Detailed information for compound 929816

Basic information

Technical information
  • TDR Targets ID: 929816
  • Name: (3S,8R,9S,10R,13S,14S)-17-(1H-imidazol-2-yl)- 10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahy dro-1H-cyclopenta[a]phenanthren-3-ol
  • MW: 338.486 | Formula: C22H30N2O
  • H donors: 2 H acceptors: 2 LogP: 3.87 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC=C2c2[nH]ccn2)C)C1)C
  • InChi: 1S/C22H30N2O/c1-21-9-7-15(25)13-14(21)3-4-16-17-5-6-19(20-23-11-12-24-20)22(17,2)10-8-18(16)21/h3,6,11-12,15-18,25H,4-5,7-10,13H2,1-2H3,(H,23,24)/t15-,16-,17-,18-,21-,22-/m0/s1
  • InChiKey: SSLMEQBZDUXKMH-CSOYKPOESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Cytochrome P450 17A1 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 17, subfamily A, polypeptide 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Drosophila melanogaster CG7241 gene product from transcript CG7241-RA Cytochrome P450 17A1   507 aa 477 aa 27.9 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 413 aa 24.5 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 502 aa 23.1 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 532 aa 25.4 %
Loa Loa (eye worm) cytochrome P450 family protein Cytochrome P450 17A1   507 aa 454 aa 25.3 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 424 aa 24.3 %
Trypanosoma cruzi cytochrome P450, putative Cytochrome P450 17A1   507 aa 428 aa 22.7 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 485 aa 24.3 %
Candida albicans cytochrome P450 similar to phenylacetate hydroxylase Cytochrome P450 17A1   507 aa 510 aa 19.6 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 502 aa 22.5 %
Onchocerca volvulus Cytochrome P450 17A1   507 aa 453 aa 24.1 %
Drosophila melanogaster shadow Cytochrome P450 17A1   507 aa 470 aa 23.0 %
Trypanosoma cruzi cytochrome P450, putative Cytochrome P450 17A1   507 aa 428 aa 22.9 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 17, subfamily A, polypeptide 1 508 aa 468 aa 25.2 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 518 aa 24.7 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 502 aa 25.5 %
Candida albicans cytochrome P450 similar to phenylacetate hydroxylase Cytochrome P450 17A1   507 aa 510 aa 19.6 %
Brugia malayi Cytochrome P450 family protein Cytochrome P450 17A1   507 aa 434 aa 25.6 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 490 aa 20.4 %
Drosophila melanogaster CG1829 gene product from transcript CG1829-RB Cytochrome P450 17A1   507 aa 476 aa 22.3 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 423 aa 22.9 %
Drosophila melanogaster Cytochrome P450-4d1 Cytochrome P450 17A1   507 aa 465 aa 24.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0159 0.1516
Onchocerca volvulus 0.0051 0.0699 0.2364
Loa Loa (eye worm) hypothetical protein 0.0051 0.0706 0.0687
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0936 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0011 0.0054 0.0034
Trypanosoma cruzi cysteine peptidase, putative 0.0009 0.0025 0.0052
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0051 0.0319
Brugia malayi hypothetical protein 0.0011 0.0054 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0054 0.0054
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0143 0.0143
Onchocerca volvulus 0.001 0.0049 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0049 0.0029
Echinococcus multilocularis carboxylesterase 5A 0.0628 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0143 0.0143
Schistosoma mansoni histamine h1 receptor 0.0011 0.0054 0.0034
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0049 0.0029
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0054 0.0054
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.0025 0.0025
Plasmodium vivax vivapain-2 0.0017 0.0159 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.001 0.0051 0.0319
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Brugia malayi hypothetical protein 0.0011 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Echinococcus granulosus acetylcholinesterase 0.0628 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0936 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.1592 0.1575
Echinococcus granulosus tumor protein p63 0.0346 0.5462 0.5462
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0936 1
Onchocerca volvulus 0.0017 0.0159 0.0458
Echinococcus granulosus acetylcholinesterase 0.0628 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0049 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0049 0.0029
Leishmania major cathepsin L-like protease 0.0017 0.0159 0.1516
Loa Loa (eye worm) hypothetical protein 0.0106 0.1592 0.1575
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0049 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0159 0.0999
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0009
Echinococcus granulosus serotonin receptor 0.0011 0.0054 0.0054
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0159 0.0159
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0029 0.0029
Echinococcus granulosus fmrfamide receptor 0.0011 0.0054 0.0054
Echinococcus granulosus cysteine protease 0.0009 0.0025 0.0025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0054 0.0054
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0054 0.0054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0025 0.0005
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0029 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0159 0.0999
Onchocerca volvulus 0.0017 0.0159 0.0458
