TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 439.635 | Formula: C30H37N3
H donors: 0 H acceptors: 0 LogP: 6.66 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: C[C@H]1CN(CCCn2c3ccccc3c3c2cccc3)C[C@@H](N1CCCc1ccccc1)C
InChi: 1S/C30H37N3/c1-24-22-31(23-25(2)32(24)20-10-14-26-12-4-3-5-13-26)19-11-21-33-29-17-8-6-15-27(29)28-16-7-9-18-30(28)33/h3-9,12-13,15-18,24-25H,10-11,14,19-23H2,1-2H3/t24-,25-/m0/s1
InChiKey: CJLMHMFDXCFFRR-DQEYMECFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Sigma opioid receptor	Starlite/ChEMBL	References
Rattus norvegicus	Norepinephrine transporter	Starlite/ChEMBL	References
Rattus norvegicus	Dopamine transporter	Starlite/ChEMBL	References
Rattus norvegicus	Serotonin transporter	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Leishmania donovani	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	ERG2 and Sigma1 receptor like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Trypanosoma brucei gambiense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Candida albicans	sterol C8-C7 isomerase	Get druggable targets OG5_131051	All targets in OG5_131051
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Leishmania major	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Leishmania mexicana	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Leishmania braziliensis	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364
Candida albicans	sterol C8-C7 isomerase	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania infantum	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma cruzi	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131051	All targets in OG5_131051
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364
Trypanosoma congolense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131051	All targets in OG5_131051
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Trypanosoma brucei	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Trypanosoma congolense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	sodium and chloride dependent glycine	Norepinephrine transporter	597 aa	507 aa	38.9 %
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Norepinephrine transporter	597 aa	579 aa	35.1 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	Norepinephrine transporter	597 aa	581 aa	34.6 %
Loa Loa (eye worm)	hypothetical protein	Norepinephrine transporter	597 aa	551 aa	25.0 %
Schistosoma mansoni	sodium/chloride dependent transporter	Norepinephrine transporter	597 aa	529 aa	41.6 %
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	Norepinephrine transporter	597 aa	508 aa	32.7 %
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	Norepinephrine transporter	597 aa	549 aa	41.9 %
Onchocerca volvulus		Norepinephrine transporter	597 aa	570 aa	38.6 %
Onchocerca volvulus	High affinity copper uptake protein 1 homolog	Norepinephrine transporter	597 aa	551 aa	47.4 %
Onchocerca volvulus	Transmembrane protein 120 homolog	Norepinephrine transporter	597 aa	577 aa	34.0 %
Plasmodium vivax	amine transporter, putative	Norepinephrine transporter	597 aa	483 aa	21.1 %
Onchocerca volvulus		Norepinephrine transporter	597 aa	548 aa	24.8 %
Schistosoma mansoni	sodium/chloride dependent transporter	Norepinephrine transporter	597 aa	534 aa	41.0 %
Plasmodium knowlesi	transporter, putative	Serotonin transporter	630 aa	514 aa	20.2 %
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	Norepinephrine transporter	597 aa	579 aa	22.1 %
Neospora caninum	sodium-dependent transporter, putative	Norepinephrine transporter	597 aa	507 aa	30.4 %
Schistosoma japonicum	ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative	Norepinephrine transporter	597 aa	501 aa	39.7 %
Plasmodium vivax	hypothetical protein, conserved	Serotonin transporter	630 aa	528 aa	21.2 %
Drosophila melanogaster	CG13796 gene product from transcript CG13796-RD	Norepinephrine transporter	597 aa	569 aa	24.8 %
Schistosoma japonicum	ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative	Norepinephrine transporter	597 aa	545 aa	41.7 %
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Norepinephrine transporter	597 aa	595 aa	34.0 %
Echinococcus granulosus	sodium and chloride dependent glycine	Norepinephrine transporter	597 aa	507 aa	38.9 %
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	Norepinephrine transporter	597 aa	522 aa	22.0 %
Echinococcus multilocularis	sodium and chloride dependent glycine	Norepinephrine transporter	597 aa	529 aa	42.0 %
Onchocerca volvulus		Norepinephrine transporter	597 aa	554 aa	38.6 %
Echinococcus granulosus	sodium and chloride dependent glycine	Norepinephrine transporter	597 aa	529 aa	42.5 %
Plasmodium yoelii	hypothetical protein	Norepinephrine transporter	597 aa	478 aa	19.7 %
Drosophila melanogaster	CG1698 gene product from transcript CG1698-RA	Norepinephrine transporter	597 aa	513 aa	38.4 %
