TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 549.626 | Formula: C30H31N9O2
H donors: 0 H acceptors: 5 LogP: 2.11 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: N#Cc1cccc(c1)c1ccc(=O)n(n1)C[C@H]1OCCN(C1)c1ncc(cn1)c1ccc(nc1)N1CCN(CC1)C
InChi: 1S/C30H31N9O2/c1-36-9-11-37(12-10-36)28-7-5-24(17-32-28)25-18-33-30(34-19-25)38-13-14-41-26(20-38)21-39-29(40)8-6-27(35-39)23-4-2-3-22(15-23)16-31/h2-8,15,17-19,26H,9-14,20-21H2,1H3/t26-/m0/s1
InChiKey: RSHVSHQCLHTDJZ-SANMLTNESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	MET proto-oncogene, receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	biogenic amine receptor	0.0046	0.798	0.798
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0046	0.798	0.798
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.798	0.798
Echinococcus multilocularis	g-protein coupled receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Schistosoma mansoni	neuropeptide receptor	0.0046	0.798	0.798
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.798	0.798
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.798	0.798
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0046	0.798	0.798
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0049	0.8675	0.8456
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Echinococcus granulosus	neuropeptides capa receptor	0.0046	0.798	0.798
Echinococcus multilocularis	neuropeptide receptor A26	0.0046	0.798	0.798
Trypanosoma brucei	protein kinase, putative	0.0049	0.8675	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.798	0.798
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0046	0.798	0.798
Onchocerca volvulus		0.0046	0.798	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0046	0.798	0.798
Brugia malayi	neuropeptide F receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.798	0.798
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0049	0.8675	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0046	0.798	0.798
Brugia malayi	Serotonin receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0052	0.9202	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Echinococcus granulosus	sex peptide receptor	0.0046	0.798	0.798
Echinococcus granulosus	dro:myosuppressin receptor	0.0046	0.798	0.798
Schistosoma mansoni	amine GPCR	0.0046	0.798	0.798
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.798	0.798
Schistosoma mansoni	neuropeptide F-like receptor	0.0046	0.798	0.798
Echinococcus granulosus	orexin receptor type 2	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Loa Loa (eye worm)	neuropeptide F receptor	0.0046	0.798	0.8673
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0049	0.8675	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Schistosoma mansoni	opsin-like receptor	0.0046	0.798	0.798
Schistosoma mansoni	neuropeptide receptor	0.0046	0.798	0.798
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0046	0.798	0.798
Schistosoma mansoni	hypothetical protein	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Schistosoma mansoni	hypothetical protein	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Onchocerca volvulus		0.0046	0.798	1
Brugia malayi	Dopamine receptor protein 1	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Echinococcus granulosus	serotonin receptor	0.0046	0.798	0.798
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0056	1	1
Echinococcus multilocularis	neuropeptide receptor	0.0046	0.798	0.798
Echinococcus granulosus	hypothetical protein	0.0046	0.798	0.798
Echinococcus granulosus	neuropeptide receptor	0.0046	0.798	0.798
Echinococcus granulosus	plexin a4	0.0025	0.3403	0.3403
Schistosoma mansoni	amine GPCR	0.0046	0.798	0.798
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0046	0.798	0.798
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	1	1
Echinococcus granulosus	allatostatin A receptor	0.0046	0.798	0.798
Brugia malayi	hypothetical protein	0.0046	0.798	0.798
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.798	0.798
Echinococcus granulosus	neuropeptide s receptor	0.0046	0.798	0.798
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0046	0.798	0.798
Echinococcus multilocularis	plexin a4	0.0025	0.3403	0.3403
Loa Loa (eye worm)	G-protein coupled receptor	0.0046	0.798	0.8673
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.798	0.798
Echinococcus multilocularis	neuropeptides capa receptor	0.0046	0.798	0.798
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0049	0.8675	0.8675
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Brugia malayi	hypothetical protein	0.0046	0.798	0.798
Echinococcus multilocularis	neuropeptides capa receptor	0.0046	0.798	0.798
Onchocerca volvulus		0.0046	0.798	1
Schistosoma mansoni	hypothetical protein	0.0012	0.0731	0.0731
Echinococcus granulosus	neuropeptide receptor	0.0046	0.798	0.798
Echinococcus granulosus	biogenic amine 5HT receptor	0.0046	0.798	0.798
Echinococcus granulosus	fmrfamide receptor	0.0046	0.798	0.798
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0021	0.2589	0.2814
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0046	0.798	0.798
Schistosoma mansoni	plexin	0.0012	0.0731	0.0731
Loa Loa (eye worm)	neuropeptide F receptor	0.0046	0.798	0.8673
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.798	0.798
Loa Loa (eye worm)	cytochrome P450 family protein	0.0015	0.1416	0.1539
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Schistosoma mansoni	adenoreceptor	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Schistosoma mansoni	hypothetical protein	0.0046	0.798	0.798
