Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | selectin P (granule membrane protein 140kDa, antigen CD62) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0185 | 0.1527 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1527 | 0.1527 |
Echinococcus granulosus | carboxylesterase 5A | 0.1097 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1527 | 0.1527 |
Onchocerca volvulus | 0.0185 | 0.1527 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0185 | 0.1527 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1097 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0185 | 0.1527 | 0.1527 |
Echinococcus granulosus | acetylcholinesterase | 0.1097 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1097 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0185 | 0.1527 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0185 | 0.1527 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1527 | 0.1527 |
Echinococcus granulosus | acetylcholinesterase | 0.1097 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1097 | 1 | 1 |
Onchocerca volvulus | 0.0185 | 0.1527 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1527 | 0.1527 |
Onchocerca volvulus | 0.0185 | 0.1527 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0185 | 0.1527 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1527 | 0.1527 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1097 | 1 | 1 |
Onchocerca volvulus | 0.0185 | 0.1527 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.1097 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1097 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1527 | 0.1527 |
Loa Loa (eye worm) | hypothetical protein | 0.1097 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1527 | 0.1527 |
Loa Loa (eye worm) | carboxylesterase | 0.0185 | 0.1527 | 0.1527 |
Loa Loa (eye worm) | hypothetical protein | 0.1097 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0185 | 0.1527 | 0.5 |
Onchocerca volvulus | 0.0185 | 0.1527 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.1097 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Antagonist activity at P-selectin (unknown origin) assessed as adhesion to [3H]thymidine-labelled human HL60 cells by static assay | ChEMBL. | 25221666 | |
IC50 (binding) | Antagonist activity at E-selectin (unknown origin) assessed as adhesion to [3H]thymidine-labelled human HL60 cells by static assay | ChEMBL. | 25221666 | |
IC50 (binding) | = 0.008 mM | Antagonist activity at P-selectin (unknown origin) by surface plasmon resonance-based dynamic assay | ChEMBL. | 25221666 |
Ratio IC50 (binding) | Ratio of compound IC50 to sialyl Lewisx IC50 for E-selectin (unknown origin) adhesion to [3H]thymidine-labelled human HL60 cells by static assay | ChEMBL. | 25221666 | |
Ratio IC50 (binding) | Ratio of compound IC50 to sialyl Lewisx IC50 for P-selectin (unknown origin) adhesion to [3H]thymidine-labelled human HL60 cells by static assay | ChEMBL. | 25221666 | |
Ratio IC50 (binding) | = 82 | Ratio of compound IC50 to sialyl Lewisx IC50 for P-selectin (unknown origin) by surface plasmon resonance-based dynamic assay | ChEMBL. | 25221666 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.