Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Transactivation of XBP1 (unknown origin) transfected in rat IEC-6 cells at 10 uM after 48 hrs by dual luciferase reporter gene assay | ChEMBL. | 26321079 | |
Activity (functional) | Anti-ulcerative colitis activity in DSS-induced acute C57Bl/6J mouse ulcerative colitis model | ChEMBL. | 26321079 | |
GI (functional) | = 6.81 % | Cytotoxicity against human A549 cells assessed as growth inhibition rate at 0.1 to 100 umol/L after 96 hrs by MTT assay | ChEMBL. | 25203783 |
IC50 (functional) | > 10 umol/L | Cytotoxicity against human A549 cells assessed as growth inhibition rate after 96 hrs by MTT assay | ChEMBL. | 25203783 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 25203783 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.