Detailed information for compound 929284

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.825 | Formula: C21H18ClNO4
  • H donors: 0 H acceptors: 0 LogP: 5.09 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1c2[n+](CCc3c2cc2OCOc2c3)cc2c1ccc1c2OCO1.[Cl-]
  • InChi: 1S/C21H18NO4.ClH/c1-2-13-14-3-4-17-21(26-11-23-17)16(14)9-22-6-5-12-7-18-19(25-10-24-18)8-15(12)20(13)22;/h3-4,7-9H,2,5-6,10-11H2,1H3;1H/q+1;/p-1
  • InChiKey: RSEQFAAJKLAYMA-UHFFFAOYSA-M  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0108 0.0829 0.2467
Trichomonas vaginalis ABC transporter, putative 0.0108 0.0829 0.2467
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0137 0.0173
Trypanosoma cruzi agmatinase, putative 0.0124 0.098 0.1601
Echinococcus granulosus ATP binding cassette sub family B 0.0034 0.0087 0.0067
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0964 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0034 0.0087 0.0067
Brugia malayi hypoxia-induced factor 1 0.0163 0.1369 0.2366
Echinococcus multilocularis multidrug resistance protein 1 0.0108 0.0829 0.1107
Schistosoma mansoni terminal deoxycytidyl transferase 0.0036 0.0113 0.0103
Brugia malayi Matrixin family protein 0.0152 0.1264 0.2179
Brugia malayi nuclear hormone receptor 0.003 0.0048 0.0016
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.046 0.0747
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0273 0.0327
Entamoeba histolytica P-glycoprotein-2 0.0108 0.0829 0.2467
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0081 0.056 0.618
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0142 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0048 0.0014
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0108 0.0829 0.5
Plasmodium falciparum glutathione reductase 0.0048 0.0228 0.0398
Echinococcus multilocularis carbonic anhydrase 0.039 0.3636 0.5041
Echinococcus granulosus multidrug resistance protein 1 0.0076 0.0503 0.065
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0048 0.0012
Echinococcus multilocularis dna polymerase eta 0.0036 0.0113 0.0103
Trypanosoma brucei DNA polymerase eta, putative 0.0036 0.0113 0.0199
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0148 0.0262
Schistosoma mansoni rab6-interacting 0.0043 0.0174 0.0188
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0142 0.0816
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0254 0.0382
Loa Loa (eye worm) hypoxia-induced factor 1 0.0163 0.1369 0.134
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0036 0.0113 0.0103
Brugia malayi ImpB/MucB/SamB family protein 0.0036 0.0113 0.013
Brugia malayi prostaglandin transporter 0.0174 0.1486 0.2573
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0254 0.0221
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0108 0.0829 0.2467
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0108 0.0829 0.2467
Schistosoma mansoni rab6-interacting 0.0043 0.0174 0.0188
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.046 0.0589
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0403 0.0509
Plasmodium vivax multidomain scavenger receptor, putative 0.0043 0.0174 0.0284
Loa Loa (eye worm) hypothetical protein 0.0184 0.1578 0.1549
Loa Loa (eye worm) transcription factor SMAD2 0.0366 0.3398 0.3376
Trichomonas vaginalis abcb9, putative 0.0108 0.0829 0.2467
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0048 0.0012
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0108 0.0829 0.2467
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0107 0.0189
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0403 0.4347
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0174 0.0188
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.039 0.3636 0.6398
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0048 0.0012
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0174 0.0244
Schistosoma mansoni ap endonuclease 0.0039 0.0142 0.0144
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0114 0.0889 1
Echinococcus granulosus Polycystic kidney disease protein 0.0043 0.0174 0.0188
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.0937 0.1258
Loa Loa (eye worm) hypothetical protein 0.0034 0.0087 0.0053
Echinococcus granulosus ATP binding cassette sub family B 0.0034 0.0087 0.0067
Echinococcus granulosus carbonic anhydrase II 0.0593 0.5661 0.7879
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.006 0.0347 0.0731
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0142 0.0108
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.046 0.0668
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0593 0.5661 0.5646
Echinococcus granulosus dna polymerase kappa 0.0065 0.0399 0.0504
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0014
Brugia malayi sodium-independent organic anion transporter family protein 0.0174 0.1486 0.2573
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.006 0.0347 0.0546
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0108 0.0829 0.1107
