Detailed information for compound 931229

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1983.47 | Formula: C90H147N23O21S3
  • H donors: 20 H acceptors: 21 LogP: -1.97 Rotable bonds: 50
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N)CCC(=O)O)NC(=O)[C@@H]1CSSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)C)NC(=O)C)CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N2[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)Cc1ccccc1)CO)C)CCC2)CCCCC
  • InChi: 1S/C90H147N23O21S3/c1-9-10-12-27-61-86(131)110-41-20-30-67(110)83(128)97-53(6)74(119)108-65(49-114)81(126)107-64(48-55-24-13-11-14-25-55)80(125)109-66(82(127)105-62(28-16-18-39-92)87(132)113-44-23-33-70(113)88(133)111-42-21-31-68(111)84(129)99-56(73(93)118)34-35-71(116)117)50-137-136-46-37-60(102-77(122)59(36-45-135-8)103-85(130)69-32-22-43-112(69)89(134)72(52(4)5)98-54(7)115)78(123)106-63(47-51(2)3)79(124)101-58(29-19-40-96-90(94)95)75(120)100-57(76(121)104-61)26-15-17-38-91/h11,13-14,24-25,51-53,56-70,72,114H,9-10,12,15-23,26-50,91-92H2,1-8H3,(H2,93,118)(H,97,128)(H,98,115)(H,99,129)(H,100,120)(H,101,124)(H,102,122)(H,103,130)(H,104,121)(H,105,127)(H,106,123)(H,107,126)(H,108,119)(H,109,125)(H,116,117)(H4,94,95,96)/t53-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,72-/m0/s1
  • InChiKey: FMFQQQHCFDLITQ-GOLAZCNBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei RNA helicase, putative 0.0135 0.0738 0.3594
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0187 0.11 0.1615
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0005 0.0008
Echinococcus multilocularis serine:threonine protein kinase N2 0.0462 0.3028 0.3028
Loa Loa (eye worm) hypothetical protein 0.0181 0.1062 0.1559
Entamoeba histolytica diacylglycerol kinase, putative 0.0181 0.1062 0.5412
Echinococcus multilocularis serine:threonine protein kinase N2 0.0256 0.1588 0.1588
Echinococcus granulosus protein kinase c eta type 0.0181 0.1062 0.1062
Trypanosoma cruzi Aph-1 protein, putative 0.0322 0.2053 1
Onchocerca volvulus 0.0686 0.4602 1
Echinococcus granulosus jumonji domain containing protein 0.0043 0.009 0.009
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0187 0.11 0.1615
Echinococcus granulosus unc 13 munc13 0.0211 0.1271 0.1271
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0256 0.1588 0.1588
Schistosoma mansoni hypothetical protein 0.0119 0.0622 0.0622
Trichomonas vaginalis AGC family protein kinase 0.0256 0.1588 0.8097
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0256 0.1588 0.1588
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0256 0.1588 0.2332
Echinococcus granulosus lipoxygenase domain containing protein 0.0119 0.0622 0.0622
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.1588 0.1588
Schistosoma mansoni loxhd1 0.0119 0.0622 0.0622
Toxoplasma gondii diacylglycerol kinase, putative 0.0181 0.1062 0.6684
Trypanosoma cruzi Aph-1 protein, putative 0.0322 0.2053 1
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0211 0.1271 0.1271
Brugia malayi diacylglycerol kinase 0.0181 0.1062 0.1504
Echinococcus granulosus geminin 0.0179 0.1049 0.1049
Brugia malayi Protein kinase domain containing protein 0.0256 0.1588 0.225
Brugia malayi RhoGAP domain containing protein 0.0181 0.1062 0.1504
Leishmania major hypothetical protein, conserved 0.003 0 0.5
Echinococcus multilocularis raf serine:threonine protein kinase 0.0181 0.1062 0.1062
Loa Loa (eye worm) hypothetical protein 0.0087 0.0404 0.0593
Loa Loa (eye worm) hypothetical protein 0.0181 0.1062 0.1559
Brugia malayi Protein kinase c protein 2 0.1036 0.706 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0239 0.0239
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0165 0.0948 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0063 0.0092
Echinococcus multilocularis lipoxygenase domain containing protein 0.0119 0.0622 0.0622
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0256 0.1588 0.2332
Leishmania major hypothetical protein, conserved 0.003 0 0.5
