Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 0.0656 | 1 | 0.5 | |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0656 | 1 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0656 | 1 | 0.5 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0656 | 1 | 0.5 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0656 | 1 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0656 | 1 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0656 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0656 | 1 | 0.5 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0656 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 76.4 uM | Inhibition of human dopamine D3 receptor | ChEMBL. | 25221667 |
IC50 (binding) | > 100 uM | Inhibition of human dopamine D1 receptor | ChEMBL. | 25221667 |
IC50 (binding) | > 100 uM | Inhibition of human dopamine D2 receptor | ChEMBL. | 25221667 |
IC50 (binding) | > 100 uM | Inhibition of human dopamine D4 receptor | ChEMBL. | 25221667 |
Ki (binding) | = 25.9 uM | Inhibition of human dopamine D3 receptor | ChEMBL. | 25221667 |
Ki (binding) | > 100 uM | Inhibition of human dopamine D1 receptor | ChEMBL. | 25221667 |
Ki (binding) | > 100 uM | Inhibition of human dopamine D2 receptor | ChEMBL. | 25221667 |
Ki (binding) | > 100 uM | Inhibition of human dopamine D4 receptor | ChEMBL. | 25221667 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.