Onchocerca volvulus		Norepinephrine transporter	597 aa	540 aa	46.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1	0.0927	0.3678	1
Echinococcus granulosus	beta tubulin	0.0081	0.0129	0.0086
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0942	0.3741	0.3714
Trypanosoma cruzi	glutamine-dependent carbamoyl-phosphate synthetase, putative	0.021	0.0667	0.1029
Leishmania major	alpha tubulin	0.0151	0.0421	0.038
Trichomonas vaginalis	tubulin beta chain, putative	0.0151	0.0421	0.1022
Wolbachia endosymbiont of Brugia malayi	Acetyl-CoA carboxylase, carboxyltransferase component	0.033	0.1172	0.2905
Trypanosoma cruzi	target of rapamycin kinase 3	0.075	0.2936	0.4767
Giardia lamblia	Beta tubulin	0.0081	0.0129	0.0231
Leishmania major	beta tubulin	0.0081	0.0129	0.0086
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0701	0.2728	0.7261
Treponema pallidum	sodium- and chloride- dependent transporter	0.0292	0.1013	1
Plasmodium falciparum	alpha tubulin 1	0.0151	0.0421	0.053
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0228	0.0193
Echinococcus granulosus	Tubulin alpha 1 chain	0.0151	0.0421	0.038
Echinococcus multilocularis	acetyl coenzyme A carboxylase 1	0.2434	1	1
Giardia lamblia	GTOR	0.0942	0.3741	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0151	0.0421	0.038
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0942	0.3741	0.3714
Wolbachia endosymbiont of Brugia malayi	carbamoyl phosphate synthase large subunit	0.021	0.0667	0.1476
Echinococcus multilocularis	propionyl coenzyme A carboxylase alpha chain	0.0927	0.3678	0.365
Leishmania major	beta tubulin	0.0081	0.0129	0.0086
Echinococcus granulosus	Tubulin alpha 1 chain	0.0151	0.0421	0.038
Toxoplasma gondii	beta-1 tubulin, putative	0.0081	0.0129	0.0086
Leishmania major	dihydrolipoamide branched chain transacylase, putative	0.0085	0.0146	0.0103
Trypanosoma cruzi	beta tubulin, putative	0.0081	0.0129	0.0141
Schistosoma mansoni	alpha tubulin	0.0151	0.0421	0.0421
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0749	0.2932	0.7813
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0292	0.1013	0.1013
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0316	0.1114	0.1075
Plasmodium vivax	tubulin epsilon chain, putative	0.0081	0.0129	0.012
Trypanosoma brucei	2-oxoglutarate dehydrogenase E2 component, putative	0.0085	0.0146	0.0103
Echinococcus multilocularis	peroxisome assembly protein 26	0.0151	0.0421	0.038
Brugia malayi	Tubulin alpha chain	0.0151	0.0421	0.0394
Schistosoma mansoni	tubulin subunit alpha	0.0151	0.0421	0.0421
Trypanosoma brucei	glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative	0.021	0.0667	0.0627
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0061	0.0043	0.0043
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0178	0.0536	0.1332
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0178	0.0536	0.0812
Plasmodium falciparum	tubulin gamma chain	0.0081	0.0129	0.012
Leishmania major	methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein	0.0927	0.3678	0.365
Echinococcus granulosus	Tubulin alpha 1 chain	0.0151	0.0421	0.038
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0942	0.3741	0.3741
Loa Loa (eye worm)	tubulin beta-4 chain	0.0081	0.0129	0.0089
Trypanosoma brucei	epsilon tubulin	0.0081	0.0129	0.0086
Leishmania major	alpha tubulin	0.0151	0.0421	0.038
Trypanosoma brucei	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.033	0.1172	0.1134
Brugia malayi	Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor	0.0085	0.0146	0.0107
Echinococcus multilocularis	dihydrolipoyllysine residue succinyltransferase	0.0085	0.0146	0.0103
Echinococcus granulosus	serotonin transporter	0.0292	0.1013	0.0974
Trypanosoma brucei	epsilon tubulin	0.0081	0.0129	0.0086
Echinococcus granulosus	tubulin alpha chain	0.0151	0.0421	0.038
Chlamydia trachomatis	biotin carboxylase	0.0842	0.332	1
Trypanosoma brucei	alpha tubulin	0.0151	0.0421	0.038
Trypanosoma cruzi	tubulin gamma chain	0.0081	0.0129	0.0141
Echinococcus granulosus	tubulin beta 1 chain	0.0081	0.0129	0.0086
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0508	0.1919	0.5074
Trypanosoma cruzi	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.033	0.1172	0.186
Trypanosoma brucei	3-methylcrotonyl-CoA carboxylase alpha subunit, putative	0.0927	0.3678	0.365
Echinococcus multilocularis	tubulin alpha 1C chain	0.0151	0.0421	0.038
Leishmania major	beta tubulin	0.0081	0.0129	0.0086
Mycobacterium ulcerans	acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3	0.033	0.1172	0.2905
Trichomonas vaginalis	tubulin beta chain, putative	0.0081	0.0129	0.0231
Toxoplasma gondii	2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein	0.0085	0.0146	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0146	0.0107
Echinococcus granulosus	muscleblind protein	0.0318	0.1122	0.1084
Schistosoma mansoni	pyruvate carboxylase	0.0927	0.3678	0.3678