Brugia malayi Ras association domain family 1 isoform A 0.0181 0.1062 0.1504
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0181 0.1062 0.1559
Brugia malayi Protein kinase domain containing protein 0.0256 0.1588 0.225
Brugia malayi Pleckstrin Homology Domain 0.0181 0.1062 0.1504
Leishmania major hypothetical protein, conserved 0.003 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0181 0.1062 0.1559
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0165 0.0948 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0211 0.127 0.127
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0063 0.0063
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.0494 0.0494
Echinococcus granulosus myotubularin protein 13 0.0181 0.1062 0.1062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.1962 1
Brugia malayi jmjC domain containing protein 0.0039 0.0063 0.0089
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0165 0.0948 0.5966
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0087 0.0404 0.206
Schistosoma mansoni serine/threonine kinase 0.0256 0.1588 0.1588
Toxoplasma gondii hypothetical protein 0.0057 0.0189 0.1192
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.11 0.11
Trichomonas vaginalis AGC family protein kinase 0.0256 0.1588 0.8097
Loa Loa (eye worm) hypothetical protein 0.0211 0.1271 0.1866
Loa Loa (eye worm) AGC/NDR protein kinase 0.0256 0.1588 0.2332
Plasmodium falciparum LCCL domain-containing protein 0.0119 0.0622 0.6566
Leishmania major c2 domain protein, putative 0.003 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0686 0.4602 0.6756
Loa Loa (eye worm) hypothetical protein 0.0867 0.5873 0.8622
Echinococcus granulosus protein kinase c epsilon type 0.0673 0.4509 0.4509
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0002 0.0003
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0181 0.1062 0.1062
Loa Loa (eye worm) hypothetical protein 0.0052 0.0159 0.0233
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0005 0.0034
Leishmania major hypothetical protein, conserved 0.003 0 0.5
Echinococcus granulosus cpg binding protein 0.0032 0.0014 0.0014
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0256 0.1588 0.1588
Entamoeba histolytica diacylglycerol kinase, putative 0.0181 0.1062 0.5412
Giardia lamblia Fructose-bisphosphate aldolase 0.0309 0.1962 1
Schistosoma mansoni diacylglycerol kinase theta 0.0181 0.1062 0.1062
Loa Loa (eye worm) hypothetical protein 0.0181 0.1062 0.1559
Echinococcus granulosus protein kinase c iota type 0.0437 0.2859 0.2859
Loa Loa (eye worm) hypothetical protein 0.082 0.5541 0.8134
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0165 0.0948 0.5
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0187 0.11 0.1559
Brugia malayi RhoGAP domain containing protein 0.0181 0.1062 0.1504
Schistosoma mansoni microtubule-associated protein tau 0.1455 1 1
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0251 0.155 0.7899
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0309 0.1962 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.1287 0.8819 0.8819
Echinococcus granulosus Polycystic kidney disease protein 0.0119 0.0622 0.0622
Echinococcus granulosus Rac GTPase activating protein 1 0.0181 0.1062 0.1062
Brugia malayi jmjC domain containing protein 0.01 0.0494 0.07
Schistosoma mansoni vav2 0.0181 0.1062 0.1062
Brugia malayi Doublecortin family protein 0.0119 0.0622 0.0881
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0057 0.0189 0.1998
Loa Loa (eye worm) hypothetical protein 0.0181 0.1062 0.1559
Loa Loa (eye worm) AGC/PKN protein kinase 0.0256 0.1588 0.2332
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0151 0.0851 1
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0256 0.1588 0.1588
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0709 0.4765 0.4765
Trypanosoma brucei rac serine-threonine kinase, putative 0.0256 0.1588 0.7737
Echinococcus multilocularis unc 13 (munc13) 0.0211 0.1271 0.1271
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.11 0.11