Schistosoma mansoni coup transcription factor 0.003 0.0048 0.0012
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0142 0.0183
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0033 0.0078 0.0568
Schistosoma mansoni thyroid hormone receptor 0.003 0.0048 0.0012
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0014
Loa Loa (eye worm) hypothetical protein 0.0174 0.1486 0.1457
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0048 0.0012
Trypanosoma brucei unspecified product 0.0058 0.0328 0.0579
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0108 0.0829 0.2467
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.046 0.0668
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0034 0.0087 0.0154
Schistosoma mansoni carbonic anhydrase-related 0.039 0.3636 0.5041
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0228 0.0265
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0403 0.3726
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0034 0.0087 0.0678
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0107 0.0817 0.109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0192 0.0214
Plasmodium falciparum arginase 0.0339 0.3131 0.8577
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.2241 0.2215
Loa Loa (eye worm) hypothetical protein 0.0176 0.1505 0.1476
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0161 0.017
Trichomonas vaginalis Arginase, putative 0.0339 0.3131 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0108 0.0829 0.0798
Schistosoma mansoni multidrug resistance protein 0.0034 0.0087 0.0067
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0403 0.0509
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0034 0.0087 0.0201
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0058 0.033 0.2915
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0108 0.0829 0.1331
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0071 0.0125
Trypanosoma cruzi arginase, putative 0.0124 0.098 0.1601
Entamoeba histolytica multidrug resistance protein, putative 0.0034 0.0087 0.0039
Schistosoma mansoni inositol monophosphatase 0.0036 0.0107 0.0094
Echinococcus granulosus carbonic anhydrase 0.039 0.3636 0.5041
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0034 0.0087 0.0678
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0399 0.0705
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.006 0.0347 0.0313
Onchocerca volvulus 0.0043 0.0174 0.0483
Onchocerca volvulus Putative organic anion transporter 0.0174 0.1486 0.5206
Loa Loa (eye worm) hypothetical protein 0.0174 0.1486 0.1457
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0048 0.0016
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0174 0.1486 0.2027
Echinococcus multilocularis microtubule associated protein 2 0.0745 0.7174 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0113 0.0079
Schistosoma mansoni multidrug resistance protein 0.0108 0.0829 0.1107
Loa Loa (eye worm) matrixin family protein 0.0152 0.1264 0.1234
Echinococcus granulosus follistatin 0.006 0.0347 0.043
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0148 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0399 0.0705
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0014
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0228 0.0253
Leishmania major agmatinase-like protein 0.0124 0.098 0.1601
Loa Loa (eye worm) hypothetical protein 0.0174 0.1486 0.1457
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0048 0.0012
Brugia malayi ImpB/MucB/SamB family protein 0.0036 0.0113 0.013
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0184 0.1578 0.5539
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0065 0.0399 0.1058
Brugia malayi P-glycoprotein-like protein 0.0034 0.0087 0.0085
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0174 0.0188
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0048 0.0016
Entamoeba histolytica deoxycytidyl transferase, putative 0.0036 0.0113 0.0122
Loa Loa (eye worm) glutathione reductase 0.0048 0.0228 0.0195
Echinococcus multilocularis multidrug resistance associated protein 7 0.0034 0.0087 0.0067
Onchocerca volvulus 0.0053 0.0282 0.0871
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0192 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0048 0.0016
Loa Loa (eye worm) hypothetical protein 0.0104 0.0785 0.0753
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0048 0.0012
Loa Loa (eye worm) hypothetical protein 0.004 0.0148 0.0114
Loa Loa (eye worm) matrixin family protein 0.0075 0.0499 0.0466
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0399 0.0705
Entamoeba histolytica ATP-binding cassette protein, putative 0.0034 0.0087 0.0039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0403 0.4347
Onchocerca volvulus 0.0174 0.1486 0.5206
Brugia malayi Trypsin family protein 0.0308 0.2818 0.4942
Schistosoma mansoni hypothetical protein 0.0048 0.0229 0.0265
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.039 0.3636 0.6398
