Detailed information for compound 931935

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 367.227 | Formula: C17H16Cl2N2O3
  • H donors: 3 H acceptors: 3 LogP: 1.24 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C[C@@H](C(=O)O)N)Nc1ccc(c(c1)C)c1ccc(c(c1)Cl)Cl
  • InChi: 1S/C17H16Cl2N2O3/c1-9-6-11(21-16(22)8-15(20)17(23)24)3-4-12(9)10-2-5-13(18)14(19)7-10/h2-7,15H,8,20H2,1H3,(H,21,22)(H,23,24)/t15-/m0/s1
  • InChiKey: MBQGVKLYPFNSIW-HNNXBMFYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 1 (glial high affinity glutamate transporter), member 3 Starlite/ChEMBL References
Homo sapiens solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 Starlite/ChEMBL References
Homo sapiens solute carrier family 1 (glial high affinity glutamate transporter), member 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus neutral amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis sodium:dicarboxylate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Onchocerca volvulus Excitatory amino acid transporter homolog Get druggable targets OG5_126739 All targets in OG5_126739
Loa Loa (eye worm) excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma japonicum Excitatory amino acid transporter 2, putative Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus excitatory amino acid transporter 3 Get druggable targets OG5_126739 All targets in OG5_126739
Theileria parva glutamate transporter, putative Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus sodium:dicarboxylate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Brugia malayi Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Chlamydia trachomatis glutamate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis excitatory amino acid transporter 3 Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma japonicum ko:K05613 solute carrier family 1 (glial high affinity glutamate transporter),, putative Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma japonicum ko:K05614 solute carrier family 1 (glial high affinity glutamate transporter),, putative Get druggable targets OG5_126739 All targets in OG5_126739
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tensin 0.0019 0.008 0.0118
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0019 0.008 0.0118
Schistosoma mansoni patched 1 0.0041 0.0309 0.0456
Brugia malayi SRC-1 0.0019 0.008 0.0036
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0096 0.087 0.0829
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0036
Mycobacterium ulcerans monoamine oxidase 0.002 0.0095 0.0113
Loa Loa (eye worm) carboxylesterase 0.0552 0.5537 0.5517
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0064 0.0095
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0124 0.008
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.022 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0093 0.0842 0.1748
Echinococcus granulosus acetylcholinesterase 0.0552 0.5537 0.8175
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.022 0.0176
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0019 0.008 0.0118
Loa Loa (eye worm) hypothetical protein 0.005 0.0404 0.0361
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0019 0.008 0.0118
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0491 0.1538
Echinococcus granulosus neuroligin 0.0093 0.0842 0.1243
Schistosoma mansoni pyruvate kinase 0.0017 0.0058 0.0086
Chlamydia trachomatis pyruvate kinase 0.0033 0.022 0.0347
Schistosoma mansoni hypothetical protein 0.004 0.0294 0.0433
Mycobacterium tuberculosis Possible oxidoreductase 0.002 0.0095 0.0091
Echinococcus granulosus expressed conserved protein 0.009 0.081 0.1196
Echinococcus multilocularis 0.002 0.0095 0.0119
Echinococcus multilocularis tensin 0.0019 0.008 0.01
Schistosoma mansoni tyrosine kinase 0.0019 0.008 0.0118
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0093 0.0842 0.1055
Brugia malayi Carboxylesterase family protein 0.0093 0.0842 0.0801
Brugia malayi Protein kinase domain containing protein 0.0019 0.008 0.0036
Echinococcus granulosus tyrosine protein kinase Src64B 0.0019 0.008 0.0118
Brugia malayi Carboxylesterase family protein 0.0093 0.0842 0.0801
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0093 0.0842 0.1243
Brugia malayi RhoGAP domain containing protein 0.0019 0.008 0.0036
