Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0078 | 0.1388 | 0.1388 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0078 | 0.1388 | 0.1388 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0078 | 0.1388 | 0.1388 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0018 | 0.0049 | 0.0049 |
Onchocerca volvulus | 0.0078 | 0.1388 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1388 | 0.1388 |
Onchocerca volvulus | 0.0078 | 0.1388 | 1 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0078 | 0.1388 | 0.1388 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0078 | 0.1388 | 0.1388 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0078 | 0.1388 | 0.1388 |
Loa Loa (eye worm) | carboxylesterase | 0.0078 | 0.1388 | 0.1388 |
Echinococcus multilocularis | carboxylesterase 5A | 0.046 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0078 | 0.1388 | 0.1388 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0078 | 0.1388 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.046 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0078 | 0.1388 | 0.1388 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0027 | 0.024 | 0.024 |
Echinococcus granulosus | carboxylesterase 5A | 0.046 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.046 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1388 | 0.1388 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0078 | 0.1388 | 0.1388 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0027 | 0.024 | 0.024 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0078 | 0.1388 | 0.1388 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.046 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0049 | 0.0049 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0078 | 0.1388 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0078 | 0.1388 | 0.5 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0214 | 0.4448 | 0.4448 |
Brugia malayi | hypothetical protein | 0.0078 | 0.1388 | 0.1388 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0078 | 0.1388 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1388 | 0.1388 |
Brugia malayi | Carboxylesterase family protein | 0.0078 | 0.1388 | 0.1388 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0078 | 0.1388 | 0.1388 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1388 | 0.1388 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0078 | 0.1388 | 0.1388 |
Loa Loa (eye worm) | carboxylesterase | 0.046 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.046 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0078 | 0.1388 | 0.1388 |
Echinococcus multilocularis | acetylcholinesterase | 0.046 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0078 | 0.1388 | 0.1388 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0214 | 0.4448 | 0.4448 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.024 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0078 | 0.1388 | 0.1388 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0078 | 0.1388 | 0.5 |
Onchocerca volvulus | 0.0078 | 0.1388 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.046 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1388 | 0.1388 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0078 | 0.1388 | 0.1388 |
Onchocerca volvulus | 0.0078 | 0.1388 | 1 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0027 | 0.024 | 0.024 |
Onchocerca volvulus | 0.0078 | 0.1388 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0049 | 0.0049 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0078 | 0.1388 | 0.1388 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1388 | 0.1388 |
Loa Loa (eye worm) | carboxylesterase | 0.0078 | 0.1388 | 0.1388 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1388 | 0.1388 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0078 | 0.1388 | 0.1388 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0078 | 0.1388 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.046 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 37.65 nM | Inhibition of human factor 10a using N-Z-D-Arg-Gly-Arg-pNA, S-2765 chromogenic substrate | ChEMBL. | 25179681 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.