Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2381 | 0.745 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.043 | 0.1067 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2381 | 0.745 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0904 | 0.2617 | 0.2617 |
Schistosoma mansoni | P2X receptor subunit | 0.0288 | 0.0603 | 0.0603 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0288 | 0.0603 | 0.0603 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0288 | 0.0603 | 0.0603 |
Echinococcus granulosus | thymidylate synthase | 0.0904 | 0.2617 | 0.2617 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3161 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0288 | 0.0603 | 0.0603 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.2381 | 0.745 | 0.5 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0288 | 0.0603 | 0.0603 |
Schistosoma mansoni | P2X receptor subunit | 0.0288 | 0.0603 | 0.0603 |
Brugia malayi | thymidylate synthase | 0.0904 | 0.2617 | 0.2617 |
Schistosoma mansoni | P2X receptor subunit | 0.0288 | 0.0603 | 0.0603 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0288 | 0.0603 | 0.0603 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3161 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.3161 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0904 | 0.2617 | 0.2617 |
Schistosoma mansoni | P2X receptor subunit | 0.0288 | 0.0603 | 0.0603 |
Brugia malayi | hypothetical protein | 0.043 | 0.1067 | 0.1067 |
Brugia malayi | Dihydrofolate reductase | 0.3161 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0904 | 0.2617 | 0.2617 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3161 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3161 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.3161 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3161 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2381 | 0.745 | 0.5 |
Onchocerca volvulus | 0.0904 | 0.2617 | 1 | |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0904 | 0.2617 | 0.1735 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3161 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0288 | 0.0603 | 0.0603 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2381 | 0.745 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2381 | 0.745 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 39 % | Binding affinity to DRAK2 (unknown origin) ATP site at 10 uM relative to control | ChEMBL. | 25178155 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.