Brugia malayi Bromodomain containing protein 0.0031 0.0005 0.0008
Toxoplasma gondii AGC kinase 0.0256 0.1588 1
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0181 0.1062 0.1559
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0057 0.0189 0.1998
Schistosoma mansoni serine/threonine protein kinase 0.129 0.884 0.884
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0709 0.4765 0.4765
Schistosoma mansoni rab6-interacting 0.0119 0.0622 0.0622
Loa Loa (eye worm) hypothetical protein 0.0942 0.64 0.9395
Brugia malayi protein kinase C3,putative 0.0187 0.11 0.1559
Loa Loa (eye worm) hypothetical protein 0.0119 0.0622 0.0913
Brugia malayi CXXC zinc finger family protein 0.003 0.0002 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.1962 1
Loa Loa (eye worm) hypothetical protein 0.1001 0.6812 1
Schistosoma mansoni gamma-secretase subunit aph-1 0.0828 0.5596 0.5596
Loa Loa (eye worm) hypothetical protein 0.0181 0.1062 0.1559
Loa Loa (eye worm) hypothetical protein 0.0181 0.1062 0.1559
Echinococcus multilocularis geminin 0.0179 0.1049 0.1049
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.009 0.009
Loa Loa (eye worm) doublecortin family protein 0.0119 0.0622 0.0913
Plasmodium falciparum phd finger protein, putative 0.0031 0.0005 0.0058
Echinococcus multilocularis protein kinase c iota type 0.0437 0.2859 0.2859
Onchocerca volvulus 0.0119 0.0622 0.1352
Entamoeba histolytica protein kinase, putative 0.0035 0.0039 0.0198
Treponema pallidum fructose-bisphosphate aldolase 0.0309 0.1962 1
Onchocerca volvulus 0.0211 0.1271 0.2762
Echinococcus granulosus gamma secretase subunit aph 1 0.0828 0.5596 0.5596
Onchocerca volvulus 0.0181 0.1062 0.2307
Schistosoma mansoni cpg binding protein 0.003 0.0002 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.1962 1
Schistosoma mansoni rac gtpase activating protein 0.0181 0.1062 0.1062
Brugia malayi hypothetical protein 0.0119 0.0622 0.0881
Loa Loa (eye worm) hypothetical protein 0.0119 0.0622 0.0913
Brugia malayi Protein kinase domain containing protein 0.0187 0.11 0.1559
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0005 0.0058
Schistosoma mansoni serine/threonine protein kinase 0.1287 0.8819 0.8819
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0256 0.1588 0.1588
Brugia malayi protein kinase C II. 0.0673 0.4509 0.6386
Echinococcus multilocularis peptidase Clp (S14 family) 0.0108 0.0549 0.0549
Echinococcus multilocularis protein kinase c eta type 0.0181 0.1062 0.1062
Onchocerca volvulus 0.0119 0.0622 0.1352
Leishmania major hypothetical protein, conserved 0.003 0 0.5
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0192 0.1206
Echinococcus multilocularis lipoxygenase domain containing protein 0.0119 0.0622 0.0622
Schistosoma mansoni protein kinase C mu 0.0181 0.1062 0.1062
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0005 0.0005
Echinococcus granulosus N chimaerin 0.0181 0.1062 0.1062
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0256 0.1588 0.2332
Loa Loa (eye worm) AGC/AKT protein kinase 0.0256 0.1588 0.2332
Brugia malayi hypothetical protein 0.0119 0.0622 0.0881
Brugia malayi gamma-secretase subunit aph-1 0.0828 0.5596 0.7927
Echinococcus multilocularis serine:threonine protein kinase 38 0.0256 0.1588 0.1588
Brugia malayi Hr1 repeat family protein 0.0256 0.1588 0.225
Brugia malayi C1-like domain containing protein 0.0187 0.11 0.1559
Schistosoma mansoni diacylglycerol kinase theta 0.0181 0.1062 0.1062
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.1588 0.1588
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.1588 0.1588
Plasmodium vivax multidomain scavenger receptor, putative 0.0119 0.0622 0.6566
Trichomonas vaginalis AGC family protein kinase 0.0256 0.1588 0.8097
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0211 0.1271 0.1271
Brugia malayi Variant SH3 domain containing protein 0.0181 0.1062 0.1504
Echinococcus multilocularis RNA directed DNA polymerase 0.0823 0.5562 0.5562
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0181 0.1062 0.1062