Leishmania major	alpha tubulin	0.0151	0.0421	0.038
Trypanosoma cruzi	epsilon tubulin, putative	0.0081	0.0129	0.0141
Echinococcus multilocularis	tubulin beta 1 chain	0.0081	0.0129	0.0086
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0253	0.0849	0.2178
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0178	0.0536	0.0536
Schistosoma mansoni	methylcrotonyl-CoA carboxylase	0.0927	0.3679	0.3679
Leishmania major	alpha tubulin	0.0151	0.0421	0.038
Leishmania major	2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative	0.0085	0.0146	0.0103
Schistosoma mansoni	dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase	0.0085	0.0146	0.0146
Toxoplasma gondii	alpha-tubulin I, putative	0.0151	0.0421	0.038
Trypanosoma cruzi	epsilon tubulin, putative	0.0081	0.0129	0.0141
Echinococcus multilocularis	Tubulin beta 2C chain	0.0081	0.0129	0.0086
Leishmania major	alpha tubulin	0.0151	0.0421	0.038
Schistosoma mansoni	dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase	0.0085	0.0146	0.0146
Schistosoma mansoni	propionyl-CoA carboxylase beta chain mitochondrial precursor	0.033	0.1172	0.1172
Schistosoma mansoni	sodium/chloride dependent transporter	0.0292	0.1013	0.1013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0178	0.0536	0.1332
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0069	0.0077	0.0077
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0316	0.1114	0.1765
Echinococcus multilocularis	hypothetical protein	0.0151	0.0421	0.038
Loa Loa (eye worm)	tubulin gamma chain	0.0081	0.0129	0.0089
Leishmania major	beta tubulin	0.0081	0.0129	0.0086
Loa Loa (eye worm)	phosphatidylinositol 3	0.0316	0.1114	0.1115
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0749	0.2932	0.7813
Echinococcus granulosus	peroxisome assembly protein 26	0.0151	0.0421	0.038
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0701	0.2728	0.7261
Leishmania major	dihydrolipoamide acetyltransferase precursor, putative	0.0085	0.0146	0.0103
Echinococcus multilocularis	microtubule associated protein 2	0.0495	0.1867	0.1832
Echinococcus granulosus	dihydrolipoyllysine residue succinyltransferase	0.0085	0.0146	0.0103
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0117	0.0281	0.0642
Trypanosoma cruzi	acetyl-CoA carboxylase, putative	0.033	0.1172	0.186
Trypanosoma cruzi	alpha tubulin, putative	0.0151	0.0421	0.0623
Trypanosoma brucei	dihydrolipoamide acetyltransferase E2 subunit, putative	0.0085	0.0146	0.0103
Leishmania major	beta tubulin	0.0081	0.0129	0.0086
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0061	0.0043	0.0043
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0105	0.0228	0.0193
Mycobacterium ulcerans	acetyl-/propionyl-CoA carboxylase subunit beta	0.033	0.1172	0.2905
Loa Loa (eye worm)	phosphatidylinositol 3	0.0942	0.3741	0.3852
Loa Loa (eye worm)	tubulin beta chain	0.0081	0.0129	0.0089
Mycobacterium tuberculosis	Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase)	0.033	0.1172	0.3106
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0116	0.0273	0.024
Giardia lamblia	Alpha-tubulin	0.0151	0.0421	0.1022
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0942	0.3741	1
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0316	0.1114	0.1075
Giardia lamblia	Beta tubulin	0.0081	0.0129	0.0231
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0701	0.2728	0.7261
Brugia malayi	dihydrolipoamide S-acetyltransferase precursor, putative	0.0085	0.0146	0.0107
Schistosoma mansoni	hypothetical protein	0.0061	0.0043	0.0043
Mycobacterium ulcerans	bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3	0.0927	0.3678	1
Mycobacterium tuberculosis	DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase	0.0085	0.0146	0.0282
Schistosoma mansoni	tubulin subunit gamma	0.0081	0.0129	0.0129
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0105	0.0228	0.0501
Mycobacterium tuberculosis	Probable branched-chain keto acid dehydrogenase E2 component BkdC	0.0085	0.0146	0.0282
Plasmodium falciparum	tubulin beta chain	0.0081	0.0129	0.012
Leishmania major	beta tubulin	0.0081	0.0129	0.0086
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0942	0.3741	0.3714
Echinococcus multilocularis	Tubulin beta 2C chain	0.0081	0.0129	0.0086
Leishmania major	alpha tubulin	0.0151	0.0421	0.038
Trichomonas vaginalis	tubulin alpha chain, putative	0.0081	0.0129	0.0231
Schistosoma mansoni	tubulin subunit alpha	0.0151	0.0421	0.0421
Onchocerca volvulus		0.0292	0.1013	0.8027
Echinococcus granulosus	tubulin beta 4A class IVa	0.0081	0.0129	0.0086
Echinococcus multilocularis	tubulin alpha chain	0.0151	0.0421	0.038
Echinococcus multilocularis	tubulin subunit TubB	0.0151	0.0421	0.038
Trypanosoma cruzi	dihydrolipoamide acetyltransferase precursor, putative	0.0085	0.0146	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0146	0.0107
