Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/FER protein kinase | 0.0043 | 1 | 1 |
Brugia malayi | SH2 domain containing protein | 0.0043 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0043 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0043 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.0043 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0043 | 1 | 1 |
Echinococcus multilocularis | tyrosine kinase | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0043 | 1 | 1 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0043 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0043 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0043 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0043 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0043 | 1 | 1 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0043 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0043 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0043 | 1 | 1 |
Onchocerca volvulus | 0.0043 | 1 | 1 | |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0043 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0043 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0043 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0043 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0043 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0043 | 1 | 1 |
Brugia malayi | SRC-1 | 0.0043 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0043 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0043 | 1 | 1 |
Onchocerca volvulus | 0.0043 | 1 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0043 | 1 | 1 |
Brugia malayi | SH2 domain containing protein | 0.0043 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0043 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0043 | 1 | 1 |
Echinococcus granulosus | c src tyrosine kinase | 0.0043 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0043 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0043 | 1 | 1 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0043 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0043 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0043 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0043 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0043 | 1 | 1 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0043 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0043 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0043 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0043 | 1 | 1 |
Brugia malayi | protein-tyrosine kinase | 0.0043 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0043 | 1 | 1 |
Onchocerca volvulus | 0.0043 | 1 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0043 | 1 | 1 |
Onchocerca volvulus | 0.0043 | 1 | 1 | |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0043 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0043 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0043 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0043 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0043 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0043 | 1 | 1 |
Onchocerca volvulus | 0.0043 | 1 | 1 | |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0043 | 1 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0043 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0043 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0043 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0043 | 1 | 1 |
Onchocerca volvulus | 0.0043 | 1 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0043 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0043 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kb (binding) | = 3 nM | Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressing reporter plasmid in a reporter gene assay | ChEMBL. | 15876531 |
Ki (binding) | = 10 nM | Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cells | ChEMBL. | 15876531 |
Ki (binding) | = 197 nM | Displacement of [3H]-DPCPX from human adenosine A1 receptors transfected in CHO cells | ChEMBL. | 15876531 |
Ki (binding) | = 1670 nM | Displacement of [3H]-ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cells | ChEMBL. | 15876531 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.