Detailed information for compound 929233

Basic information

Technical information
  • TDR Targets ID: 929233
  • Name: 2-(6-chloro-4-oxoquinazolin-3-yl)-N-phenylace tamide
  • MW: 313.738 | Formula: C16H12ClN3O2
  • H donors: 1 H acceptors: 2 LogP: 2.42 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1cnc2c(c1=O)cc(cc2)Cl)Nc1ccccc1
  • InChi: 1S/C16H12ClN3O2/c17-11-6-7-14-13(8-11)16(22)20(10-18-14)9-15(21)19-12-4-2-1-3-5-12/h1-8,10H,9H2,(H,19,21)
  • InChiKey: APBLKSCCPNBOGP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(6-chloro-4-oxo-quinazolin-3-yl)-N-phenyl-acetamide
  • 2-(6-chloro-4-oxo-3-quinazolinyl)-N-phenylacetamide
  • 2-(6-chloro-4-keto-quinazolin-3-yl)-N-phenyl-acetamide
  • 2-(6-chloro-4-oxo-quinazolin-3-yl)-N-phenyl-ethanamide
  • ZINC02529401

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) Get druggable targets OG5_130466 All targets in OG5_130466
Chlamydia trachomatis enoyl-acyl-carrier protein reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium berghei enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium yoelii enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium vivax enoyl-acyl carrier protein reductase Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) Get druggable targets OG5_130466 All targets in OG5_130466
Neospora caninum enoyl-acyl carrier reductase, putative Get druggable targets OG5_130466 All targets in OG5_130466
Trichomonas vaginalis hypothetical protein Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium knowlesi enoyl-acyl carrier reductase, putative Get druggable targets OG5_130466 All targets in OG5_130466
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium falciparum enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Toxoplasma gondii enoyl-acyl carrier reductase ENR Get druggable targets OG5_130466 All targets in OG5_130466
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0002 0.0002
Brugia malayi Dopamine receptor protein 1 0.0077 0.1032 0.3124
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0398 0.1071
Echinococcus granulosus insulin receptor 0.0047 0.0494 0.0495
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0077 0.1032 0.1182
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.042
Toxoplasma gondii hypothetical protein 0.0025 0.0114 0.012
Loa Loa (eye worm) hypothetical protein 0.0041 0.0398 0.0486
Trypanosoma brucei carbonic anhydrase-like protein 0.0119 0.1778 1
Schistosoma mansoni neuropeptide F-like receptor 0.0077 0.1032 0.1182
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0025 0.0114 0.0114
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.008 0.0009
Onchocerca volvulus 0.0023 0.0072 0.0183
Onchocerca volvulus 0.006 0.0735 0.2202
Echinococcus granulosus sex peptide receptor 0.0077 0.1032 0.1034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0002
Schistosoma mansoni lipoxygenase 0.0054 0.0625 0.0715
Brugia malayi G protein-coupled receptor F59B2.13 0.0077 0.1032 0.3124
Echinococcus multilocularis rhodopsin orphan GPCR 0.0077 0.1032 0.1034
Brugia malayi tailless protein 0.0038 0.0344 0.1037
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.008 0.001
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0077 0.1032 0.1034
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0011 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0077 0.1032 0.1034
Mycobacterium ulcerans monoamine oxidase 0.0041 0.0398 0.0329
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0114 0.0114
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0344 0.1037
Onchocerca volvulus 0.0023 0.008 0.021
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0081 0.1098 0.3323
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0038 0.0344 0.0392
Entamoeba histolytica hypothetical protein 0.0035 0.0292 0.3588
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0424 0.1282
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0625 0.0626
Loa Loa (eye worm) hypothetical protein 0.0066 0.0842 0.1029
Schistosoma mansoni biogenic amine receptor 0.0077 0.1032 0.1182
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0345 0.5763 0.7037
Schistosoma mansoni neuropeptide receptor 0.0077 0.1032 0.1182
Onchocerca volvulus 0.0029 0.0185 0.0528
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0025 0.0114 0.0114
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0002 0.0002
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0038 0.0344 0.0344
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0077 0.1032 0.126
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Echinococcus multilocularis snurportin 1 0.0345 0.5763 0.5775
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0114 0.0129
Brugia malayi RE40412p 0.0029 0.0185 0.0555
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0081 0.1098 0.1257
Brugia malayi nuclear receptor NHR-88 0.0081 0.1098 0.3323
Schistosoma mansoni tyrosine kinase 0.0047 0.0494 0.0565
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0041 0.0398 0.0897
Brugia malayi Protein kinase domain containing protein 0.0047 0.0494 0.1494
Echinococcus multilocularis neuropeptide Y receptor 0.0077 0.1032 0.1034
Loa Loa (eye worm) inositol-1 0.0036 0.0309 0.0377
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Brugia malayi Dopamine receptor 0.0077 0.1032 0.3124
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0081 0.1098 0.3323
Echinococcus granulosus neuropeptides capa receptor 0.0077 0.1032 0.1034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0077 0.1032 0.1182
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0009
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0812 0.0929
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0002 0.0002
Onchocerca volvulus 0.0077 0.1032 0.3104
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0091 0.5
Brugia malayi hypothetical protein 0.0077 0.1032 0.3124
Brugia malayi G-protein coupled receptor 0.0077 0.1032 0.3124
Entamoeba histolytica hypothetical protein 0.0035 0.0292 0.3588
Echinococcus granulosus conserved hypothetical protein 0.0029 0.0185 0.0185
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0223 0.362 1
Onchocerca volvulus 0.0077 0.1032 0.3104
Schistosoma mansoni tyrosine kinase 0.0078 0.1041 0.1192
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0238
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0081 0.1098 0.134
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0081 0.1098 0.1257
