Detailed information for compound 928984

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 307.3 | Formula: C18H13NO4
  • H donors: 1 H acceptors: 2 LogP: 3.27 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2[nH]c3c(c2cc1OC)C(=O)c1c(C3=O)cccc1
  • InChi: 1S/C18H13NO4/c1-22-13-7-11-12(8-14(13)23-2)19-16-15(11)17(20)9-5-3-4-6-10(9)18(16)21/h3-8,19H,1-2H3
  • InChiKey: QKHCUQKZVJIGBH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0039 0.0288 0.0329
Giardia lamblia Alpha-tubulin 0.0556 0.6724 0.701
Loa Loa (eye worm) tubulin alpha chain 0.0556 0.6724 0.7671
Echinococcus multilocularis tubulin alpha chain 0.0556 0.6724 0.6724
Schistosoma mansoni survival motor neuron protein 0.0049 0.0411 0.0469
Giardia lamblia Alpha-tubulin 0.0556 0.6724 0.701
Trichomonas vaginalis tubulin alpha chain, putative 0.0395 0.4718 0.4073
Echinococcus granulosus peroxisome assembly protein 26 0.0556 0.6724 0.7671
Schistosoma mansoni hypothetical protein 0.034 0.4032 0.46
Trichomonas vaginalis tubulin gamma chain, putative 0.0395 0.4718 0.4073
Trypanosoma cruzi beta tubulin, putative 0.072 0.8764 1
Entamoeba histolytica tubulin family protein 0.072 0.8764 1
Giardia lamblia Beta tubulin 0.072 0.8764 1
Brugia malayi Tubulin alpha-2 chain 0.0556 0.6724 0.7671
Plasmodium vivax delta tubulin, putative 0.0171 0.1938 0.1946
Leishmania major alpha tubulin 0.0556 0.6724 0.701
Loa Loa (eye worm) hypothetical protein 0.0384 0.459 0.5237
Schistosoma mansoni tubulin subunit delta 0.0171 0.1938 0.2211
Loa Loa (eye worm) tubulin beta-2A chain 0.072 0.8764 1
Leishmania major beta tubulin 0.072 0.8764 1
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.2778 0.2778
Trypanosoma brucei beta tubulin 0.072 0.8764 1
Leishmania major beta tubulin 0.072 0.8764 1
Loa Loa (eye worm) tubulin alpha 2 0.0384 0.459 0.5237
Plasmodium falciparum tubulin gamma chain 0.0395 0.4718 0.5226
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0395 0.4718 0.4073
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0288 0.0329
Trypanosoma brucei epsilon tubulin 0.0395 0.4718 0.4073
Schistosoma mansoni tubulin subunit gamma 0.0395 0.4718 0.5383
Trypanosoma cruzi epsilon tubulin, putative 0.0395 0.4718 0.4073
Trypanosoma brucei epsilon tubulin 0.0395 0.4718 0.4073
Leishmania major beta tubulin 0.072 0.8764 1
Echinococcus granulosus Tubulin beta 2C chain 0.072 0.8764 1
Trypanosoma cruzi alpha tubulin, putative 0.0556 0.6724 0.701
Brugia malayi Tubulin gamma chain 0.0395 0.4718 0.5383
Echinococcus multilocularis Tubulin alpha 1 chain 0.0556 0.6724 0.6724
Schistosoma mansoni tubulin subunit alpha 0.0556 0.6724 0.7671
Onchocerca volvulus 0.0039 0.0288 0.0566
Leishmania major alpha tubulin 0.0556 0.6724 0.701
Brugia malayi Tubulin beta-1 chain 0.072 0.8764 1
Plasmodium vivax tubulin beta chain, putative 0.072 0.8764 1
Schistosoma mansoni lipoxygenase 0.0162 0.1827 0.2085
Loa Loa (eye worm) hypothetical protein 0.0174 0.1976 0.2254
Entamoeba histolytica tubulin alpha-1 chain 0.0556 0.6724 0.4956
Toxoplasma gondii beta-1 tubulin, putative 0.072 0.8764 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.0151 0.0172
Loa Loa (eye worm) tubulin alpha chain 0.0556 0.6724 0.7671
Leishmania major alpha tubulin 0.0556 0.6724 0.701
