TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 330.766 | Formula: C17H15ClN2O3
H donors: 3 H acceptors: 3 LogP: 0.25 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C[C@@H](C(=O)O)N)Nc1ccc2c(c1)Cc1c2ccc(c1)Cl
InChi: 1S/C17H15ClN2O3/c18-11-1-3-13-9(6-11)5-10-7-12(2-4-14(10)13)20-16(21)8-15(19)17(22)23/h1-4,6-7,15H,5,8,19H2,(H,20,21)(H,22,23)/t15-/m0/s1
InChiKey: WXVBLLQGBPMCBA-HNNXBMFYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus granulosus	neutral amino acid transporter	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	neutral amino acid transporter A	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus granulosus	excitatory amino acid transporter 2	Get druggable targets OG5_126739	All targets in OG5_126739
Schistosoma mansoni	solute carrier family 1 (glial high affinity glutamate transporter	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	excitatory amino acid transporter 2	Get druggable targets OG5_126739	All targets in OG5_126739
Wolbachia endosymbiont of Brugia malayi	Na+/H+-dicarboxylate symporter	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus granulosus	Excitatory amino acid transporter	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus granulosus	neutral amino acid transporter A	Get druggable targets OG5_126739	All targets in OG5_126739
Mycobacterium tuberculosis	Probable C4-dicarboxylate-transport transmembrane protein DctA	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	sodium:dicarboxylate symporter	Get druggable targets OG5_126739	All targets in OG5_126739
Onchocerca volvulus	Excitatory amino acid transporter homolog	Get druggable targets OG5_126739	All targets in OG5_126739
Loa Loa (eye worm)	excitatory amino acid transporter	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus granulosus	Excitatory amino acid transporter	Get druggable targets OG5_126739	All targets in OG5_126739
Schistosoma japonicum	Excitatory amino acid transporter 2, putative	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	Excitatory amino acid transporter	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus granulosus	neutral amino acid transporter A	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus granulosus	excitatory amino acid transporter 3	Get druggable targets OG5_126739	All targets in OG5_126739
Theileria parva	glutamate transporter, putative	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	excitatory amino acid transporter 2	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus granulosus	sodium:dicarboxylate symporter	Get druggable targets OG5_126739	All targets in OG5_126739
Brugia malayi	Excitatory amino acid transporter	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	neutral amino acid transporter A	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	neutral amino acid transporter A	Get druggable targets OG5_126739	All targets in OG5_126739
Chlamydia trachomatis	glutamate symporter	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	excitatory amino acid transporter 3	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	Excitatory amino acid transporter	Get druggable targets OG5_126739	All targets in OG5_126739
Schistosoma japonicum	ko:K05613 solute carrier family 1 (glial high affinity glutamate transporter),, putative	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus granulosus	excitatory amino acid transporter 2	Get druggable targets OG5_126739	All targets in OG5_126739
Schistosoma japonicum	ko:K05614 solute carrier family 1 (glial high affinity glutamate transporter),, putative	Get druggable targets OG5_126739	All targets in OG5_126739

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1398	0.2415
Brugia malayi	hypothetical protein	0.002	0.0148	0.0256
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.002	0.0148	0.0254
Schistosoma mansoni	neuropeptide receptor	0.002	0.0148	0.0203
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0186	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.002	0.0148	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1398	0.2415
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1398	0.2415
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0186	0.8783
Echinococcus granulosus	p2X purinoceptor 4	0.0278	0.3473	0.6005
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0339	0.0338
Echinococcus granulosus	neuropeptide s receptor	0.002	0.0148	0.0254
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0186	0.5
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1398	0.2415
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0757	0.1307
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0186	0.0153
Schistosoma mansoni	hypothetical protein	0.0039	0.0398	0.0638
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.002	0.0148	0.0147
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0148	0.0147
Brugia malayi	hypothetical protein	0.0054	0.0586	0.1013
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.002	0.0148	0.0203
Brugia malayi	hypothetical protein	0.0024	0.0205	0.0354
