3331514

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 928732