Detailed information for compound 931885

Basic information

Technical information
  • TDR Targets ID: 931885
  • Name: 3-chloro-8,10-dimethyl-6-[3-(4-phenylpiperazi n-1-yl)propyl]pyridazino[3,4-b][1,5]benzoxaze pin-5-one
  • MW: 477.986 | Formula: C26H28ClN5O2
  • H donors: 0 H acceptors: 3 LogP: 4.48 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)c2c(c1)N(CCCN1CCN(CC1)c1ccccc1)C(=O)c1c(O2)nnc(c1)Cl
  • InChi: 1S/C26H28ClN5O2/c1-18-15-19(2)24-22(16-18)32(26(33)21-17-23(27)28-29-25(21)34-24)10-6-9-30-11-13-31(14-12-30)20-7-4-3-5-8-20/h3-5,7-8,15-17H,6,9-14H2,1-2H3
  • InChiKey: XRZIVBKESMOPEZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-chloro-8,10-dimethyl-6-[3-(4-phenyl-1-piperazinyl)propyl]-5-pyridazino[3,4-b][1,5]benzoxazepinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0173 0.0417
Trypanosoma brucei polo-like protein kinase 0.0103 0.1615 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0276 0.0276
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0284 0.0284
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0038 0.005
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0164 0.0164
Leishmania major trypanothione reductase 0.0099 0.1542 0.9544
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0432 0.0432
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.0432 0.1042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0432 0.2676
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0173 0.1121
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1615 0.1615
Loa Loa (eye worm) hypothetical protein 0.0048 0.0674 0.0674
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0885 0.1178
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0155 0.0373
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.0432 0.2676
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0005
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0003 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0155 0.0373
Schistosoma mansoni zinc finger protein 0.0023 0.0242 0.0242
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.0304 0.1884
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0432 0.2676
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.0432 0.2676
Trypanosoma cruzi ISWI complex protein 0.0017 0.0131 0.0809
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0034 0.042 0.2723
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.02 0.0266
Loa Loa (eye worm) glutathione reductase 0.0099 0.1542 0.1542
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.1615 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0284 0.1759
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0251 0.4149 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.02 0.02
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0226 0.3717 0.8958
Loa Loa (eye worm) glutaminase 2 0.0593 1 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.02 0.0266
Echinococcus multilocularis expressed protein 0.0009 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0173 0.0173
Echinococcus multilocularis thioredoxin glutathione reductase 0.0099 0.1542 0.2052
Brugia malayi hypothetical protein 0.0016 0.0123 0.0123
Brugia malayi CXXC zinc finger family protein 0.0031 0.0382 0.0382
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0432 0.2676
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.1615 0.215
Entamoeba histolytica recQ family helicase, putative 0.001 0.0018 0.0113
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0284 0.0284
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.001 0.0014
Loa Loa (eye worm) MH2 domain-containing protein 0.025 0.4131 0.4131
Toxoplasma gondii thioredoxin reductase 0.0099 0.1542 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0034 0.0427 0.2768
Trichomonas vaginalis ferritin, putative 0.0009 0.0003 0.0003
Trypanosoma cruzi ISWI complex protein 0.0017 0.0131 0.0809
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0284 0.1759
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0885 0.0885
Schistosoma mansoni hypothetical protein 0.017 0.2751 0.2751
Schistosoma mansoni hypothetical protein 0.0023 0.0231 0.0231
Loa Loa (eye worm) Smad1 0.0017 0.0136 0.0136
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0432 0.2676
Entamoeba histolytica recQ family helicase, putative 0.0027 0.0304 0.1884
Schistosoma mansoni apoferritin-2 0.0009 0.0003 0.0003
Echinococcus granulosus bloom syndrome protein 0.005 0.0706 0.0939
Echinococcus granulosus smad 0.0017 0.0136 0.0181
Loa Loa (eye worm) thioredoxin reductase 0.0099 0.1542 0.1542
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0175 0.0175
Echinococcus multilocularis smad 0.0017 0.0136 0.0181
Loa Loa (eye worm) hypothetical protein 0.0026 0.0284 0.0284
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0136 0.0181
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0025 0.0156
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0276 0.0276
Brugia malayi hypothetical protein 0.0025 0.0276 0.0276
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1615 0.1615
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0432 0.2676
Plasmodium falciparum glutathione reductase 0.0034 0.0432 0.2803
Loa Loa (eye worm) hypothetical protein 0.0019 0.0173 0.0173
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0432 0.2676
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.0432 0.2676
Loa Loa (eye worm) hypothetical protein 0.0019 0.0173 0.0173
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.0432 0.2803
Schistosoma mansoni Smad4 0.0017 0.0136 0.0136
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0018 0.0119
Loa Loa (eye worm) RecQ helicase 0.005 0.0706 0.0706
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0432 1
Schistosoma mansoni ferritin light chain 0.0009 0.0003 0.0003
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0885 0.0885
Brugia malayi glutathione reductase 0.0099 0.1542 0.1542
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0284 0.0284
Trypanosoma cruzi trypanothione reductase, putative 0.0099 0.1542 0.9544
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0885 0.2134
Schistosoma mansoni cpg binding protein 0.0035 0.0449 0.0449
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.1615 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0164 0.0218
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0994 0.1323
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0136 0.0136
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0175 0.0233
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0038 0.005