Echinococcus granulosus	Excitatory amino acid transporter	0.0457	0.5783	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0117	0.1398	0.2415
Echinococcus granulosus	expressed conserved protein	0.0089	0.1044	0.1802
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.1137	0.1922
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0117	0.1398	0.2416
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0186	0.8783
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0702	0.1212
Brugia malayi	Cation transporter family protein	0.0117	0.1398	0.2416
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0054	0.0586	0.0584
Echinococcus granulosus	serotonin receptor	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0702	0.1212
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0292	0.029
Onchocerca volvulus	Putative nachr subunit	0.0261	0.3254	0.5587
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0117	0.1398	0.2415
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0292	0.0502
Schistosoma mansoni	hypothetical protein	0.0031	0.0292	0.0452
Echinococcus granulosus	7TM GPCR rhodopsin	0.002	0.0148	0.0254
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0098	0.1158	0.2
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0586	0.1011
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Brugia malayi	hypothetical protein	0.002	0.0148	0.0256
Echinococcus granulosus	neutral amino acid transporter A	0.0457	0.5783	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0063	0.0702	0.1166
Echinococcus multilocularis	Excitatory amino acid transporter	0.0457	0.5783	0.5783
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0117	0.1398	0.2416
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0586	0.1011
Treponema pallidum	glutamate/aspartate transporter	0.0202	0.2502	0.5
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1398	0.2415
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Echinococcus multilocularis	orexin receptor type 2	0.002	0.0148	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0051	0.0087
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0261	0.3254	0.3253
Schistosoma mansoni	biogenic amine (5HT) receptor	0.002	0.0148	0.0203
Echinococcus granulosus	fmrfamide receptor	0.002	0.0148	0.0254
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0117	0.1398	0.2416
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0098	0.1158	0.2002
Brugia malayi	hypothetical protein	0.002	0.0148	0.0256
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.002	0.0148	0.0256
Echinococcus granulosus	7tm_1 domain containing protein	0.002	0.0148	0.0254
Onchocerca volvulus		0.002	0.0148	0.0169
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.0111	0.3912
Schistosoma mansoni	nAChR subunit	0.0117	0.1398	0.2375
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0063	0.0702	0.1166
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0054	0.0586	0.1013
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0117	0.1398	0.2415
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0117	0.1398	0.2416
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1398	0.2415
Brugia malayi	RE15519p	0.002	0.0148	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1398	0.2415
Echinococcus granulosus	peptide allatostatin:somatostatin	0.002	0.0148	0.0254
Echinococcus granulosus	neuropeptide receptor A26	0.002	0.0148	0.0254
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0205	1
Giardia lamblia	Sentrin specific protease, putative	0.0012	0.0051	0.5
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.002	0.0148	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0586	0.1011
Schistosoma mansoni	hypothetical protein	0.002	0.0148	0.0203
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.002	0.0148	0.0147
Schistosoma mansoni	hypothetical protein	0.0031	0.0292	0.0452
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0117	0.1398	0.2416
Brugia malayi	Dopamine receptor protein 2	0.002	0.0148	0.0256
Onchocerca volvulus		0.0117	0.1398	0.2348
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.002	0.0148	0.0147
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0186	1
Schistosoma mansoni	hypothetical protein	0.0039	0.0398	0.0638
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0186	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0339	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1398	0.2415
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.002	0.0148	0.0147
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0117	0.1398	0.2416
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Schistosoma mansoni	biogenic amine (5HT) receptor	0.002	0.0148	0.0203
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0117	0.1398	0.1396
Loa Loa (eye worm)	neuropeptide F receptor	0.002	0.0148	0.0254
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0186	1
Schistosoma mansoni	cpg binding protein	0.0028	0.0249	0.0377
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0292	0.029
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0249	0.043
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0117	0.1398	0.1396
Echinococcus granulosus	g protein coupled receptor	0.002	0.0148	0.0254
