TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 395.501 | Formula: C21H29N7O
H donors: 0 H acceptors: 4 LogP: 2.74 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCN(C(=O)c1c(N2CCN(CC2)C)c2cccnc2n2c1nnc2CC)CC
InChi: 1S/C21H29N7O/c1-5-16-23-24-20-17(21(29)26(6-2)7-3)18(27-13-11-25(4)12-14-27)15-9-8-10-22-19(15)28(16)20/h8-10H,5-7,11-14H2,1-4H3
InChiKey: LGNLJZJREJEUKF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0195	0.3731	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0195	0.3731	1
Entamoeba histolytica	cysteine proteinase 2	0.0101	0.1539	0.4054
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0128	0.2171	0.5768
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0108	0.1706	0.4574
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0195	0.3731	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0195	0.3731	0.3731
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.005	0.005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0195	0.3731	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.005	0.0016
Loa Loa (eye worm)	ctsf protein	0.0195	0.3731	1
Brugia malayi	hypothetical protein	0.0142	0.2486	0.6663
Trypanosoma cruzi	cysteine peptidase, putative	0.0195	0.3731	1
Entamoeba histolytica	cysteine protease, putative	0.0101	0.1539	0.4054
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0278	0.0744
Entamoeba histolytica	cysteine protease, putative	0.0101	0.1539	0.4054
Toxoplasma gondii	ABC1 family protein	0.0036	0.005	0.0016
Trypanosoma cruzi	cysteine proteinase, putative	0.0101	0.1539	0.4054
Schistosoma mansoni	aldehyde dehydrogenase	0.0128	0.2171	0.5818
Brugia malayi	Cathepsin L-like precursor	0.0131	0.2236	0.5994
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0131	0.2236	0.5994
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1706	0.4574
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0195	0.3731	1
Entamoeba histolytica	cysteine proteinase, putative	0.0101	0.1539	0.4054
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0036	0.0044	0.0119
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.0705	0.1791
Brugia malayi	beta-lactamase	0.0036	0.005	0.0135
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0036	0.0044	0.0119
Onchocerca volvulus		0.0195	0.3731	1
Giardia lamblia	Cathepsin L precursor	0.0036	0.0044	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.005	0.0135
Trypanosoma cruzi	cysteine peptidase, putative	0.0195	0.3731	1
Loa Loa (eye worm)	cathepsin B	0.0036	0.0044	0.0119
Entamoeba histolytica	cysteine protease, putative	0.0101	0.1539	0.4054
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0278	0.0744
Giardia lamblia	Cathepsin L precursor	0.0036	0.0044	0.5
Giardia lamblia	Cysteine protease	0.0036	0.0044	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.005	0.0016
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.005	0.005
Toxoplasma gondii	cathepsin CPL	0.0195	0.3731	1
Brugia malayi	Cathepsin L-like precursor	0.0195	0.3731	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0195	0.3731	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0128	0.2171	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0128	0.2171	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0131	0.2236	0.5994
Brugia malayi	Cathepsin L-like precursor	0.0195	0.3731	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0195	0.3731	1
Entamoeba histolytica	cysteine protease, putative	0.0101	0.1539	0.4054
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0278	0.0278
Brugia malayi	Papain family cysteine protease containing protein	0.0195	0.3731	1
Echinococcus granulosus	cathepsin l1	0.0195	0.3731	0.3731
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0108	0.1706	0.4574
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0195	0.3731	1
Giardia lamblia	Cathepsin B precursor	0.0036	0.0044	0.5
Entamoeba histolytica	cysteine proteinase 1, putative	0.0101	0.1539	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0195	0.3731	1
Trypanosoma cruzi	cysteine protease, putative	0.0101	0.1539	0.4054
Giardia lamblia	Cathepsin L-like protease	0.0036	0.0044	0.5
Onchocerca volvulus	Cathepsin F homolog	0.0195	0.3731	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0133	0.0133
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0101	0.1539	0.4125
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0195	0.3731	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0232	0.4577	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0101	0.1539	0.4054
Echinococcus granulosus	cathepsin b	0.0036	0.0044	0.0044
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0278	0.0744
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0065	0.0705	0.1889
Schistosoma mansoni	cathepsin F (C01 family)	0.0195	0.3731	1
Giardia lamblia	Cathepsin L precursor	0.0036	0.0044	0.5
Schistosoma mansoni	aldehyde dehydrogenase	0.0128	0.2171	0.5818
Brugia malayi	cathepsin F-like cysteine proteinase	0.0036	0.0044	0.0119
Entamoeba histolytica	cysteine proteinase, putative	0.0131	0.2236	0.5946
Onchocerca volvulus	Cathepsin L homolog	0.0195	0.3731	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0467	1	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0101	0.1539	0.4054