Echinococcus multilocularis RUN 0.0039 0.0288 0.0288
Schistosoma mansoni alpha tubulin 0.0556 0.6724 0.7671
Echinococcus granulosus tubulin alpha 1C chain 0.0556 0.6724 0.7671
Leishmania major beta tubulin 0.072 0.8764 1
Schistosoma mansoni alpha tubulin 0.0556 0.6724 0.7671
Schistosoma mansoni polycystin 1-related 0.0039 0.0288 0.0329
Brugia malayi Protein kinase domain containing protein 0.0028 0.0151 0.0172
Loa Loa (eye worm) tubulin gamma chain 0.0395 0.4718 0.5383
Entamoeba histolytica tubulin alpha chain, putative 0.0556 0.6724 0.4956
Brugia malayi RNA binding protein 0.0061 0.0567 0.0647
Schistosoma mansoni tubulin subunit beta 0.072 0.8764 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0028 0.0151 0.0172
Leishmania major beta tubulin 0.072 0.8764 1
Leishmania major alpha tubulin 0.0556 0.6724 0.701
Leishmania major epsilon tubulin, putative 0.0395 0.4718 0.4073
Plasmodium falciparum tubulin epsilon chain, putative 0.0395 0.4718 0.5226
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0422 0.0481
Entamoeba histolytica tubulin family protein 0.072 0.8764 1
Echinococcus multilocularis netrin receptor unc 5 0.0028 0.0151 0.0151
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0042 0.0333 0.0333
Schistosoma mansoni tubulin subunit beta 0.0171 0.1938 0.2211
Leishmania major gamma-tubulin 0.0395 0.4718 0.4073
Trichomonas vaginalis tubulin epsilon chain, putative 0.072 0.8764 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0556 0.6724 0.701
Leishmania major alpha tubulin 0.0556 0.6724 0.701
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0567 0.0647
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0028 0.0151 0.0151
Echinococcus granulosus tubulin epsilon chain 0.0395 0.4718 0.5383
Loa Loa (eye worm) hypothetical protein 0.0556 0.6724 0.7671
Schistosoma mansoni tubulin subunit alpha 0.0556 0.6724 0.7671
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0288 0.0288
Loa Loa (eye worm) tubulin beta-1 chain 0.072 0.8764 1
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0567 0.0567
Echinococcus granulosus Tubulin beta 2C chain 0.072 0.8764 1
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.2778 0.317
Trichomonas vaginalis tubulin beta chain, putative 0.0556 0.6724 0.701
Echinococcus granulosus tar DNA binding protein 0.0061 0.0567 0.0647
Brugia malayi MH2 domain containing protein 0.0119 0.1282 0.1462
Schistosoma mansoni hypothetical protein 0.0028 0.0151 0.0172
Trichomonas vaginalis tubulin epsilon chain, putative 0.072 0.8764 1
Echinococcus multilocularis geminin 0.034 0.4032 0.4032
Loa Loa (eye worm) alpha-tubulin 0.0556 0.6724 0.7671
Trichomonas vaginalis tubulin beta chain, putative 0.0556 0.6724 0.701
Leishmania major alpha tubulin 0.0556 0.6724 0.701
Echinococcus granulosus Tubulin beta 2C chain 0.072 0.8764 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0288 0.0329
Trichomonas vaginalis tubulin beta chain, putative 0.0223 0.2585 0.0947
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1282 0.1462
Echinococcus granulosus tubulin alpha 0.0395 0.4718 0.5383
Echinococcus multilocularis tubulin alpha 3 chain 0.0556 0.6724 0.6724
Echinococcus multilocularis tubulin subunit beta 0.072 0.8764 0.8764
Schistosoma mansoni alpha tubulin 0.0556 0.6724 0.7671