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0791 0.7979 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0036
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0064 0.0365
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0124 0.0721
Echinococcus granulosus neutral amino acid transporter A 0.0457 0.4559 0.6731
Echinococcus multilocularis acetylcholinesterase 0.0552 0.5537 0.694
Schistosoma mansoni tyrosine kinase 0.0019 0.008 0.0118
Loa Loa (eye worm) carboxylesterase 0.0093 0.0842 0.0801
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0202 0.1958 0.2454
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0457 0.4559 0.6731
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0093 0.0842 0.1748
Schistosoma mansoni growth factor receptor-bound protein 0.0019 0.008 0.0118
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.022 0.0368
Schistosoma mansoni hypothetical protein 0.004 0.0294 0.0433
Brugia malayi Uncoordinated protein 44 0.0028 0.0173 0.0129
Echinococcus granulosus excitatory amino acid transporter 3 0.0457 0.4559 0.6731
Brugia malayi Sex muscle abnormal protein 5 0.0019 0.008 0.0036
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.008 0.0118
Echinococcus multilocularis microtubule associated protein 2 0.0673 0.6774 0.8489
Brugia malayi Variant SH3 domain containing protein 0.0019 0.008 0.0036
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0139 0.3484
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0124 0.2287
Schistosoma mansoni amine oxidase 0.002 0.0095 0.0141
Brugia malayi Variant SH3 domain containing protein 0.0019 0.008 0.0036
Loa Loa (eye worm) TK/ABL protein kinase 0.0019 0.008 0.0036
Echinococcus granulosus SH2 motif 0.0019 0.008 0.0118
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0036
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0019 0.008 0.01
Echinococcus granulosus excitatory amino acid transporter 2 0.0457 0.4559 0.6731
Echinococcus multilocularis tyrosine protein kinase Abl 0.0019 0.008 0.01
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0045 0.0066
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0124 0.0215
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0019 0.008 0.01
Echinococcus multilocularis pyruvate kinase 0.0017 0.0058 0.0073
Brugia malayi SH2 domain containing protein 0.0019 0.008 0.0036
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.008 0.0118
Brugia malayi Tensin 0.0019 0.008 0.0036
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.008 0.0036
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0019 0.008 0.01
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.022 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0019 0.008 0.0036
Onchocerca volvulus 0.0093 0.0842 0.1701
Echinococcus granulosus pyruvate kinase 0.0017 0.0058 0.0086
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0028 0.0173 0.0256
Echinococcus multilocularis excitatory amino acid transporter 3 0.0457 0.4559 0.5714
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.008 0.0036
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0064 0.0365
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0019 0.008 0.0118
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0457 0.4559 0.5714
Echinococcus granulosus carboxylesterase 5A 0.0552 0.5537 0.8175
Schistosoma mansoni hypothetical protein 0.0019 0.008 0.0118
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0124 0.0721
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0029 0.0037
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.002 0.0095 0.2294
Echinococcus multilocularis Excitatory amino acid transporter 0.0457 0.4559 0.5714
Loa Loa (eye worm) hypothetical protein 0.0093 0.0842 0.0801
Brugia malayi SWIRM domain containing protein 0.002 0.0095 0.0051
Onchocerca volvulus 0.0093 0.0842 0.1701
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0124 0.0721
Leishmania major pyruvate kinase 0.0033 0.022 0.3153
Brugia malayi hypothetical protein 0.0035 0.0246 0.0203
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0019 0.008 0.01
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.008 0.0036
Brugia malayi Protein kinase domain containing protein 0.0019 0.008 0.0036
Chlamydia trachomatis neutral amino acid transporter 0.0202 0.1958 0.4213
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0019
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0019 0.008 0.01