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0117	0.1398	0.2416
Loa Loa (eye worm)	hypothetical protein	0.0261	0.3254	0.5625
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0292	0.0504
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.002	0.0148	0.0203
Echinococcus granulosus	Niemann Pick C1 protein	0.0095	0.1118	0.1931
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Onchocerca volvulus		0.0028	0.0249	0.0344
Echinococcus granulosus	somatostatin receptor	0.002	0.0148	0.0254
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0261	0.3254	0.5625
Echinococcus multilocularis	neuropeptide Y receptor	0.002	0.0148	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0186	0.032
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0117	0.1398	0.2415
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0148	0.0203
Brugia malayi	follicle stimulating hormone receptor	0.002	0.0148	0.0256
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Schistosoma mansoni	biogenic amine receptor	0.002	0.0148	0.0203
Schistosoma mansoni	neuropeptide f receptor 76f	0.002	0.0148	0.0203
Echinococcus granulosus	g protein coupled receptor	0.002	0.0148	0.0254
Brugia malayi	hypothetical protein	0.002	0.0148	0.0256
Echinococcus granulosus	expressed conserved protein	0.013	0.1571	0.2715
Loa Loa (eye worm)	acetylcholine receptor protein	0.0054	0.0586	0.1011
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.002	0.0148	0.0147
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0054	0.0586	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1398	0.2415
Echinococcus multilocularis	Excitatory amino acid transporter	0.0457	0.5783	0.5783
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0186	0.032
Onchocerca volvulus		0.0054	0.0586	0.0932
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.002	0.0148	0.0203
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0148	0.0254
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0292	0.0502
Schistosoma mansoni	cpg binding protein	0.0029	0.0269	0.0413
Echinococcus multilocularis	allatostatin A receptor	0.002	0.0148	0.0147
Schistosoma mansoni	P2X receptor subunit	0.0278	0.3473	0.5984
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Schistosoma mansoni	adenoreceptor	0.002	0.0148	0.0203
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.002	0.0148	0.0256
Onchocerca volvulus		0.0117	0.1398	0.2348
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.0202	0.2502	0.4296
Onchocerca volvulus		0.002	0.0148	0.0169
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0117	0.1398	0.2415
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.002	0.0148	0.0147
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.0202	0.2502	0.2501
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0117	0.1398	0.2415
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0148	0.0254
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0417	0.0416
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0117	0.1398	0.2415
Echinococcus multilocularis	protein patched	0.0041	0.0417	0.0416
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0186	0.8783
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.002	0.0148	0.0203
Echinococcus multilocularis	p2X purinoceptor 4	0.0278	0.3473	0.3472
Schistosoma mansoni	hypothetical protein	0.002	0.0148	0.0203
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0054	0.0586	0.1013
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.002	0.0148	0.0254
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0148	0.0203
Schistosoma mansoni	amine GPCR	0.002	0.0148	0.0203
Brugia malayi	ORL1-like opioid receptor	0.002	0.0148	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0205	0.0352
Entamoeba histolytica	hypothetical protein	0.0063	0.0702	0.3873
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0586	0.1011
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Schistosoma mansoni	nAChR subunit	0.0117	0.1398	0.2375
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0148	0.0203
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0054	0.0586	0.0963
Entamoeba histolytica	hypothetical protein	0.0035	0.0339	0.1712
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0586	0.1011
Loa Loa (eye worm)	TYRA-2 protein	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0702	0.1212
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0417	1
Schistosoma mansoni	nAChR subunit	0.0117	0.1398	0.2375
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.002	0.0148	0.0147
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0143	0.1732	0.2957
Echinococcus granulosus	p2X purinoceptor 4	0.0278	0.3473	0.6005
Echinococcus granulosus	tm gpcr rhodopsin	0.002	0.0148	0.0254
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0186	0.0322
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Schistosoma mansoni	myosin xvIII	0.002	0.0148	0.0203
Echinococcus multilocularis	dro:myosuppressin receptor	0.002	0.0148	0.0147
Schistosoma mansoni	hypothetical protein	0.0039	0.0398	0.0638
Echinococcus granulosus	biogenic amine 5HT receptor	0.002	0.0148	0.0254