Giardia lamblia	Cathepsin L-like protease	0.0036	0.0044	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0195	0.3731	1
Entamoeba histolytica	cysteine protease, putative	0.0101	0.1539	0.4054
Schistosoma mansoni	cathepsin S (C01 family)	0.0036	0.0044	0.0119
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0036	0.0044	0.0119
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0101	0.1539	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0044	0.0119
Onchocerca volvulus	Huntingtin homolog	0.0142	0.2486	0.6623
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0101	0.1539	0.4125
Entamoeba histolytica	hypothetical protein	0.004	0.0133	0.024
Echinococcus multilocularis	cathepsin L	0.0036	0.0044	0.0044
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0036	0.0044	0.0119
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0195	0.3731	1
Schistosoma mansoni	hypothetical protein	0.004	0.0133	0.0356
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0195	0.3731	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0195	0.3731	0.3731
Giardia lamblia	Encystation-specific protease	0.0036	0.0044	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0195	0.3731	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.3731	1
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.1996	0.535
Leishmania major	cathepsin L-like protease	0.0195	0.3731	1
Onchocerca volvulus	Cathepsin L homolog	0.0195	0.3731	1
Giardia lamblia	Cathepsin L precursor	0.0036	0.0044	0.5
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0131	0.2236	0.5946
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0195	0.3731	0.3731
Echinococcus granulosus	cathepsin L	0.0101	0.1539	0.1539
Brugia malayi	MH2 domain containing protein	0.012	0.1996	0.535
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0128	0.2171	0.2171
Echinococcus granulosus	neuropeptide receptor A26	0.0467	1	1
Brugia malayi	hypothetical protein	0.004	0.0133	0.0356
Onchocerca volvulus		0.0195	0.3731	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0036	0.0044	0.0119
Trypanosoma cruzi	cruzipain precursor, putative	0.0065	0.0705	0.1791
Loa Loa (eye worm)	beta-lactamase	0.0036	0.005	0.0135
Entamoeba histolytica	cysteine protease, putative	0.0101	0.1539	0.4054
Schistosoma mansoni	cathepsin C	0.0036	0.0044	0.0119
Entamoeba histolytica	cysteine proteinase, putative	0.0195	0.3731	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0101	0.1539	0.4054
Onchocerca volvulus		0.0195	0.3731	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0036	0.0044	0.0119
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0036	0.0044	0.0119
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0133	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0916	0.2457
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0195	0.3731	1
Entamoeba histolytica	hypothetical protein	0.004	0.0133	0.024
Entamoeba histolytica	cysteine protease, putative	0.0101	0.1539	0.4054
Brugia malayi	cathepsin L-like precursor	0.0131	0.2236	0.5994
Giardia lamblia	Cathepsin B precursor	0.0036	0.0044	0.5
Onchocerca volvulus		0.0036	0.005	0.0016
Echinococcus multilocularis	cysteine protease	0.0195	0.3731	0.3731
Echinococcus granulosus	cathepsin b	0.0036	0.0044	0.0044
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0044	0.0119
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0195	0.3731	1
Loa Loa (eye worm)	hypothetical protein	0.0131	0.2236	0.5994
Echinococcus multilocularis	cathepsin L	0.0101	0.1539	0.1539
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0278	0.0278
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0128	0.2171	0.2171
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0044	0.0119
Echinococcus multilocularis	cathepsin b	0.0036	0.0044	0.0044
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.005	0.0135
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0195	0.3731	1
Loa Loa (eye worm)	cysteine protease	0.0195	0.3731	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0195	0.3731	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0705	0.1889
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0036	0.0044	0.0119
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0036	0.0044	0.0119
Entamoeba histolytica	cysteine proteinase, putative	0.0101	0.1539	0.4054
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.005	0.0135
Plasmodium vivax	unspecified product	0.0101	0.1539	0.4054
Leishmania major	cathepsin L-like protease	0.0195	0.3731	1
Onchocerca volvulus		0.0036	0.005	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0131	0.2236	0.5994
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0131	0.2236	0.5946
Echinococcus granulosus	cathepsin L	0.0036	0.0044	0.0044
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0195	0.3731	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0036	0.0044	0.0119
Onchocerca volvulus		0.0195	0.3731	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0195	0.3731	1
Loa Loa (eye worm)	hypothetical protein	0.0131	0.2236	0.5994
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0195	0.3731	1
Onchocerca volvulus		0.0036	0.005	0.0016