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0119 0.1101 0.1626
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0491 0.1538
Brugia malayi tRNA modification GTPase TrmE family protein 0.0019 0.008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0036
Echinococcus granulosus tensin 0.0019 0.008 0.0118
Brugia malayi Excitatory amino acid transporter 0.0457 0.4559 0.4535
Echinococcus granulosus pyruvate kinase 0.0017 0.0058 0.0086
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0036
Loa Loa (eye worm) hypothetical protein 0.002 0.0095 0.0051
Loa Loa (eye worm) hypothetical protein 0.002 0.0095 0.0051
Echinococcus multilocularis tyrosine protein kinase Blk 0.0019 0.008 0.01
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0124 0.0215
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0093 0.0842 0.1748
Echinococcus granulosus GPCR family 2 0.0015 0.0045 0.0066
Echinococcus granulosus N chimaerin 0.0019 0.008 0.0118
Brugia malayi hypothetical protein 0.0019 0.008 0.0036
Echinococcus multilocularis pyruvate kinase 0.0017 0.0058 0.0073
Echinococcus multilocularis SH2 motif 0.0019 0.008 0.01
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0227 0.0183
Echinococcus granulosus neutral amino acid transporter 0.0457 0.4559 0.6731
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.3956 0.4958
Echinococcus multilocularis netrin receptor unc 5 0.0028 0.0173 0.0217
Schistosoma mansoni tumor necrosis factor receptor related 0.0043 0.0324 0.0478
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.0173 0.0129
Schistosoma mansoni hypothetical protein 0.0015 0.0045 0.0066
Chlamydia trachomatis protoporphyrinogen oxidase 0.002 0.0095 0.007
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0124 0.0553
Loa Loa (eye worm) SH2 domain-containing protein 0.0019 0.008 0.0036
Brugia malayi Carboxylesterase family protein 0.0552 0.5537 0.5517
Entamoeba histolytica hypothetical protein 0.0035 0.0246 0.2103
Brugia malayi Tyrosine-protein kinase abl-1 0.0019 0.008 0.0036
Schistosoma mansoni hypothetical protein 0.0398 0.3956 0.5841
Echinococcus multilocularis Ankyrin 0.0028 0.0173 0.0217
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0885 0.1306
Loa Loa (eye worm) hypothetical protein 0.0093 0.0842 0.0801
Brugia malayi Protein kinase domain containing protein 0.0019 0.008 0.0036
Echinococcus granulosus Ankyrin 0.0028 0.0173 0.0256
Echinococcus multilocularis cpg binding protein 0.0059 0.0492 0.0617
Treponema pallidum glutamate transporter 0.0202 0.1958 0.5
Plasmodium falciparum protoporphyrinogen oxidase 0.002 0.0095 0.2294
Trichomonas vaginalis spcc417.12 protein, putative 0.0093 0.0842 1
Echinococcus granulosus excitatory amino acid transporter 2 0.0457 0.4559 0.6731
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.008 0.0036
Onchocerca volvulus Netrin receptor homolog 0.0028 0.0173 0.0208
Echinococcus multilocularis pyruvate kinase 0.0017 0.0058 0.0073
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0019 0.008 0.01
Loa Loa (eye worm) hypothetical protein 0.0023 0.0124 0.008
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0019 0.008 0.01
Echinococcus granulosus tyrosine protein kinase ABL1 0.0019 0.008 0.0118
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0045 0.0056
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0124 0.0553
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0024 0.013 0.0789
Brugia malayi hypothetical protein 0.0019 0.008 0.0036
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0019 0.008 0.0118
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0119 0.0497
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0019 0.008 0.01
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0457 0.4559 0.5714
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1291 0.1906
Loa Loa (eye worm) hypothetical protein 0.0033 0.022 0.0176
Echinococcus multilocularis pyruvate kinase 0.0033 0.022 0.0276
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0246 0.0363
Giardia lamblia Pyruvate kinase 0.0033 0.022 1
Brugia malayi Protein kinase domain containing protein 0.0019 0.008 0.0036
Schistosoma mansoni hypothetical protein 0.0015 0.0045 0.0066
Loa Loa (eye worm) hypothetical protein 0.0033 0.0227 0.0183
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0124 0.0154
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0019 0.008 0.01