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0095 0.0098
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0108 0.0829 0.2467
Schistosoma mansoni hypothetical protein 0.0035 0.0095 0.0077
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0108 0.0829 0.1107
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0034 0.0087 0.0085
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0137 0.0136
Loa Loa (eye worm) hypothetical protein 0.0108 0.0829 0.0798
Onchocerca volvulus Putative organic anion transporter 0.0174 0.1486 0.5206
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0399 0.0559
Loa Loa (eye worm) hypothetical protein 0.0051 0.0254 0.0221
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0399 0.0559
Schistosoma mansoni single-minded 0.0053 0.0273 0.0327
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.006 0.0347 0.0731
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0041
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0107 0.0035
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.0937 0.1258
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0108 0.0829 0.1107
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0282 0.0339
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0044 0.0184 0.1279
Giardia lamblia DINP protein human, muc B family 0.0044 0.0184 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0048 0.0016
Brugia malayi Matrixin family protein 0.0034 0.0087 0.0085
Loa Loa (eye worm) matrix metalloproteinase 0.0034 0.0087 0.0053
Brugia malayi SPARC precursor 0.006 0.0347 0.0546
Echinococcus multilocularis expressed protein 0.006 0.0347 0.043
Brugia malayi Inositol-1 0.0036 0.0107 0.012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0048 0.0012
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.046 0.0668
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0108 0.0829 0.2091
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0108 0.0829 0.2467
Brugia malayi sodium-independent organic anion transporter family protein 0.0174 0.1486 0.2573
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0048 0.0014
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0174 0.1486 0.2027
Mycobacterium tuberculosis Probable reductase 0.011 0.0842 0.8637
Onchocerca volvulus Putative organic anion transporter 0.0174 0.1486 0.5206
Leishmania major DNA polymerase eta, putative 0.0036 0.0113 0.0046
Loa Loa (eye worm) hypothetical protein 0.0174 0.1486 0.1457
Brugia malayi follicle stimulating hormone receptor 0.025 0.2241 0.3917
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.046 0.0812
Loa Loa (eye worm) inositol-1 0.0036 0.0107 0.0073
Entamoeba histolytica ATP-binding cassette protein, putative 0.0034 0.0087 0.0039
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0193 0.1676 0.2293
Toxoplasma gondii hypothetical protein 0.039 0.3636 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0107 0.0035
Leishmania major p-glycoprotein 0.0108 0.0829 0.1331
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0014
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0842 0.8637
Brugia malayi Cytochrome P450 family protein 0.0053 0.0274 0.0417
Schistosoma mansoni DNA polymerase eta 0.0036 0.0113 0.0103
Leishmania major arginase 0.0339 0.3131 0.5461
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0048 0.0032
Schistosoma mansoni multidrug resistance protein 0.0033 0.0075 0.005
Brugia malayi ecdysteroid receptor 0.003 0.0048 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0048 0.0016
Echinococcus granulosus ATP binding cassette sub family B 0.0033 0.0075 0.005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0036 0.0113 0.0486
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.004 0.0151 0.0156
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0034 0.0087 0.0678
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.006 0.0347 0.0546
Echinococcus multilocularis tumor protein p63 0.0365 0.3385 0.4689
Schistosoma mansoni agrin 0.006 0.0347 0.043
Brugia malayi ABC transporter family protein 0.0034 0.0087 0.0085
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0048 0.0012
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0108 0.0829 0.2467
Entamoeba histolytica P-glycoprotein 5, putative 0.0108 0.0829 0.2467
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.0399 0.4302
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.006 0.0347 0.0731
Onchocerca volvulus 0.0174 0.1486 0.5206
Loa Loa (eye worm) hypothetical protein 0.0034 0.0087 0.0053
Loa Loa (eye worm) agrin synaptic family protein 0.006 0.0347 0.0313
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0593 0.5661 1
Entamoeba histolytica P-glycoprotein-1 0.0108 0.0829 0.2467
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0071 0.0125
Loa Loa (eye worm) hypothetical protein 0.0108 0.0829 0.0798
Schistosoma mansoni lipoxygenase 0.0119 0.0937 0.1258