Echinococcus granulosus	tubulin alpha chain	0.0151	0.0421	0.038
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0178	0.0536	0.0513
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0316	0.1114	0.1075
Schistosoma mansoni	alpha tubulin	0.0151	0.0421	0.0421
Echinococcus granulosus	beta tubulin	0.0081	0.0129	0.0086
Mycobacterium tuberculosis	Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie	0.0927	0.3678	1
Trypanosoma brucei	beta tubulin	0.0081	0.0129	0.0086
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0701	0.2728	0.7261
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0942	0.3741	1
Echinococcus multilocularis	tubulin alpha	0.0081	0.0129	0.0086
Leishmania major	alpha tubulin	0.0151	0.0421	0.038
Echinococcus multilocularis	Tubulin beta 2C chain	0.0081	0.0129	0.0086
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0557	0.2127	0.5634
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0146	0.0107
Leishmania major	epsilon tubulin, putative	0.0081	0.0129	0.0086
Trichomonas vaginalis	tubulin gamma chain, putative	0.0081	0.0129	0.0231
Loa Loa (eye worm)	BEN-1 protein	0.0081	0.0129	0.0089
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0069	0.0077	0.0035
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0061	0.0043	0.0043
Trichomonas vaginalis	tubulin, putative	0.0081	0.0129	0.0231
Echinococcus granulosus	tubulin gamma 1 chain	0.0081	0.0129	0.0086
Trypanosoma brucei	acetyl-CoA carboxylase	0.2434	1	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0151	0.0421	0.038
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.075	0.2936	0.2905
Giardia lamblia	Alpha-tubulin	0.0151	0.0421	0.1022
Loa Loa (eye worm)	hypothetical protein	0.0455	0.1695	0.1721
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0366	0.0336
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0557	0.2127	0.5634
Toxoplasma gondii	beta-tubulin, putative	0.0081	0.0129	0.0086
Entamoeba histolytica	tubulin family protein	0.0081	0.0129	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0318	0.1122	0.1124
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.075	0.2936	0.2905
Loa Loa (eye worm)	hypothetical protein	0.0199	0.0621	0.0602
Entamoeba histolytica	tubulin family protein	0.0081	0.0129	0.0231
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0889	0.3519	0.3621
Echinococcus granulosus	alpha tubulin	0.0151	0.0421	0.038
Mycobacterium leprae	Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase)	0.033	0.1172	0.3106
Trypanosoma brucei	tubulin gamma chain	0.0081	0.0129	0.0086
Brugia malayi	Muscleblind-like protein	0.0318	0.1122	0.1124
Toxoplasma gondii	dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase	0.0085	0.0146	0.0103
Mycobacterium leprae	Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE)	0.033	0.1172	0.3106
Trichomonas vaginalis	tubulin beta chain, putative	0.0151	0.0421	0.1022
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0316	0.1114	0.1075
Trypanosoma brucei	alpha tubulin	0.0151	0.0421	0.038
Echinococcus granulosus	Tubulin beta 2C chain	0.0081	0.0129	0.0086
Mycobacterium ulcerans	propionyl-CoA carboxylase beta chain 4 AccD4	0.033	0.1172	0.2905
Echinococcus granulosus	microtubule associated protein 2	0.0495	0.1867	0.1832
Plasmodium falciparum	tubulin epsilon chain, putative	0.0081	0.0129	0.012
Loa Loa (eye worm)	alpha-tubulin	0.0151	0.0421	0.0394
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0081	0.0129	0.0231
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0292	0.1013	0.1011
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0292	0.1013	0.1011
Toxoplasma gondii	dihydrolipoamide acyltransferase, putative	0.0085	0.0146	0.0103
Giardia lamblia	Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative	0.0415	0.153	0.402
Plasmodium falciparum	dihydrolipoamide acyltransferase component E2	0.0085	0.0146	0.0144
Brugia malayi	Carboxyl transferase domain containing protein	0.2349	0.9642	1
Leishmania major	dihydrolipoamide acetyltransferase precursorlike protein	0.0085	0.0146	0.0103
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0061	0.0043	0.0043
Trypanosoma brucei	beta tubulin	0.0081	0.0129	0.0086
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0151	0.0421	0.1022
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0117	0.0281	0.0392
Brugia malayi	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta	0.0085	0.0146	0.0107
Echinococcus multilocularis	serine protein kinase ATM	0.0178	0.0536	0.0495
Giardia lamblia	Gamma tubulin	0.0081	0.0129	0.0231
Plasmodium vivax	tubulin beta chain, putative	0.0081	0.0129	0.012
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0316	0.1114	0.1075
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0178	0.0536	0.0495
Brugia malayi	FAT domain containing protein	0.0138	0.0366	0.0336
Mycobacterium tuberculosis	Probable pyruvate carboxylase Pca (pyruvic carboxylase)	0.0927	0.3678	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0701	0.2728	0.7261