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0077 0.1032 0.1034
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0002 0.0002
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0047 0.0494 0.0495
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0241 0.0478
Schistosoma mansoni cpg binding protein 0.0064 0.0796 0.0911
Echinococcus multilocularis allatostatin A receptor 0.0077 0.1032 0.1034
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Plasmodium falciparum enoyl-acyl carrier reductase 0.0223 0.362 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Brugia malayi ecdysteroid receptor 0.0081 0.1098 0.3323
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0331 0.0332
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0133 0.0363
Brugia malayi nuclear hormone receptor 0.0081 0.1098 0.3323
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0081 0.1098 0.3323
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0223 0.362 1
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0205 0.3299 1
Echinococcus granulosus neuropeptide receptor A26 0.0077 0.1032 0.1034
Loa Loa (eye worm) hypothetical protein 0.0081 0.1098 0.134
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0081 0.1098 0.3323
Brugia malayi Melatonin receptor type 1A 0.0077 0.1032 0.3124
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0077 0.1032 0.1034
Schistosoma mansoni growth hormone secretagogue receptor 0.0077 0.1032 0.1182
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.0114 0.0129
Schistosoma mansoni tyrosine kinase 0.0047 0.0494 0.0565
Brugia malayi CXXC zinc finger family protein 0.006 0.0735 0.2225
Schistosoma mansoni biogenic amine (5HT) receptor 0.0077 0.1032 0.1182
Entamoeba histolytica Ran family GTPase 0.0024 0.0091 0.1095
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0119 0.1778 0.2037
Onchocerca volvulus Protein ultraspiracle homolog 0.0081 0.1098 0.3304
Brugia malayi ORL1-like opioid receptor 0.0077 0.1032 0.3124
Echinococcus granulosus neuropeptides capa receptor 0.0077 0.1032 0.1034
Brugia malayi G-protein coupled receptor 0.0077 0.1032 0.3124
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0114 0.0129
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0029 0.0185 0.0481
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0543 0.9273 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0077 0.1032 0.1182
Brugia malayi conserved hypotetical protein 0.0038 0.0344 0.1037
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0398 0.0355
Brugia malayi hypothetical protein 0.0035 0.0292 0.0881
Onchocerca volvulus 0.0025 0.0114 0.0312
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0029 0.0185 0.0481
Loa Loa (eye worm) nuclear hormone receptor 0.0038 0.0344 0.042
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0223 0.362 0.3574
Brugia malayi hypothetical protein 0.0077 0.1032 0.3124
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0077 0.1032 0.1034
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0091 0.0091
Echinococcus multilocularis serotonin transporter 0.0148 0.2283 0.2288
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.0139
Loa Loa (eye worm) hypothetical protein 0.0043 0.0424 0.0518
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0114 0.034
Brugia malayi hypothetical protein 0.0025 0.0114 0.034
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0424 0.1282
Brugia malayi RE15519p 0.0077 0.1032 0.3124
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Echinococcus multilocularis neuropeptide Y receptor 0.0077 0.1032 0.1034
Loa Loa (eye worm) hypothetical protein 0.0043 0.0424 0.0518
Echinococcus multilocularis insulin receptor 0.0047 0.0494 0.0495
Schistosoma mansoni ran 0.0024 0.0091 0.0102
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Echinococcus multilocularis epidermal growth factor receptor 0.0078 0.1056 0.1058
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0091 0.0111
Chlamydia trachomatis protoporphyrinogen oxidase 0.0041 0.0398 0.081
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0151 0.0151
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0842 0.0964
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0398 0.0399
Plasmodium falciparum transporter, putative 0.0025 0.0114 0.0284
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0081 0.1098 0.1257
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0077 0.1032 0.1034
Echinococcus multilocularis neuropeptide receptor 0.0077 0.1032 0.1034
Schistosoma mansoni hypothetical protein 0.0019 0.0011 0.0011
Echinococcus multilocularis cpg binding protein 0.0064 0.0796 0.0798
Mycobacterium ulcerans oxidoreductase 0.0041 0.0398 0.0329
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Echinococcus granulosus geminin 0.0166 0.26 0.2605
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0081 0.1098 0.3323
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Loa Loa (eye worm) hypothetical protein 0.0205 0.3299 0.4028
Echinococcus multilocularis rhodopsin orphan GPCR 0.0077 0.1032 0.1034
Loa Loa (eye worm) hypothetical protein 0.0043 0.0424 0.0518
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0041 0.0398 0.1071
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0344 0.0344
Echinococcus granulosus epidermal growth factor receptor 0.0146 0.2249 0.2253
Loa Loa (eye worm) hypothetical protein 0.0041 0.0398 0.0486
Echinococcus multilocularis protoporphyrinogen oxidase 0.0041 0.0398 0.0399
Echinococcus granulosus snurportin 1 0.0345 0.5763 0.5775
Brugia malayi ecdysone receptor 0.0038 0.0344 0.1037
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0344 0.0392
Echinococcus multilocularis neuropeptide FF receptor 2 0.0077 0.1032 0.1034
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0077 0.1032 0.3124
Toxoplasma gondii histone lysine-specific demethylase 0.0041 0.0398 0.092
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.042
Schistosoma mansoni tyrosine kinase 0.0078 0.1041 0.1192
Echinococcus granulosus rhodopsin orphan GPCR 0.0077 0.1032 0.1034
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0077 0.1032 0.1182
Plasmodium falciparum importin beta, putative 0.0032 0.0241 0.0637
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0077 0.1032 0.1182
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0098
Toxoplasma gondii PfMNL-2 CISD1 family iron-sulfur protein, putative 0.0029 0.0185 0.032