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0964 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0108 0.0829 0.2467
Trichomonas vaginalis ABC transporter, putative 0.0108 0.0829 0.2467
Echinococcus granulosus single minded 2 0.0039 0.0137 0.0136
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0036 0.0113 0.0103
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0399 0.0559
Leishmania major trypanothione reductase 0.0048 0.0228 0.0253
Echinococcus multilocularis ATP binding cassette sub family B 0.0034 0.0087 0.0067
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0274 0.0241
Plasmodium falciparum carbonic anhydrase 0.039 0.3636 1
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0399 0.0705
Echinococcus multilocularis geminin 0.0183 0.1573 0.2149
Trypanosoma brucei trypanothione reductase 0.0048 0.0228 0.0404
Onchocerca volvulus 0.0174 0.1486 0.5206
Loa Loa (eye worm) hypothetical protein 0.0174 0.1486 0.1457
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0142 0.0219
Loa Loa (eye worm) hypothetical protein 0.0174 0.1486 0.1457
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0034 0.0087 0.0201
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0048 0.0032
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0142 0.0219
Onchocerca volvulus 0.0048 0.0229 0.068
Schistosoma mansoni nuclear hormone receptor 0.003 0.0048 0.0012
Loa Loa (eye worm) hypothetical protein 0.0034 0.0087 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0048 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0339 0.3131 1
Echinococcus granulosus multidrug resistance protein 1 0.0108 0.0829 0.1107
Echinococcus granulosus multidrug resistance associated protein 7 0.0034 0.0087 0.0067
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0005
Schistosoma mansoni hypothetical protein 0.0183 0.1573 0.2149
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0142 0.0251
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0048 0.0014
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0048 0.0016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0142 0.0099
Onchocerca volvulus 0.0043 0.0174 0.0483
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0107 0.0094
Schistosoma mansoni multidrug resistance protein 0.0108 0.0829 0.1107
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.046 0.0589
Echinococcus multilocularis 0.0034 0.0087 0.0067
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0108 0.0829 0.1107
Trichomonas vaginalis aldehyde oxidase, putative 0.0173 0.1469 0.4562
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0403 0.0566
Echinococcus multilocularis 0.0339 0.3131 0.4333
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0108 0.0829 0.2467
Schistosoma mansoni microtubule-associated protein tau 0.0745 0.7174 1
Leishmania major carbonic anhydrase-like protein 0.0593 0.5661 1
Brugia malayi polk-prov protein 0.004 0.0148 0.0193
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0014
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0034 0.0087 0.0053
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0108 0.0829 0.2467
Schistosoma mansoni smdr1 0.0034 0.0087 0.0067
Brugia malayi secreted modular calcium-binding protein 1 0.006 0.0347 0.0546
Brugia malayi ABC transporter family protein 0.0034 0.0087 0.0085
Loa Loa (eye worm) hypothetical protein 0.006 0.0347 0.0313
Echinococcus granulosus Solute carrier organic anion transporter family 0.0174 0.1486 0.2027
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0399 0.0559
Trichomonas vaginalis conserved hypothetical protein 0.0339 0.3131 1
Trichomonas vaginalis ABC transporter, putative 0.0108 0.0829 0.2467
Schistosoma mansoni multidrug resistance protein 0.0108 0.0829 0.1107
Brugia malayi glutathione reductase 0.0048 0.0228 0.0336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0048 0.0014
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0108 0.0829 0.1107
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0076 0.0503 0.14
Mycobacterium leprae PROBABLE HYDROLASE 0.0041 0.0161 0.1024
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0142 0.0181
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0593 0.5661 0.7879
Brugia malayi ABC transporter family protein 0.0108 0.0829 0.1405
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0048 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0048 0.0016
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0174 0.1486 0.1457
Loa Loa (eye worm) hypothetical protein 0.0053 0.0282 0.0248
Onchocerca volvulus 0.0034 0.0087 0.0172
Onchocerca volvulus Matrilysin homolog 0.0145 0.1197 0.4165
Brugia malayi Matrixin family protein 0.0034 0.0087 0.0085
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0048 0.0012
Loa Loa (eye worm) hypothetical protein 0.0034 0.0087 0.0053
Brugia malayi hypothetical protein 0.0174 0.1486 0.2573
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0228 0.1779
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0048 0.0016