Plasmodium falciparum	alpha tubulin 2	0.0151	0.0421	0.053
Echinococcus multilocularis	Tubulin beta 2C chain	0.0081	0.0129	0.0086
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0081	0.0129	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1252	0.1259
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0563	0.215	0.5698
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0151	0.0421	0.038
Echinococcus multilocularis	Tubulin beta 2C chain	0.0081	0.0129	0.0086
Trypanosoma brucei	alpha tubulin	0.0151	0.0421	0.038
Plasmodium vivax	tubulin alpha chain, putative	0.0151	0.0421	0.053
Trypanosoma brucei	epsilon tubulin	0.0081	0.0129	0.0086
Toxoplasma gondii	alpha tubulin TUBA1	0.0151	0.0421	0.038
Plasmodium vivax	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.1761	0.7178	1
Mycobacterium leprae	Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP)	0.0927	0.3678	1
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0178	0.0536	0.0495
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0178	0.0536	0.0812
Leishmania major	beta tubulin	0.0081	0.0129	0.0086
Plasmodium vivax	carbamoyl phosphate synthetase, putative	0.021	0.0667	0.0875
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.0281	0.0642
Entamoeba histolytica	hypothetical protein	0.0178	0.0536	0.1332
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0081	0.0129	0.0086
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0391	0.143	0.1393
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0069	0.0077	0.0034
Echinococcus granulosus	tubulin epsilon chain	0.0081	0.0129	0.0086
Mycobacterium leprae	Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB	0.0085	0.0146	0.0282
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0316	0.1114	0.1075
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.02	0.0628	0.0609
Schistosoma mansoni	acetyl-CoA carboxylase	0.2434	1	1
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0594	0.0574
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0701	0.2728	0.7261
Trypanosoma cruzi	glutamine dependent carbamoyl-phosphate synthase, putative	0.021	0.0667	0.1029
Leishmania major	beta tubulin	0.0081	0.0129	0.0086
Chlamydia trachomatis	acetyl-coenzyme A carboxylase carboxyl transferase subunit beta	0.033	0.1172	0.3233
Trichomonas vaginalis	tubulin beta chain, putative	0.0151	0.0421	0.1022
Trichomonas vaginalis	tubulin alpha chain, putative	0.0081	0.0129	0.0231
Leishmania major	alpha tubulin	0.0151	0.0421	0.038
Wolbachia endosymbiont of Brugia malayi	Acetyl/propionyl-CoA carboxylase, alpha subunit	0.0927	0.3678	1
Schistosoma mansoni	methylcrotonyl-CoA carboxylase	0.0927	0.3679	0.3679
Loa Loa (eye worm)	hypothetical protein	0.0318	0.1122	0.1124
Loa Loa (eye worm)	alpha-tubulin	0.0151	0.0421	0.0394
Trypanosoma brucei	dihydrolipoamide branched chain transacylase, putative	0.0085	0.0146	0.0103
Echinococcus granulosus	dihydrolipoyllysine residue acetyltransferase	0.0085	0.0146	0.0103
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0509	0.1923	0.5082
Trichomonas vaginalis	tubulin beta chain, putative	0.0151	0.0421	0.1022
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0509	0.1923	0.5082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0749	0.2932	0.7813
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0509	0.1923	0.5082
Echinococcus multilocularis	muscleblind protein 1	0.0318	0.1122	0.1084
Plasmodium vivax	tubulin alpha chain, putative	0.0151	0.0421	0.053
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0316	0.1114	0.2895
Leishmania major	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.033	0.1172	0.1134
Trypanosoma brucei	pyruvate dehydrogenase complex E3 binding protein, putative	0.0085	0.0146	0.0103
Trypanosoma cruzi	3-methylcrotonyl-CoA carboxylase, putative	0.0927	0.3678	0.5991
Echinococcus multilocularis	dihydrolipoyllysine residue acetyltransferase	0.0085	0.0146	0.0103
Trypanosoma cruzi	dihydrolipoamide branched chain transacylase, putative	0.0085	0.0146	0.0169
Brugia malayi	hypothetical protein	0.0349	0.1252	0.1259
Echinococcus multilocularis	propionyl coenzyme A carboxylase beta chain	0.033	0.1172	0.1134
Entamoeba histolytica	acetyl-coA carboxylase, putative	0.0415	0.153	0.402
Schistosoma mansoni	tubulin subunit beta	0.0081	0.0129	0.0129
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0138	0.0366	0.0324
Schistosoma mansoni	tubulin subunit beta	0.0081	0.0129	0.0129
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0069	0.0077	0.0034
Brugia malayi	beta-tubulin, identical	0.0081	0.0129	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1013	0.1011
Schistosoma mansoni	carbamoyl-phosphate synthetase	0.021	0.0667	0.0667
Brugia malayi	Tubulin alpha-2 chain	0.0151	0.0421	0.0394
Leishmania major	beta tubulin	0.0081	0.0129	0.0086