Brugia malayi	hypothetical protein	0.002	0.0148	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0111	0.019
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0186	0.032
Schistosoma mansoni	opsin-like receptor	0.002	0.0148	0.0203
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0117	0.1398	0.2375
Onchocerca volvulus		0.002	0.0148	0.0169
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0117	0.1398	0.2415
Schistosoma mansoni	amine GPCR	0.002	0.0148	0.0203
Brugia malayi	hypothetical protein	0.0035	0.0339	0.0586
Onchocerca volvulus		0.002	0.0148	0.0169
Schistosoma mansoni	nAChR subunit	0.0117	0.1398	0.2375
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Echinococcus multilocularis	excitatory amino acid transporter 2	0.0457	0.5783	0.5783
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0148	0.0147
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0117	0.1398	0.2375
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0117	0.1398	0.2415
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0012	0.0051	0.0089
Loa Loa (eye worm)	ACC-1 protein	0.0117	0.1398	0.2415
Echinococcus multilocularis	neuropeptide FF receptor 2	0.002	0.0148	0.0147
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0292	0.0504
Echinococcus multilocularis	nAChR subunit	0.0117	0.1398	0.1396
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1158	0.2
Brugia malayi	Cation transporter family protein	0.0117	0.1398	0.2416
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0186	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0186	1
Brugia malayi	larval opioid receptor	0.002	0.0148	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1398	0.2415
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.002	0.0148	0.0256
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Schistosoma mansoni	neurotransmitter gated ion channel	0.0054	0.0586	0.0963
Brugia malayi	hypothetical protein	0.002	0.0148	0.0256
Echinococcus multilocularis	neutral amino acid transporter A	0.0457	0.5783	0.5783
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0117	0.1398	0.2416
Echinococcus multilocularis	neuropeptide Y receptor	0.002	0.0148	0.0147
Onchocerca volvulus		0.002	0.0148	0.0169
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0148	0.0147
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.002	0.0148	0.0147
Brugia malayi	Tachykinin-like peptides receptor 99D	0.002	0.0148	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0586	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0051	0.0087
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0186	0.0322
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.065	0.1075
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0586	0.1011
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.002	0.0148	0.0256
Echinococcus granulosus	tachykinin peptides receptor 99D	0.002	0.0148	0.0254
Echinococcus multilocularis	neuropeptide receptor A26	0.002	0.0148	0.0147
Onchocerca volvulus		0.0117	0.1398	0.2348
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0054	0.0586	0.1013
Loa Loa (eye worm)	GABA receptor subunit	0.0063	0.0702	0.1212
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0117	0.1398	0.2416
Brugia malayi	neuropeptide F receptor	0.002	0.0148	0.0256
Echinococcus multilocularis	glycine receptor subunit beta	0.0117	0.1398	0.1396
Echinococcus granulosus	sex peptide receptor	0.002	0.0148	0.0254
Echinococcus multilocularis	glycine receptor subunit beta	0.0117	0.1398	0.1396
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0117	0.1398	0.2415
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0586	0.1011
Schistosoma mansoni	solute carrier family 1 (glial high affinity glutamate transporter	0.0457	0.5783	1
Echinococcus multilocularis	neuropeptides capa receptor	0.002	0.0148	0.0147
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0205	1
Echinococcus granulosus	neuropeptide Y receptor	0.002	0.0148	0.0254
Echinococcus multilocularis	neutral amino acid transporter A	0.0457	0.5783	0.5783
Echinococcus granulosus	g protein coupled receptor	0.002	0.0148	0.0254
Schistosoma mansoni	alpha-1 adrenergic receptor	0.002	0.0148	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1398	0.2415
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0205	1
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0117	0.1398	0.1396
Schistosoma mansoni	biogenic amine receptor	0.002	0.0148	0.0203
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0417	0.0719
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0117	0.1398	0.2415
Echinococcus multilocularis	sex peptide receptor	0.002	0.0148	0.0147
Brugia malayi	excitatory GABA receptor EXP-1A	0.0117	0.1398	0.2416
Onchocerca volvulus		0.002	0.0148	0.0169
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0492	0.049
Schistosoma mansoni	growth hormone secretagogue receptor	0.002	0.0148	0.0203
Echinococcus multilocularis	neuropeptide receptor	0.002	0.0148	0.0147
Onchocerca volvulus		0.002	0.0148	0.0169
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Brugia malayi	Excitatory amino acid transporter	0.0457	0.5783	1
