Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | p2X purinoceptor 4 | 0.0288 | 0.0603 | 0.0603 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0288 | 0.0603 | 0.0603 |
Schistosoma mansoni | P2X receptor subunit | 0.0288 | 0.0603 | 0.0603 |
Echinococcus multilocularis | thymidylate synthase | 0.0904 | 0.2617 | 0.2617 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2381 | 0.745 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.043 | 0.1067 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2381 | 0.745 | 0.5 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0288 | 0.0603 | 0.0603 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3161 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0904 | 0.2617 | 0.2617 |
Brugia malayi | thymidylate synthase | 0.0904 | 0.2617 | 0.2617 |
Schistosoma mansoni | P2X receptor subunit | 0.0288 | 0.0603 | 0.0603 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0288 | 0.0603 | 0.0603 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.2381 | 0.745 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0904 | 0.2617 | 0.2617 |
Schistosoma mansoni | dihydrofolate reductase | 0.3161 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3161 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0288 | 0.0603 | 0.0603 |
Schistosoma mansoni | P2X receptor subunit | 0.0288 | 0.0603 | 0.0603 |
Brugia malayi | Dihydrofolate reductase | 0.3161 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.043 | 0.1067 | 0.1067 |
Schistosoma mansoni | P2X receptor subunit | 0.0288 | 0.0603 | 0.0603 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3161 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.3161 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3161 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0904 | 0.2617 | 0.2617 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3161 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0904 | 0.2617 | 0.1735 |
Onchocerca volvulus | 0.0904 | 0.2617 | 1 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2381 | 0.745 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2381 | 0.745 | 0.5 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0288 | 0.0603 | 0.0603 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2381 | 0.745 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3161 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 42 % | Binding affinity to DRAK2 (unknown origin) ATP site at 10 uM relative to control | ChEMBL. | 25178155 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.