Schistosoma mansoni serine/threonine protein kinase 0.0673 0.4509 0.4509
Echinococcus granulosus serine:threonine protein kinase N2 0.0256 0.1588 0.1588
Schistosoma mansoni rab6-interacting 0.0119 0.0622 0.0622
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0181 0.1062 0.1559
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.1962 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0165 0.0948 0.0948
Entamoeba histolytica protein kinase, putative 0.0035 0.0039 0.0198
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0165 0.0948 0.5966
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0005 0.0005
Onchocerca volvulus 0.003 0.0002 0.0005
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0063 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0256 0.1588 0.8097
Echinococcus multilocularis serine threonine protein kinase 0.1106 0.7548 0.7548
Loa Loa (eye worm) hypothetical protein 0.0686 0.4602 0.6756
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0108 0.0549 0.4744
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0051 0.0051
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0165 0.0948 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0256 0.1588 0.2332
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0673 0.4509 0.6619
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0234 0.0344
Schistosoma mansoni hypothetical protein 0.0179 0.1049 0.1049
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.0494 0.0494
Onchocerca volvulus Alhambra homolog 0.0031 0.0005 0.0012
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0165 0.0948 0.0948
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0165 0.0948 0.5
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0087 0.0404 0.206
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0187 0.11 0.11
Brugia malayi RhoGEF domain containing protein 0.0181 0.1062 0.1504
Echinococcus multilocularis cpg binding protein 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0031 0.0005 0.0008
Echinococcus multilocularis Diacylglycerol kinase theta 0.0181 0.1062 0.1062
Schistosoma mansoni unc-13 (munc13) 0.0211 0.1271 0.1271
Loa Loa (eye worm) RasGEF domain-containing protein 0.0181 0.1062 0.1559
Echinococcus multilocularis N chimaerin 0.0181 0.1062 0.1062
Echinococcus granulosus peptidase Clp S14 family 0.0108 0.0549 0.0549
Schistosoma mansoni lipoxygenase 0.0496 0.3268 0.3268
Schistosoma mansoni atypical protein kinase C 0.0437 0.2859 0.2859
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0256 0.1588 0.1588
Echinococcus multilocularis microtubule associated protein 2 0.1455 1 1
Echinococcus granulosus raf serine:threonine protein kinase 0.0181 0.1062 0.1062
Schistosoma mansoni polycystin 1-related 0.0119 0.0622 0.0622
Schistosoma mansoni cpg binding protein 0.0032 0.0014 0.0014
Schistosoma mansoni jumonji domain containing protein 0.008 0.035 0.035
Trichomonas vaginalis AGC family protein kinase 0.0256 0.1588 0.8097
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0063 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0256 0.1588 0.8097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.1962 1
Schistosoma mansoni hypothetical protein 0.0135 0.0738 0.0738
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0005 0.0005
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0151 0.0851 0.8728
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0165 0.0948 1
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0855 0.5789 0.8498
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0187 0.11 0.11
Entamoeba histolytica protein kinase, putative 0.0256 0.1588 0.8097
Leishmania major copine i-like protein 0.003 0 0.5
Brugia malayi Probable ClpP-like protease 0.0165 0.0948 0.1342
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0005 0.0034
Loa Loa (eye worm) raf kinase 0.0181 0.1062 0.1559
Echinococcus multilocularis myotubularin protein 13 0.0181 0.1062 0.1062
Echinococcus multilocularis Polycystic kidney disease protein 0.0119 0.0622 0.0622