Loa Loa (eye worm)	LGC-31 protein	0.0117	0.1398	0.2415
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0569	1
Schistosoma mansoni	opsin-like receptor	0.002	0.0148	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0702	0.1212
Loa Loa (eye worm)	G-protein coupled receptor	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0586	0.1011
Schistosoma mansoni	neurotransmitter gated ion channel	0.0063	0.0702	0.1166
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.0757	0.1309
Onchocerca volvulus		0.0054	0.0586	0.0932
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0012	0.0051	0.0035
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0261	0.3254	0.5625
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0148	0.0203
Echinococcus multilocularis	neuropeptides capa receptor	0.002	0.0148	0.0147
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.002	0.0148	0.0254
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0292	0.0502
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.002	0.0148	0.0203
Echinococcus multilocularis	somatostatin receptor	0.002	0.0148	0.0147
Echinococcus multilocularis	cpg binding protein	0.0029	0.0269	0.0268
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.002	0.0148	0.0203
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.0457	0.5783	0.5783
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0111	0.019
Echinococcus granulosus	g-protein coupled receptor	0.002	0.0148	0.0254
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0063	0.0702	0.1215
Brugia malayi	G-protein coupled receptor	0.002	0.0148	0.0256
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.002	0.0148	0.0147
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0205	1
Schistosoma mansoni	nAChR subunit	0.0054	0.0586	0.0963
Treponema pallidum	glutamate transporter	0.0202	0.2502	0.5
Schistosoma mansoni	hypothetical protein	0.0039	0.0398	0.0638
Schistosoma mansoni	hypothetical protein	0.002	0.0148	0.0203
Brugia malayi	G protein-coupled receptor	0.002	0.0148	0.0256
Echinococcus multilocularis	Niemann Pick C1 protein	0.0095	0.1118	0.1117
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0586	0.1011
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0339	0.0584
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0186	0.5
Echinococcus granulosus	allatostatin A receptor	0.002	0.0148	0.0254
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0051	0.0087
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.002	0.0148	0.0203
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0205	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0117	0.1398	0.2416
Echinococcus multilocularis	sentrin specific protease 1	0.0012	0.0051	0.005
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0186	0.0153
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Echinococcus granulosus	glycine receptor subunit beta	0.0117	0.1398	0.2415
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0186	0.0802
Schistosoma mansoni	opsin-like receptor	0.002	0.0148	0.0203
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.002	0.0148	0.0203
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0702	0.1212
Echinococcus granulosus	neuropeptides capa receptor	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0586	0.1011
Loa Loa (eye worm)	neuropeptide F receptor	0.002	0.0148	0.0254
Onchocerca volvulus		0.002	0.0148	0.0169
Echinococcus granulosus	alpha 1A adrenergic receptor	0.002	0.0148	0.0254
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.002	0.0148	0.0254
Schistosoma mansoni	P2X receptor subunit	0.0278	0.3473	0.5984
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.002	0.0148	0.0203
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.002	0.0148	0.0203
Brugia malayi	G protein-coupled receptor F59B2.13	0.002	0.0148	0.0256
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0117	0.1398	0.2375
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0111	0.0105
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0292	0.0502
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0148	0.0203
Brugia malayi	Serotonin receptor	0.002	0.0148	0.0256
Echinococcus multilocularis	g-protein coupled receptor	0.002	0.0148	0.0147
Schistosoma mansoni	biogenic amine receptor	0.002	0.0148	0.0203
Schistosoma mansoni	neurotransmitter gated ion channel	0.0054	0.0586	0.0963
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0261	0.3254	0.5625
Echinococcus multilocularis	g protein coupled receptor	0.002	0.0148	0.0147
Echinococcus granulosus	nAChR subunit	0.0063	0.0702	0.1212
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0186	0.0322
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0063	0.0702	0.1215
Brugia malayi	hypothetical protein	0.0054	0.0586	0.1013
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0063	0.0702	0.1215
Echinococcus granulosus	orexin receptor type 2	0.002	0.0148	0.0254
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0117	0.1398	0.2416
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0186	1
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0117	0.1398	0.1396