Schistosoma mansoni lipoxygenase 0.0019 0.0011 0.0011
Onchocerca volvulus 0.0025 0.0114 0.0312
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0148 0.2283 0.2788
Schistosoma mansoni neuropeptide receptor 0.0077 0.1032 0.1182
Schistosoma mansoni hypothetical protein 0.0035 0.0292 0.0333
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0091 0.0111
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0309 0.1392
Echinococcus multilocularis g protein coupled receptor 0.0077 0.1032 0.1034
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0025 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0344 0.0344
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0038 0.0344 0.0344
Schistosoma mansoni neuropeptide F-like receptor 0.0077 0.1032 0.1182
Echinococcus granulosus rhodopsin orphan GPCR 0.0077 0.1032 0.1034
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0114 0.034
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0128 0.1929 0.2211
Brugia malayi Carboxylesterase family protein 0.0066 0.0842 0.2549
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0114 0.0129
Loa Loa (eye worm) hypothetical protein 0.0482 0.819 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0114 0.0114
Onchocerca volvulus 0.0077 0.1032 0.3104
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.008 0.0969
Schistosoma mansoni alpha-1 adrenergic receptor 0.0077 0.1032 0.1182
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0398 0.1913
Echinococcus multilocularis g protein coupled receptor 0.0077 0.1032 0.1034
Brugia malayi larval opioid receptor 0.0077 0.1032 0.3124
Echinococcus granulosus rhodopsin orphan GPCR 0.0077 0.1032 0.1034
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0081 0.1098 0.11
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0151 0.0171
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0114 0.012
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0077 0.1032 0.3124
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0729 0.0715
Echinococcus multilocularis FTZ F1 alpha 0.0081 0.1098 0.11
Brugia malayi photoreceptor-specific nuclear receptor 0.0081 0.1098 0.3323
Echinococcus granulosus importin subunit beta 1 0.0032 0.0241 0.0242
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0002 0.0002
Echinococcus multilocularis dro:myosuppressin receptor 0.0077 0.1032 0.1034
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0309 0.031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0077 0.1032 0.1182
Echinococcus granulosus somatostatin receptor 0.0077 0.1032 0.1034
Schistosoma mansoni neuropeptide receptor 0.0077 0.1032 0.1182
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0151 0.0452
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Brugia malayi nuclear receptor NHR-67 0.0038 0.0344 0.1037
Brugia malayi Tachykinin-like peptides receptor 99D 0.0077 0.1032 0.3124
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0114 0.0114
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0114 0.0139
Schistosoma mansoni hypothetical protein 0.0077 0.1032 0.1182
Brugia malayi Importin beta-1 subunit 0.0032 0.0241 0.0726
Brugia malayi Inositol-1 0.0036 0.0309 0.0931
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.008 0.0052
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0309 0.0849
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0081 0.1098 0.3323
Echinococcus granulosus neuropeptide FF receptor 2 0.0077 0.1032 0.1034
Brugia malayi hypothetical protein 0.0019 0.0011 0.0029
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0002 0.0002
Onchocerca volvulus 0.0077 0.1032 0.3104
Onchocerca volvulus 0.0148 0.2283 0.6909
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0241 0.0994
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0842 0.0844
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0081 0.1098 0.134
Schistosoma mansoni tyrosine kinase 0.0078 0.1056 0.1209
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0027 0.0151 0.0452
Echinococcus multilocularis G-protein coupled receptor, putative 0.0077 0.1032 0.1034
Loa Loa (eye worm) norepinephrine transporter 0.0148 0.2283 0.2788
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0025 0.0114 0.0114
Echinococcus granulosus alpha 1A adrenergic receptor 0.0077 0.1032 0.1034
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.042
Schistosoma mansoni cpg binding protein 0.0064 0.0796 0.0911
Schistosoma mansoni hypothetical protein 0.0267 0.4393 0.5037
Schistosoma mansoni amine GPCR 0.0077 0.1032 0.1182
Loa Loa (eye worm) hypothetical protein 0.0081 0.1098 0.134
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0038 0.0344 0.0344
Brugia malayi hypothetical protein 0.0077 0.1032 0.3124
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0185 0.0481
Brugia malayi hypothetical protein 0.0077 0.1032 0.3124
Echinococcus multilocularis rhodopsin orphan GPCR 0.0077 0.1032 0.1034
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0002 0.0002
Schistosoma mansoni importin beta-1 0.0032 0.0241 0.0275
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0223 0.362 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0077 0.1032 0.1182
Loa Loa (eye worm) hypothetical protein 0.0043 0.0424 0.0518
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Onchocerca volvulus 0.0077 0.1032 0.3104
Echinococcus granulosus fmrfamide receptor 0.0077 0.1032 0.1034
Loa Loa (eye worm) TK/EGFR protein kinase 0.0146 0.2249 0.2746
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0114 0.0129
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0309 0.1392
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0041 0.0398 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0081 0.1098 0.3323
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0011 0.0011
Echinococcus multilocularis g-protein coupled receptor 0.0077 0.1032 0.1034
Loa Loa (eye worm) hypothetical protein 0.0148 0.2283 0.2788
Toxoplasma gondii zinc finger CDGSH-type domain-containing protein 0.0029 0.0185 0.032
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0512 0.872 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0398 0.0486
Echinococcus granulosus thyroid hormone receptor alpha 0.0038 0.0344 0.0344
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0077 0.1032 0.126
Echinococcus granulosus rhodopsin orphan GPCR 0.0077 0.1032 0.1034
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0091 0.0111