Treponema pallidum ATP-dependent DNA helicase 0.0011 0.0025 0.0583
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1615 0.1615
Mycobacterium tuberculosis Probable oxidoreductase 0.0251 0.4149 1
Echinococcus multilocularis dnaJ subfamily B 0.0448 0.7515 1
Schistosoma mansoni blooms syndrome DNA helicase 0.004 0.0524 0.0524
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0026 0.0284 0.0284
Schistosoma mansoni DNA helicase recq5 0.0021 0.02 0.02
Leishmania major hypothetical protein, conserved 0.0025 0.0276 0.171
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0.0003 0.0065
Loa Loa (eye worm) hypothetical protein 0.0025 0.0276 0.0276
Schistosoma mansoni ferritin light chain 0.0009 0.0003 0.0003
Onchocerca volvulus 0.0031 0.0382 0.2367
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0155 0.0373
Schistosoma mansoni hypothetical protein 0.017 0.2751 0.2751
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0175 0.0175
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0284 0.1759
Schistosoma mansoni smad1 5 8 and 0.0017 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0173 0.0173
Brugia malayi MH1 domain containing protein 0.0009 0.0005 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0432 0.2676
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0226 0.3717 0.8958
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.0432 0.0432
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0432 0.2803
Schistosoma mansoni DNA helicase recq1 0.0021 0.02 0.02
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0251 0.4149 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.1615 0.1615
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0885 0.0885
Echinococcus granulosus ferritin 0.0009 0.0003 0.0004
Echinococcus granulosus expressed protein 0.0009 0.0003 0.0004
Echinococcus granulosus thioredoxin glutathione reductase 0.0099 0.1542 0.2052
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0175 0.0233
Schistosoma mansoni glutaminase 0.0593 1 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0044 0.0601 0.3899
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.02 0.1295
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0986 0.0986
Brugia malayi Thioredoxin reductase 0.0099 0.1542 0.1542
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.02 0.0266
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0382 0.0382
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0276 0.1792
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0136 0.0181
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0226 0.3717 0.8958
Schistosoma mansoni apoferritin-2 0.0009 0.0003 0.0003
Schistosoma mansoni kinase 0.0053 0.0744 0.0744
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.0432 0.2676
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.0432 0.0432
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0432 0.2803
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1615 0.1615
Schistosoma mansoni ferritin 0.0009 0.0003 0.0003
Echinococcus granulosus zinc finger protein 0.0023 0.0242 0.0322
Mycobacterium tuberculosis Probable reductase 0.0226 0.3717 0.8958
Loa Loa (eye worm) hypothetical protein 0.0019 0.0175 0.0175
Echinococcus multilocularis Smad4 0.0017 0.0136 0.0181
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0003 0.0007
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0276 0.171
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0432 0.2676
Loa Loa (eye worm) nuclear factor I 0.0009 0.0005 0.0005
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0432 0.0432
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0432 0.0432
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0136 0.0181
Brugia malayi MH1 domain containing protein 0.0009 0.0005 0.0005
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.0432 0.0432
Brugia malayi MH2 domain containing protein 0.0017 0.0136 0.0136
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.02 0.0266
Trichomonas vaginalis glutaminase, putative 0.0593 1 1
Leishmania major hypothetical protein, conserved 0.0017 0.0131 0.0809
Mycobacterium tuberculosis Probable dehydrogenase 0.0226 0.3717 0.8958
Brugia malayi Smad1 0.0017 0.0136 0.0136
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0044 0.0044
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0175 0.0175
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0284 0.0284
Echinococcus granulosus geminin 0.017 0.2751 0.366
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0276 0.171
Schistosoma mansoni smad 0.0017 0.0136 0.0136
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.0432 0.2803
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0284 0.0685
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.1615 1
Treponema pallidum NADH oxidase 0.0034 0.0432 1
Brugia malayi MH2 domain containing protein 0.0017 0.0136 0.0136
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0284 0.0284
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0432 0.2676
Schistosoma mansoni bromodomain containing protein 0.0071 0.1061 0.1061
Echinococcus multilocularis ferritin 0.0009 0.0003 0.0004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0885 0.0885
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0432 0.2676
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1615 0.1615
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1615 0.1615
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0136 0.0181
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0173 0.4
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.0432 0.2803
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0721 0.0721
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0025 0.0025
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.0432 0.0432
Loa Loa (eye worm) histone methyltransferase 0.001 0.001 0.001
Trichomonas vaginalis DNA helicase recq, putative 0.005 0.0706 0.0706
Brugia malayi Bromodomain containing protein 0.0084 0.1281 0.1281
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0025 0.0156
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0721 0.0721
Schistosoma mansoni ferritin 0.0009 0.0003 0.0003
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.1615 0.1615
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0432 0.2676
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.0432 0.2803
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0276 0.171
Schistosoma mansoni ferritin 0.0009 0.0003 0.0003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0284 0.0685
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0284 0.1759
