Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Endothelin-converting enzyme 1 | Starlite/ChEMBL | References |
Homo sapiens | renin | Starlite/ChEMBL | References |
Bos taurus | Cathepsin D | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dihydrofolate reductase | 0.0516 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0516 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0516 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0516 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0516 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0516 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0516 | 1 | 1 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0118 | 0.1319 | 0.0235 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0516 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.1233 | 0.0689 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0348 | 0.6334 | 0.6334 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0627 | 0.0046 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0348 | 0.6334 | 0.6334 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0627 | 0.0046 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0282 | 0.4898 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0282 | 0.4898 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.1233 | 0.0689 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0282 | 0.4898 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0516 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0282 | 0.4898 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0114 | 0.1233 | 0.1233 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.1319 | 0.0781 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0118 | 0.1319 | 0.0098 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0118 | 0.1319 | 0.0098 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0627 | 0.0046 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0118 | 0.1319 | 0.0781 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.1233 | 0.0689 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0118 | 0.1319 | 0.1319 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0282 | 0.4898 | 1 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0118 | 0.1319 | 0.0235 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0118 | 0.1319 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0627 | 0.0046 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0282 | 0.4898 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0627 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0627 | 0.0046 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.2 nM | Inhibition of conversion of big endothelial-1(Big ET-1) to ET-1 by endothelin converting enzyme(ECE) in rat lung membrane. | ChEMBL. | 8474103 |
IC50 (binding) | = 37 nM | Inhibition of conversion of hemoglobin by commercially purchased bovine spleen cathepsin D. | ChEMBL. | 8474103 |
IC50 (binding) | > 1000 nM | In vitro inhibition of partially purified human renin at pH 6.0. | ChEMBL. | 8474103 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.