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.0139
Schistosoma mansoni tyrosine kinase 0.0146 0.2249 0.2577
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0077 0.1032 0.1182
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0077 0.1032 0.1182
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0098
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0027 0.0151 0.0452
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0038 0.0344 0.0392
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0114 0.0284
Brugia malayi nuclear hormone receptor family member odr-7 0.0038 0.0344 0.1037
Loa Loa (eye worm) neuropeptide F receptor 0.0077 0.1032 0.126
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0309 0.0849
Echinococcus multilocularis neuropeptide s receptor 0.0077 0.1032 0.1034
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0241 0.0994
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0344 0.1011
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Echinococcus granulosus g-protein coupled receptor 0.0077 0.1032 0.1034
Schistosoma mansoni sodium/chloride dependent transporter 0.0148 0.2283 0.2617
Schistosoma mansoni carbonic anhydrase 0.0027 0.0151 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0081 0.1098 0.134
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.1098 0.11
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0077 0.1032 0.126
Onchocerca volvulus Neuropeptide F receptor homolog 0.0077 0.1032 0.3104
Loa Loa (eye worm) serotonin transporter b 0.0148 0.2283 0.2788
Onchocerca volvulus 0.0077 0.1032 0.3104
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0077 0.1032 0.1034
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0812 0.4338
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0077 0.1032 0.1034
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0002
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0078 0.1056 0.1058
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0077 0.1032 0.1182
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0483 0.8205 0.8223
Brugia malayi nuclear receptor NHR-88 0.0038 0.0344 0.1037
Loa Loa (eye worm) hypothetical protein 0.0027 0.0151 0.0184
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.1098 0.11
Brugia malayi putative neuropeptide receptor NPR1 0.0077 0.1032 0.3124
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0041 0.0398 0.0399
Loa Loa (eye worm) hypothetical protein 0.0043 0.0424 0.0518
Echinococcus multilocularis rhodopsin orphan GPCR 0.0077 0.1032 0.1034
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0002 0.0002
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0812 0.4338
Onchocerca volvulus 0.0077 0.1032 0.3104
Schistosoma mansoni biogenic amine receptor 0.0077 0.1032 0.1182
Entamoeba histolytica hypothetical protein 0.0035 0.0292 0.3588
Brugia malayi Doublecortin family protein 0.0019 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.042
Schistosoma mansoni rab6-interacting 0.0019 0.0011 0.0011
Echinococcus granulosus carbonic anhydrase 0.0027 0.0151 0.0151
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.1098 0.11
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0081 0.1098 0.1257
Echinococcus multilocularis g protein coupled receptor 0.0077 0.1032 0.1034
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.042
Loa Loa (eye worm) hypothetical protein 0.0041 0.0398 0.0486
Leishmania major UDP-galactopyranose mutase 0.0041 0.0398 0.1913
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0812 0.0813
Brugia malayi Furin-like cysteine rich region family protein 0.0146 0.2249 0.6814
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0812 0.0813
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0114 0.0129
Echinococcus multilocularis epidermal growth factor receptor 0.0146 0.2249 0.2253
Echinococcus granulosus 7tm_1 domain containing protein 0.0077 0.1032 0.1034
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0309 0.1392
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0043 0.0424 0.0518
Loa Loa (eye worm) G-protein coupled receptor 0.0077 0.1032 0.126
Echinococcus granulosus allatostatin A receptor 0.0077 0.1032 0.1034
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0002 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0238
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0842 0.0844
Brugia malayi hypothetical protein 0.0041 0.0398 0.1201
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0081 0.1098 0.11
Echinococcus multilocularis rhodopsin orphan GPCR 0.0077 0.1032 0.1034
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0114 0.012
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.042
Schistosoma mansoni amine GPCR 0.0077 0.1032 0.1182
Brugia malayi hypothetical protein 0.0077 0.1032 0.3124
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0077 0.1032 0.1034
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0077 0.1032 0.1034
Onchocerca volvulus 0.0077 0.1032 0.3104
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0002
Echinococcus granulosus tm gpcr rhodopsin 0.0077 0.1032 0.1034
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0077 0.1032 0.1034
Echinococcus granulosus g protein coupled receptor 0.0077 0.1032 0.1034
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0041 0.0398 0.0454
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0267 0.4393 0.4402
Schistosoma mansoni hypothetical protein 0.0166 0.26 0.298
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.0114 0.0129
Brugia malayi hypothetical protein 0.0043 0.0424 0.1282
Echinococcus multilocularis somatostatin receptor 0.0077 0.1032 0.1034
Entamoeba histolytica hypothetical protein 0.0026 0.0133 0.1622
Brugia malayi follicle stimulating hormone receptor 0.0077 0.1032 0.3124
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.008 0.0009
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0309 0.3793
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0344 0.1011
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0077 0.1032 0.1034
Plasmodium vivax importin-beta 2, putative 0.0032 0.0241 0.0637
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.0398 0.1071
Loa Loa (eye worm) TK/INSR protein kinase 0.0047 0.0494 0.0604
Schistosoma mansoni steroid hormone receptor ad4bp 0.0081 0.1098 0.1257
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0081 0.1098 0.3323
Echinococcus granulosus acetylcholinesterase 0.0066 0.0842 0.0844
