TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 397.491 | Formula: C21H23N3O3S
H donors: 1 H acceptors: 3 LogP: 4.75 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1OC)c1cnc2c(c1)c(ns2)NC(=O)C1CCCCC1
InChi: 1S/C21H23N3O3S/c1-26-17-9-8-14(11-18(17)27-2)15-10-16-19(24-28-21(16)22-12-15)23-20(25)13-6-4-3-5-7-13/h8-13H,3-7H2,1-2H3,(H,23,24,25)
InChiKey: AYOYQYCMTQUYJP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	serine/threonine kinase 17b	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	protein lipid droplet kinase (LDK)	serine/threonine kinase 17b	372 aa	342 aa	23.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.1053	1
Brugia malayi	tailless protein	0.0039	0.1381	0.2599
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0039	0.1381	0.2599
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.1053	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0083	0.5315	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0044	0.1802	0.3391
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0039	0.1381	0.0771
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0044	0.1802	0.3391
Brugia malayi	Cathepsin L-like precursor	0.0035	0.1053	0.1981
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.1053	1
Schistosoma mansoni	zinc finger protein	0.0039	0.1381	0.2599
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	1	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0083	0.5315	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0035	0.1053	0.1981
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0035	0.1053	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0083	0.5315	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0083	0.5315	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.1053	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0083	0.5315	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0135	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0035	0.1053	1
Brugia malayi	hypothetical protein	0.0039	0.1381	0.2599
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.1053	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0083	0.5315	1
Brugia malayi	Nuclear hormone receptor E75	0.0039	0.1381	0.2599
Loa Loa (eye worm)	hypothetical protein	0.0083	0.5315	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0083	0.5315	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	1	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0039	0.1381	0.2599
Brugia malayi	hypothetical protein	0.0044	0.1802	0.3391
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0083	0.5315	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.1053	1
Brugia malayi	hypothetical protein	0.0044	0.1802	0.3391
Loa Loa (eye worm)	hypothetical protein	0.0044	0.1802	0.3391
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0083	0.5315	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0083	0.5315	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0035	0.1053	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	1	0.5
Echinococcus multilocularis	nuclear receptor nhr 48	0.0039	0.1381	0.0771
Schistosoma mansoni	nuclear hormone receptor	0.0039	0.1381	0.2599
Onchocerca volvulus		0.0035	0.1053	0.1981
Echinococcus multilocularis	FTZ F1 alpha	0.0083	0.5315	1
Onchocerca volvulus	Cathepsin F homolog	0.0035	0.1053	0.1981
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0083	0.5315	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.1053	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	1	0.5
Onchocerca volvulus		0.0035	0.1053	0.1981
Brugia malayi	Cathepsin L-like precursor	0.0035	0.1053	0.1981
Brugia malayi	Cathepsin L-like precursor	0.0035	0.1053	0.1981
Onchocerca volvulus		0.0035	0.1053	0.1981
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0083	0.5315	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0083	0.5315	1
Onchocerca volvulus	Bile acid receptor homolog	0.0083	0.5315	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0039	0.1381	0.2599
Loa Loa (eye worm)	hypothetical protein	0.0083	0.5315	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1381	0.2599
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1381	0.2599
Brugia malayi	orphan nuclear receptor NR2E1	0.0039	0.1381	0.2599
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1381	0.2599
Schistosoma mansoni	RAR-like nuclear receptor	0.0083	0.5315	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.1053	1
Loa Loa (eye worm)	DR-78	0.0039	0.1381	0.2599
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.1053	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.5315	1
Leishmania major	cathepsin L-like protease	0.0135	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0123	0.8947	0.8824
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	1	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0083	0.5315	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.1053	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0039	0.1381	0.2599
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0039	0.1381	0.0771
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0083	0.5315	1
Entamoeba histolytica	cysteine proteinase, putative	0.0035	0.1053	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0083	0.5315	1
Brugia malayi	nuclear receptor NHR-67	0.0039	0.1381	0.2599
Brugia malayi	conserved hypotetical protein	0.0039	0.1381	0.2599
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0039	0.1381	0.2599
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0083	0.5315	1
Brugia malayi	nuclear receptor NHR-88	0.0083	0.5315	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0035	0.1053	0.1981
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0083	0.5315	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0039	0.1381	0.2599
Onchocerca volvulus		0.0035	0.1053	0.1981
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1381	0.2599
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0039	0.1381	0.2599
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.1053	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0039	0.1381	0.0771
Brugia malayi	Steroid receptor seven-up type 2	0.0083	0.5315	1
Brugia malayi	Cathepsin L-like precursor	0.0035	0.1053	0.1981
Brugia malayi	nuclear hormone receptor	0.0083	0.5315	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.1053	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0083	0.5315	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0035	0.1053	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0083	0.5315	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0044	0.1802	0.3391
Onchocerca volvulus		0.0035	0.1053	0.1981
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1381	0.2599
Leishmania major	cathepsin L-like protease	0.0135	1	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0039	0.1381	0.2599
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.1053	1
Schistosoma mansoni	nuclear hormone receptor	0.0083	0.5315	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0106	0.7404	0.7098
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0039	0.1381	0.2599
Onchocerca volvulus		0.0039	0.1381	0.2599
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1381	0.2599
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0083	0.5315	1
Loa Loa (eye worm)	fibroinase	0.0035	0.1053	0.1981
Onchocerca volvulus		0.0039	0.1381	0.2599
Brugia malayi	nuclear hormone receptor	0.0039	0.1381	0.2599