Plasmodium falciparum alpha tubulin 2 0.0556 0.6724 0.7592
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1282 0.1462
Brugia malayi Doublecortin family protein 0.0039 0.0288 0.0329
Echinococcus granulosus tubulin alpha chain 0.0556 0.6724 0.7671
Trichomonas vaginalis tubulin alpha chain, putative 0.0223 0.2585 0.0947
Trichomonas vaginalis tubulin gamma chain, putative 0.0395 0.4718 0.4073
Schistosoma mansoni tubulin subunit beta 0.072 0.8764 1
Echinococcus granulosus beta tubulin 0.072 0.8764 1
Brugia malayi hypothetical protein 0.0039 0.0288 0.0329
Schistosoma mansoni tubulin subunit beta 0.072 0.8764 1
Trypanosoma brucei alpha tubulin 0.0556 0.6724 0.701
Echinococcus granulosus beta tubulin 0.072 0.8764 1
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0288 0.0329
Echinococcus granulosus tubulin gamma 1 chain 0.0395 0.4718 0.5383
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0232 0.2698 0.3078
Trypanosoma brucei alpha tubulin 0.0556 0.6724 0.701
Echinococcus granulosus tubulin subunit TubB 0.0556 0.6724 0.7671
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0567 0.0647
Echinococcus multilocularis tubulin alpha 0.0395 0.4718 0.4718
Echinococcus granulosus tubulin beta 1 chain 0.072 0.8764 1
Leishmania major beta tubulin 0.072 0.8764 1
Leishmania major beta tubulin 0.072 0.8764 1
Trypanosoma brucei alpha tubulin, putative 0.0223 0.2585 0.0947
Toxoplasma gondii beta-tubulin, putative 0.072 0.8764 1
Schistosoma mansoni hypothetical protein 0.0039 0.0288 0.0329
Trypanosoma brucei beta tubulin 0.0395 0.4718 0.4073
Trichomonas vaginalis tubulin beta chain, putative 0.0556 0.6724 0.701
Trypanosoma brucei beta tubulin 0.072 0.8764 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0411 0.0469
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0223 0.2585 0.0947
Brugia malayi N-terminal motif family protein 0.0174 0.1976 0.2254
Trypanosoma brucei beta tubulin 0.072 0.8764 1
Brugia malayi hypothetical protein 0.0039 0.0288 0.0329
Trypanosoma brucei beta tubulin 0.072 0.8764 1
Toxoplasma gondii beta tubulin 0.072 0.8764 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0556 0.6724 0.6724
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0422 0.0481
Schistosoma mansoni tumor necrosis factor receptor related 0.0042 0.0333 0.038
Echinococcus multilocularis tubulin alpha 3 chain 0.0556 0.6724 0.6724
Echinococcus multilocularis Tubulin beta 2C chain 0.072 0.8764 0.8764
Echinococcus granulosus tubulin subunit beta 0.072 0.8764 1
Echinococcus granulosus tubulin alpha chain 0.0556 0.6724 0.7671
Onchocerca volvulus 0.0049 0.0411 0.1071
Loa Loa (eye worm) BEN-1 protein 0.072 0.8764 1
Trichomonas vaginalis tubulin, putative 0.0223 0.2585 0.0947
Schistosoma mansoni netrin receptor unc5 0.0028 0.0151 0.0172
Echinococcus granulosus Tubulin alpha 1 chain 0.0556 0.6724 0.7671
Plasmodium falciparum tubulin delta chain, putative 0.0171 0.1938 0.1946
Echinococcus multilocularis tubulin subunit TubB 0.0556 0.6724 0.6724
Echinococcus granulosus death domain containing protein 0.0028 0.0151 0.0172
Echinococcus multilocularis tubulin delta chain 0.0171 0.1938 0.1938
Trichomonas vaginalis tubulin, putative 0.072 0.8764 1
Toxoplasma gondii alpha tubulin TUBA1 0.0556 0.6724 0.701