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0044 0.0184 0.0173
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0107 0.0055
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0174 0.0188
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0399 0.0705
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0192 0.0158
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0108 0.0829 0.0798
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0399 0.0705
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0193 0.1676 0.2293
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0081 0.056 0.618
Brugia malayi multidrug resistance related protein 1 0.0034 0.0087 0.0085
Echinococcus granulosus carbonic anhydrase 0.039 0.3636 0.5041
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0104 0.0785 0.1045
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0107 0.0102
Loa Loa (eye worm) hypothetical protein 0.0107 0.0817 0.0786
Entamoeba histolytica ABC transporter, putative 0.0034 0.0087 0.0039
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0034 0.0087 0.0201
Brugia malayi Matrixin family protein 0.0034 0.0087 0.0085
Schistosoma mansoni hypothetical protein 0.0183 0.1573 0.2149
Echinococcus granulosus carbonic anhydrase 0.039 0.3636 0.5041
Echinococcus granulosus agrin 0.006 0.0347 0.043
Loa Loa (eye worm) hypothetical protein 0.039 0.3636 0.3614
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0192 0.0271
Entamoeba histolytica hypothetical protein 0.0034 0.0087 0.0039
Toxoplasma gondii thioredoxin reductase 0.0048 0.0228 0.0398
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0034 0.0087 0.0039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0403 0.4347
Leishmania major DNA polymerase kappa, putative 0.0044 0.0184 0.0173
Onchocerca volvulus 0.0308 0.2818 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0108 0.0829 0.2467
Toxoplasma gondii exonuclease III APE 0.0039 0.0142 0.0155
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0403 0.0509
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0192 0.0214
Loa Loa (eye worm) ABC transporter 0.0034 0.0087 0.0053
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.046 0.0589
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.006 0.0347 0.0546
Trypanosoma cruzi MFS transporter, putative 0.0174 0.1486 0.2509
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0108 0.0829 0.8494
Giardia lamblia Multidrug resistance-associated protein 1 0.0034 0.0087 0.1088
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0142 0.0144
Brugia malayi N-terminal motif family protein 0.0184 0.1578 0.2737
Echinococcus granulosus tumor protein p63 0.0365 0.3385 0.4689
Loa Loa (eye worm) intermediate filament protein 0.0029 0.004 0.0005
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.006 0.0347 0.0731
Echinococcus multilocularis carbonic anhydrase 0.039 0.3636 0.5041
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0108 0.0829 0.1107
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0048 0.0012
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0964 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0048 0.0014
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0048 0.0016
Loa Loa (eye worm) hypothetical protein 0.0308 0.2818 0.2793
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0048 0.0016
Schistosoma mansoni organic anion transporter 0.0174 0.1486 0.2027
Trypanosoma brucei carbonic anhydrase-like protein 0.0593 0.5661 1
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0041 0.0161 0.0216
Schistosoma mansoni lipoxygenase 0.0043 0.0174 0.0188
Echinococcus multilocularis arginase 2, mitochondrial 0.0339 0.3131 0.4333
Brugia malayi ABC transporter 0.0034 0.0087 0.0085
Loa Loa (eye worm) hypothetical protein 0.0043 0.0174 0.014
Onchocerca volvulus 0.0285 0.2593 0.9191
Loa Loa (eye worm) ABC transporter 0.0034 0.0087 0.0053
Loa Loa (eye worm) hypothetical protein 0.006 0.0347 0.0313
Loa Loa (eye worm) hypothetical protein 0.039 0.3636 0.3614
Onchocerca volvulus 0.0174 0.1486 0.5206
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0108 0.0829 0.2467
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0033 0.0075 0.005
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0014
Brugia malayi ABC transporter family protein 0.0034 0.0087 0.0085
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0593 0.5661 0.7879
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0108 0.0829 0.2467
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0173 0.1469 0.4562
Brugia malayi ABC transporter transmembrane region family protein 0.0034 0.0087 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0048 0.0016
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.039 0.3636 0.6398
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0142 0.6169
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0048 0.0016
Echinococcus multilocularis ATP binding cassette sub family B 0.0107 0.0817 0.109
