Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | TK/KIN16 protein kinase | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Onchocerca volvulus | Get druggable targets OG5_130320 | All targets in OG5_130320 | |
Onchocerca volvulus | Tyrosine kinase homolog | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Brugia malayi | Immunoglobulin I-set domain containing protein | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0183 | 0.36 | 0.3622 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0077 | 0.0077 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0183 | 0.36 | 0.3622 |
Brugia malayi | dihydrofolate reductase family protein | 0.0484 | 0.9939 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0137 | 0.0138 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0137 | 0.0138 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0487 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0484 | 0.9939 | 1 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.006 | 0.0061 |
Brugia malayi | hypothetical protein | 0.0115 | 0.2175 | 0.2189 |
Brugia malayi | thymidylate synthase | 0.0241 | 0.4833 | 0.4862 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0241 | 0.4833 | 0.3423 |
Schistosoma mansoni | nephrin | 0.0014 | 0.006 | 0.0061 |
Onchocerca volvulus | 0.0241 | 0.4833 | 1 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0241 | 0.4833 | 0.4862 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0137 | 0.0138 |
Loa Loa (eye worm) | thymidylate synthase | 0.0241 | 0.4833 | 0.4862 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0171 | 0.3348 | 0.0522 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0487 | 1 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0137 | 0.0138 |
Schistosoma mansoni | dihydrofolate reductase | 0.0484 | 0.9939 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0077 | 0.0077 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0484 | 0.9939 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0241 | 0.4833 | 0.4862 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0077 | 0.0077 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0484 | 0.9939 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0115 | 0.2175 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0484 | 0.9939 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0484 | 0.9939 | 1 |
Echinococcus granulosus | neuroglian | 0.0014 | 0.006 | 0.0061 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0487 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0484 | 0.9939 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0484 | 0.9939 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0484 | 0.9939 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0487 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0487 | 1 | 0.5 |
Echinococcus granulosus | twitchin | 0.0014 | 0.006 | 0.0061 |
Echinococcus granulosus | thymidylate synthase | 0.0241 | 0.4833 | 0.4862 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 481 nM | Inhibitory activity against VEGF stimulated autophosphorylation of VEGFR2 expressed in KDR15 cells | ChEMBL. | 16302797 |
IC50 (binding) | = 491.3 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP | ChEMBL. | 16302797 |
IC50 (binding) | = 542.9 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 1 mm ATP | ChEMBL. | 16302797 |
IC50 (binding) | > 1000 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathione | ChEMBL. | 16302797 |
IC50 (binding) | > 1000 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma | ChEMBL. | 16302797 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.