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0148	0.0147
Brugia malayi	hypothetical protein	0.002	0.0148	0.0256
Echinococcus granulosus	hypothetical protein	0.002	0.0148	0.0254
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0117	0.1398	0.1396
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Schistosoma mansoni	hypothetical protein	0.0031	0.0292	0.0452
Schistosoma mansoni	neuropeptide F-like receptor	0.002	0.0148	0.0203
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.0202	0.2502	0.2501
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0148	0.0147
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0186	1
Echinococcus granulosus	sentrin specific protease 7	0.0143	0.1732	0.2993
Brugia malayi	CHE-14 protein	0.0041	0.0417	0.0722
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0261	0.3254	0.3253
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1398	0.2415
Echinococcus multilocularis	p2X purinoceptor 4	0.0278	0.3473	0.3472
Entamoeba histolytica	hypothetical protein	0.0035	0.0339	0.1712
Echinococcus granulosus	excitatory amino acid transporter 2	0.0457	0.5783	1
Brugia malayi	Melatonin receptor type 1A	0.002	0.0148	0.0256
Echinococcus multilocularis	fmrfamide receptor	0.002	0.0148	0.0147
Onchocerca volvulus		0.0117	0.1398	0.2348
Schistosoma mansoni	acetylcholine receptor-related	0.0054	0.0586	0.0963
Schistosoma mansoni	histamine h1 receptor	0.002	0.0148	0.0203
Schistosoma mansoni	nAChR subunit	0.0054	0.0586	0.0963
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.0202	0.2502	0.4296
Schistosoma mansoni	hypothetical protein	0.002	0.0148	0.0203
Echinococcus granulosus	p2X purinoceptor 4	0.0278	0.3473	0.6005
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0117	0.1398	0.2415
Brugia malayi	Niemann-Pick C1 protein precursor	0.0095	0.1118	0.1933
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Echinococcus multilocularis	Niemann Pick C1 protein	0.0136	0.1645	0.1644
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0417	0.0719
Schistosoma mansoni	neuropeptide receptor	0.002	0.0148	0.0203
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0339	0.0535
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.002	0.0148	0.0256
Echinococcus multilocularis	G-protein coupled receptor, putative	0.002	0.0148	0.0147
Onchocerca volvulus		0.002	0.0148	0.0169
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0117	0.1398	0.2416
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.002	0.0148	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0702	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0586	0.1011
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Brugia malayi	hypothetical protein	0.0054	0.0586	0.1013
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0054	0.0586	0.1013
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0111	0.0021
Schistosoma mansoni	patched 1	0.0041	0.0417	0.0671
Schistosoma mansoni	nAChR subunit	0.0117	0.1398	0.2375
Brugia malayi	hypothetical protein	0.002	0.0148	0.0256
Onchocerca volvulus		0.0063	0.0702	0.1136
Loa Loa (eye worm)	Ulp1 protease	0.0012	0.0051	0.0087
Schistosoma mansoni	hypothetical protein	0.0067	0.0757	0.1261
Onchocerca volvulus		0.002	0.0148	0.0169
Brugia malayi	Cation transporter family protein	0.0117	0.1398	0.2416
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0063	0.0702	0.1215
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.002	0.0148	0.0254
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.002	0.0148	0.0254
Brugia malayi	G-protein coupled receptor	0.002	0.0148	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0586	0.1011
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0143	0.1732	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0148	0.0147
Onchocerca volvulus		0.0117	0.1398	0.2348
Echinococcus multilocularis	neuropeptide receptor	0.002	0.0148	0.0147
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0095	0.1118	0.6346
Entamoeba histolytica	hypothetical protein	0.0035	0.0339	0.1712
Brugia malayi	neuropeptide F receptor	0.002	0.0148	0.0256
Mycobacterium tuberculosis	Probable C4-dicarboxylate-transport transmembrane protein DctA	0.0457	0.5783	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0111	0.019
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0186	0.0802
Onchocerca volvulus		0.002	0.0148	0.0169
Echinococcus granulosus	sentrin specific protease 8	0.0012	0.0051	0.0087
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0117	0.1398	0.2415
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0117	0.1398	0.1396
Onchocerca volvulus		0.002	0.0148	0.0169
Schistosoma mansoni	P2X receptor subunit	0.0278	0.3473	0.5984
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0032	0.003
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0261	0.3254	0.3253
Echinococcus multilocularis	serotonin receptor	0.002	0.0148	0.0147
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.002	0.0148	0.0147
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0148	0.0254
Loa Loa (eye worm)	ACC-1 protein	0.0117	0.1398	0.2415
Entamoeba histolytica	hypothetical protein	0.0035	0.0339	0.1712
