Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0084 | 0.2385 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.106 | 0.1321 |
Leishmania major | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0084 | 0.2385 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0056 | 0.0237 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0056 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0187 | 0.8028 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0147 | 0.579 | 0.7213 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0223 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0187 | 0.8028 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 1 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0056 | 0.007 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0223 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0056 | 0.5 |
Echinococcus multilocularis | NADH dehydrogenase (ubiquinone) flavoprotein 1 | 0.0084 | 0.2385 | 0.2971 |
Loa Loa (eye worm) | NADH-ubiquinone oxidoreductase 51 kDa subunit | 0.0084 | 0.2385 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0056 | 0.0097 |
Trichomonas vaginalis | hypothetical protein | 0.0223 | 1 | 1 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative | 0.0084 | 0.2385 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0147 | 0.579 | 0.7213 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0056 | 0.007 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0056 | 0.007 |
Onchocerca volvulus | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog | 0.0045 | 0.024 | 1 |
Brugia malayi | NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor | 0.0084 | 0.2385 | 1 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | 0.0084 | 0.2385 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0056 | 0.5 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0084 | 0.2385 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0147 | 0.579 | 1 |
Echinococcus granulosus | NADH dehydrogenase ubiquinone flavoprotein 1 | 0.0084 | 0.2385 | 0.4119 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0056 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0223 | 1 | 0.5 |
Schistosoma mansoni | NADH-ubiquinone oxidoreductase | 0.0084 | 0.2385 | 0.2971 |
Schistosoma mansoni | thyroid hormone receptor | 0.0187 | 0.8028 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0223 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.16 uM | Inhibition of Mycobacterium tuberculosis recombinant InhA expressed in Escherichia coli BL21 (DE3) using 2-trans-decenoyl substrate by spectrophotometry | ChEMBL. | 25218910 |
Inhibition (ADMET) | = 25.76 % | Cytotoxicity against mouse RAW264.7 cells at 100 uM after 72 hrs by MTT assay | ChEMBL. | 25218910 |
Inhibition (binding) | = 62.12 % | Inhibition of Mycobacterium tuberculosis recombinant InhA expressed in Escherichia coli BL21 (DE3) using 2-trans-decenoyl substrate at 10 uM by spectrophotometry | ChEMBL. | 25218910 |
MIC (functional) | = 3.62 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 28 days by two-fold serial dilution assay in presence of 8 mg/mL piperine efflux pump inhibitor | ChEMBL. | 25218910 |
MIC (functional) | = 7.26 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 28 days by two-fold serial dilution assay | ChEMBL. | 25218910 |
MIC (functional) | = 29.05 uM | Antimycobacterial activity against isoniazid, rifampicin, ofloxacin and kanamycin-resistant Mycobacterium tuberculosis H37Rv ATCC 27294 clinical isolate after 28 days by two-fold serial dilution assay in presence of 8 mg/mL piperine efflux pump inhibitor | ChEMBL. | 25218910 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.