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.087 0.1284
Echinococcus multilocularis SH2 domain containing protein 7 0.0019 0.008 0.01
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0124 0.0154
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0119 0.0075
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0043 0.0324 0.0478
Echinococcus multilocularis para nitrobenzyl esterase 0.0093 0.0842 0.1055
Echinococcus granulosus lysine specific histone demethylase 1A 0.002 0.0095 0.0141
Echinococcus multilocularis BC026374 protein (S09 family) 0.0093 0.0842 0.1055
Loa Loa (eye worm) acetylcholinesterase 1 0.0552 0.5537 0.5517
Echinococcus multilocularis GPCR, family 2 0.0015 0.0045 0.0056
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0202 0.1958 0.2891
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0019
Brugia malayi Carboxylesterase family protein 0.0552 0.5537 0.5517
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.002 0.0095 0.2294
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0019 0.008 0.01
Loa Loa (eye worm) hypothetical protein 0.0552 0.5537 0.5517
Leishmania major hypothetical protein, conserved 0.0025 0.0139 0.1098
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0019 0.008 0.01
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0491 0.0616
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0491 0.0725
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0036
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.087 0.109
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0457 0.4559 1
Schistosoma mansoni Lysine-specific histone demethylase 1 0.002 0.0095 0.0141
Loa Loa (eye worm) excitatory amino acid transporter 0.0457 0.4559 0.4535
Schistosoma mansoni pyruvate kinase 0.0033 0.022 0.0325
Brugia malayi CXXC zinc finger family protein 0.0056 0.0459 0.0417
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0045 0.0066
Brugia malayi hypothetical protein 0.0093 0.0842 0.0801
Schistosoma mansoni nck2/grb4 0.0019 0.008 0.0118
Schistosoma mansoni tensin 0.0019 0.008 0.0118
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.022 1
Echinococcus granulosus tyrosine kinase 0.0019 0.008 0.0118
Schistosoma mansoni ankyrin 23/unc44 0.0028 0.0173 0.0256
Echinococcus multilocularis growth factor receptor bound protein 2 0.0019 0.008 0.01
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0036
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0019 0.008 0.0118
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0491 0.0725
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0019
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0139 0.0883
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0491 0.4743
Mycobacterium ulcerans carboxylesterase, LipT 0.0093 0.0842 0.2801
Schistosoma mansoni signal transduction protein lnk-related 0.0019 0.008 0.0118
Schistosoma mansoni growth factor receptor-bound protein 0.0019 0.008 0.0118
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0093 0.0842 0.1243
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0309 0.3539
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.008 0.0036
Echinococcus multilocularis SH2 motif 0.0019 0.008 0.01
Schistosoma mansoni cpg binding protein 0.0059 0.0492 0.0727
Schistosoma mansoni hypothetical protein 0.0028 0.0173 0.0256
Brugia malayi SH2 domain containing protein 0.0019 0.008 0.0036
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.022 0.2463
Echinococcus granulosus signal transduction protein lnk realted 0.0019 0.008 0.0118
Loa Loa (eye worm) pyruvate kinase 0.0033 0.022 0.0176
Echinococcus granulosus acetylcholinesterase 0.0552 0.5537 0.8175
Echinococcus granulosus SH2 domain containing adapter protein F 0.0019 0.008 0.0118
Schistosoma mansoni cpg binding protein 0.0059 0.0492 0.0727
Loa Loa (eye worm) hypothetical protein 0.0028 0.0173 0.0129
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0019 0.008 0.0036
Onchocerca volvulus 0.0093 0.0842 0.1701
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.008 0.0036
Echinococcus multilocularis neuroligin 0.0093 0.0842 0.1055
Echinococcus multilocularis neutral amino acid transporter A 0.0457 0.4559 0.5714
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0095 0.0091
Schistosoma mansoni vav2 0.0019 0.008 0.0118