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.002	0.0148	0.0203
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0148	0.0254
Onchocerca volvulus		0.002	0.0148	0.0169
Brugia malayi	hypothetical protein	0.0054	0.0586	0.1013
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Onchocerca volvulus		0.0117	0.1398	0.2348
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1118	0.1931
Brugia malayi	hypothetical protein	0.0054	0.0586	0.1013
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0032	0.0052
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0148	0.0203
Echinococcus granulosus	Excitatory amino acid transporter	0.0457	0.5783	1
Loa Loa (eye worm)	Ulp1 protease	0.0012	0.0051	0.0087
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0054	0.0586	0.1013
Schistosoma mansoni	hypothetical protein	0.0031	0.0292	0.0452
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0054	0.0586	0.1013
Echinococcus granulosus	neuropeptides capa receptor	0.002	0.0148	0.0254
Chlamydia trachomatis	glutamate symporter	0.0457	0.5783	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0111	0.019
Schistosoma mansoni	neuropeptide receptor	0.002	0.0148	0.0203
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0012	0.0051	0.0089
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0012	0.0051	0.0089
Onchocerca volvulus	Excitatory amino acid transporter homolog	0.0457	0.5783	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0148	0.0147
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0117	0.1398	0.2416
Echinococcus granulosus	neuropeptide FF receptor 2	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0702	0.1212
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.002	0.0148	0.0147
Echinococcus multilocularis	expressed conserved protein	0.013	0.1571	0.157
Chlamydia trachomatis	neutral amino acid transporter	0.0202	0.2502	0.4276
Echinococcus granulosus	tm gpcr rhodopsin	0.002	0.0148	0.0254
Echinococcus multilocularis	neuropeptide s receptor	0.002	0.0148	0.0147
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.002	0.0148	0.0147
Echinococcus multilocularis	expressed conserved protein	0.0089	0.1044	0.1042
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1398	0.2415
Loa Loa (eye worm)	excitatory amino acid transporter	0.0457	0.5783	1
Echinococcus granulosus	cpg binding protein	0.0029	0.0269	0.0463
Echinococcus granulosus	neuropeptide Y receptor	0.002	0.0148	0.0254
Leishmania major	hypothetical protein, conserved	0.0024	0.0205	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.0457	0.5783	0.5783
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0098	0.1158	0.2002
Schistosoma mansoni	P2X receptor subunit	0.0278	0.3473	0.5984
Onchocerca volvulus	Neuropeptide F receptor homolog	0.002	0.0148	0.0169
Schistosoma mansoni	nAChR subunit	0.0117	0.1398	0.2375
Schistosoma mansoni	neuropeptide receptor	0.002	0.0148	0.0203
Echinococcus granulosus	sodium:dicarboxylate symporter	0.0457	0.5783	1
Echinococcus multilocularis	neutral amino acid transporter A	0.0457	0.5783	0.5783
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.002	0.0148	0.0254
Echinococcus granulosus	dro:myosuppressin receptor	0.002	0.0148	0.0254
Brugia malayi	AKH receptor	0.002	0.0148	0.0256
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.002	0.0148	0.0203
Loa Loa (eye worm)	G-protein coupled receptor	0.002	0.0148	0.0254
Echinococcus multilocularis	serotonin receptor	0.002	0.0148	0.0147
Schistosoma mansoni	amine GPCR	0.002	0.0148	0.0203
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0261	0.3254	0.5625
Loa Loa (eye worm)	melatonin receptor type 1A	0.002	0.0148	0.0254
Echinococcus granulosus	neuropeptide receptor	0.002	0.0148	0.0254
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0012	0.0051	0.0035
Echinococcus granulosus	neutral amino acid transporter A	0.0457	0.5783	1
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0054	0.0586	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1398	0.2415
Echinococcus multilocularis	g protein coupled receptor	0.002	0.0148	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0702	0.1212
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0117	0.1398	0.2416
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0292	0.029
Echinococcus granulosus	neutral amino acid transporter	0.0457	0.5783	1
Schistosoma mansoni	amine GPCR	0.002	0.0148	0.0203
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Schistosoma mansoni	amine GPCR	0.002	0.0148	0.0203
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Schistosoma mansoni	neuropeptide F-like receptor	0.002	0.0148	0.0203
Brugia malayi	putative neuropeptide receptor NPR1	0.002	0.0148	0.0256
Brugia malayi	hypothetical protein	0.002	0.0148	0.0256
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0117	0.1398	0.2416
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Brugia malayi	hypothetical protein	0.002	0.0148	0.0256
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1398	0.2415
Brugia malayi	hypothetical protein	0.0016	0.0094	0.0162
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0148	0.0203