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0284 0.0284
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0518 0.0689
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0284 0.0284
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0284 0.1759
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0909 0.5894
Loa Loa (eye worm) glutaminase 0.0593 1 1
Plasmodium falciparum thioredoxin reductase 0.0034 0.0432 0.2803
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0284 0.0284
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0284 0.0284
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0226 0.3717 0.8958
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0173 0.1121
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0885 0.1178
Echinococcus multilocularis zinc finger protein 0.0023 0.0242 0.0322
Onchocerca volvulus 0.0026 0.0284 0.1759
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0251 0.4149 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.1615 1
Brugia malayi MH2 domain containing protein 0.025 0.4131 0.4131
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0276 0.1792
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0432 0.2676
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0231 0.0231
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0885 0.5743
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0164 0.0164
Echinococcus granulosus dnaJ subfamily B 0.0448 0.7515 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.02 0.02
Plasmodium vivax glutathione reductase, putative 0.0099 0.1542 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0432 0.0575
Brugia malayi Bromodomain containing protein 0.0042 0.0562 0.0562
Schistosoma mansoni cpg binding protein 0.0035 0.0449 0.0449
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0003 0.0007
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0136 0.0136
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0284 0.0685
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.0304 0.1884
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0297 0.0396
Schistosoma mansoni cpg binding protein 0.0031 0.0382 0.0382
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0885 0.5481
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.001 0.0014
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0284 0.0284
Echinococcus granulosus Smad4 0.0017 0.0136 0.0181
Loa Loa (eye worm) hypothetical protein 0.0077 0.117 0.117
Mycobacterium ulcerans hypothetical protein 0.0026 0.0284 0.0284
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.1615 0.1615
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0432 1
Schistosoma mansoni smad1 5 8 and 0.0017 0.0136 0.0136
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0003 0.0065
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0518 0.0689
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0164 0.0218
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1615 0.1615
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0304 0.0304
Brugia malayi Bloom's syndrome protein homolog 0.005 0.0706 0.0706
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.0432 0.2676
Brugia malayi MH1 domain containing protein 0.0017 0.0136 0.0136
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.02 0.02
Echinococcus multilocularis bloom syndrome protein 0.005 0.0706 0.0939
Schistosoma mansoni zinc finger protein 0.0017 0.0131 0.0131
Schistosoma mansoni hypothetical protein 0.0017 0.0131 0.0131
Echinococcus granulosus cpg binding protein 0.0035 0.0449 0.0597
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0994 0.1323
Giardia lamblia Kinase, PLK 0.0103 0.1615 1
Mycobacterium ulcerans glutaminase 0.0593 1 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0045 0.0608 0.0608
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0155 0.0373
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.1615 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0432 0.2676
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0003 0.0007
Plasmodium falciparum thioredoxin reductase 0.0099 0.1542 1
Brugia malayi MH1 domain containing protein 0.0017 0.0136 0.0136
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0284 0.1759
Echinococcus multilocularis geminin 0.017 0.2751 0.366
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0025 0.0156
Plasmodium falciparum glutathione reductase 0.0099 0.1542 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0173 0.0173
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.1615 0.215
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.0432 1
Schistosoma mansoni smad1 5 8 and 0.0017 0.0136 0.0136
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.02 0.1295
Trichomonas vaginalis DNA helicase recq1, putative 0.005 0.0706 0.0706
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0136 0.0136
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0284 0.0685
Trypanosoma brucei trypanothione reductase 0.0099 0.1542 0.9544
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.02 0.02
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0276 0.1792
Loa Loa (eye worm) hypothetical protein 0.0253 0.4183 0.4183
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0885 0.0885
Schistosoma mansoni hypothetical protein 0.0011 0.0038 0.0038
Plasmodium vivax thioredoxin reductase, putative 0.0099 0.1542 1
Schistosoma mansoni hypothetical protein 0.0448 0.7515 0.7515
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0226 0.3717 0.8958
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.02 0.1236
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.0304 0.1884
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0099 0.1542 0.3716
Schistosoma mansoni ferritin 0.0009 0.0003 0.0003
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0297 0.0396
Brugia malayi PHD-finger family protein 0.0029 0.0342 0.0342
Trypanosoma brucei ISWI complex protein 0.0017 0.0131 0.0809
Loa Loa (eye worm) transcription factor SMAD2 0.025 0.4131 0.4131
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0276 0.1792
Echinococcus multilocularis cpg binding protein 0.0035 0.0449 0.0597
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0432 0.0575
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.02 0.1295
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0284 0.0284
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0025 0.0163
Loa Loa (eye worm) hypothetical protein 0.0042 0.0563 0.0563

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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