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0567 0.0647
Leishmania major beta tubulin 0.072 0.8764 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0567 0.0647
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0332 0.3944 0.2938
Brugia malayi tubulin alpha chain - mouse 0.0556 0.6724 0.7671
Echinococcus granulosus tubulin alpha chain 0.0556 0.6724 0.7671
Echinococcus multilocularis tubulin alpha chain 0.0556 0.6724 0.6724
Leishmania major alpha tubulin 0.0556 0.6724 0.701
Echinococcus granulosus Tubulin alpha 1 chain 0.0556 0.6724 0.7671
Trypanosoma brucei tubulin gamma chain 0.0395 0.4718 0.4073
Echinococcus multilocularis Tubulin beta 2C chain 0.072 0.8764 0.8764
Giardia lamblia Gamma tubulin 0.0395 0.4718 0.4073
Loa Loa (eye worm) hypothetical protein 0.0039 0.0288 0.0329
Plasmodium vivax tubulin gamma chain, putative 0.0395 0.4718 0.5226
Loa Loa (eye worm) hypothetical protein 0.005 0.0422 0.0481
Trypanosoma cruzi epsilon tubulin, putative 0.0395 0.4718 0.4073
Schistosoma mansoni hypothetical protein 0.0049 0.0411 0.0469
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0042 0.0333 0.0333
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0567 0.0647
Trichomonas vaginalis tubulin beta chain, putative 0.072 0.8764 1
Loa Loa (eye worm) tubulin alpha 2 0.0384 0.459 0.5237
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0384 0.459 0.3885
Echinococcus multilocularis Tubulin alpha 1 chain 0.0556 0.6724 0.6724
Mycobacterium tuberculosis Cell division protein FtsZ 0.0171 0.1938 0.5
Schistosoma mansoni hypothetical protein 0.034 0.4032 0.46
Schistosoma mansoni tubulin subunit beta 0.072 0.8764 1
Echinococcus granulosus tubulin alpha chain 0.0556 0.6724 0.7671
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0567 0.0647
Echinococcus multilocularis beta tubulin 0.072 0.8764 0.8764
Trichomonas vaginalis tubulin alpha chain, putative 0.0223 0.2585 0.0947
Trypanosoma brucei alpha tubulin 0.0556 0.6724 0.701
Brugia malayi Death domain containing protein 0.0028 0.0151 0.0172
Schistosoma mansoni rab6-interacting 0.0039 0.0288 0.0329
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0288 0.0288
Trypanosoma cruzi tubulin gamma chain 0.0395 0.4718 0.4073
Leishmania major beta tubulin 0.072 0.8764 1
Leishmania major beta tubulin 0.072 0.8764 1
Brugia malayi TAR-binding protein 0.0061 0.0567 0.0647
Brugia malayi Uncoordinated protein 44 0.0028 0.0151 0.0172
Trypanosoma brucei alpha tubulin 0.0556 0.6724 0.701
Leishmania major beta tubulin 0.072 0.8764 1
Echinococcus multilocularis Tubulin beta 2C chain 0.072 0.8764 0.8764
Echinococcus multilocularis Tubulin alpha 1 chain 0.0556 0.6724 0.6724
Schistosoma mansoni ankyrin 23/unc44 0.0028 0.0151 0.0172
Trichomonas vaginalis tubulin, putative 0.0223 0.2585 0.0947
Echinococcus multilocularis tubulin beta 1 chain 0.072 0.8764 0.8764
Schistosoma mansoni tubulin subunit beta 0.072 0.8764 1
Trypanosoma brucei epsilon tubulin 0.0395 0.4718 0.4073
Loa Loa (eye worm) tubulin alpha-3 chain 0.0332 0.3944 0.45
Loa Loa (eye worm) tubulin beta chain 0.072 0.8764 1
Loa Loa (eye worm) beta-tubulin 0.072 0.8764 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0232 0.2698 0.2698
Leishmania major alpha tubulin 0.0556 0.6724 0.701
Plasmodium vivax tubulin alpha chain, putative 0.0556 0.6724 0.7592