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0049	0.8675	1
Brugia malayi	putative neuropeptide receptor	0.0046	0.798	0.798
Schistosoma mansoni	plexin	0.0021	0.2589	0.2589
Schistosoma mansoni	opsin-like receptor	0.0046	0.798	0.798
Echinococcus granulosus	neuropeptides capa receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	cytochrome P450 family protein	0.0015	0.1416	0.1539
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0046	0.798	0.798
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Schistosoma mansoni	myosin xvIII	0.0046	0.798	0.798
Brugia malayi	G-protein coupled receptor	0.0046	0.798	0.798
Onchocerca volvulus		0.0046	0.798	1
Giardia lamblia	Kinase, CMGC MAPK	0.0049	0.8675	0.5
Brugia malayi	Plexin repeat family protein	0.0021	0.2589	0.2589
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0046	0.798	0.798
Brugia malayi	hypothetical protein	0.0046	0.798	0.798
Schistosoma mansoni	amine GPCR	0.0046	0.798	0.798
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0046	0.798	0.8673
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0049	0.8675	1
Onchocerca volvulus		0.0046	0.798	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0046	0.798	0.798
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0046	0.798	0.798
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0046	0.798	0.8673
Brugia malayi	RE15519p	0.0046	0.798	0.798
Echinococcus granulosus	g protein coupled receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0046	0.798	0.798
Echinococcus granulosus	g protein coupled receptor	0.0046	0.798	0.798
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0046	0.798	0.798
Echinococcus multilocularis	dro:myosuppressin receptor	0.0046	0.798	0.798
Brugia malayi	Cytochrome P450 family protein	0.0015	0.1416	0.1416
Loa Loa (eye worm)	G-protein coupled receptor	0.0046	0.798	0.8673
Echinococcus granulosus	neuropeptide Y receptor	0.0046	0.798	0.798
Onchocerca volvulus		0.0046	0.798	1
Echinococcus granulosus	g protein coupled receptor	0.0046	0.798	0.798
Schistosoma mansoni	hypothetical protein	0.0046	0.798	0.798
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0056	1	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0046	0.798	0.798
Brugia malayi	neuropeptide F receptor	0.0046	0.798	0.798
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0046	0.798	0.798
Brugia malayi	Cytochrome P450 family protein	0.0015	0.1416	0.1416
Echinococcus granulosus	neuropeptide receptor A26	0.0046	0.798	0.798
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0046	0.798	0.798
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.8675	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Brugia malayi	plexin A	0.0025	0.3403	0.3403
Schistosoma mansoni	histamine h1 receptor	0.0046	0.798	0.798
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.798	0.798
Brugia malayi	follicle stimulating hormone receptor	0.0046	0.798	0.798
Schistosoma mansoni	neuropeptide receptor	0.0046	0.798	0.798
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.798	0.798
Brugia malayi	MAP kinase sur-1	0.0049	0.8675	0.8675
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0046	0.798	0.8673
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Echinococcus multilocularis	neuropeptide Y receptor	0.0046	0.798	0.798
Echinococcus multilocularis	somatostatin receptor	0.0046	0.798	0.798
Onchocerca volvulus		0.0046	0.798	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.798	0.798
Schistosoma mansoni	amine GPCR	0.0046	0.798	0.798
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.798	0.798
Onchocerca volvulus		0.0021	0.2589	0.3244
Brugia malayi	hypothetical protein	0.0046	0.798	0.798
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.798	0.798
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Loa Loa (eye worm)	CYP4Cod1	0.0015	0.1416	0.1539
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0046	0.798	0.798
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	1	1
Brugia malayi	hypothetical protein	0.0046	0.798	0.798
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.798	0.798
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0046	0.798	0.798
Schistosoma mansoni	neuropeptide F-like receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	TYRA-2 protein	0.0046	0.798	0.8673
Brugia malayi	hypothetical protein	0.0046	0.798	0.798
Echinococcus granulosus	g-protein coupled receptor	0.0046	0.798	0.798
Echinococcus granulosus	G protein coupled receptor 139	0.0046	0.798	0.798
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Brugia malayi	hypothetical protein	0.0046	0.798	0.798
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.798	0.798
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.8675	0.8675
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0046	0.798	0.8673
Echinococcus multilocularis	G protein coupled receptor 139	0.0046	0.798	0.798
Brugia malayi	G protein-coupled receptor F59B2.13	0.0046	0.798	0.798
Schistosoma mansoni	growth hormone secretagogue receptor	0.0046	0.798	0.798
Echinococcus multilocularis	neuropeptide s receptor	0.0046	0.798	0.798
Echinococcus granulosus	7TM GPCR rhodopsin	0.0046	0.798	0.798
Onchocerca volvulus		0.0046	0.798	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0046	0.798	0.798
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.8675	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Echinococcus multilocularis	neuropeptide receptor	0.0046	0.798	0.798
Echinococcus granulosus	neuropeptide FF receptor 2	0.0046	0.798	0.798
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0049	0.8675	0.8456