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0049 0.0049
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0054 0.0054
Echinococcus multilocularis neuroligin 0.0106 0.1592 0.1592
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0049 0.0029
Onchocerca volvulus 0.0011 0.0054 0.0086
Brugia malayi AKH receptor 0.0011 0.0054 0.0034
Entamoeba histolytica cysteine protease, putative 0.0017 0.0159 1
Loa Loa (eye worm) hypothetical protein 0.0628 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0051 0.0051
Onchocerca volvulus 0.0011 0.0054 0.0086
Schistosoma mansoni amine GPCR 0.0011 0.0054 0.0034
Echinococcus granulosus orexin receptor type 2 0.0011 0.0054 0.0054
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0159 1
Onchocerca volvulus 0.0011 0.0054 0.0086
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.0054 0.0034
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0054 0.0054
Echinococcus multilocularis GPCR, family 2 0.0016 0.0143 0.0143
Echinococcus multilocularis BC026374 protein (S09 family) 0.0106 0.1592 0.1592
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0049 0.0029
Entamoeba histolytica P-glycoprotein-5 0.001 0.0051 0.1925
Loa Loa (eye worm) cysteine protease 0.0017 0.0159 0.0139
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0054 0.0034
Mycobacterium ulcerans carboxylesterase, LipT 0.0106 0.1592 1
Onchocerca volvulus 0.0011 0.0054 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0049 0.0029
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.0054 0.0054
Schistosoma mansoni amine GPCR 0.0011 0.0054 0.0034
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0936 1
Schistosoma mansoni amine GPCR 0.0011 0.0054 0.0034
Onchocerca volvulus 0.0017 0.0159 0.0458
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.0054 0.0034
Plasmodium vivax vivapain-2 0.0017 0.0159 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0049 0.0049
Onchocerca volvulus 0.0017 0.0159 0.0458
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0106 0.1592 0.1575
Onchocerca volvulus 0.0011 0.0054 0.0086
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0049 0.0071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0029
Schistosoma mansoni neuroligin 3 (S09 family) 0.0106 0.1592 0.1575
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.0054 0.0054
Entamoeba histolytica P-glycoprotein-2, putative 0.001 0.0051 0.1925
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Trichomonas vaginalis abcb9, putative 0.001 0.0051 0.0319
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0936 1
Schistosoma mansoni coup transcription factor 0.001 0.0049 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0159 0.0999
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0049 0.0049
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0706 0.0687
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0029 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0054 0.0054
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0159 0.0159
Onchocerca volvulus 0.0106 0.1592 0.5514
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0159 0.0999
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0029 0.0009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Loa Loa (eye worm) carboxylesterase 0.0628 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Schistosoma mansoni dep domain containing protein 0.0009 0.0029 0.0009
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0029 0.0009
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.0054 0.0034
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0159 0.0999
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.0185 0.2864 0.2849
Toxoplasma gondii cathepsin CPL 0.0017 0.0159 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0049 0.0029
Leishmania major cathepsin L-like protease 0.0017 0.0159 0.1516
Echinococcus granulosus cathepsin L 0.0009 0.0025 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0009 0.0025 0.0052
Schistosoma mansoni biogenic amine receptor 0.0011 0.0054 0.0034
Brugia malayi multidrug resistance protein 3 0.001 0.0051 0.0031
Leishmania major cathepsin L-like protease 0.0065 0.0936 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0054 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0049 0.0029
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Schistosoma mansoni adenoreceptor 0.0011 0.0054 0.0034
Entamoeba histolytica P-glycoprotein 5, putative 0.001 0.0051 0.1925
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0706 0.0687
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0159 0.0999
Loa Loa (eye worm) hypothetical protein 0.0035 0.0445 0.0426
Plasmodium vivax multidrug resistance protein 1, putative 0.001 0.0051 0.1925
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0054 0.0054
Loa Loa (eye worm) ctsf protein 0.0017 0.0159 0.0139
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0054 0.0054
Echinococcus multilocularis sex peptide receptor 0.0011 0.0054 0.0054
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0051 0.0319
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0029 0.0029
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0054 0.0054
Echinococcus multilocularis serotonin receptor 0.0011 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0159 0.0999
Brugia malayi hypothetical protein 0.0009 0.0029 0.0009
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.0054 0.0054
Brugia malayi RE15519p 0.0011 0.0054 0.0034