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0942	0.3741	0.6095
Schistosoma mansoni	carbamoyl-phosphate synthetase	0.021	0.0667	0.0667
Echinococcus multilocularis	tubulin alpha 3 chain	0.0151	0.0421	0.038
Entamoeba histolytica	tubulin gamma chain	0.0081	0.0129	0.0231
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0942	0.3741	0.3714
Trypanosoma cruzi	acetyl-CoA carboxylase	0.1507	0.611	1
Brugia malayi	Tubulin gamma chain	0.0081	0.0129	0.0089
Mycobacterium ulcerans	carbamoyl phosphate synthase large subunit	0.021	0.0667	0.1476
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0563	0.215	0.5698
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0178	0.0536	0.0513
Toxoplasma gondii	FATC domain-containing protein	0.0178	0.0536	0.0495
Trypanosoma brucei	beta tubulin	0.0081	0.0129	0.0086
Schistosoma mansoni	dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase	0.0085	0.0146	0.0146
Trypanosoma cruzi	dihydrolipoamide acetyltransferase, putative	0.0085	0.0146	0.0169
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0942	0.3741	0.3852
Loa Loa (eye worm)	hypothetical protein	0.0889	0.3519	0.3621
Trichomonas vaginalis	tubulin beta chain, putative	0.0151	0.0421	0.1022
Toxoplasma gondii	acetyl-coA carboxylase ACC2	0.2434	1	1
Entamoeba histolytica	tubulin alpha chain, putative	0.0151	0.0421	0.1022
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0612	0.2354	0.625
Echinococcus granulosus	serine protein kinase ATM	0.0178	0.0536	0.0495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0316	0.1114	0.2895
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0316	0.1114	0.2895
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0069	0.0077	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0281	0.0247
Schistosoma mansoni	dihydrolipoamide S-acetyltransferase	0.0085	0.0146	0.0146
Echinococcus granulosus	propionyl coenzyme A carboxylase beta chain	0.033	0.1172	0.1134
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0178	0.0536	0.0536
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0273	0.024
Echinococcus multilocularis	tubulin alpha chain	0.0151	0.0421	0.038
Schistosoma mansoni	tubulin subunit beta	0.0081	0.0129	0.0129
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0316	0.1114	0.1765
Echinococcus granulosus	Tubulin beta 2C chain	0.0081	0.0129	0.0086
Leishmania major	gamma-tubulin	0.0081	0.0129	0.0086
Mycobacterium leprae	Probable biotinylated protein homolog TB7.3	0.0085	0.0146	0.0282
Echinococcus multilocularis	tubulin alpha chain	0.0151	0.0421	0.038
Trichomonas vaginalis	tubulin beta chain, putative	0.0151	0.0421	0.1022
Toxoplasma gondii	acetyl-CoA carboxylase ACC1	0.2434	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0151	0.0421	0.038
Mycobacterium ulcerans	propionyl-CoA carboxylase beta chain 5 AccD5	0.033	0.1172	0.2905
Plasmodium vivax	lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative	0.0085	0.0146	0.0144
Echinococcus multilocularis	tubulin alpha 1C chain	0.0151	0.0421	0.038
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0942	0.3741	0.3714
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0316	0.1114	0.2895
Toxoplasma gondii	pyruvate carboxylase	0.0927	0.3678	0.365
Loa Loa (eye worm)	BEN-1 protein	0.0081	0.0129	0.0089
Mycobacterium tuberculosis	Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6	0.033	0.1172	0.3106
Mycobacterium ulcerans	acetyl/propionyl CoA carboxylase subunit beta	0.033	0.1172	0.2905
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0536	0.0513
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0942	0.3741	1
Schistosoma mansoni	tubulin subunit beta	0.0081	0.0129	0.0129
Trypanosoma brucei	beta tubulin	0.0081	0.0129	0.0086
Schistosoma mansoni	tubulin subunit beta	0.0081	0.0129	0.0129
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0061	0.0043	0.0043
Loa Loa (eye worm)	tubulin alpha 2	0.0116	0.0273	0.024
Leishmania major	alpha tubulin	0.0151	0.0421	0.038
Echinococcus multilocularis	tubulin alpha chain	0.0151	0.0421	0.038
Trichomonas vaginalis	conserved hypothetical protein	0.0138	0.0366	0.0873
Plasmodium falciparum	lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex	0.0085	0.0146	0.0144
Leishmania major	alpha tubulin	0.0151	0.0421	0.038
Schistosoma mansoni	tubulin subunit beta	0.0081	0.0129	0.0129
Leishmania major	propionyl-coa carboxylase beta chain, putative	0.033	0.1172	0.1134
Brugia malayi	Protein kinase domain containing protein	0.02	0.0628	0.0609
Echinococcus multilocularis	Biotin lipoyl attachment	0.0085	0.0146	0.0103
Brugia malayi	Tubulin beta-1 chain	0.0081	0.0129	0.0089
Toxoplasma gondii	beta tubulin	0.0081	0.0129	0.0086
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0316	0.1114	0.1114
Echinococcus multilocularis	tubulin epsilon chain	0.0081	0.0129	0.0086
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0632	0.244	0.6481