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0035	0.1053	0.1981
Brugia malayi	hypothetical protein	0.0039	0.1381	0.2599
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1381	0.2599
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0083	0.5315	1
Onchocerca volvulus		0.0035	0.1053	0.1981
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0083	0.5315	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1381	0.2599
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1381	0.2599
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.1053	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0083	0.5315	1
Plasmodium vivax	vivapain-2	0.0035	0.1053	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1053	0.1981
Echinococcus multilocularis	ecdysone induced protein 78C	0.0083	0.5315	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0044	0.1802	0.1759
Plasmodium vivax	vivapain-2	0.0035	0.1053	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.1053	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0039	0.1381	0.2599
Loa Loa (eye worm)	hypothetical protein	0.0083	0.5315	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0083	0.5315	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0039	0.1381	0.2599
Brugia malayi	nuclear receptor RXR	0.0039	0.1381	0.2599
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	1	0.5
Brugia malayi	Cathepsin L-like precursor	0.0035	0.1053	0.1981
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0044	0.1802	0.3391
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.1053	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0083	0.5315	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.1053	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	1	0.5
Loa Loa (eye worm)	ctsf protein	0.0035	0.1053	0.1981
Brugia malayi	ecdysteroid receptor	0.0083	0.5315	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.1053	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.5315	1
Brugia malayi	nuclear receptor NHR-88	0.0039	0.1381	0.2599
Echinococcus granulosus	FTZ F1 alpha	0.0083	0.5315	1
Schistosoma mansoni	thyroid hormone receptor	0.0083	0.5315	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0135	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0083	0.5315	1
Echinococcus granulosus	cathepsin l1	0.0035	0.1053	0.1981
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0083	0.5315	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0083	0.5315	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0083	0.5315	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0135	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0035	0.1053	0.5
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1381	0.2599
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0083	0.5315	1
Brugia malayi	steroid hormone receptor	0.0083	0.5315	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1381	0.2599
Schistosoma mansoni	nuclear receptor nhr-48	0.0039	0.1381	0.2599
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.1053	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	1	0.5
Brugia malayi	ecdysone receptor	0.0039	0.1381	0.2599
Schistosoma mansoni	nuclear receptor	0.0039	0.1381	0.2599
Entamoeba histolytica	cysteine protease, putative	0.0035	0.1053	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0083	0.5315	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0035	0.1053	0.1981
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0035	0.1053	0.1981
Loa Loa (eye worm)	hypothetical protein	0.0083	0.5315	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0039	0.1381	0.0771
Brugia malayi	Papain family cysteine protease containing protein	0.0035	0.1053	0.1981
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0083	0.5315	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0083	0.5315	1
Onchocerca volvulus		0.0035	0.1053	0.1981
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0039	0.1381	0.2599
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.1053	1
Schistosoma mansoni	nuclear receptor	0.0039	0.1381	0.2599
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1381	0.2599
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0039	0.1381	0.2599
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0083	0.5315	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.1802	0.3391
Trypanosoma cruzi	cruzipain precursor, putative	0.0135	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0083	0.5315	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.1053	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0083	0.5315	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0035	0.1053	0.1981
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0083	0.5315	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	1	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0083	0.5315	1
Loa Loa (eye worm)	steroid hormone receptor	0.0083	0.5315	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.1802	0.3391
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0083	0.5315	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0083	0.5315	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0083	0.5315	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0083	0.5315	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0044	0.1802	0.3391
Brugia malayi	nuclear receptor RXR	0.0044	0.1802	0.3391
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0083	0.5315	1
Brugia malayi	Nuclear hormone receptor E75	0.0039	0.1381	0.2599
Echinococcus granulosus	ecdysone induced protein 78C	0.0083	0.5315	1
Onchocerca volvulus	Cathepsin L homolog	0.0035	0.1053	0.1981
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.1053	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0083	0.5315	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0083	0.5315	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0039	0.1381	0.2599
Schistosoma mansoni	coup transcription factor	0.0083	0.5315	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0039	0.1381	0.2599
Loa Loa (eye worm)	hypothetical protein	0.0083	0.5315	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.1053	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.1802	0.3391
Toxoplasma gondii	cathepsin CPL	0.0035	0.1053	0.5
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1381	0.2599
Brugia malayi	Nuclear hormone receptor-like 1	0.0083	0.5315	1
Onchocerca volvulus	Cathepsin L homolog	0.0035	0.1053	0.1981
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0083	0.5315	1
Loa Loa (eye worm)	cysteine protease	0.0035	0.1053	0.1981
Loa Loa (eye worm)	hypothetical protein	0.0044	0.1802	0.3391
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0039	0.1381	0.0771
Brugia malayi	Cathepsin L-like precursor	0.0035	0.1053	0.1981
Onchocerca volvulus		0.0083	0.5315	1
Entamoeba histolytica	cysteine proteinase, putative	0.0035	0.1053	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0044	0.1802	0.3391
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0039	0.1381	0.2599
Echinococcus granulosus	nuclear receptor nhr 48	0.0039	0.1381	0.2599

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 5.9 %	Binding affinity to DRAK2 (unknown origin) ATP site at 10 uM relative to control	ChEMBL.	25178155
Kd (binding)	= 1.6 uM	Binding affinity to DRAK2 (unknown origin) ATP site	ChEMBL.	25178155

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3334955

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 931504