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0159 0.0139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0936 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0054 0.0034
Brugia malayi Carboxylesterase family protein 0.0106 0.1592 0.1575
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0699 0.068
Onchocerca volvulus 0.0011 0.0054 0.0086
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0051 0.0051
Onchocerca volvulus 0.0011 0.0054 0.0086
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0049 0.0029
Echinococcus granulosus hypothetical protein 0.0011 0.0054 0.0054
Brugia malayi G-protein coupled receptor 0.0011 0.0054 0.0034
Schistosoma mansoni hypothetical protein 0.0011 0.0054 0.0034
Schistosoma mansoni biogenic amine receptor 0.0011 0.0054 0.0034
Schistosoma mansoni amine GPCR 0.0011 0.0054 0.0034
Onchocerca volvulus 0.0017 0.0159 0.0458
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0029 0.0009
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0029 0.0009
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0159 0.0999
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0029 0.0029
Brugia malayi Dopamine receptor protein 1 0.0011 0.0054 0.0034
Brugia malayi hypothetical protein 0.0011 0.0054 0.0034
Brugia malayi Carboxylesterase family protein 0.0628 1 1
Entamoeba histolytica P-glycoprotein-2 0.001 0.0051 0.1925
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0106 0.1592 0.1575
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Onchocerca volvulus 0.0011 0.0054 0.0086
Echinococcus multilocularis 0.0009 0.002 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0159 0.0999
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0936 1
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0049 0.0049
Brugia malayi putative neuropeptide receptor 0.0011 0.0054 0.0034
Trypanosoma cruzi cysteine protease, putative 0.0009 0.0025 0.0052
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0009
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0143 0.0123
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0185 0.2864 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0054 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0049 0.0029
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0106 0.1592 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0025 0.0005
Onchocerca volvulus 0.0011 0.0054 0.0086
Schistosoma mansoni hypothetical protein 0.0035 0.0445 0.0426
Toxoplasma gondii hypothetical protein 0.0009 0.0029 0.0654
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0054 0.0054
Brugia malayi GnHR receptor homolog 0.0011 0.0054 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0054 0.0054
Schistosoma mansoni opsin-like receptor 0.0011 0.0054 0.0034
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.0054 0.0054
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0031
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0049 0.0029
Trichomonas vaginalis ABC transporter, putative 0.001 0.0051 0.0319
Onchocerca volvulus Neuropeptide F receptor homolog 0.0011 0.0054 0.0086
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0054 0.0054
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.001 0.0051 0.2204
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0049 0.0049
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0029 0.0029
Brugia malayi hypothetical protein 0.0011 0.0054 0.0034
Schistosoma mansoni multidrug resistance protein 0.001 0.0051 0.0031
Echinococcus multilocularis serotonin receptor 0.0011 0.0054 0.0054
Brugia malayi Carboxylesterase family protein 0.0106 0.1592 0.1575
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0051 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0054 0.0034
Echinococcus granulosus g protein coupled receptor 0.0011 0.0054 0.0054
Loa Loa (eye worm) carboxylesterase 0.0106 0.1592 0.1575
Echinococcus multilocularis allatostatin A receptor 0.0011 0.0054 0.0054
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0011 0.0054 0.0034
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0051 0.0319
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0159 1
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0054 0.0054
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.0054 0.0034
Schistosoma mansoni smdr2 0.001 0.0051 0.0031
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0051 0.0319
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0068 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0159 0.0999
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0936 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0051 0.0319
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0049 0.0029
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0936 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0049 0.0049
Onchocerca volvulus 0.0011 0.0054 0.0086
Schistosoma mansoni amine GPCR 0.0011 0.0054 0.0034
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0049 0.0071
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0068 0.3182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0159 0.0999
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0159 1
Trichomonas vaginalis ABC transporter, putative 0.001 0.0051 0.0319
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0049 0.0049
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0054 0.0054
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0054 0.0054
Brugia malayi hypothetical protein 0.0011 0.0054 0.0034
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.0054 0.0034
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.001 0.0051 0.5