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0165 0.0948 0.0948
Echinococcus multilocularis gamma secretase subunit aph 1 0.0828 0.5596 0.5596
Echinococcus granulosus protein kinase C gamma type 0.1106 0.7548 0.7548
Leishmania major phospholipase c-like protein 0.003 0 0.5
Entamoeba histolytica protein kinase, putative 0.0256 0.1588 0.8097
Schistosoma mansoni unc-13 (munc13) 0.0211 0.1271 0.1271
Brugia malayi p70 ribosomal S6 kinase beta 0.0256 0.1588 0.225
Leishmania major hypothetical protein, conserved 0.003 0 0.5
Trichomonas vaginalis AGC family protein kinase 0.0256 0.1588 0.8097
Brugia malayi diacylglycerol kinase 0.0181 0.1062 0.1504
Schistosoma mansoni serine/threonine protein kinase 0.0181 0.1062 0.1062
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0823 0.5562 0.5562
Echinococcus multilocularis peregrin 0.0031 0.0005 0.0005
Schistosoma mansoni protein kinase C mu 0.0187 0.11 0.11
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0181 0.1062 0.1062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.1962 1
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0828 0.5596 0.8215
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0309 0.1962 1
Trypanosoma brucei Aph-1 protein, putative 0.0322 0.2053 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.1962 1
Trichomonas vaginalis AGC family protein kinase 0.0256 0.1588 0.8097
Echinococcus multilocularis Rac GTPase activating protein 1 0.0181 0.1062 0.1062
Leishmania major c2 domain protein, putative 0.003 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0181 0.1062 0.1559
Schistosoma mansoni lipoxygenase 0.0709 0.4765 0.4765
Echinococcus granulosus RNA directed DNA polymerase 0.0823 0.5562 0.5562
Entamoeba histolytica protein kinase, putative 0.0256 0.1588 0.8097
Trichomonas vaginalis AGC family protein kinase 0.0256 0.1588 0.8097
Echinococcus granulosus RUN 0.0119 0.0622 0.0622
Echinococcus multilocularis RUN 0.0119 0.0622 0.0622
Trichomonas vaginalis AGC family protein kinase 0.0256 0.1588 0.8097
Schistosoma mansoni hypothetical protein 0.0031 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0181 0.1062 0.1062
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0181 0.1062 0.1062
Echinococcus granulosus lipoxygenase domain containing protein 0.0119 0.0622 0.0622
Leishmania major hypothetical protein, conserved 0.003 0 0.5
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0165 0.0948 0.5
Brugia malayi PHD-finger family protein 0.0031 0.0005 0.0008
Echinococcus granulosus peregrin 0.0031 0.0005 0.0005
Entamoeba histolytica protein kinase, putative 0.0256 0.1588 0.8097
Entamoeba histolytica PH domain containing protein kinase, putative 0.0211 0.127 0.6472
Echinococcus granulosus NDR protein kinase 0.0256 0.1588 0.1588
Entamoeba histolytica hypothetical protein 0.0181 0.1062 0.5412
Leishmania major hypothetical protein, conserved 0.003 0 0.5
Onchocerca volvulus 0.0181 0.1062 0.2307
Loa Loa (eye worm) hypothetical protein 0.0165 0.0948 0.1391
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0165 0.0948 0.4279
Echinococcus multilocularis protein kinase c epsilon type 0.0673 0.4509 0.4509
Brugia malayi Protein kinase domain containing protein 0.0256 0.1588 0.225
Schistosoma mansoni cpg binding protein 0.0032 0.0014 0.0014
Schistosoma mansoni protein kinase C 0.0211 0.1271 0.1271
Echinococcus granulosus Protein kinase C brain isozyme 0.1287 0.8819 0.8819
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.1588 0.1588
Loa Loa (eye worm) hypothetical protein 0.0686 0.4602 0.6756
Schistosoma mansoni hypothetical protein 0.0179 0.1049 0.1049
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0165 0.0948 1
Echinococcus granulosus Diacylglycerol kinase theta 0.0181 0.1062 0.1062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.1962 1
Trichomonas vaginalis AGC family protein kinase 0.0256 0.1588 0.8097
Loa Loa (eye worm) hypothetical protein 0.0181 0.1062 0.1559

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.