Echinococcus multilocularis dnaJ subfamily B 0.04 0.6742 0.6755
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0133 0.0362
Leishmania major importin beta-1 subunit, putative 0.0026 0.0133 0.0362
Brugia malayi nuclear hormone receptor 0.0038 0.0344 0.1037
Loa Loa (eye worm) hypothetical protein 0.0081 0.1098 0.134
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0009
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0077 0.1032 0.1034
Brugia malayi nuclear receptor RXR 0.0043 0.0424 0.1282
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0223 0.362 0.3857
Echinococcus granulosus g protein coupled receptor 0.0077 0.1032 0.1034
Echinococcus granulosus biogenic amine 5HT receptor 0.0077 0.1032 0.1034
Schistosoma mansoni adenoreceptor 0.0077 0.1032 0.1182
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0223 0.362 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Loa Loa (eye worm) hypothetical protein 0.0041 0.0398 0.0486
Plasmodium falciparum protoporphyrinogen oxidase 0.0041 0.0398 0.1071
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0151 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0081 0.1098 0.3323
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0077 0.1032 0.1182
Echinococcus multilocularis carbonic anhydrase II 0.0119 0.1778 0.1781
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Schistosoma mansoni RAR-like nuclear receptor 0.0081 0.1098 0.1257
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0309 0.031
Schistosoma mansoni cpg binding protein 0.006 0.0735 0.0841
Toxoplasma gondii zinc finger cdgsh type protein 0.0029 0.0185 0.032
Onchocerca volvulus 0.0077 0.1032 0.3104
Brugia malayi hypothetical protein 0.0077 0.1032 0.3124
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0185 0.0481
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0081 0.1098 0.1257
Brugia malayi hypothetical protein 0.0019 0.0011 0.0029
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0081 0.1098 0.11
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0424 0.0485
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0735 0.0898
Schistosoma mansoni loxhd1 0.0019 0.0011 0.0011
Trichomonas vaginalis hypothetical protein 0.0223 0.362 1
Schistosoma mansoni opsin-like receptor 0.0077 0.1032 0.1182
Loa Loa (eye worm) hypothetical protein 0.0027 0.0151 0.0184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0081 0.1098 0.134
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0584 1 1
Echinococcus granulosus neuropeptide receptor 0.0077 0.1032 0.1034
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.042
Echinococcus multilocularis fmrfamide receptor 0.0077 0.1032 0.1034
Brugia malayi neuropeptide F receptor 0.0077 0.1032 0.3124
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0309 0.0669
Onchocerca volvulus 0.0077 0.1032 0.3104
Echinococcus granulosus RUN 0.0019 0.0011 0.0011
Echinococcus multilocularis neuropeptide receptor 0.0077 0.1032 0.1034
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0238
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Brugia malayi GnHR receptor homolog 0.0077 0.1032 0.3124
Echinococcus granulosus rhodopsin orphan GPCR 0.0077 0.1032 0.1034
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0091 0.0269
Onchocerca volvulus Bile acid receptor homolog 0.0081 0.1098 0.3304
Echinococcus granulosus g protein coupled receptor 0.0077 0.1032 0.1034
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.0139
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0091 0.0054
Echinococcus granulosus expressed protein 0.0365 0.6123 0.6136
Onchocerca volvulus 0.0077 0.1032 0.3104
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0077 0.1032 0.1034
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0011 0.0011
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.1688 0.4555
Schistosoma mansoni hypothetical protein 0.0512 0.872 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0148 0.2283 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0077 0.1032 0.1182
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0267 0.4393 0.4402
Brugia malayi SWIRM domain containing protein 0.0041 0.0398 0.1201
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0398 0.1913
Brugia malayi Nuclear hormone receptor-like 1 0.0081 0.1098 0.3323
Schistosoma mansoni hypothetical protein 0.0077 0.1032 0.1182
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0091 0.0219
Schistosoma mansoni hypothetical protein 0.04 0.6742 0.7731
Schistosoma mansoni hypothetical protein 0.0051 0.0565 0.0645
Schistosoma mansoni rab6-interacting 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.0139
Echinococcus multilocularis orexin receptor type 2 0.0077 0.1032 0.1034
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0625 0.0626
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0151 0.0452
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.008 0.0969
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0002 0.0002
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0081 0.1098 0.11
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0151 0.0452
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0002 0.0002
Echinococcus granulosus cpg binding protein 0.0064 0.0796 0.0798
Toxoplasma gondii hypothetical protein 0.0025 0.0114 0.012
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0081 0.1098 0.3323
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0114 0.012
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0081 0.1098 0.3323
Echinococcus granulosus rhodopsin orphan GPCR 0.0077 0.1032 0.1034
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0119 0.1778 0.2171
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0081 0.1098 0.3323
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.042
Brugia malayi Carboxylesterase family protein 0.0066 0.0842 0.2549
Echinococcus granulosus tm gpcr rhodopsin 0.0077 0.1032 0.1034
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0292 0.0333
Schistosoma mansoni neuropeptide f receptor 76f 0.0077 0.1032 0.1182
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0242 0.0185
Loa Loa (eye worm) hypothetical protein 0.0081 0.1098 0.134
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0398 0.0399
Echinococcus multilocularis rhodopsin orphan GPCR 0.0077 0.1032 0.1034
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0002 0.0002