Echinococcus granulosus neuropeptide s receptor 0.0011 0.0054 0.0054
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0051 0.0319
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0049 0.0029
Brugia malayi Dopamine receptor protein 2 0.0011 0.0054 0.0034
Trichomonas vaginalis ABC transporter, putative 0.001 0.0051 0.0319
Brugia malayi cathepsin L-like precursor 0.0011 0.0068 0.0048
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0054 0.0054
Leishmania major cathepsin L-like protease 0.0065 0.0936 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0159 0.0999
Onchocerca volvulus 0.0106 0.1592 0.5514
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0049 0.0029
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0159 0.0999
Echinococcus multilocularis acetylcholinesterase 0.0628 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.0054 0.0034
Echinococcus granulosus allatostatin A receptor 0.0011 0.0054 0.0054
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0049 0.0049
Schistosoma mansoni myosin xvIII 0.0011 0.0054 0.0034
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0051 0.0051
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0051 0.0319
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0025 0.0005
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0054 0.0054
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0706 0.0687
Brugia malayi Dopamine receptor 0.0011 0.0054 0.0034
Brugia malayi N-terminal motif family protein 0.0185 0.2864 0.2849
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0054 0.0034
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0049 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0936 1
Schistosoma mansoni opsin-like receptor 0.0011 0.0054 0.0034
Brugia malayi Carboxylesterase family protein 0.0106 0.1592 0.1575
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Brugia malayi neuropeptide F receptor 0.0011 0.0054 0.0034
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0445 0.0426
Leishmania major cathepsin L-like protease 0.0017 0.0159 0.1516
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0049 0.0029
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0159 0.0999
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0159 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0049 0.0029
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Schistosoma mansoni gliotactin 0.0106 0.1592 0.1575
Mycobacterium leprae putative cytochrome p450 0.0009 0.002 0.5
Echinococcus granulosus GPCR family 2 0.0016 0.0143 0.0143
Trichomonas vaginalis abcb9, putative 0.001 0.0051 0.0319
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0159 0.0159
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0054 0.0054
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0711 0.7538
Trichomonas vaginalis ABC transporter, putative 0.001 0.0051 0.0319
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.0054 0.0034
Trichomonas vaginalis abcb9, putative 0.001 0.0051 0.0319
Loa Loa (eye worm) hypothetical protein 0.0628 1 1
Brugia malayi follicle stimulating hormone receptor 0.0011 0.0054 0.0034
Schistosoma mansoni neuropeptide receptor 0.0011 0.0054 0.0034
Schistosoma mansoni multidrug resistance protein 0.001 0.0051 0.0031
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0068 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0936 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0054 0.0054
Echinococcus multilocularis somatostatin receptor 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0051 0.0051
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0029 0.0009
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0054 0.0034
Echinococcus multilocularis para nitrobenzyl esterase 0.0106 0.1592 0.1592
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0159 0.0999
Onchocerca volvulus 0.0017 0.0159 0.0458
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.0051 0.0699 0.068
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0054 0.0054
Brugia malayi G protein-coupled receptor 0.0011 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0159 0.0159
Trichomonas vaginalis spcc417.12 protein, putative 0.0106 0.1592 1
Brugia malayi hypothetical protein 0.0106 0.1592 0.1575
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0159 0.0999
Schistosoma mansoni hypothetical protein 0.0011 0.0054 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0936 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0143 0.0123
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0159 0.0458
Leishmania major p-glycoprotein 0.001 0.0051 0.0334
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0016 0.0143 0.0123
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Brugia malayi Cathepsin L-like precursor 0.0017 0.0159 0.0139
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.0054 0.0034
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0049 0.0049
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0054 0.0034
Schistosoma mansoni opsin-like receptor 0.0011 0.0054 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0068 0.0425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0025 0.0157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0049 0.0029
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0106 0.1592 0.1575
Brugia malayi Cathepsin L-like precursor 0.0011 0.0068 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0054 0.0054
Brugia malayi ORL1-like opioid receptor 0.0011 0.0054 0.0034
Onchocerca volvulus 0.0011 0.0054 0.0086
