Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycogen synthase kinase 3 alpha | References | |
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.158 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.158 | 1 | 1 |
Leishmania major | 0.158 | 1 | 1 | |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.158 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.158 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.2595 | 0.2595 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.158 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.158 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0116 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0116 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0116 | 0 | 0.5 |
Toxoplasma gondii | fructose-bisphospatase II | 0.158 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0116 | 0 | 0.5 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0116 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0116 | 0 | 0.5 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.158 | 1 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0588 | 0.3221 | 0.3221 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0116 | 0 | 0.5 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0588 | 0.3221 | 0.3221 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.2595 | 0.2595 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0588 | 0.3221 | 0.3221 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0116 | 0 | 0.5 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0588 | 0.3221 | 0.3221 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0588 | 0.3221 | 0.3221 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (ADMET) | = 28 uM | Cytotoxicity against human MRC5 cells assessed as growth inhibition after 72 hrs | ChEMBL. | 25198388 |
EC50 (functional) | > 50 uM | Trypanocidal activity against bloodstream stage of Trypanosoma brucei brucei assessed as inhibition of proliferation after 72 hrs | ChEMBL. | 25198388 |
IC50 (binding) | = 0.005 uM | Inhibition of human GSK3 using biotinylated GSP2 substrate by flashplate assay | ChEMBL. | 25198388 |
IC50 (binding) | = 22 uM | Inhibition of human CDK2/cyclin A using Biotin-C6-PKTPKKAKKL substrate | ChEMBL. | 25198388 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.