Schistosoma mansoni amine oxidase 0.0041 0.0398 0.0454
Onchocerca volvulus 0.0077 0.1032 0.3104
Echinococcus granulosus tm gpcr rhodopsin 0.0583 0.9979 1
Brugia malayi Serotonin receptor 0.0077 0.1032 0.3124
Echinococcus multilocularis 0.0041 0.0398 0.0399
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0344 0.0392
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Echinococcus multilocularis serotonin receptor 0.0077 0.1032 0.1034
Schistosoma mansoni myosin xvIII 0.0077 0.1032 0.1182
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0812 0.0991
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0842 0.0844
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0014
Onchocerca volvulus 0.0077 0.1032 0.3104
Loa Loa (eye worm) hypothetical protein 0.0081 0.1098 0.134
Brugia malayi Dopamine receptor protein 2 0.0077 0.1032 0.3124
Echinococcus multilocularis conserved hypothetical protein 0.0029 0.0185 0.0185
Echinococcus granulosus hypothetical protein 0.0077 0.1032 0.1034
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0081 0.1098 0.11
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0098
Echinococcus granulosus tachykinin peptides receptor 99D 0.0077 0.1032 0.1034
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0114 0.0129
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0077 0.1032 0.3104
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0081 0.1098 0.134
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0119 0.1778 0.5385
Loa Loa (eye worm) solute carrier family 6 member 4 0.0148 0.2283 0.2788
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.042
Onchocerca volvulus 0.0077 0.1032 0.3104
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0309 0.0239
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0729 0.2205
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0002 0.0002
Brugia malayi Serotonin receptor 0.0077 0.1032 0.3124
Echinococcus multilocularis serotonin receptor 0.0077 0.1032 0.1034
Brugia malayi RE40412p 0.0029 0.0185 0.0555
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0242 0.0457
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0081 0.1098 0.3304
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0067 0.0863 0.1054
Echinococcus multilocularis neuropeptides capa receptor 0.0077 0.1032 0.1034
Brugia malayi sulfakinin receptor protein 0.0077 0.1032 0.3124
Loa Loa (eye worm) carbonic anhydrase 3 0.0119 0.1778 0.2171
Brugia malayi hypothetical protein 0.0077 0.1032 0.3124
Mycobacterium tuberculosis Possible oxidoreductase 0.0041 0.0398 0.0355
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0114 0.0114
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0344 0.0344
Schistosoma mansoni neuropeptide receptor 0.0077 0.1032 0.1182
Echinococcus multilocularis ecdysone induced protein 78C 0.0081 0.1098 0.11
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0077 0.1032 0.1182
Brugia malayi steroid hormone receptor 0.0081 0.1098 0.3323
Schistosoma mansoni opsin-like receptor 0.0077 0.1032 0.1182
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0029 0.0185 0.0481
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0077 0.1032 0.1182
Echinococcus granulosus FTZ F1 alpha 0.0081 0.1098 0.11
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0398 0.1071
Echinococcus granulosus neuropeptide Y receptor 0.0077 0.1032 0.1034
Echinococcus granulosus acetylcholinesterase 0.0066 0.0842 0.0844
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.008 0.0009
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0041 0.0398 0.1071
Plasmodium falciparum carbonic anhydrase 0.0027 0.0151 0.0387
Echinococcus granulosus neuropeptide Y receptor 0.0077 0.1032 0.1034
Echinococcus granulosus epidermal growth factor receptor 0.0078 0.1056 0.1058
Loa Loa (eye worm) hypothetical protein 0.0148 0.2283 0.2788
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0077 0.1032 0.1034
Loa Loa (eye worm) melatonin receptor type 1A 0.0077 0.1032 0.126
Onchocerca volvulus 0.0077 0.1032 0.3104
Loa Loa (eye worm) hypothetical protein 0.0029 0.0185 0.0226
Loa Loa (eye worm) hypothetical protein 0.0029 0.0185 0.0226
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0002 0.0002
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0483 0.8205 0.8223
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0729 0.0834
Echinococcus granulosus biogenic amine 5HT receptor 0.0077 0.1032 0.1034
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0729 0.0731
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0077 0.1032 0.3124
Loa Loa (eye worm) carboxylesterase 0.0066 0.0842 0.1029
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0081 0.1098 0.11
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0077 0.1032 0.1034
Mycobacterium ulcerans dehydrogenase 0.0041 0.0398 0.0329
Echinococcus multilocularis expressed protein 0.0365 0.6123 0.6136
Brugia malayi hypothetical protein 0.0043 0.0424 0.1282
Echinococcus granulosus ecdysone induced protein 78C 0.0081 0.1098 0.11
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0081 0.1098 0.11
Schistosoma mansoni hypothetical protein 0.0029 0.0185 0.021
Schistosoma mansoni hypothetical protein 0.0027 0.0151 0.0171
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0309 0.0849
Echinococcus granulosus serotonin receptor 0.0077 0.1032 0.1034
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0002 0.0002
Loa Loa (eye worm) steroid hormone receptor 0.0081 0.1098 0.134
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0148 0.2283 0.2617
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0077 0.1032 0.1034
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0043 0.0424 0.0425
Echinococcus granulosus rhodopsin orphan GPCR 0.0077 0.1032 0.1034
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0077 0.1032 0.1034
Plasmodium vivax amine transporter, putative 0.0025 0.0114 0.0284
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0223 0.362 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0114 0.0114
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0133 0.0363
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0292 0.0293
Echinococcus granulosus orexin receptor type 2 0.0077 0.1032 0.1034
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0038 0.0344 0.042
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0077 0.1032 0.3124
Loa Loa (eye worm) DR-78 0.0038 0.0344 0.042
Brugia malayi RNA, U transporter 1 0.0092 0.1293 0.3917