Loa Loa (eye worm)	tubulin alpha 2	0.0116	0.0273	0.024
Leishmania major	beta tubulin	0.0081	0.0129	0.0086
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0701	0.2728	0.2697
Echinococcus granulosus	tubulin alpha chain	0.0151	0.0421	0.038
Schistosoma mansoni	alpha tubulin	0.0151	0.0421	0.0421
Trypanosoma cruzi	dihydrolipoamide acetyltransferase precursor, putative	0.0085	0.0146	0.0169
Echinococcus multilocularis	tubulin alpha 3 chain	0.0151	0.0421	0.038
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0942	0.3741	0.6095
Leishmania major	beta tubulin	0.0081	0.0129	0.0086
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0178	0.0536	0.0495
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0069	0.0077	0.0077
Entamoeba histolytica	protein kinase rad3, putative	0.0178	0.0536	0.1332
Trypanosoma cruzi	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.033	0.1172	0.186
Mycobacterium ulcerans	acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2	0.0927	0.3678	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0061	0.0043	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0199	0.0621	0.1563
Mycobacterium tuberculosis	Biotinylated protein TB7.3	0.0085	0.0146	0.0282
Trypanosoma brucei	alpha tubulin	0.0151	0.0421	0.038
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0509	0.1923	0.5082
Echinococcus multilocularis	serotonin transporter	0.0292	0.1013	0.0974
Echinococcus granulosus	tubulin alpha	0.0081	0.0129	0.0086
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0151	0.0421	0.1022
Trichomonas vaginalis	tubulin gamma chain, putative	0.0081	0.0129	0.0231
Echinococcus multilocularis	tubulin subunit beta	0.0081	0.0129	0.0086
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0749	0.2932	0.7813
Trypanosoma brucei	unspecified product	0.0609	0.2345	0.2312
Plasmodium falciparum	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.1761	0.7178	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0178	0.0536	0.1332
Toxoplasma gondii	carbamoylphosphate synthetase	0.021	0.0667	0.0627
Echinococcus granulosus	Biotin lipoyl attachment	0.0085	0.0146	0.0103
Brugia malayi	tubulin alpha chain - mouse	0.0151	0.0421	0.0394
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0942	0.3741	1
Leishmania major	beta tubulin	0.0081	0.0129	0.0086
Loa Loa (eye worm)	tubulin beta-1 chain	0.0081	0.0129	0.0089
Entamoeba histolytica	tubulin alpha-1 chain	0.0151	0.0421	0.1022
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0889	0.3519	0.573
Echinococcus granulosus	tubulin subunit TubB	0.0151	0.0421	0.038
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0069	0.0077	0.0034
Plasmodium falciparum	dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex	0.0085	0.0146	0.0144
Brugia malayi	alpha-tubulin	0.0151	0.0421	0.0394
Mycobacterium ulcerans	propionyl-CoA carboxylase beta chain 4 AccD4_2	0.033	0.1172	0.2905
Trypanosoma cruzi	3-methylcrotonyl-CoA carboxylase, putative	0.0927	0.3678	0.5991
Loa Loa (eye worm)	tubulin alpha chain	0.0151	0.0421	0.0394
Leishmania major	beta tubulin	0.0081	0.0129	0.0086
Leishmania major	beta tubulin	0.0081	0.0129	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1013	0.1011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0316	0.1114	0.2895
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0942	0.3741	0.3714
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0069	0.0077	0.0035
Mycobacterium leprae	ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6	0.033	0.1172	0.3106
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0178	0.0536	0.1332
Leishmania major	beta tubulin	0.0081	0.0129	0.0086
Echinococcus granulosus	tubulin alpha chain	0.0151	0.0421	0.038
Plasmodium falciparum	carbamoyl phosphate synthetase	0.021	0.0667	0.0875
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0081	0.0129	0.0231
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0446	0.1658	0.1621
Schistosoma mansoni	tubulin subunit alpha	0.0151	0.0421	0.0421
Loa Loa (eye worm)	tubulin beta-2A chain	0.0081	0.0129	0.0089
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0804	0.3163	0.8437
Brugia malayi	Tubulin alpha-2 chain	0.0151	0.0421	0.0394
Echinococcus multilocularis	tubulin gamma 1 chain	0.0081	0.0129	0.0086
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0942	0.3741	1
Schistosoma mansoni	tubulin subunit epsilon	0.0081	0.0129	0.0129
Loa Loa (eye worm)	carboxyl transferase domain-containing protein	0.2349	0.9642	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0151	0.0421	0.038
Toxoplasma gondii	biotin-requiring enzyme domain-containing protein	0.0085	0.0146	0.0103
Schistosoma mansoni	aspartate carbamoyltransferase	0.021	0.0667	0.0667
Schistosoma mansoni	hypothetical protein	0.0138	0.0366	0.0366
Leishmania major	C-8 sterol isomerase-like protein	0.0889	0.3519	0.3491
Loa Loa (eye worm)	norepinephrine transporter	0.0292	0.1013	0.1011