Plasmodium falciparum tubulin beta chain 0.072 0.8764 1
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0042 0.0333 0.038
Echinococcus granulosus geminin 0.034 0.4032 0.46
Plasmodium falciparum alpha tubulin 1 0.0556 0.6724 0.7592
Trichomonas vaginalis tubulin beta chain, putative 0.0556 0.6724 0.701
Mycobacterium ulcerans cell division protein FtsZ 0.0171 0.1938 0.5
Brugia malayi Tubulin beta chain 0.0223 0.2585 0.2949
Leishmania major beta tubulin 0.072 0.8764 1
Plasmodium vivax tubulin alpha chain, putative 0.0556 0.6724 0.7592
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0567 0.0647
Leishmania major alpha tubulin 0.0556 0.6724 0.701
Brugia malayi Tubulin beta chain 0.0171 0.1938 0.2211
Echinococcus multilocularis tubulin alpha chain 0.0556 0.6724 0.6724
Schistosoma mansoni hypothetical protein 0.0034 0.0226 0.0258
Echinococcus granulosus tubulin alpha 3 chain 0.0556 0.6724 0.7671
Leishmania major beta tubulin 0.072 0.8764 1
Echinococcus granulosus Ankyrin 0.0028 0.0151 0.0172
Trichomonas vaginalis tubulin beta chain, putative 0.0556 0.6724 0.701
Echinococcus granulosus tubulin delta chain 0.0171 0.1938 0.2211
Leishmania major beta tubulin 0.072 0.8764 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0556 0.6724 0.701
Brugia malayi Tubulin alpha chain 0.0171 0.1938 0.2211
Brugia malayi beta-tubulin, identical 0.072 0.8764 1
Loa Loa (eye worm) tubulin alpha-2 chain 0.0556 0.6724 0.7671
Loa Loa (eye worm) hypothetical protein 0.0028 0.0151 0.0172
Mycobacterium leprae cell division protein FtsZ 0.0171 0.1938 0.5
Plasmodium vivax tubulin epsilon chain, putative 0.0395 0.4718 0.5226
Trichomonas vaginalis tubulin alpha chain, putative 0.072 0.8764 1
Leishmania major alpha tubulin 0.0556 0.6724 0.701
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0288 0.0329
Leishmania major beta tubulin 0.072 0.8764 1
Leishmania major beta tubulin 0.072 0.8764 1
Leishmania major alpha tubulin 0.0556 0.6724 0.701
Loa Loa (eye worm) hypothetical protein 0.0239 0.2778 0.317
Schistosoma mansoni tubulin subunit epsilon 0.0395 0.4718 0.5383
Loa Loa (eye worm) hypothetical protein 0.0028 0.0151 0.0172
Echinococcus granulosus tubulin alpha chain 0.0556 0.6724 0.7671
Loa Loa (eye worm) tubulin alpha 2 0.0161 0.181 0.2065
Loa Loa (eye worm) BEN-1 protein 0.072 0.8764 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0556 0.6724 0.7671
Schistosoma mansoni lipoxygenase 0.0232 0.2698 0.3078
Loa Loa (eye worm) tubulin beta-4 chain 0.072 0.8764 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.072 0.8764 0.8764
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0171 0.1938 0.5
Toxoplasma gondii alpha-tubulin I, putative 0.0556 0.6724 0.701
Loa Loa (eye worm) hypothetical protein 0.0332 0.3944 0.45
Echinococcus multilocularis beta tubulin 0.072 0.8764 0.8764
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0226 0.0258
Trichomonas vaginalis tubulin beta chain, putative 0.0556 0.6724 0.701
Giardia lamblia Beta tubulin 0.072 0.8764 1
Echinococcus multilocularis tubulin alpha chain 0.0556 0.6724 0.6724
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0151 0.0172
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0028 0.0151 0.0172