Echinococcus granulosus	biogenic amine 5HT receptor	0.002	0.0148	0.0254
Echinococcus multilocularis	fmrfamide receptor	0.002	0.0148	0.0147
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.0111	0.3912
Echinococcus multilocularis	nAChR subunit	0.0063	0.0702	0.0701
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0205	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.002	0.0148	0.0254
Onchocerca volvulus		0.0054	0.0586	0.0932
Echinococcus multilocularis	G protein coupled receptor 139	0.002	0.0148	0.0147
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0054	0.0586	0.1011
Echinococcus multilocularis	excitatory amino acid transporter 2	0.0457	0.5783	0.5783
Echinococcus multilocularis	p2X purinoceptor 4	0.0278	0.3473	0.3472
Brugia malayi	GnHR receptor homolog	0.002	0.0148	0.0256
Schistosoma mansoni	cpg binding protein	0.0029	0.0269	0.0413
Wolbachia endosymbiont of Brugia malayi	Na+/H+-dicarboxylate symporter	0.0457	0.5783	0.5
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0117	0.1398	0.2375
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0417	0.0719
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0117	0.1398	0.1396
Brugia malayi	Dopamine receptor protein 1	0.002	0.0148	0.0256
Echinococcus granulosus	GPCR family 2	0.0031	0.0292	0.0502
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.002	0.0148	0.0254
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0054	0.0586	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1398	0.2415
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Echinococcus granulosus	glycine receptor subunit beta	0.0117	0.1398	0.2415
Brugia malayi	sulfakinin receptor protein	0.002	0.0148	0.0256
Brugia malayi	Serotonin receptor	0.002	0.0148	0.0256
Brugia malayi	Dopamine receptor	0.002	0.0148	0.0256
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0012	0.0051	0.0035
Echinococcus granulosus	G protein coupled receptor 139	0.002	0.0148	0.0254
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0117	0.1398	0.2375
Onchocerca volvulus		0.0023	0.0186	0.0235
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0148	0.0203
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.002	0.0148	0.0203
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0054	0.0586	0.0584
Echinococcus granulosus	excitatory amino acid transporter 3	0.0457	0.5783	1
Brugia malayi	putative neuropeptide receptor	0.002	0.0148	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0586	0.1011
Onchocerca volvulus		0.002	0.0148	0.0169
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0186	0.0802
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0117	0.1398	0.2375
Echinococcus multilocularis	sentrin specific protease 8	0.0012	0.0051	0.005
Echinococcus granulosus	sentrin specific protease 1	0.0012	0.0051	0.0087
Echinococcus multilocularis	sentrin specific protease 7	0.0143	0.1732	0.1731
Echinococcus multilocularis	excitatory amino acid transporter 3	0.0457	0.5783	0.5783
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1398	0.2415
Onchocerca volvulus		0.0063	0.0702	0.1136
Echinococcus granulosus	excitatory amino acid transporter 2	0.0457	0.5783	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0249	0.0428
Schistosoma mansoni	nAChR subunit	0.0117	0.1398	0.2375
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0261	0.3254	0.5626
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0012	0.0051	0.0089
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0148	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0111	0.019
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Echinococcus granulosus	nAChR subunit	0.0117	0.1398	0.2415
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0148	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0586	0.1011
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.002	0.0148	0.0254
Onchocerca volvulus		0.002	0.0148	0.0169
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0417	0.0719
Echinococcus multilocularis	g protein coupled receptor	0.002	0.0148	0.0147
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0054	0.0586	0.1011
Echinococcus granulosus	neuropeptide receptor	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1398	0.2415
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0205	0.2965
Onchocerca volvulus		0.002	0.0148	0.0169
Echinococcus granulosus	tm gpcr rhodopsin	0.002	0.0148	0.0254
Echinococcus granulosus	Niemann Pick C1 protein	0.0136	0.1645	0.2842
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0702	0.1212
Loa Loa (eye worm)	hypothetical protein	0.002	0.0148	0.0254
Loa Loa (eye worm)	hypothetical protein	0.005	0.0536	0.0924
Onchocerca volvulus		0.002	0.0148	0.0169

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.1 uM	Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2	ChEMBL.	16165356
IC50 (binding)	= 0.15 uM	Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1	ChEMBL.	16165356
IC50 (binding)	= 0.2 uM	Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3	ChEMBL.	16165356

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2113116

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 931937