Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0569 | 0.5283 | 0.8453 |
Onchocerca volvulus | 0.0195 | 0 | 0.5 | |
Schistosoma mansoni | glutamate receptor NMDA | 0.0407 | 0.2988 | 0.4781 |
Schistosoma mansoni | glutamate receptor kainate | 0.0275 | 0.112 | 0.1793 |
Echinococcus multilocularis | acetylcholinesterase | 0.0637 | 0.625 | 0.6918 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0408 | 0.3007 | 0.3317 |
Brugia malayi | Serotonin receptor | 0.0624 | 0.607 | 0.9711 |
Echinococcus multilocularis | serotonin receptor | 0.0216 | 0.0289 | 0.03 |
Loa Loa (eye worm) | carboxylesterase | 0.0637 | 0.625 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.0122 | 0.0194 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0637 | 0.625 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0637 | 0.625 | 0.6243 |
Echinococcus granulosus | carboxylesterase 5A | 0.0637 | 0.625 | 0.6243 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0216 | 0.0289 | 0.027 |
Schistosoma mansoni | glutamate receptor kainate | 0.0275 | 0.112 | 0.1793 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.625 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.0289 | 0.0463 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0311 | 0.1641 | 0.18 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.0122 | 0.0194 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0479 | 0.4008 | 0.6413 |
Echinococcus granulosus | glutamate receptor 4 | 0.0204 | 0.0122 | 0.0102 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0275 | 0.112 | 0.1793 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0479 | 0.4008 | 0.6413 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0516 | 0.4529 | 0.5007 |
Echinococcus multilocularis | acetylcholinesterase | 0.0637 | 0.625 | 0.6918 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0414 | 0.309 | 0.341 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0275 | 0.112 | 0.1793 |
Brugia malayi | Carboxylesterase family protein | 0.0637 | 0.625 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0414 | 0.309 | 0.3077 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0311 | 0.1641 | 0.1624 |
Onchocerca volvulus | 0.0195 | 0 | 0.5 | |
Echinococcus multilocularis | conserved hypothetical protein | 0.0833 | 0.9025 | 1 |
Echinococcus granulosus | glutamate receptor 1 | 0.0204 | 0.0122 | 0.0102 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0216 | 0.0289 | 0.0463 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0516 | 0.4529 | 0.5007 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0311 | 0.1641 | 0.18 |
Echinococcus multilocularis | glutamate receptor 4 | 0.0204 | 0.0122 | 0.0113 |
Echinococcus granulosus | acetylcholinesterase | 0.0637 | 0.625 | 0.6243 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0637 | 0.625 | 1 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0479 | 0.4008 | 0.6413 |
Echinococcus multilocularis | serotonin receptor | 0.0216 | 0.0289 | 0.03 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0306 | 0.156 | 0.1543 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0275 | 0.112 | 0.1793 |
Brugia malayi | Carboxylesterase family protein | 0.0637 | 0.625 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0569 | 0.5283 | 0.8453 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0311 | 0.1641 | 0.1624 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.0122 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.0289 | 0.0463 |
Onchocerca volvulus | 0.0195 | 0 | 0.5 | |
Schistosoma mansoni | glutamate receptor NMDA | 0.0408 | 0.3007 | 0.4811 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0275 | 0.112 | 0.1793 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.625 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0516 | 0.4529 | 0.4518 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0311 | 0.1641 | 0.1624 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0311 | 0.1641 | 0.18 |
Schistosoma mansoni | glutamate receptor kainate | 0.0275 | 0.112 | 0.1793 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0637 | 0.625 | 0.6918 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0408 | 0.3007 | 0.2993 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0306 | 0.156 | 0.171 |
Schistosoma mansoni | amine GPCR | 0.0469 | 0.3868 | 0.6189 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0479 | 0.4008 | 0.4429 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0516 | 0.4529 | 0.4518 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Inhibition of CYP1A2 | ChEMBL. | 16821797 | |
Activity (functional) | Activity at alpha7 nAChR assessed as stimulation of relative inward current in cultured hippocampal neurons relative to choline | ChEMBL. | 16821797 | |
Activity (functional) | Antagonist activity against 5HT3 receptor assessed as inhibition of 5HT-induced contraction of guinea pig ileum | ChEMBL. | 16821797 | |
Activity (ADMET) | Inhibition of CYP2C19 | ChEMBL. | 16821797 | |
Activity (ADMET) | Inhibition of CYP2C9 | ChEMBL. | 16821797 | |
Activity (ADMET) | Inhibition of CYP3A4 | ChEMBL. | 16821797 | |
IC50 (binding) | = 10 nmol/L | Binding affinity to 5HT3 receptor | ChEMBL. | 16821797 |
IC50 (binding) | > 10000 nmol/L | Binding affinity to NMDA receptor glycine site | ChEMBL. | 16821797 |
IC50 (binding) | > 10000 nmol/L | Binding affinity to NMDA receptor PCP site | ChEMBL. | 16821797 |
IC50 (binding) | > 10000 nmol/L | Binding affinity to AMPA receptor | ChEMBL. | 16821797 |
IC50 (binding) | > 10000 nmol/L | Binding affinity to histamine H3 receptor | ChEMBL. | 16821797 |
IC50 (binding) | > 10000 nmol/L | Binding affinity to histamine H1 receptor | ChEMBL. | 16821797 |
IC50 (binding) | > 10000 nmol/L | Binding affinity to D4 receptor | ChEMBL. | 16821797 |
IC50 (binding) | > 10000 nmol/L | Binding affinity to D3 receptor | ChEMBL. | 16821797 |
IC50 (binding) | > 10000 nmol/L | Binding affinity to D2 receptor | ChEMBL. | 16821797 |
IC50 (binding) | > 10000 nmol/L | Binding affinity to D1 receptor | ChEMBL. | 16821797 |
IC50 (binding) | > 10000 nmol/L | Binding affinity to adrenergic beta receptor | ChEMBL. | 16821797 |
IC50 (binding) | > 10000 nmol/L | Binding affinity to adrenergic alpha2 receptor | ChEMBL. | 16821797 |
IC50 (binding) | > 10000 nmol/L | Binding affinity to adrenergic alpha1 receptor | ChEMBL. | 16821797 |
IC50 (binding) | > 10000 nmol/L | Binding affinity to 5HT2 receptor | ChEMBL. | 16821797 |
IC50 (binding) | > 10000 nmol/L | Binding affinity to 5HT1A receptor | ChEMBL. | 16821797 |
IC50 (binding) | > 10000 nmol/L | Binding affinity to muscarinic receptor | ChEMBL. | 16821797 |
IC50 (binding) | > 10000 nmol/L | Inhibition of [3H]Cytisine binding to alpha4beta2 nACh receptor in rat cerebral cortex membrane | ChEMBL. | 16821797 |
IC50 (ADMET) | > 30 umol/L | Inhibition of CYP2D6 | ChEMBL. | 16821797 |
Ki (binding) | = 3 nmol/L | Displacement of [125I]alpha-BTX from alpha7 nAChR in rat hippocampus membrane | ChEMBL. | 16821797 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.