Echinococcus multilocularis Excitatory amino acid transporter 0.0457 0.4559 0.5714
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0019 0.008 0.0118
Echinococcus multilocularis carboxylesterase 5A 0.0552 0.5537 0.694
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0173 0.0129
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0036
Echinococcus granulosus netrin receptor unc 5 0.0028 0.0173 0.0256
Echinococcus multilocularis signal transduction protein lnk realted 0.0019 0.008 0.01
Echinococcus granulosus SH2 domain containing protein 7 0.0019 0.008 0.0118
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0064 0.0021
Schistosoma mansoni hypothetical protein 0.0015 0.0045 0.0066
Echinococcus multilocularis expressed conserved protein 0.009 0.081 0.1015
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.087 0.0829
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0019 0.008 0.0036
Echinococcus granulosus tyrosine protein kinase Fyn 0.0019 0.008 0.0118
Echinococcus multilocularis 0.0019 0.008 0.01
Brugia malayi SH2 domain containing protein 0.0019 0.008 0.0036
Brugia malayi Protein kinase domain containing protein 0.0028 0.0173 0.0129
Echinococcus granulosus pyruvate kinase 0.0017 0.0058 0.0086
Loa Loa (eye worm) TK protein kinase 0.0019 0.008 0.0036
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0043 0.0324 0.0406
Echinococcus multilocularis protoporphyrinogen oxidase 0.002 0.0095 0.0119
Echinococcus granulosus neutral amino acid transporter A 0.0457 0.4559 0.6731
Schistosoma mansoni tensin-related 0.0019 0.008 0.0118
Schistosoma mansoni netrin receptor unc5 0.0028 0.0173 0.0256
Echinococcus multilocularis tyrosine kinase 0.0019 0.008 0.01
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0309 0.0456
Mycobacterium ulcerans hypothetical protein 0.0023 0.0124 0.0215
Schistosoma mansoni acetylcholinesterase 0.0093 0.0842 0.1243
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0202 0.1958 0.2454
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0124 0.0553
Brugia malayi SH2 domain containing protein 0.0019 0.008 0.0036
Echinococcus multilocularis pyruvate kinase 0.0033 0.022 0.0276
Schistosoma mansoni microtubule-associated protein tau 0.0673 0.6774 1
Echinococcus granulosus microtubule associated protein 2 0.0673 0.6774 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0019 0.008 0.01
Onchocerca volvulus 0.002 0.0095 0.0034
Echinococcus granulosus tyrosine protein kinase Fyn 0.0019 0.008 0.0118
Brugia malayi SH2 domain containing protein 0.0019 0.008 0.0036
Brugia malayi Variant SH3 domain containing protein 0.0019 0.008 0.0036
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0139 0.4979
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0036
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.008 0.0036
Echinococcus granulosus expressed conserved protein 0.0019 0.008 0.0118
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0309 0.0387
Schistosoma mansoni gliotactin 0.0093 0.0842 0.1243
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0093 0.0842 0.1243
Plasmodium vivax pyruvate kinase, putative 0.0033 0.022 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0019 0.008 0.01
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0019 0.008 0.01
Brugia malayi hypothetical protein 0.0016 0.005 0.0005
Leishmania major pyruvate kinase 0.0033 0.022 0.3153
Loa Loa (eye worm) SH2 domain-containing protein 0.0019 0.008 0.0036
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.022 0.0312
Schistosoma mansoni hypothetical protein 0.004 0.0294 0.0433
Schistosoma mansoni suppressor of cytokine signaling 0.0019 0.008 0.0118
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0019 0.008 0.0036
Echinococcus granulosus sodium:dicarboxylate symporter 0.0457 0.4559 0.6731
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0457 0.4559 1
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0043 0.0324 0.0406
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0029 0.0037
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.022 0.0312
Loa Loa (eye worm) hypothetical protein 0.0025 0.0139 0.0095
Loa Loa (eye worm) hypothetical protein 0.0093 0.0842 0.0801
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0036
Brugia malayi cytokine inducible SH2-containing protein 5 0.0019 0.008 0.0036
Echinococcus granulosus death domain containing protein 0.0028 0.0173 0.0256