Giardia lamblia	Cysteine protease	0.0036	0.0044	0.5
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0036	0.0044	0.0119
Mycobacterium leprae	Probable lipase LipE	0.0036	0.005	0.5
Brugia malayi	latrophilin 2 splice variant baaae	0.0074	0.0916	0.2457
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0195	0.3731	1
Brugia malayi	Cathepsin L-like precursor	0.0195	0.3731	1
Entamoeba histolytica	cysteine proteinase, putative	0.0101	0.1539	0.4054
Giardia lamblia	Cathepsin B precursor	0.0036	0.0044	0.5
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0195	0.3731	0.3731
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0195	0.3731	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0044	0.0119
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0195	0.3731	1
Plasmodium vivax	vivapain-3	0.0101	0.1539	0.4054
Leishmania major	cathepsin L-like protease	0.0195	0.3731	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0128	0.2171	0.4683
Plasmodium vivax	vivapain-2	0.0195	0.3731	1
Giardia lamblia	Cathepsin B precursor	0.0036	0.0044	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0133	0.0356
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0195	0.3731	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.005	0.0016
Brugia malayi	fibroinase precursor	0.0036	0.0044	0.0119
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.005	0.0016
Brugia malayi	Papain family cysteine protease containing protein	0.0101	0.1539	0.4125
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.005	0.0016
Giardia lamblia	Cathepsin B precursor	0.0036	0.0044	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.005	0.0016
Echinococcus multilocularis	cathepsin b	0.0036	0.0044	0.0044
Echinococcus granulosus	cysteine protease	0.0101	0.1539	0.1539
Entamoeba histolytica	cysteine protease, putative	0.0101	0.1539	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0195	0.3731	1
Onchocerca volvulus		0.0131	0.2236	0.5946
Giardia lamblia	Cathepsin B precursor	0.0036	0.0044	0.5
Giardia lamblia	Cysteine protease	0.0036	0.0044	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0044	0.0119
Giardia lamblia	Cathepsin B precursor	0.0036	0.0044	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0195	0.3731	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0108	0.1706	0.4574
Giardia lamblia	Hypothetical protein	0.0036	0.0044	0.5
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0036	0.0044	0.5
Entamoeba histolytica	cysteine protease, putative	0.0101	0.1539	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0195	0.3731	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0195	0.3731	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0195	0.3731	1
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0036	0.0044	0.5
Leishmania major	cathepsin L-like protease	0.0195	0.3731	1
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.005	0.5
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0705	0.1889
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2486	0.6663
Brugia malayi	cathepsin B-like cysteine proteinase	0.0036	0.0044	0.0119
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0195	0.3731	1
Onchocerca volvulus	Huntingtin homolog	0.0142	0.2486	0.6623
Schistosoma mansoni	hypothetical protein	0.0074	0.0916	0.2457
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0036	0.0044	0.0119
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0101	0.1539	0.4125
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2486	0.6663
Leishmania major	cathepsin L-like protease	0.0195	0.3731	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0036	0.0044	0.0119
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0036	0.0044	0.0119
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0195	0.3731	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.005	0.0016
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0044	0.0119
Leishmania major	cathepsin L-like protease	0.0195	0.3731	1
Entamoeba histolytica	cysteine protease, putative	0.0101	0.1539	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0195	0.3731	1
Plasmodium vivax	unspecified product	0.0065	0.0705	0.1791
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0705	0.1889
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0195	0.3731	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0195	0.3731	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0101	0.1539	0.1539
Entamoeba histolytica	cysteine protease, putative	0.0195	0.3731	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0195	0.3731	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0278	0.0744
Leishmania major	cathepsin L-like protease	0.0195	0.3731	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0036	0.0044	0.0119
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.005	0.0016
Echinococcus multilocularis	cysteine protease	0.0195	0.3731	0.3731
Entamoeba histolytica	cysteine protease, putative	0.0101	0.1539	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0195	0.3731	1
Brugia malayi	Cathepsin L-like precursor	0.0131	0.2236	0.5994
Schistosoma mansoni	cathepsin s	0.0065	0.0705	0.1889
Leishmania major	hypothetical protein, conserved	0.0036	0.005	0.0016