Brugia malayi Cathepsin L-like precursor 0.0017 0.0159 0.0139
Schistosoma mansoni dishevelled 0.0009 0.0029 0.0009
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.001 0.0051 0.0334
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Brugia malayi hypothetical protein 0.0011 0.0054 0.0034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0159 0.0999
Echinococcus multilocularis cysteine protease 0.0017 0.0159 0.0159
Brugia malayi Serotonin receptor 0.0011 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Brugia malayi sulfakinin receptor protein 0.0011 0.0054 0.0034
Brugia malayi steroid hormone receptor 0.001 0.0049 0.0029
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.001 0.0049 0.0049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0054 0.0034
Brugia malayi G-protein coupled receptor 0.0011 0.0054 0.0034
Onchocerca volvulus 0.0106 0.1592 0.5514
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0068 0.0425
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0029 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0049 0.0029
Entamoeba histolytica P-glycoprotein-2 0.001 0.0051 0.1925
Brugia malayi Cathepsin L-like precursor 0.0017 0.0159 0.0139
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0051 0.0319
Echinococcus granulosus para nitrobenzyl esterase 0.0106 0.1592 0.1592
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0025 0.0157
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0051 0.0319
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0011 0.0054 0.0086
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0054 0.0034
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0049 0.0029
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0049 0.0029
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0159 0.0139
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0029
Brugia malayi Cathepsin L-like precursor 0.0017 0.0159 0.0139
Brugia malayi ecdysteroid receptor 0.001 0.0049 0.0029
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0049 0.0049
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.0054 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0936 1
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0054 0.0054
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0049 0.0049
Brugia malayi ABC transporter family protein 0.001 0.0051 0.0031
Echinococcus granulosus g protein coupled receptor 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0068 0.0048
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0051 0.0319
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0143 0.0123
Brugia malayi hypothetical protein 0.0011 0.0054 0.0034
Echinococcus multilocularis neuropeptide receptor A26 0.0011 0.0054 0.0054
Echinococcus granulosus sex peptide receptor 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0029
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0106 0.1592 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0029
Schistosoma mansoni neuropeptide receptor 0.0011 0.0054 0.0034
Brugia malayi hypothetical protein 0.0011 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Schistosoma mansoni hypothetical protein 0.0016 0.0143 0.0123
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0051 0.0319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0049 0.0029
Loa Loa (eye worm) acetylcholinesterase 1 0.0628 1 1
Leishmania major cathepsin L-like protease 0.0065 0.0936 1
Echinococcus granulosus neuropeptide receptor 0.0011 0.0054 0.0054
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0054 0.0054
Brugia malayi nuclear receptor NHR-88 0.001 0.0049 0.0029
Onchocerca volvulus 0.0011 0.0054 0.0086
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0054 0.0054
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0049 0.0029
Onchocerca volvulus 0.0106 0.1592 0.5514
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0054 0.0034
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0051 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0049 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0029
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0051 0.0051
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0106 0.1592 0.1575
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0049 0.0049
Trichomonas vaginalis taga, putative 0.001 0.0051 0.0319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0049 0.0029
Schistosoma mansoni hypothetical protein 0.0016 0.0143 0.0123
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.0054 0.0034
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.0054 0.0034
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0025 0.0005
Trypanosoma cruzi cysteine proteinase, putative 0.0009 0.0025 0.0052
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0159 1
Schistosoma mansoni neuropeptide receptor 0.0011 0.0054 0.0034
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.0054 0.0054
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0143 0.0143
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0049 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0049 0.0029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0143 0.0123
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0054 0.0034
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0049 0.0049
Onchocerca volvulus 0.0011 0.0054 0.0086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0159 0.0999
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0051 0.0051
Brugia malayi DIX domain containing protein 0.0009 0.0029 0.0009