Leishmania major hypothetical protein, unknown function 0.0029 0.0185 0.0665
Brugia malayi Steroid receptor seven-up type 2 0.0081 0.1098 0.3323
Brugia malayi AKH receptor 0.0077 0.1032 0.3124
Echinococcus multilocularis neuropeptides capa receptor 0.0077 0.1032 0.1034
Echinococcus granulosus nuclear receptor nhr 48 0.0038 0.0344 0.0344
Loa Loa (eye worm) G-protein coupled receptor 0.0077 0.1032 0.126
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0114 0.0129
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0043 0.0424 0.0485
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Brugia malayi hypothetical protein 0.0077 0.1032 0.3124
Loa Loa (eye worm) hypothetical protein 0.0081 0.1098 0.134
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0119 0.1778 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0038 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0041 0.0398 0.0486
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0077 0.1032 0.1182
Echinococcus granulosus 7TM GPCR rhodopsin 0.0077 0.1032 0.1034
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0045 0.0463 0.1103
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0002 0.0002
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0025 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.042
Echinococcus granulosus dro:myosuppressin receptor 0.0077 0.1032 0.1034
Brugia malayi hypothetical protein 0.0038 0.0344 0.1037
Echinococcus granulosus carbonic anhydrase II 0.0119 0.1778 0.1781
Schistosoma mansoni nuclear receptor 0.0038 0.0344 0.0392
Schistosoma mansoni opsin-like receptor 0.0077 0.1032 0.1182
Mycobacterium ulcerans hypothetical protein 0.0023 0.008 0.0009
Schistosoma mansoni tyrosine kinase 0.0078 0.1041 0.1192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0081 0.1098 0.134
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0002
Brugia malayi neuropeptide F receptor 0.0077 0.1032 0.3124
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0002 0.0002
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0043 0.0424 0.0425
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0241 0.0242
Brugia malayi amine oxidase, flavin-containing family protein 0.0041 0.0398 0.1201
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0309 0.1392
Echinococcus granulosus neuropeptide receptor 0.0077 0.1032 0.1034
Echinococcus multilocularis geminin 0.0166 0.26 0.2605
Schistosoma mansoni biogenic amine (5HT) receptor 0.0077 0.1032 0.1182
Echinococcus multilocularis G protein coupled receptor 139 0.0077 0.1032 0.1034
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Onchocerca volvulus 0.0041 0.0398 0.1176
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0077 0.1032 0.1182
Onchocerca volvulus 0.0205 0.3299 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0114 0.0139
Schistosoma mansoni zinc finger protein 0.0038 0.0344 0.0392
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0081 0.1098 0.11
Brugia malayi hypothetical protein 0.0077 0.1032 0.3124
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0077 0.1032 0.1182
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0011 0.0011
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.008 0.0969
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0114 0.0129
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.008 0.0052
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0185 0.0481
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Loa Loa (eye worm) hypothetical protein 0.0027 0.0151 0.0184
Schistosoma mansoni nuclear hormone receptor 0.0081 0.1098 0.1257
Brugia malayi putative neuropeptide receptor 0.0077 0.1032 0.3124
Brugia malayi G protein-coupled receptor 0.0077 0.1032 0.3124
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0077 0.1032 0.1034
Onchocerca volvulus 0.0025 0.0114 0.0312
Loa Loa (eye worm) neuropeptide F receptor 0.0077 0.1032 0.126
Onchocerca volvulus 0.0038 0.0344 0.1011
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0038 0.0344 0.1037
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0077 0.1032 0.1034
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0114 0.034
Loa Loa (eye worm) nuclear receptor NHR-67 0.0038 0.0344 0.042
Onchocerca volvulus 0.0077 0.1032 0.3104
Trichomonas vaginalis ran, putative 0.0024 0.0091 0.0245
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0729 0.0731
Schistosoma mansoni tyrosine kinase 0.0078 0.1056 0.1209
Echinococcus granulosus carbonic anhydrase 0.0027 0.0151 0.0151
Echinococcus granulosus dnaJ subfamily B 0.04 0.6742 0.6755
Schistosoma mansoni thyroid hormone receptor 0.0348 0.5821 0.6674
Schistosoma mansoni nuclear receptor nhr-48 0.0038 0.0344 0.0392
Echinococcus multilocularis neuropeptide receptor A26 0.0077 0.1032 0.1034
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0729 0.0662
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0133 0.0363
Schistosoma mansoni amine oxidase 0.0041 0.0398 0.0454
Entamoeba histolytica hypothetical protein 0.0035 0.0292 0.3588
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0812 0.4338
Schistosoma mansoni retinoic acid receptor RXR 0.0081 0.1098 0.1257
Onchocerca volvulus 0.0029 0.0185 0.0528
Echinococcus granulosus neuropeptide s receptor 0.0077 0.1032 0.1034
Schistosoma mansoni histamine h1 receptor 0.0077 0.1032 0.1182
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0119 0.1778 0.2037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0344 0.0344
Schistosoma mansoni hypothetical protein 0.0077 0.1032 0.1182
Schistosoma mansoni hypothetical protein 0.0166 0.26 0.298
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0027 0.0151 0.0184
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Leishmania major GTP-binding protein, putative 0.0024 0.0091 0.0111
Schistosoma mansoni thyroid hormone receptor 0.0348 0.5821 0.6674
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0842 0.1029
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0482 0.819 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0344 0.0344
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0344 0.1037
Schistosoma mansoni amine GPCR 0.0077 0.1032 0.1182
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0119 0.1778 0.5385
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0002 0.0002
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0002 0.0002
Loa Loa (eye worm) TYRA-2 protein 0.0077 0.1032 0.126