Echinococcus granulosus	somatostatin receptor	0.0046	0.798	0.798
Echinococcus multilocularis	serotonin receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.798	0.798
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.8675	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Echinococcus multilocularis	serotonin receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0046	0.798	0.8673
Brugia malayi	larval opioid receptor	0.0046	0.798	0.798
Brugia malayi	hypothetical protein	0.0046	0.798	0.798
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0046	0.798	0.798
Schistosoma mansoni	opsin-like receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0046	0.798	0.798
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0046	0.798	0.798
Brugia malayi	Dopamine receptor protein 2	0.0046	0.798	0.798
Echinococcus multilocularis	neuropeptide Y receptor	0.0046	0.798	0.798
Onchocerca volvulus		0.0046	0.798	1
Onchocerca volvulus		0.0046	0.798	1
Echinococcus multilocularis	allatostatin A receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0046	0.798	0.798
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.798	0.798
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	1	1
Schistosoma mansoni	biogenic amine receptor	0.0046	0.798	0.798
Brugia malayi	G-protein coupled receptor	0.0046	0.798	0.798
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0046	0.798	1
Brugia malayi	Serotonin receptor	0.0046	0.798	0.798
Onchocerca volvulus		0.0046	0.798	1
Schistosoma mansoni	amine GPCR	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.798	0.798
Brugia malayi	hypothetical protein	0.0046	0.798	0.798
Loa Loa (eye worm)	plexin A	0.0025	0.3403	0.3698
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.798	0.798
Schistosoma mansoni	biogenic amine receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Echinococcus granulosus	biogenic amine 5HT receptor	0.0046	0.798	0.798
Onchocerca volvulus		0.0046	0.798	1
Onchocerca volvulus		0.0046	0.798	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0046	0.798	0.798
Echinococcus granulosus	7tm_1 domain containing protein	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.798	0.798
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.798	0.798
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.798	0.798
Brugia malayi	Dopamine receptor	0.0046	0.798	0.798
Brugia malayi	hypothetical protein	0.0046	0.798	0.798
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0049	0.8675	0.9427
Echinococcus multilocularis	mitogen activated protein kinase	0.0049	0.8675	0.8675
Loa Loa (eye worm)	melatonin receptor type 1A	0.0046	0.798	0.8673
Brugia malayi	Melatonin receptor type 1A	0.0046	0.798	0.798
Schistosoma mansoni	neuropeptide f receptor 76f	0.0046	0.798	0.798
Onchocerca volvulus		0.0046	0.798	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.798	0.798
Brugia malayi	putative neuropeptide receptor NPR1	0.0046	0.798	0.798
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0046	0.798	0.798
Echinococcus granulosus	mitogen activated protein kinase	0.0049	0.8675	0.8675
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0046	0.798	0.798
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0049	0.8675	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.798	0.798
Brugia malayi	GnHR receptor homolog	0.0046	0.798	0.798
Brugia malayi	ORL1-like opioid receptor	0.0046	0.798	0.798
Brugia malayi	sulfakinin receptor protein	0.0046	0.798	0.798
Brugia malayi	AKH receptor	0.0046	0.798	0.798
Echinococcus multilocularis	fmrfamide receptor	0.0046	0.798	0.798
Brugia malayi	G protein-coupled receptor	0.0046	0.798	0.798
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0046	0.798	0.798
Echinococcus granulosus	neuropeptide Y receptor	0.0046	0.798	0.798
Echinococcus multilocularis	sex peptide receptor	0.0046	0.798	0.798
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0056	1	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0046	0.798	0.798
Onchocerca volvulus		0.0046	0.798	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0049	0.8675	1
Schistosoma mansoni	neuropeptide receptor	0.0046	0.798	0.798
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0046	0.798	0.798
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0046	0.798	0.798
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	1	1
Onchocerca volvulus		0.0046	0.798	1
Echinococcus multilocularis	orexin receptor type 2	0.0046	0.798	0.798
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0046	0.798	0.798
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0046	0.798	0.798
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0731	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673
Onchocerca volvulus		0.0046	0.798	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0046	0.798	1
Echinococcus granulosus	mitogen activated protein kinase 3	0.0049	0.8675	0.8675
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.8675	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.798	0.798
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0046	0.798	0.798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.798	0.8673

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.012 uM	Inhibition of c-Met (unknown origin) by HTRF assay	ChEMBL.	25282552
IC50 (functional)	= 1.3 uM	Cytotoxicity against human NCI-H1993 cells after 72 hrs by WST8 assay	ChEMBL.	25282552

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	25282552

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3335785

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 930849