Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A3 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | Alpha-1A adrenergic receptor, putative | Adenosine A3 receptor | 320 aa | 325 aa | 24.9 % |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 282 aa | 20.6 % | |
Schistosoma mansoni | neuropeptide receptor | Adenosine A3 receptor | 320 aa | 306 aa | 23.5 % |
Echinococcus multilocularis | tachykinin peptides receptor 99D | Adenosine A3 receptor | 320 aa | 297 aa | 26.6 % |
Onchocerca volvulus | Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog | Adenosine A1 receptor | 326 aa | 286 aa | 22.7 % |
Schistosoma mansoni | opsin-like receptor | Adenosine A3 receptor | 320 aa | 300 aa | 22.0 % |
Echinococcus multilocularis | neuropeptide receptor | Adenosine A3 receptor | 320 aa | 282 aa | 24.1 % |
Schistosoma japonicum | 5-hydroxytryptamine receptor 4, putative | Adenosine A3 receptor | 320 aa | 311 aa | 27.3 % |
Loa Loa (eye worm) | hypothetical protein | Adenosine A3 receptor | 320 aa | 309 aa | 24.9 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Adenosine A3 receptor | 320 aa | 296 aa | 27.0 % |
Schistosoma japonicum | ko:K04255 opsin 4 (melanopsin), putative | Adenosine A3 receptor | 320 aa | 370 aa | 21.4 % |
Onchocerca volvulus | Adenosine A2a receptor | 410 aa | 356 aa | 23.9 % | |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Adenosine A2a receptor | 410 aa | 346 aa | 28.3 % |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Adenosine A2a receptor | 410 aa | 342 aa | 23.1 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Adenosine A2a receptor | 410 aa | 340 aa | 27.9 % |
Echinococcus granulosus | allatostatin A receptor | Adenosine A2a receptor | 410 aa | 368 aa | 22.6 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Adenosine A3 receptor | 320 aa | 332 aa | 24.4 % |
Brugia malayi | hypothetical protein | Adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Schistosoma japonicum | Rhodopsin, putative | Adenosine A3 receptor | 320 aa | 320 aa | 23.8 % |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Adenosine A2a receptor | 410 aa | 342 aa | 23.1 % |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 308 aa | 20.5 % | |
Echinococcus granulosus | tachykinin peptides receptor 99D | Adenosine A3 receptor | 320 aa | 297 aa | 26.6 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Adenosine A2a receptor | 410 aa | 399 aa | 28.1 % |
Loa Loa (eye worm) | hypothetical protein | Adenosine A1 receptor | 326 aa | 300 aa | 24.3 % |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 350 aa | 24.9 % | |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Adenosine A2a receptor | 410 aa | 352 aa | 23.6 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Adenosine A2a receptor | 410 aa | 366 aa | 25.4 % |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 311 aa | 23.5 % | |
Echinococcus multilocularis | allatostatin A receptor | Adenosine A2a receptor | 410 aa | 372 aa | 22.8 % |
Schistosoma mansoni | neuropeptide receptor | Adenosine A3 receptor | 320 aa | 286 aa | 21.3 % |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 288 aa | 20.8 % | |
Schistosoma mansoni | adenoreceptor | Adenosine A3 receptor | 320 aa | 319 aa | 27.9 % |
Schistosoma mansoni | opsin-like receptor | Adenosine A3 receptor | 320 aa | 307 aa | 26.4 % |
Schistosoma mansoni | dro/myosuppressin receptor | Adenosine A1 receptor | 326 aa | 326 aa | 22.1 % |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 320 aa | 24.4 % | |
Echinococcus granulosus | neuropeptide receptor | Adenosine A3 receptor | 320 aa | 290 aa | 23.4 % |
Loa Loa (eye worm) | neuropeptide F receptor | Adenosine A3 receptor | 320 aa | 321 aa | 24.0 % |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 295 aa | 23.4 % | |
Onchocerca volvulus | Adenosine A2a receptor | 410 aa | 337 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1613 | 0.5 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.1613 | 0.5 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.1613 | 0.5 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.1613 | 0.5 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.1613 | 0.5 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.1613 | 0.5 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1613 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 18.1 nM | Displacement of specific [125 I]AB-MECA binding at human Adenosine A3 receptor expressed in HEK cells | ChEMBL. | 10052977 |
Ki (binding) | = 495 nM | Displacement of specific [125I]-AB-MECA binding at rat Adenosine A3 receptor stably expressed in CHO cells | ChEMBL. | 10052977 |
Ki (binding) | = 6140 nM | Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal membranes. | ChEMBL. | 10052977 |
Ki (binding) | = 8290 nM | Displacement of specific [3H]-CGS- 21680R-PIA binding to Adenosine A1 receptor in rat brain membranes. | ChEMBL. | 10052977 |
Log Ki (binding) | = 7.74 uM | Displacement of specific [125 I]AB-MECA binding at human Adenosine A3 receptor expressed in HEK cells | ChEMBL. | 10052977 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.