Schistosoma mansoni hypothetical protein 0.0016 0.0143 0.0123
Onchocerca volvulus 0.0011 0.0054 0.0086
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0054 0.0054
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0049 0.0049
Brugia malayi hypothetical protein 0.0011 0.0054 0.0034
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0051 0.0051
Brugia malayi Cathepsin L-like precursor 0.0017 0.0159 0.0139
Brugia malayi hypothetical protein 0.0011 0.0054 0.0034
Brugia malayi Carboxylesterase family protein 0.0106 0.1592 0.1575
Mycobacterium tuberculosis Carboxylesterase LipT 0.0106 0.1592 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0159 0.0999
Onchocerca volvulus 0.0011 0.0068 0.0135
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0054 0.0034
Echinococcus granulosus carboxylesterase 5A 0.0628 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0054 0.0034
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0051 0.0319
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0029 0.0029
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0051 0.0319
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0049 0.0029
Echinococcus granulosus FTZ F1 alpha 0.001 0.0049 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0009 0.0025 0.0052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.0106 0.1592 0.1575
Schistosoma mansoni nuclear hormone receptor 0.001 0.0049 0.0029
Loa Loa (eye worm) hypothetical protein 0.0106 0.1592 0.1575
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0054 0.0034
Brugia malayi nuclear hormone receptor 0.001 0.0049 0.0029
Loa Loa (eye worm) multidrug resistance protein 3 0.001 0.0051 0.0031
Brugia malayi Cathepsin L-like precursor 0.0017 0.0159 0.0139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0936 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0051 0.0319
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0054 0.0054
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0054 0.0054
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.0106 0.1592 0.1575
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0029 0.0029
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0159 0.0999
Echinococcus multilocularis acetylcholinesterase 0.0628 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0051 0.0051
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.0054 0.0054
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0029 0.0029
Loa Loa (eye worm) carboxylesterase 0.0106 0.1592 0.1575
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.0054 0.0034
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0054 0.0034
Entamoeba histolytica P-glyco protein 6, putative 0.001 0.0051 0.1925
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0031
Loa Loa (eye worm) hypothetical protein 0.0011 0.0068 0.0048
Schistosoma mansoni dishevelled 0.0009 0.0029 0.0009
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0051 0.0319
Schistosoma mansoni thyroid hormone receptor 0.001 0.0049 0.0029
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.0054 0.0034
Schistosoma mansoni BC026374 protein (S09 family) 0.0106 0.1592 0.1575
Entamoeba histolytica P-glycoprotein-1 0.001 0.0051 0.1925
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0051 0.0319
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0054 0.0054
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0159 1
Echinococcus multilocularis cathepsin L 0.0009 0.0025 0.0025
Loa Loa (eye worm) fibroinase 0.0017 0.0159 0.0139
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0051 0.0319
Schistosoma mansoni hypothetical protein 0.0011 0.0054 0.0034
Brugia malayi larval opioid receptor 0.0011 0.0054 0.0034
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0054 0.0054
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0106 0.1592 0.1592
Brugia malayi hypothetical protein 0.0009 0.0029 0.0009
Echinococcus granulosus neuroligin 0.0106 0.1592 0.1592
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0025 0.0005
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.0068 0.0048
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0143 0.0143
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Echinococcus granulosus neuropeptide receptor 0.0011 0.0054 0.0054
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0054 0.0034
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0051 0.0051
Schistosoma mansoni multidrug resistance protein 0.001 0.0051 0.0031
Schistosoma mansoni thyroid hormone receptor 0.001 0.0049 0.0029
Brugia malayi Melatonin receptor type 1A 0.0011 0.0054 0.0034
Leishmania major cathepsin L-like protease 0.0017 0.0159 0.1516
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0009 0.0025 0.0052
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.0054 0.0054
Onchocerca volvulus 0.0017 0.0159 0.0458
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.0054 0.0034
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0159 0.1516
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0106 0.1592 0.1575
Echinococcus granulosus cytochrome P450 2K1 0.0009 0.002 0.002
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.0054 0.0034
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0159 0.0139
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0029 0.0029
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.0054 0.0054
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.0054 0.0034
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0159 0.0458
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.0054 0.0054