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0108 0.0829 0.2467
Brugia malayi multidrug resistance protein 3 0.0108 0.0829 0.1405
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0048 0.0012
Trypanosoma cruzi agmatinase, putative 0.0124 0.098 0.1601
Schistosoma mansoni smdr2 0.0108 0.0829 0.1107
Plasmodium falciparum multidrug resistance protein 1 0.0108 0.0829 0.2091
Schistosoma mansoni follistatin 0.006 0.0347 0.043
Echinococcus multilocularis ATP binding cassette sub family B 0.0034 0.0087 0.0067
Echinococcus multilocularis carbonic anhydrase II 0.0593 0.5661 0.7879
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0048 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0399 0.0705
Entamoeba histolytica P-glycoprotein 6, putative 0.0034 0.0087 0.0039
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0142 0.1317
Toxoplasma gondii transporter, major facilitator family protein 0.0174 0.1486 0.3941
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0142 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.039 0.3636 0.3614
Treponema pallidum hypothetical protein 0.0028 0.0029 0.0543
Echinococcus granulosus 3'partial|arginase 2 mitochondrial 0.0339 0.3131 0.4333
Brugia malayi Doublecortin family protein 0.0043 0.0174 0.0239
Schistosoma mansoni multidrug resistance protein 0.0034 0.0087 0.0067
Brugia malayi ABC transporter 0.0033 0.0075 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0048 0.0014
Brugia malayi ABC transporter transmembrane region family protein 0.0033 0.0075 0.0064
Brugia malayi hypothetical protein 0.0176 0.1505 0.2607
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0048 0.0012
Echinococcus granulosus RUN 0.0043 0.0174 0.0188
Schistosoma mansoni ap endonuclease 0.0039 0.0142 0.0144
Brugia malayi hypothetical protein 0.0043 0.0174 0.0239
Trichomonas vaginalis ABC transporter, putative 0.0108 0.0829 0.2467
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0328 0.0579
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0048 0.0012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0048 0.0012
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0034 0.0087 0.0067
Plasmodium falciparum thioredoxin reductase 0.0048 0.0228 0.0398
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0108 0.0829 0.2467
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0173 0.1469 0.4562
Trichomonas vaginalis abcb9, putative 0.0108 0.0829 0.2467
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0107 0.0102
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0593 0.5661 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0842 0.8637
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0048 0.0016
Schistosoma mansoni multidrug resistance protein 0.0034 0.0087 0.0067
Brugia malayi Thioredoxin reductase 0.0048 0.0228 0.0336
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0108 0.0829 0.1107
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0107 0.0094
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0048 0.0012
Loa Loa (eye worm) hypothetical protein 0.0041 0.0161 0.0127
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0048 0.0032
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0593 0.5661 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0399 0.0705
Onchocerca volvulus Matrilysin homolog 0.0034 0.0087 0.0172
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0034 0.0087 0.0201
Entamoeba histolytica ATP-binding cassette protein, putative 0.0034 0.0087 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0192 0.0214
Echinococcus multilocularis Polycystic kidney disease protein 0.0043 0.0174 0.0188
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0034 0.0087 0.0154
Giardia lamblia Multidrug resistance-associated protein 1 0.0034 0.0087 0.1088
Trypanosoma brucei multidrug resistance protein E 0.0034 0.0087 0.0154
Brugia malayi MH2 domain containing protein 0.0366 0.3398 0.5975
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0192 0.0214
Entamoeba histolytica ATP-binding cassette protein, putative 0.0034 0.0087 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0071 0.0125
Onchocerca volvulus 0.0108 0.0829 0.2843
Echinococcus multilocularis RUN 0.0043 0.0174 0.0188
Schistosoma mansoni carbonic anhydrase-related 0.039 0.3636 0.5041
Entamoeba histolytica P-glycoprotein 6, putative 0.0034 0.0087 0.0039
Loa Loa (eye worm) carbonic anhydrase 3 0.0593 0.5661 0.5646
Toxoplasma gondii protease inhibitor PI2 0.006 0.0347 0.0731
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0048 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0048 0.0016
Schistosoma mansoni carbonic anhydrase 0.039 0.3636 0.5041
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0593 0.5661 1
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0174 0.1486 0.2027
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0107 0.0904
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0399 0.0705
Loa Loa (eye worm) hypothetical protein 0.0035 0.0095 0.0061
