Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.1781 | 0.7735 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1781 | 0.7735 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0301 | 0 | 0.5 |
Onchocerca volvulus | 0.0301 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1781 | 0.7735 | 1 |
Onchocerca volvulus | 0.0301 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.1781 | 0.7735 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0301 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0301 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1781 | 0.7735 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1781 | 0.7735 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1781 | 0.7735 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1781 | 0.7735 | 1 |
Onchocerca volvulus | 0.0301 | 0 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.1781 | 0.7735 | 1 |
Onchocerca volvulus | 0.0301 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.1781 | 0.7735 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0301 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0301 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1781 | 0.7735 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1781 | 0.7735 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0301 | 0 | 0.5 |
Onchocerca volvulus | 0.0301 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1781 | 0.7735 | 0.7735 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of human HDAC in human HCT116 cells assessed as global histone H3 lysine-9 acetylation levels at 0.01 to 1 uM after 24 hrs by Western blotting method | ChEMBL. | 25203782 | |
Inhibition (binding) | Inhibition of human HDAC6 (unknown origin) at 0.01 to 5 uM using Fluor de Lys substrate fluorimetric assay | ChEMBL. | 25203782 | |
Inhibition (binding) | <= 15 % | Inhibition of human HDAC1 (unknown origin) at 1 uM using Fluor de Lys substrate fluorimetric assay | ChEMBL. | 25203782 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.