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0159 0.0458
Trypanosoma cruzi cysteine proteinase, putative 0.0009 0.0025 0.0052
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.001 0.0051 0.0031
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0054 0.0054
Echinococcus multilocularis neuropeptide s receptor 0.0011 0.0054 0.0054
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0054 0.0034
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.0054 0.0034
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.0054 0.0034
Echinococcus granulosus g-protein coupled receptor 0.0011 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0159 0.0999
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Onchocerca volvulus 0.0011 0.0054 0.0086
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.001 0.0051 0.2204
Onchocerca volvulus 0.0106 0.1592 0.5514
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.0054 0.0034
Echinococcus granulosus g protein coupled receptor 0.0011 0.0054 0.0054
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0029
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.001 0.0051 0.0195
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0106 0.1592 0.1592
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0054 0.0034
Leishmania major cathepsin L-like protease 0.0017 0.0159 0.1516
Brugia malayi neuropeptide F receptor 0.0011 0.0054 0.0034
Echinococcus multilocularis tumor protein p63 0.0346 0.5462 0.5462
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0029 0.0009
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0049 0.0029
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0054 0.0054
Plasmodium falciparum multidrug resistance protein 1 0.001 0.0051 0.1925
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0049 0.0029
Echinococcus granulosus cathepsin l1 0.0017 0.0159 0.0159
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0049 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0054 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0936 1
Onchocerca volvulus 0.001 0.0051 0.0076
Schistosoma mansoni biogenic amine receptor 0.0011 0.0054 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0054 0.0054
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0054 0.0054
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0054 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0049 0.0029
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.0054 0.0034
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0051 0.0319
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0029
Schistosoma mansoni neuropeptide receptor 0.0011 0.0054 0.0034
Echinococcus granulosus cathepsin l1 0.0011 0.0068 0.0068
Onchocerca volvulus 0.0011 0.0054 0.0086
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0029 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0159 0.0999
Echinococcus multilocularis cysteine protease 0.0017 0.0159 0.0159
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0054 0.0034
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0054 0.0034
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0049 0.0029
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.0054 0.0054
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0106 0.1592 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.001 0.0051 0.0319
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0051 0.0319
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0049 0.0049
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.0054 0.0034
Schistosoma mansoni acetylcholinesterase 0.0106 0.1592 0.1575
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0034
Onchocerca volvulus 0.0011 0.0054 0.0086
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0054 0.0054
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0845 0.9002
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0159 0.0139
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.0054 0.0034
Echinococcus multilocularis orexin receptor type 2 0.0011 0.0054 0.0054
Echinococcus granulosus BC026374 protein S09 family 0.0106 0.1592 0.1592
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0159 0.0999
Echinococcus granulosus somatostatin receptor 0.0011 0.0054 0.0054
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.0054 0.0054
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0054 0.0034
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0051 0.0319
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0049 0.0049
Brugia malayi Serotonin receptor 0.0011 0.0054 0.0034
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0628 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0051 0.0051
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.0054 0.0054
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0159 0.0139
Mycobacterium leprae Conserved hypothetical protein 0.0009 0.002 0.5
Brugia malayi Cathepsin L-like precursor 0.0011 0.0068 0.0048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0159 0.0999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0159 0.0999

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 21 nM Inhibition of human testicular microsomal Cytochrome P450 17A1 ChEMBL. 9379450
IC50 (binding) = 1500 nM Inhibition of rat testicual micrososmal Cytochrome P450 17A1 ChEMBL. 9379450
Inhibition (binding) = 65 % Percent inhibition of rat testicular microsomal Cytochrome P450 17A1 ChEMBL. 9379450

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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