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0729 0.0662
Schistosoma mansoni ran 0.0024 0.0091 0.0102
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0025 0.0114 0.034
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0077 0.1032 0.126
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Echinococcus multilocularis fmrfamide receptor 0.0077 0.1032 0.1034
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0091 0.0091
Echinococcus granulosus carbonic anhydrase 0.0027 0.0151 0.0151
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0077 0.1032 0.1182
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0047 0.0494 0.0495
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0081 0.1098 0.134
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0812 0.2456
Plasmodium falciparum amino acid transporter, putative 0.0025 0.0114 0.0284
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0077 0.1032 0.3124
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.008 0.0052
Schistosoma mansoni coup transcription factor 0.0081 0.1098 0.1257
Loa Loa (eye worm) hypothetical protein 0.0032 0.0241 0.0295
Onchocerca volvulus 0.0081 0.1098 0.3304
Onchocerca volvulus 0.0038 0.0344 0.1011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0081 0.1098 0.1257
Echinococcus granulosus peptide allatostatin:somatostatin 0.0077 0.1032 0.1034
Schistosoma mansoni inositol monophosphatase 0.0036 0.0309 0.0352
Echinococcus granulosus G protein coupled receptor 139 0.0077 0.1032 0.1034
Echinococcus granulosus serotonin transporter 0.0148 0.2283 0.2288
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.1098 0.11
Brugia malayi hypothetical protein 0.0038 0.0344 0.1037
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0729 0.3853
Loa Loa (eye worm) hypothetical protein 0.0081 0.1098 0.134
Echinococcus multilocularis rhodopsin orphan GPCR 0.0077 0.1032 0.1034
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0041 0.0398 0.0454
Schistosoma mansoni polycystin 1-related 0.0019 0.0011 0.0011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0583 0.9979 1
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0041 0.0398 0.1071
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0081 0.1098 0.11
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0077 0.1032 0.126
Brugia malayi nuclear receptor RXR 0.0038 0.0344 0.1037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0077 0.1032 0.1182
Echinococcus multilocularis 0.0045 0.0469 0.047
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0292 0.0293
Brugia malayi hypothetical protein 0.0077 0.1032 0.3124
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.042
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0812 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0091 0.0111
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0812 0.4338
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0077 0.1032 0.1182
Echinococcus multilocularis thyroid hormone receptor alpha 0.0348 0.5821 0.5833
Loa Loa (eye worm) hypothetical protein 0.0081 0.1098 0.134
Schistosoma mansoni hypothetical protein 0.0077 0.1032 0.1182
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0151 0.0171
Leishmania major carbonic anhydrase-like protein 0.0119 0.1778 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0077 0.1032 0.1182
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0148 0.2283 0.6918
Toxoplasma gondii hypothetical protein 0.0027 0.0151 0.0224
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0331 0.0332
Onchocerca volvulus 0.0077 0.1032 0.3104
Loa Loa (eye worm) hypothetical protein 0.0066 0.0842 0.1029
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0011 0.0011
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0114 0.0114
Schistosoma mansoni amine GPCR 0.0077 0.1032 0.1182
Schistosoma mansoni sodium-dependent amino acid transporter 0.0025 0.0114 0.0129
Brugia malayi nuclear hormone receptor family member nhr-6 0.0038 0.0344 0.1037
Schistosoma mansoni inositol monophosphatase 0.0036 0.0309 0.0352
Loa Loa (eye worm) hypothetical protein 0.0077 0.1032 0.126
Brugia malayi orphan nuclear receptor NR2E1 0.0038 0.0344 0.1037
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0002 0.0002
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0091 0.0219
Schistosoma mansoni biogenic amine receptor 0.0077 0.1032 0.1182
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.042
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0077 0.1032 0.1182
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0119 0.1778 1
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0842 0.0844
Schistosoma mansoni amine GPCR 0.0077 0.1032 0.1182
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0081 0.1098 0.3323
Schistosoma mansoni hypothetical protein 0.0345 0.5763 0.6608
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.0139
Schistosoma mansoni nuclear receptor 0.0038 0.0344 0.0392
Echinococcus multilocularis RUN 0.0019 0.0011 0.0011
Echinococcus multilocularis sex peptide receptor 0.0077 0.1032 0.1034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0002

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.78 uM Inhibition of Mycobacterium tuberculosis recombinant InhA expressed in Escherichia coli BL21 (DE3) using 2-trans-decenoyl substrate by spectrophotometry ChEMBL. 25218910
Inhibition (ADMET) = 53.02 % Cytotoxicity against mouse RAW264.7 cells at 100 uM after 72 hrs by MTT assay ChEMBL. 25218910
Inhibition (binding) = 58.34 % Inhibition of Mycobacterium tuberculosis recombinant InhA expressed in Escherichia coli BL21 (DE3) using 2-trans-decenoyl substrate at 10 uM by spectrophotometry ChEMBL. 25218910
MIC (functional) = 1.24 uM Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 28 days by two-fold serial dilution assay in presence of 8 mg/mL piperine efflux pump inhibitor ChEMBL. 25218910
MIC (functional) = 4.97 uM Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 28 days by two-fold serial dilution assay ChEMBL. 25218910
MIC (functional) = 39.84 uM Antimycobacterial activity against isoniazid, rifampicin, ofloxacin and kanamycin-resistant Mycobacterium tuberculosis H37Rv ATCC 27294 clinical isolate after 28 days by two-fold serial dilution assay in presence of 8 mg/mL piperine efflux pump inhibitor ChEMBL. 25218910

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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