Loa Loa (eye worm) hypothetical protein 0.0028 0.0173 0.0129
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.022 0.2463
Echinococcus granulosus tyrosine protein kinase Srms 0.0019 0.008 0.0118
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0019
Echinococcus granulosus pyruvate kinase 0.0033 0.022 0.0325
Loa Loa (eye worm) hypothetical protein 0.0041 0.0309 0.0265
Schistosoma mansoni shc transforming protein 0.0019 0.008 0.0118
Schistosoma mansoni tensin 0.0019 0.008 0.0118
Brugia malayi amine oxidase, flavin-containing family protein 0.002 0.0095 0.0051
Echinococcus multilocularis lysine specific histone demethylase 1A 0.002 0.0095 0.0119
Chlamydia trachomatis glutamate symporter 0.0457 0.4559 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0064 0.0081
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0029 0.0043
Mycobacterium ulcerans dehydrogenase 0.002 0.0095 0.0113
Loa Loa (eye worm) hypothetical protein 0.0093 0.0842 0.0801
Echinococcus multilocularis neutral amino acid transporter A 0.0457 0.4559 0.5714
Schistosoma mansoni hypothetical protein 0.0015 0.0045 0.0066
Mycobacterium ulcerans oxidoreductase 0.002 0.0095 0.0113
Echinococcus multilocularis tyrosine protein kinase shark 0.0019 0.008 0.01
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0019 0.008 0.0118
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.022 0.0312
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0045 0.0056
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0019 0.008 0.0118
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0023 0.0124 0.008
Schistosoma mansoni tyrosine kinase 0.0019 0.008 0.0118
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0062 0.0017
Loa Loa (eye worm) hypothetical protein 0.0023 0.0124 0.008
Echinococcus multilocularis SHC transforming protein 3 0.0019 0.008 0.01
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0139 0.4979
Echinococcus granulosus pyruvate kinase 0.0033 0.022 0.0325
Schistosoma mansoni hypothetical protein 0.004 0.0294 0.0433
Schistosoma mansoni cpg binding protein 0.0056 0.0459 0.0678
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0385 0.0342
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0491 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0246 0.0309
Brugia malayi protein-tyrosine kinase 0.0019 0.008 0.0036
Schistosoma mansoni suppressor of cytokine signaling 0.0019 0.008 0.0118
Echinococcus granulosus cpg binding protein 0.0059 0.0492 0.0727
Schistosoma mansoni amine oxidase 0.002 0.0095 0.0141
Plasmodium vivax protoporphyrinogen oxidase, putative 0.002 0.0095 0.2294
Echinococcus multilocularis acetylcholinesterase 0.0552 0.5537 0.694
Mycobacterium ulcerans pyruvate kinase 0.0033 0.022 0.0562
Echinococcus granulosus growth factor receptor bound protein 2 0.0019 0.008 0.0118
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0019 0.008 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.0095 0.0051
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0019 0.008 0.0118
Schistosoma mansoni GTPase activating protein 0.0019 0.008 0.0118
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0036
Echinococcus granulosus NCK adaptor protein 0.0019 0.008 0.0118
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0093 0.0842 1
Echinococcus granulosus SH2 motif 0.0019 0.008 0.0118
Brugia malayi SH2 domain containing protein 0.0019 0.008 0.0036
Entamoeba histolytica hypothetical protein 0.0035 0.0246 0.2103
Loa Loa (eye worm) hypothetical protein 0.0093 0.0842 0.0801
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0124 0.008
Echinococcus multilocularis pyruvate kinase 0.0026 0.015 0.0188
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0289 0.2841 1
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.002 0.0095 0.2294
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0019 0.008 0.0036
Schistosoma mansoni adapter molecule crk 0.0019 0.008 0.0118
Echinococcus multilocularis tyrosine protein kinase Srms 0.0019 0.008 0.01
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.008 0.0036
Trypanosoma brucei pyruvate kinase 1 0.0033 0.022 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0019 0.008 0.0118
Echinococcus granulosus Excitatory amino acid transporter 0.0457 0.4559 0.6731
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0124 0.0215