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0048 0.0012
Echinococcus granulosus arginase 2 mitochondrial 0.0339 0.3131 0.4333
Echinococcus granulosus FTZ F1 alpha 0.003 0.0048 0.0012
Trichomonas vaginalis taga, putative 0.0108 0.0829 0.2467
Schistosoma mansoni organic anion transporter 0.0174 0.1486 0.2027
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0108 0.0829 0.2091
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0034 0.0087 0.0154
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0308 0.2818 0.3894
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0403 0.0889
Brugia malayi hypothetical protein 0.0174 0.1486 0.2573
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0108 0.0829 0.2467
Brugia malayi hypothetical protein 0.0034 0.0087 0.0085
Echinococcus multilocularis carbonic anhydrase 0.039 0.3636 0.5041
Entamoeba histolytica Arginase, putative 0.0339 0.3131 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0142 0.0219
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0051 0.0259 0.2678
Loa Loa (eye worm) hypothetical protein 0.0308 0.2818 0.2793
Brugia malayi hypothetical protein 0.0043 0.0174 0.0239
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0033 0.0078 0.0095
Echinococcus multilocularis agrin 0.006 0.0347 0.043
Brugia malayi ABC transporter transmembrane region family protein 0.0034 0.0087 0.0085
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0842 0.8637
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0184 0.0325
Schistosoma mansoni hypothetical protein 0.039 0.3636 0.5041
Echinococcus multilocularis dna polymerase kappa 0.0065 0.0399 0.0504
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0228 0.0265
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.039 0.3636 0.6398
Schistosoma mansoni arginase 0.0339 0.3131 0.4333
Loa Loa (eye worm) hypothetical protein 0.0174 0.1486 0.1457
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0403 0.0509
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0254 0.0382
Schistosoma mansoni inositol monophosphatase 0.0036 0.0107 0.0094
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0192 0.0214
Echinococcus multilocularis multidrug resistance protein 1 0.0108 0.0829 0.1107
Trichomonas vaginalis abcb9, putative 0.0108 0.0829 0.2467
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.0399 0.4302
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0107 0.0035
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0137 0.1254
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0142 0.0155
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0308 0.2818 0.3894
Trypanosoma cruzi arginase, putative 0.0124 0.098 0.1601
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0842 0.8637
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0964 1
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0041 0.0161 0.1024
Loa Loa (eye worm) doublecortin family protein 0.0043 0.0174 0.014
Brugia malayi nuclear receptor NHR-88 0.003 0.0048 0.0016
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.039 0.3636 0.6398
Brugia malayi steroid hormone receptor 0.003 0.0048 0.0016
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0058 0.033 0.3502
Schistosoma mansoni multidrug resistance protein 0.0034 0.0087 0.0067
Schistosoma mansoni hypothetical protein 0.0043 0.0174 0.0188
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0142 0.0144
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0108 0.0829 0.2467
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.004 0.0005
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0108 0.0829 0.2467
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.0842 0.8637
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0228 0.0464
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0014
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0161 0.017
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0081 0.056 0.5489
Brugia malayi sodium-independent organic anion transporter family protein 0.0174 0.1486 0.2573
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0048 0.0014
Entamoeba histolytica P-glyco protein 6, putative 0.0108 0.0829 0.2467
Trichomonas vaginalis DNA polymerase eta, putative 0.0065 0.0399 0.1058
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0108 0.0829 0.1107
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0036 0.0113 0.0079
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0108 0.0829 0.1107
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0142 0.0099
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0228 0.0195
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0108 0.0829 0.2467
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0033 0.0078 0.0568
Onchocerca volvulus Matrix metalloproteinase homolog 0.0075 0.0499 0.1653
Entamoeba histolytica P-glycoprotein-2 0.0108 0.0829 0.2467
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0142 0.0099
