Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Vasopressin V2 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Oxytocin receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Vasopressin V1a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | allatostatin A receptor | Oxytocin receptor | 388 aa | 313 aa | 23.6 % |
Onchocerca volvulus | Oxytocin receptor | 388 aa | 327 aa | 23.9 % | |
Echinococcus granulosus | orexin receptor type 2 | Oxytocin receptor | 388 aa | 338 aa | 24.3 % |
Echinococcus multilocularis | orexin receptor type 2 | Oxytocin receptor | 388 aa | 332 aa | 23.2 % |
Loa Loa (eye worm) | hypothetical protein | Vasopressin V1a receptor | 424 aa | 382 aa | 22.8 % |
Schistosoma mansoni | adenoreceptor | Vasopressin V2 receptor | 371 aa | 317 aa | 26.2 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Oxytocin receptor | 388 aa | 327 aa | 19.3 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Oxytocin receptor | 388 aa | 323 aa | 21.7 % |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Vasopressin V2 receptor | 371 aa | 310 aa | 20.3 % |
Echinococcus multilocularis | neuropeptide receptor | Oxytocin receptor | 388 aa | 324 aa | 21.6 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Oxytocin receptor | 388 aa | 346 aa | 24.0 % |
Onchocerca volvulus | Vasopressin V2 receptor | 371 aa | 315 aa | 22.5 % | |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Vasopressin V1a receptor | 424 aa | 400 aa | 21.8 % |
Onchocerca volvulus | Vasopressin V1a receptor | 424 aa | 378 aa | 21.4 % | |
Brugia malayi | GnHR receptor homolog | Vasopressin V2 receptor | 371 aa | 304 aa | 22.4 % |
Onchocerca volvulus | Vasopressin V1a receptor | 424 aa | 347 aa | 21.9 % | |
Schistosoma mansoni | biogenic amine (5HT) receptor | Vasopressin V2 receptor | 371 aa | 357 aa | 21.6 % |
Onchocerca volvulus | Vasopressin V2 receptor | 371 aa | 331 aa | 21.4 % | |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Oxytocin receptor | 388 aa | 349 aa | 22.9 % |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Vasopressin V2 receptor | 371 aa | 314 aa | 21.3 % |
Echinococcus multilocularis | allatostatin A receptor | Oxytocin receptor | 388 aa | 311 aa | 21.9 % |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | Vasopressin V2 receptor | 371 aa | 382 aa | 22.5 % |
Echinococcus granulosus | neuropeptide receptor | Oxytocin receptor | 388 aa | 324 aa | 21.9 % |
Onchocerca volvulus | Phospholipase d-related homolog | Oxytocin receptor | 388 aa | 330 aa | 20.0 % |
Echinococcus multilocularis | rhodopsin orphan GPCR | Vasopressin V1a receptor | 424 aa | 370 aa | 21.9 % |
Echinococcus multilocularis | neuropeptides capa receptor | Vasopressin V1a receptor | 424 aa | 462 aa | 19.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutamate receptor | 0.0176 | 0.2142 | 0.2142 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.6837 | 0.6837 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.6837 | 0.6837 |
Schistosoma mansoni | peroxidasin | 0.0404 | 0.6837 | 0.7567 |
Schistosoma mansoni | peroxidasin | 0.0404 | 0.6837 | 0.7567 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0404 | 0.6837 | 0.6837 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0404 | 0.6837 | 0.6837 |
Brugia malayi | Animal haem peroxidase family protein | 0.0404 | 0.6837 | 0.8701 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0453 | 0.7858 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0404 | 0.6837 | 0.8701 |
Onchocerca volvulus | 0.0404 | 0.6837 | 1 | |
Onchocerca volvulus | Peroxidase homolog | 0.0404 | 0.6837 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0404 | 0.6837 | 0.6837 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.6837 | 0.6837 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0964 | 0.0964 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0557 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0404 | 0.6837 | 0.8701 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.051 | 0.9036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.6837 | 0.6837 |
Brugia malayi | Animal haem peroxidase family protein | 0.0404 | 0.6837 | 0.8701 |
Onchocerca volvulus | Peroxidasin homolog | 0.0404 | 0.6837 | 1 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0119 | 0.0964 | 0.0964 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0404 | 0.6837 | 0.6837 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.6837 | 0.6837 |
Onchocerca volvulus | 0.0404 | 0.6837 | 1 | |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.038 | 0.6353 | 0.6353 |
Brugia malayi | Animal haem peroxidase family protein | 0.0404 | 0.6837 | 0.8701 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.6837 | 0.6837 |
Onchocerca volvulus | Peroxidasin homolog | 0.0404 | 0.6837 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0557 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.6837 | 0.6837 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0119 | 0.0964 | 0.1227 |
Brugia malayi | Animal haem peroxidase family protein | 0.0404 | 0.6837 | 0.8701 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0223 | 0.3106 | 0.3953 |
Loa Loa (eye worm) | glutamate receptor | 0.0453 | 0.7858 | 0.7858 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.6837 | 0.6837 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.038 | 0.6353 | 0.6353 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0406 | 0.6894 | 0.8773 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.6837 | 0.6837 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0119 | 0.0964 | 0.0964 |
Echinococcus granulosus | peroxidasin | 0.0404 | 0.6837 | 0.6837 |
Onchocerca volvulus | Peroxidase homolog | 0.0404 | 0.6837 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0404 | 0.6837 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0404 | 0.6837 | 0.6837 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0404 | 0.6837 | 0.6837 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.6837 | 0.6837 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.6837 | 0.6837 |
Onchocerca volvulus | 0.0404 | 0.6837 | 1 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0404 | 0.6837 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.6837 | 0.6837 |
Brugia malayi | Peroxidasin | 0.0404 | 0.6837 | 0.8701 |
Brugia malayi | Animal haem peroxidase family protein | 0.0404 | 0.6837 | 0.8701 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.6837 | 0.6837 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.038 | 0.6353 | 0.7031 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0223 | 0.3106 | 0.3438 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.6837 | 0.6837 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.8 nM | Displacement of [3H]-OT from binding to oxytocin receptor of rat uterus | ChEMBL. | 8126695 |
IC50 (binding) | = 240 nM | Displacement of [3H]-AVP from binding to Vasopressin receptor V2 of rat kidney | ChEMBL. | 8126695 |
IC50 (binding) | = 650 nM | Displacement of [3H]-AVP from binding to arginine vasopressin 1a (V1a) column of rat liver | ChEMBL. | 8126695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.