Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cell death protein 3 precursor | 0.0018 | 0.0038 | 0.0036 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0021 | 0.0045 | 0.0044 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.0443 | 0.1256 | 0.1255 |
Brugia malayi | Isocitrate dehydrogenase | 0.0012 | 0.002 | 0.0018 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0021 | 0.0045 | 0.0044 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0046 | 0.0117 | 0.0115 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0041 | 0.0103 | 0.0218 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0.0038 | 0.9972 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0038 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0018 | 0.0038 | 0.9972 |
Loa Loa (eye worm) | histone methyltransferase | 0.0007 | 0.0005 | 0.0003 |
Schistosoma mansoni | tyrosine kinase | 0.0009 | 0.0013 | 0.0011 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0024 | 0.0056 | 0.0054 |
Onchocerca volvulus | 0.0021 | 0.0048 | 0.1145 | |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3492 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0009 | 0.0013 | 0.0011 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0038 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0018 | 0.0038 | 0.0047 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0.0038 | 0.9972 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0024 | 0.0056 | 0.0054 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.008 | 0.0078 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0012 | 0.002 | 0.0019 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0009 | 0.0013 | 0.0011 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0012 | 0.002 | 0.0018 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0067 | 0.0179 | 0.0178 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0038 | 0.0037 |
Trypanosoma brucei | metacaspase MCA2 | 0.0018 | 0.0038 | 0.0047 |
Echinococcus granulosus | NCK adaptor protein | 0.0008 | 0.0008 | 0.0007 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0067 | 0.0179 | 0.0178 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0029 | 0.0028 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0024 | 0.0056 | 0.0054 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0038 | 0.0047 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1335 | 0.3815 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0018 | 0.0038 | 0.0047 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0029 | 0.0028 |
Schistosoma mansoni | P2X receptor subunit | 0.1104 | 0.3152 | 0.3151 |
Echinococcus multilocularis | NCK adaptor protein | 0.0008 | 0.0008 | 0.0007 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0038 | 0.0047 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0038 | 0.0036 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0024 | 0.0056 | 0.0054 |
Echinococcus granulosus | caspase | 0.0067 | 0.0179 | 0.0178 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0024 | 0.0056 | 0.0054 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0018 | 0.0038 | 0.0047 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0038 | 1 |
Schistosoma mansoni | nck2/grb4 | 0.0008 | 0.0008 | 0.0007 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0018 | 0.0038 | 0.0047 |
Plasmodium vivax | metacaspase 1, putative | 0.0018 | 0.0038 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0029 | 0.0028 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0018 | 0.0038 | 0.0036 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0024 | 0.0056 | 0.0054 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.2599 | 0.7438 | 0.7438 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0008 | 0.0008 | 0.0007 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0007 | 0.0005 | 0.0003 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0012 | 0.002 | 0.0019 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0018 | 0.0038 | 0.9972 |
Trypanosoma brucei | metacaspase 5, putative | 0.0018 | 0.0038 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0038 | 0.0036 |
Echinococcus multilocularis | caspase 8 | 0.0018 | 0.0038 | 0.0036 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0038 | 0.0037 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0067 | 0.0179 | 0.0178 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.008 | 0.0078 |
Trypanosoma brucei | metacaspase | 0.0018 | 0.0038 | 0.0047 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0024 | 0.0056 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0008 | 0.0006 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0018 | 0.0038 | 0.9972 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0.0038 | 0.9972 |
Echinococcus multilocularis | caspase 3 | 0.0049 | 0.0128 | 0.0126 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0005 | 0.0004 |
Echinococcus granulosus | c src tyrosine kinase | 0.0009 | 0.0013 | 0.0011 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0012 | 0.002 | 0.0019 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0008 | 0.0008 | 0.0007 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0017 | 0.0034 | 0.0032 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0009 | 0.0013 | 0.0011 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0029 | 0.0028 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0024 | 0.0056 | 0.0054 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0029 | 0.0028 |
Plasmodium falciparum | metacaspase 1 | 0.0018 | 0.0038 | 0.0047 |
Schistosoma mansoni | dihydrofolate reductase | 0.3492 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0038 | 0.0047 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0038 | 0.0047 |
Loa Loa (eye worm) | TK protein kinase | 0.0017 | 0.0034 | 0.0032 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0018 | 0.0038 | 0.9972 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0.0038 | 0.9972 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0018 | 0.0038 | 0.9972 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0018 | 0.0038 | 0.0897 |
Echinococcus granulosus | caspase 2 | 0.0018 | 0.0038 | 0.0036 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0038 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0012 | 0.002 | 0.0019 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0.0038 | 0.9972 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0038 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0023 | 0.0051 | 0.005 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0029 | 0.0028 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0012 | 0.002 | 0.0019 |
Schistosoma mansoni | P2X receptor subunit | 0.2599 | 0.7438 | 0.7438 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0024 | 0.0056 | 0.0054 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1335 | 0.3815 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.008 | 0.0079 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0038 | 0.0047 |
Trypanosoma brucei | Metacaspase-4 | 0.0018 | 0.0038 | 0.0047 |
Echinococcus multilocularis | caspase | 0.0067 | 0.0179 | 0.0178 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0008 | 0.0008 | 0.0007 |
Brugia malayi | CXXC zinc finger family protein | 0.0021 | 0.0048 | 0.0046 |
Trypanosoma cruzi | metacaspase, putative | 0.0018 | 0.0038 | 0.0047 |
Echinococcus granulosus | tyrosine kinase | 0.0021 | 0.0045 | 0.0044 |