Entamoeba histolytica	cysteine protease, putative	0.0101	0.1539	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0044	0.0119
Brugia malayi	Papain family cysteine protease containing protein	0.0101	0.1539	0.4125
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0195	0.3731	1
Giardia lamblia	Cysteine protease	0.0036	0.0044	0.5
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0065	0.0705	0.1889
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0101	0.1539	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0195	0.3731	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0131	0.2236	0.5946
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0044	0.0119
Entamoeba histolytica	hypothetical protein	0.004	0.0133	0.024
Plasmodium vivax	vivapain-2	0.0195	0.3731	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.005	0.0135
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0195	0.3731	1
Brugia malayi	beta-lactamase family protein	0.0036	0.005	0.0135
Giardia lamblia	Cathepsin L precursor	0.0036	0.0044	0.5
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.005	0.0135
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0278	0.0744
Trypanosoma cruzi	cysteine peptidase, putative	0.0195	0.3731	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0101	0.1539	0.4054
Entamoeba histolytica	hypothetical protein	0.004	0.0133	0.024
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0278	0.0278
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.1996	0.535
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0044	0.0119
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0036	0.0044	0.0119
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0101	0.1539	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0195	0.3731	1
Brugia malayi	beta-lactamase family protein	0.0036	0.005	0.0135
Trichomonas vaginalis	esterase, putative	0.0036	0.005	0.0016
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0036	0.0044	0.0119
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0128	0.2171	1
Echinococcus multilocularis	neuropeptide s receptor	0.0467	1	1
Brugia malayi	cathepsin L precursor	0.0036	0.0044	0.0119
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.0044	0.0119
Giardia lamblia	Hypothetical protein	0.0036	0.0044	0.5
Plasmodium vivax	vivapain-1	0.0101	0.1539	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0195	0.3731	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0036	0.0044	0.5
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.0044	0.0119
Trypanosoma cruzi	cysteine peptidase, putative	0.0195	0.3731	1
Entamoeba histolytica	cysteine protease, putative	0.0101	0.1539	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0101	0.1539	0.4054
Leishmania major	cysteine peptidase A (CPA)	0.0195	0.3731	1
Giardia lamblia	Cathepsin L precursor	0.0036	0.0044	0.5
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0195	0.3731	0.3731
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0044	0.0119
Brugia malayi	cathepsin F-like cysteine proteinase	0.0065	0.0705	0.1889
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0036	0.0044	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0036	0.005	0.0135
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.005	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0036	0.005	0.0135
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.005	0.0135
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0195	0.3731	1
Loa Loa (eye worm)	fibroinase	0.0195	0.3731	1
Echinococcus granulosus	cathepsin l1	0.0131	0.2236	0.2236
Toxoplasma gondii	aldehyde dehydrogenase	0.0128	0.2171	0.5768
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0036	0.0044	0.5
Onchocerca volvulus		0.0195	0.3731	1
Onchocerca volvulus		0.0195	0.3731	1
Entamoeba histolytica	cysteine proteinase, putative	0.0195	0.3731	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0195	0.3731	1
Onchocerca volvulus		0.0195	0.3731	1
Giardia lamblia	Cathepsin B precursor	0.0036	0.0044	0.5
Schistosoma mansoni	cathepsin B (C01 family)	0.0036	0.0044	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0036	0.005	0.0135
Entamoeba histolytica	cysteine proteinase, putative	0.0101	0.1539	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0195	0.3731	1
Brugia malayi	Cathepsin L-like precursor	0.0065	0.0705	0.1889
Leishmania major	cathepsin L-like protease	0.0195	0.3731	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0036	0.005	0.0135
Brugia malayi	cathepsin L-like cysteine proteinase	0.0036	0.0044	0.0119
Trypanosoma cruzi	cruzipain precursor, putative	0.0195	0.3731	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0195	0.3731	0.3731

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 10 %	Antinociceptive activity in Swiss mouse assessed as inhibition of acetic acid-induced writhing at 25 mg/kg, po administered 1 hr prior to acetic acid challenge measured for 30 mins	ChEMBL.	25194932

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3330689

Bibliographic References

No literature references available for this target.

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Detailed information for compound 928894