Echinococcus granulosus BC026374 protein S09 family 0.0093 0.0842 0.1243
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0036
Loa Loa (eye worm) STAT protein 0.0988 1 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0093 0.0842 0.1243
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.008 0.0036
Mycobacterium ulcerans protoporphyrinogen oxidase 0.002 0.0095 0.0113
Echinococcus granulosus c src tyrosine kinase 0.0019 0.008 0.0118
Brugia malayi Protein kinase domain containing protein 0.0019 0.008 0.0036
Brugia malayi Death domain containing protein 0.0028 0.0173 0.0129
Echinococcus granulosus tyrosine protein kinase Blk 0.0019 0.008 0.0118
Echinococcus multilocularis N chimaerin 0.0019 0.008 0.01
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0385 0.0342
Echinococcus granulosus hypothetical protein 0.0019 0.008 0.0118
Brugia malayi SH2 domain containing protein 0.0019 0.008 0.0036
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0019 0.008 0.01
Loa Loa (eye worm) pyruvate kinase 0.0033 0.022 0.0176
Echinococcus granulosus tyrosine protein kinase Fyn 0.0019 0.008 0.0118
Echinococcus granulosus dnaJ subfamily B 0.0398 0.3956 0.5841
Schistosoma mansoni hypothetical protein 0.0035 0.0246 0.0363
Onchocerca volvulus 0.0056 0.0459 0.0847
Schistosoma mansoni tyrosine kinase 0.0019 0.008 0.0118
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0385 0.0342
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0491 0.097
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0552 0.5537 0.8175
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.087 1
Echinococcus multilocularis NCK adaptor protein 0.0019 0.008 0.01
Echinococcus granulosus suppressor of cytokine signaling 6 0.0019 0.008 0.0118
Loa Loa (eye worm) pyruvate kinase 0.0033 0.022 0.0176
Brugia malayi SH2 domain containing protein 0.0019 0.008 0.0036
Echinococcus granulosus Excitatory amino acid transporter 0.0457 0.4559 0.6731
Plasmodium vivax hypothetical protein, conserved 0.002 0.0095 0.2294
Toxoplasma gondii histone lysine methyltransferase SET1 0.0106 0.0971 1
Brugia malayi hypothetical protein 0.0025 0.0139 0.0095
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0124 0.0215
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.008 0.0036
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0246 0.0363
Echinococcus granulosus tyrosine protein kinase Lyn 0.0019 0.008 0.0118
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0019 0.008 0.01
Treponema pallidum glutamate/aspartate transporter 0.0202 0.1958 0.5
Echinococcus multilocularis tensin 0.0019 0.008 0.01
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0491 0.1538
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.022 0.0176
Schistosoma mansoni BC026374 protein (S09 family) 0.0093 0.0842 0.1243
Schistosoma mansoni tensin-related 0.0019 0.008 0.0118
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0139 0.3484
Schistosoma mansoni pyruvate kinase 0.0033 0.022 0.0325
Brugia malayi SH2 domain containing protein 0.0019 0.008 0.0036
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0309 0.0456
Echinococcus multilocularis protein dispatched 1 0.0047 0.0368 0.0462
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0019 0.008 0.01
Echinococcus granulosus tyrosine protein kinase Src42A 0.0019 0.008 0.0118
Loa Loa (eye worm) hypothetical protein 0.002 0.0095 0.0051
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.002 0.0095 0.0141
Echinococcus granulosus lysine specific histone demethylase 1A 0.002 0.0095 0.0141
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0019
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.022 1
Entamoeba histolytica hypothetical protein 0.0035 0.0246 0.2103
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0036
Loa Loa (eye worm) carboxylesterase 0.0093 0.0842 0.0801
Echinococcus granulosus SHC transforming protein 3 0.0019 0.008 0.0118
Schistosoma mansoni hypothetical protein 0.0033 0.0227 0.0335
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0124 0.008
Loa Loa (eye worm) hypothetical protein 0.002 0.0095 0.0051
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0457 0.4559 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0019 0.008 0.01
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1291 0.1618
Onchocerca volvulus 0.0023 0.0124 0.0097
Echinococcus granulosus para nitrobenzyl esterase 0.0093 0.0842 0.1243