Echinococcus granulosus | dihydrofolate reductase | 0.3492 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.2599 | 0.7438 | 0.7438 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0038 | 0.0047 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0018 | 0.0038 | 0.0036 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.2599 | 0.7438 | 0.7438 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0024 | 0.0056 | 0.0054 |
Leishmania major | metacaspase, putative | 0.0018 | 0.0038 | 0.0047 |
Schistosoma mansoni | P2X receptor subunit | 0.2599 | 0.7438 | 0.7438 |
Trypanosoma brucei | metacaspase MCA3 | 0.0018 | 0.0038 | 0.0047 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0019 | 0.004 | 0.0039 |
Loa Loa (eye worm) | SRC-1 | 0.0024 | 0.0056 | 0.0054 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0067 | 0.0179 | 0.0178 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.2599 | 0.7438 | 0.7438 |
Onchocerca volvulus | 0.0145 | 0.0402 | 1 | |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0019 | 0.004 | 0.0039 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3492 | 1 | 0.5 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0018 | 0.0038 | 0.0047 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0024 | 0.0056 | 0.0054 |
Plasmodium vivax | hypothetical protein, conserved | 0.0018 | 0.0038 | 0.0047 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0123 | 0.0122 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3492 | 1 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0029 | 0.0028 |
Schistosoma mansoni | tyrosine kinase | 0.0024 | 0.0056 | 0.0054 |
Echinococcus granulosus | caspase 3 | 0.0049 | 0.0128 | 0.0126 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0024 | 0.0056 | 0.0054 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0029 | 0.0028 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.2599 | 0.7438 | 0.7438 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0018 | 0.0038 | 0.0036 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0021 | 0.0045 | 0.0044 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0038 | 0.0037 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0029 | 0.0028 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0029 | 0.0028 |
Plasmodium falciparum | metacaspase-like protein | 0.0018 | 0.0038 | 0.0047 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0123 | 0.0122 |
Schistosoma mansoni | adapter molecule crk | 0.0008 | 0.0008 | 0.0007 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0029 | 0.0028 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0024 | 0.0056 | 0.0054 |
Schistosoma mansoni | tyrosine kinase | 0.0024 | 0.0056 | 0.0054 |
Schistosoma mansoni | cpg binding protein | 0.0023 | 0.0051 | 0.005 |
Echinococcus multilocularis | cpg binding protein | 0.0023 | 0.0051 | 0.005 |
Schistosoma mansoni | tyrosine kinase | 0.0009 | 0.0013 | 0.0011 |
Brugia malayi | protein-tyrosine kinase | 0.0021 | 0.0045 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0402 | 0.0401 |
Loa Loa (eye worm) | TK protein kinase | 0.0021 | 0.0045 | 0.0043 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0018 | 0.0038 | 0.0047 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0024 | 0.0056 | 0.0054 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1335 | 0.3815 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0012 | 0.002 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0123 | 0.0122 |
Brugia malayi | hypothetical protein | 0.0145 | 0.0402 | 0.0401 |
Entamoeba histolytica | protein kinase, putative | 0.0017 | 0.0034 | 0.8863 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0024 | 0.0056 | 0.0054 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0008 | 0.0008 | 0.0006 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0012 | 0.002 | 0.0019 |
Brugia malayi | isocitrate dehydrogenase | 0.0012 | 0.002 | 0.0018 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0021 | 0.0045 | 0.0044 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0029 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0038 | 0.0036 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.2599 | 0.7438 | 0.7438 |
Echinococcus granulosus | caspase 8 | 0.0018 | 0.0038 | 0.0036 |
Brugia malayi | SRC-1 | 0.0024 | 0.0056 | 0.0054 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0009 | 0.0013 | 0.0011 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0018 | 0.0038 | 0.9972 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0021 | 0.0045 | 0.0044 |
Schistosoma mansoni | cpg binding protein | 0.0023 | 0.0051 | 0.005 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0018 | 0.0038 | 0.9972 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1335 | 0.3815 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0038 | 0.0036 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0009 | 0.0013 | 0.0011 |
Trypanosoma cruzi | metacaspase, putative | 0.0018 | 0.0038 | 0.0047 |
Brugia malayi | Variant SH3 domain containing protein | 0.0008 | 0.0008 | 0.0006 |
Echinococcus multilocularis | caspase 2 | 0.0018 | 0.0038 | 0.0036 |
Schistosoma mansoni | cpg binding protein | 0.0021 | 0.0048 | 0.0046 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0.0038 | 0.9972 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0008 | 0.0008 | 0.0007 |
Brugia malayi | Variant SH3 domain containing protein | 0.0008 | 0.0008 | 0.0006 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3492 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3492 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.3492 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3492 | 1 | 1 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0081 | 0.0217 | 0.0216 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0005 | 0.0004 |
Schistosoma mansoni | P2X receptor subunit | 0.1104 | 0.3152 | 0.3151 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0029 | 0.0028 |
Trypanosoma cruzi | metacaspase, putative | 0.0018 | 0.0038 | 0.0047 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0029 | 0.0028 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0008 | 0.0008 | 0.0006 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0024 | 0.0056 | 0.0054 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0018 | 0.0038 | 0.9972 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0017 | 0.0034 | 0.0032 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0009 | 0.0013 | 0.0011 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0008 | 0.0008 | 0.0006 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0021 | 0.0048 | 0.0046 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0038 | 0.0018 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0038 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0018 | 0.0038 | 0.9972 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0024 | 0.0056 | 0.0054 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1335 | 0.3815 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0123 | 0.0122 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0038 | 0.0037 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1335 | 0.3815 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0038 | 0.0047 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0008 | 0.0008 | 0.0007 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 100 mM | The invitro binding constant of the compound in presence of Na+ measured in live Jurkat cells | ChEMBL. | 15780620 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.