Trypanosoma brucei agmatinase, putative 0.0124 0.098 0.1731
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0048 0.0016
Loa Loa (eye worm) hypothetical protein 0.006 0.0347 0.0313
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0048 0.0012
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0842 0.8637
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0041
Loa Loa (eye worm) hypothetical protein 0.0043 0.0174 0.014
Brugia malayi Hemopexin family protein 0.0048 0.0229 0.0336
Brugia malayi Matrixin family protein 0.0034 0.0087 0.0085
Giardia lamblia MRP-like ABC transporter 0.0034 0.0087 0.1088
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0399 0.0705
Brugia malayi PAS domain containing protein 0.0053 0.0273 0.0415
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.046 0.1257
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0048 0.0016
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0107 0.0102
Echinococcus multilocularis multidrug resistance associated protein 1 0.0034 0.0087 0.0067
Entamoeba histolytica P-glycoprotein-5 0.0108 0.0829 0.2467
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0048 0.0012
Echinococcus granulosus microtubule associated protein 2 0.0745 0.7174 1
Loa Loa (eye worm) ABC transporter 0.0034 0.0087 0.0053
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0107 0.0102
Echinococcus multilocularis follistatin 0.006 0.0347 0.043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0192 0.0214
Echinococcus granulosus multidrug resistance protein 1 0.0108 0.0829 0.1107
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0399 0.0705
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0048 0.0012
Echinococcus granulosus multidrug resistance protein 1 0.0076 0.0503 0.065
Plasmodium vivax arginase, putative 0.0339 0.3131 1
Echinococcus granulosus dna polymerase eta 0.0036 0.0113 0.0103
Onchocerca volvulus 0.006 0.0347 0.1105
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0034 0.0087 0.0678
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0113 0.0046
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0048 0.0012
Schistosoma mansoni thyroid hormone receptor 0.003 0.0048 0.0012
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.006 0.0347 0.0546
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0107 0.354
Loa Loa (eye worm) MH2 domain-containing protein 0.0366 0.3398 0.3376
Entamoeba histolytica P-glycoprotein-2, putative 0.0108 0.0829 0.2467
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.046 0.0427
Onchocerca volvulus 0.0174 0.1486 0.5206
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0108 0.0829 0.2467
Giardia lamblia ABC transporter, putative 0.0034 0.0087 0.1088
Plasmodium vivax multidrug resistance protein 1, putative 0.0108 0.0829 0.2438
Plasmodium vivax glutathione reductase, putative 0.0048 0.0228 0.0464
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0108 0.0829 0.2467
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0048 0.0012
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0034 0.0087 0.0678
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0048 0.0012
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0036 0.0113 0.0103
Echinococcus granulosus geminin 0.0183 0.1573 0.2149
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0048 0.0012
Onchocerca volvulus 0.0039 0.0137 0.035
Mycobacterium ulcerans hydrolase 0.0041 0.0161 0.1535
Loa Loa (eye worm) hypothetical protein 0.0034 0.0087 0.0053
Loa Loa (eye worm) hypothetical protein 0.006 0.0347 0.0313
Schistosoma mansoni loxhd1 0.0043 0.0174 0.0188
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0174 0.0188
Schistosoma mansoni carbonic anhydrase-related 0.039 0.3636 0.5041
Schistosoma mansoni multidrug resistance protein 0.0034 0.0087 0.0067
Echinococcus granulosus multidrug resistance associated protein 1 0.0034 0.0087 0.0067
Onchocerca volvulus 0.003 0.0048 0.0032
Echinococcus multilocularis ATP binding cassette sub family B 0.0034 0.0087 0.0067
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0058 0.033 0.3502
Schistosoma mansoni polycystin 1-related 0.0043 0.0174 0.0188
Trypanosoma brucei p-glycoprotein 0.0034 0.0087 0.0154
Echinococcus granulosus multidrug resistance protein 1 0.0108 0.0829 0.1107
Echinococcus multilocularis multidrug resistance protein 1 0.0076 0.0503 0.065
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0034 0.0087 0.0154

Activities

Activity type Activity value Assay description Source Reference
GI (functional) = 41.74 % Cytotoxicity against human A549 cells assessed as growth inhibition rate at 0.1 to 100 umol/L after 96 hrs by MTT assay ChEMBL. 25203783
IC50 (functional) > 5 ug ml-1 Cytotoxicity against human A549 cells assessed as growth inhibition rate after 96 hrs by MTT assay ChEMBL. 25203783

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 25203783

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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