Trichomonas vaginalis tubulin gamma chain, putative 0.072 0.8764 1
Leishmania major beta tubulin 0.072 0.8764 1
Loa Loa (eye worm) tubulin beta chain 0.0171 0.1938 0.2211
Giardia lamblia Beta tubulin 0.072 0.8764 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0223 0.2585 0.0947
Echinococcus multilocularis Ankyrin 0.0028 0.0151 0.0151
Brugia malayi Cell division protein ftsZ 0.0171 0.1938 0.2211
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0422 0.0481
Brugia malayi tubulin alpha-2 chain 0.0556 0.6724 0.7671
Onchocerca volvulus 0.0039 0.0288 0.0566
Brugia malayi hypothetical protein 0.0239 0.2778 0.317
Echinococcus granulosus Tubulin beta 2C chain 0.072 0.8764 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0556 0.6724 0.6724
Brugia malayi alpha-tubulin 0.0556 0.6724 0.7671
Leishmania major alpha tubulin 0.0556 0.6724 0.701
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0384 0.459 0.5237
Schistosoma mansoni rab6-interacting 0.0039 0.0288 0.0329
Brugia malayi Tubulin alpha-2 chain 0.0556 0.6724 0.7671
Echinococcus granulosus netrin receptor unc 5 0.0028 0.0151 0.0172
Echinococcus multilocularis tubulin gamma 1 chain 0.0395 0.4718 0.4718
Loa Loa (eye worm) hypothetical protein 0.0034 0.0226 0.0258
Loa Loa (eye worm) RNA binding protein 0.0061 0.0567 0.0647
Schistosoma mansoni tubulin subunit alpha 0.0171 0.1938 0.2211
Echinococcus granulosus tubulin alpha 3 chain 0.0556 0.6724 0.7671
Echinococcus multilocularis hypothetical protein 0.0556 0.6724 0.6724
Echinococcus granulosus Tubulin beta 2C chain 0.072 0.8764 1
Leishmania major beta tubulin 0.072 0.8764 1
Treponema pallidum cell division protein FtsZ 0.0171 0.1938 0.5
Echinococcus granulosus tubulin beta 4A class IVa 0.072 0.8764 1
Schistosoma mansoni tubulin subunit beta 0.072 0.8764 1
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0042 0.0333 0.038
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0288 0.0288
Brugia malayi Tubulin alpha chain 0.0556 0.6724 0.7671
Echinococcus granulosus tubulin alpha 1C chain 0.0556 0.6724 0.7671
Echinococcus granulosus RUN 0.0039 0.0288 0.0329
Echinococcus multilocularis Tubulin beta 2C chain 0.072 0.8764 0.8764
Echinococcus multilocularis tubulin epsilon chain 0.0395 0.4718 0.4718
Echinococcus multilocularis Tubulin beta 2C chain 0.072 0.8764 0.8764
Schistosoma mansoni tubulin subunit alpha 0.0556 0.6724 0.7671
Echinococcus multilocularis peroxisome assembly protein 26 0.0556 0.6724 0.6724
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0174 0.1976 0.7498
Loa Loa (eye worm) alpha-tubulin 0.0556 0.6724 0.7671
Echinococcus multilocularis tubulin alpha chain 0.0556 0.6724 0.6724
Onchocerca volvulus 0.0223 0.2585 1
Schistosoma mansoni loxhd1 0.0039 0.0288 0.0329
Echinococcus granulosus alpha tubulin 0.0556 0.6724 0.7671
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0556 0.6724 0.701
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0567 0.0647

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) Trypanocidal activity against epimastigote stage of Trypanosoma cruzi infected in african green monkey Vero cells assessed as cell viability after 24 hrs by MTT assay ChEMBL. 25127463

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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