Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | opioid receptor, delta 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0076 | 0.0542 | 0.5 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0554 | 0.7946 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.0554 | 0.7946 | 1 |
Schistosoma mansoni | fk506 binding protein | 0.0076 | 0.0542 | 0.0628 |
Loa Loa (eye worm) | hypothetical protein | 0.0478 | 0.6764 | 0.8513 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0478 | 0.6764 | 0.7317 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0554 | 0.7946 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0554 | 0.7946 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0554 | 0.7946 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0554 | 0.7946 | 1 |
Leishmania major | fk506-binding protein 1-like protein | 0.0554 | 0.7946 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 | 0.0076 | 0.0542 | 0.0613 |
Onchocerca volvulus | 0.0076 | 0.0542 | 1 | |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0554 | 0.7946 | 1 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0076 | 0.0542 | 0.0152 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0554 | 0.7946 | 1 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0076 | 0.0542 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0076 | 0.0542 | 0.0682 |
Schistosoma mansoni | immunophilin | 0.0478 | 0.6764 | 0.8504 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0554 | 0.7946 | 0.8678 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0554 | 0.7946 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0076 | 0.0542 | 0.0682 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0628 | 0.9094 | 1 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0209 | 0.2596 | 0.5 |
Echinococcus multilocularis | fk506 binding protein | 0.0554 | 0.7946 | 0.8678 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0554 | 0.7946 | 0.8678 |
Onchocerca volvulus | 0.0076 | 0.0542 | 1 | |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0209 | 0.2596 | 1 |
Schistosoma mansoni | immunophilin | 0.0554 | 0.7946 | 1 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0076 | 0.0542 | 0.0152 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0554 | 0.7946 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 | 0.0076 | 0.0542 | 0.0613 |
Echinococcus multilocularis | 0.0076 | 0.0542 | 0.0152 | |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0554 | 0.7946 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0554 | 0.7946 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0554 | 0.7946 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0554 | 0.7946 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0542 | 0.0628 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0554 | 0.7946 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0554 | 0.7946 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0045 | 0.0058 | 0.0073 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0628 | 0.9094 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0554 | 0.7946 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0076 | 0.0542 | 0.0682 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0478 | 0.6764 | 0.7317 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 | 0.0076 | 0.0542 | 0.0613 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0554 | 0.7946 | 1 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0076 | 0.0542 | 0.5 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0554 | 0.7946 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0554 | 0.7946 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0542 | 0.0682 |
Schistosoma mansoni | immunophilin | 0.0554 | 0.7946 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0554 | 0.7946 | 0.8678 |
Echinococcus granulosus | FK506 binding protein 2 | 0.0076 | 0.0542 | 0.0152 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0076 | 0.0542 | 0.5 |
Loa Loa (eye worm) | FKBP5 protein | 0.0554 | 0.7946 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0554 | 0.7946 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0554 | 0.7946 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1394 nM | Binding affinity was measured in cloned Opioid receptor delta 1 expressed in CHO cells using [3H]- DPDPE as radioligand. | ChEMBL. | 11052799 |
IC50 (binding) | = 87700 nM | Binding affinity was measured in cloned Opioid receptor mu 1 expressed in CHO cells using [3H]- DAMGO as radioligand. | ChEMBL. | 11052799 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.