Entamoeba histolytica hypothetical protein 0.0035 0.0246 0.2103
Schistosoma mansoni hypothetical protein 0.0019 0.008 0.0118
Echinococcus multilocularis neutral amino acid transporter A 0.0457 0.4559 0.5714
Echinococcus granulosus tyrosine kinase 0.0019 0.008 0.0118
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0491 0.0725
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0268 0.2633 0.5725
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0309 0.0265
Brugia malayi Carboxylesterase family protein 0.0093 0.0842 0.0801
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.022 0.1774
Loa Loa (eye worm) SRC-1 0.0019 0.008 0.0036
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0028 0.0173 0.0217
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0019 0.008 0.01
Toxoplasma gondii histone lysine-specific demethylase 0.002 0.0095 0.0407
Echinococcus granulosus tyrosine protein kinase Src42A 0.0019 0.008 0.0118
Loa Loa (eye worm) hypothetical protein 0.0023 0.0119 0.0075
Loa Loa (eye worm) SH2 domain-containing protein 0.0019 0.008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0036
Echinococcus granulosus suppressor of cytokine signaling 7 0.0019 0.008 0.0118
Echinococcus multilocularis protein patched 0.0041 0.0309 0.0387
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0019 0.008 0.0118
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0043 0.0324 0.0478
Loa Loa (eye worm) hypothetical protein 0.0093 0.0842 0.0801
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0124 0.0215
Schistosoma mansoni SH2A 0.0019 0.008 0.0118
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0124 0.0215
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0036
Onchocerca volvulus 0.0093 0.0842 0.1701
Schistosoma mansoni tyrosine kinase 0.0019 0.008 0.0118
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0459 0.0417
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0093 0.0842 0.1243
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0019 0.008 0.0118
Brugia malayi Carboxylesterase family protein 0.0093 0.0842 0.0801
Brugia malayi CHE-14 protein 0.0041 0.0309 0.0265
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0028 0.0173 0.0256
Plasmodium falciparum pyruvate kinase 0.0033 0.022 1
Onchocerca volvulus 0.0093 0.0842 0.1701
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0019 0.008 0.01
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0019 0.008 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.0095 0.0051
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0124 0.2287
Echinococcus multilocularis excitatory amino acid transporter 2 0.0457 0.4559 0.5714
Loa Loa (eye worm) hypothetical protein 0.0552 0.5537 0.5517
Echinococcus multilocularis SH2 motif 0.0019 0.008 0.01
Loa Loa (eye worm) hypothetical protein 0.0093 0.0842 0.0801
Echinococcus multilocularis excitatory amino acid transporter 2 0.0457 0.4559 0.5714
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0019 0.008 0.0118
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0124 0.0215
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0139 0.4979
Echinococcus granulosus tyrosine protein kinase shark 0.0019 0.008 0.0118
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0289 0.2841 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0202 0.1958 0.2891
Schistosoma mansoni tyrosine kinase 0.0019 0.008 0.0118
Echinococcus multilocularis c src tyrosine kinase 0.0019 0.008 0.01
Brugia malayi Variant SH3 domain containing protein 0.0019 0.008 0.0036
Plasmodium vivax hypothetical protein, conserved 0.002 0.0095 0.2294
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0064 0.002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0029 0.0043
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0029 0.0043
Brugia malayi hypothetical protein 0.002 0.0095 0.0051
Loa Loa (eye worm) hypothetical protein 0.0049 0.0385 0.0342

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.1 uM Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2 ChEMBL. 16165356
IC50 (binding) = 0.7 uM Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1 ChEMBL. 16165356
IC50 (binding) = 0.85 uM Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3 ChEMBL. 16165356

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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