Leishmania major	beta tubulin	0.0081	0.0129	0.0086
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0151	0.0421	0.038
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0316	0.1114	0.1115
Echinococcus granulosus	propionyl coenzyme A carboxylase alpha chain	0.0927	0.3678	0.365
Mycobacterium ulcerans	pyruvate carboxylase	0.0927	0.3678	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0081	0.0129	0.0086
Echinococcus granulosus	tubulin alpha 1C chain	0.0151	0.0421	0.038
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0116	0.0273	0.0622
Onchocerca volvulus		0.0349	0.1252	1
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E2	0.0085	0.0146	0.0103
Toxoplasma gondii	acyl-CoA carboxyltransferase beta chain, putative	0.033	0.1172	0.1134
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0508	0.1919	0.5074
Loa Loa (eye worm)	serotonin transporter b	0.0292	0.1013	0.1011
Echinococcus granulosus	tubulin subunit beta	0.0081	0.0129	0.0086
Trichomonas vaginalis	tubulin gamma chain, putative	0.0081	0.0129	0.0231
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0151	0.0421	0.1022
Echinococcus multilocularis	tubulin alpha chain	0.0151	0.0421	0.038
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0199	0.0621	0.0581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0563	0.215	0.5698
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1013	0.1011
Echinococcus multilocularis	beta tubulin	0.0081	0.0129	0.0086
Leishmania major	alpha tubulin	0.0151	0.0421	0.038
Leishmania major	carbamoyl-phosphate synthase, putative	0.021	0.0667	0.0627
Loa Loa (eye worm)	tubulin alpha chain	0.0151	0.0421	0.0394
Leishmania major	beta tubulin	0.0081	0.0129	0.0086
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0061	0.0043	0.0043
Loa Loa (eye worm)	tubulin alpha 2	0.007	0.008	0.0039
Schistosoma mansoni	serine/threonine protein kinase	0.02	0.0628	0.0628
Trypanosoma cruzi	2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative	0.0085	0.0146	0.0169
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0749	0.2932	0.7813
Echinococcus multilocularis	beta tubulin	0.0081	0.0129	0.0086
Echinococcus multilocularis	muscleblind protein	0.0318	0.1122	0.1084
Leishmania major	carboxylase, putative	0.0927	0.3678	0.365
Loa Loa (eye worm)	beta-tubulin	0.0081	0.0129	0.0089
Trypanosoma cruzi	dihydrolipoamide branched chain transacylase, putative	0.0085	0.0146	0.0169
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0069	0.0077	0.0077
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0889	0.3519	0.3491
Trypanosoma cruzi	2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative	0.0085	0.0146	0.0169
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0138	0.0366	0.0324
Echinococcus granulosus	Tubulin beta 2C chain	0.0081	0.0129	0.0086
Plasmodium vivax	tubulin gamma chain, putative	0.0081	0.0129	0.012
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0421	0.0394
Brugia malayi	tubulin alpha-2 chain	0.0151	0.0421	0.0394
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0508	0.1919	0.5074
Trypanosoma brucei	beta tubulin	0.0081	0.0129	0.0086
Trypanosoma brucei	3-methylcrotonyl-CoA carboxylase alpha subunit, putative	0.0927	0.3678	0.365
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0701	0.2728	0.7261
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1252	0.1259
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0151	0.0421	0.0394
Echinococcus granulosus	Tubulin beta 2C chain	0.0081	0.0129	0.0086
Giardia lamblia	Beta tubulin	0.0081	0.0129	0.0231
Leishmania major	alpha tubulin	0.0151	0.0421	0.038
Plasmodium vivax	dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative	0.0085	0.0146	0.0144
Leishmania major	beta tubulin	0.0081	0.0129	0.0086
Schistosoma mansoni	microtubule-associated protein tau	0.0495	0.1867	0.1867
Echinococcus granulosus	tubulin alpha chain	0.0151	0.0421	0.038
Leishmania major	acetyl-CoA carboxylase, putative	0.2434	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 639 nM	Inhibition of Dopamine uptake in male Sprague-Dawley rats using [3H]-DA ligand	ChEMBL.	10543888
Ki (binding)	= 44.5 nM	Binding affinity against Serotonin transporter in male Sprague-Dawley rats using [3H]-paroxetine ligand	ChEMBL.	10543888
Ki (binding)	= 145 nM	The compound was tested for binding affinity of Sigma opioid receptor type 2 in rat liver membranes using [3H]-DTG ligand	ChEMBL.	10543888
Ki (binding)	= 263 nM	Binding affinity Sprague-Dawley rats using [3H]-WIN- 35,428 ligand	ChEMBL.	10543888
Ki (binding)	= 2490 nM	The compound was tested for binding affinity nisoxatine ligand	ChEMBL.	10543888

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2112783

Bibliographic References

No literature references available for this target.

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Detailed information for compound 930137