TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 375.424 | Formula: C21H21N5O2
H donors: 1 H acceptors: 5 LogP: 2.91 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)Cc1cn(c2c1ccc(n2)C)c1ccc(cc1Cn1nncc1C)C
InChi: 1S/C21H21N5O2/c1-13-4-7-19(17(8-13)12-26-15(3)10-22-24-26)25-11-16(9-20(27)28)18-6-5-14(2)23-21(18)25/h4-8,10-11H,9,12H2,1-3H3,(H,27,28)
InChiKey: JKVCLGBXNKAWEQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	prostaglandin D2 receptor 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0035	0.0026
Brugia malayi	fructose-1,6-bisphosphatase	0.1865	0.3761	0.3755
Schistosoma mansoni	protein kinase	0.0054	0.0026	0.0016
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0054	0.0026	0.0026
Schistosoma mansoni	tyrosine kinase	0.0054	0.0026	0.0016
Echinococcus granulosus	mitogen activated protein kinase 14	0.0419	0.0777	0.0777
Plasmodium falciparum	tyrosine kinase-like protein	0.0054	0.0026	0.4606
Loa Loa (eye worm)	TK/FAK protein kinase	0.0054	0.0026	0.0016
Echinococcus granulosus	protein kinase	0.0054	0.0026	0.0026
Echinococcus granulosus	receptor type guanylyl cyclase	0.0054	0.0026	0.0026
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0.0026	0.173
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Schistosoma mansoni	tyrosine kinase	0.0087	0.0093	0.0083
Echinococcus granulosus	tyrosine protein kinase Srms	0.0076	0.007	0.007
Schistosoma mansoni	tyrosine kinase	0.0054	0.0026	0.0016
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0054	0.0026	0.4606
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0.0026	0.173
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0092	0.0103	0.0248
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Plasmodium vivax	serine/threonine kinase-1, putative	0.0064	0.0045	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0054	0.0026	0.4606
Schistosoma mansoni	protein kinase	0.0059	0.0036	0.0026
Entamoeba histolytica	hypothetical protein	0.0054	0.0026	0.173
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0419	0.0777	0.2046
Loa Loa (eye worm)	TK/DDR protein kinase	0.0054	0.0026	0.0016
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Entamoeba histolytica	receptor protein kinase, putative	0.0054	0.0026	0.173
Loa Loa (eye worm)	hypothetical protein	0.006	0.0037	0.0028
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0054	0.0026	0.0016
Entamoeba histolytica	hypothetical protein	0.0054	0.0026	0.173
Echinococcus granulosus	activated cdc42 kinase 1	0.0054	0.0026	0.0026
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0054	0.0026	0.0026
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0087	0.0093	0.0093
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.2639	0.5358	0.5358
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0303	0.0538	0.0538
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0026	0.0016
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Schistosoma mansoni	serine/threonine RGC	0.0054	0.0026	0.0016
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0026	0.173
Entamoeba histolytica	hypothetical protein	0.0054	0.0026	0.173
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0061	0.004	0.003
Schistosoma mansoni	tyrosine kinase	0.4888	1	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0054	0.0026	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0026	0.173
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Echinococcus granulosus	tyrosine kinase	0.0054	0.0026	0.0026
Brugia malayi	Guanylyl cyclase protein 23	0.0054	0.0026	0.0016
Echinococcus granulosus	activated cdc42 kinase 1	0.0054	0.0026	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Entamoeba histolytica	protein kinase, putative	0.0054	0.0026	0.173
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.006	0.0038	0.0076
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0054	0.0026	0.0016
Entamoeba histolytica	tyrosin kinase, putative	0.0054	0.0026	0.173
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0419	0.0777	0.2046
Echinococcus multilocularis	cyclin dependent kinase 1	0.0047	0.001	0.001
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Loa Loa (eye worm)	TK/INSR protein kinase	0.158	0.3174	0.3168
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0054	0.0026	0.0016
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0026	0.173
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0026	0.0016
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0086	0.0092	0.0092
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0026	0.0016
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Echinococcus multilocularis	c src tyrosine kinase	0.0087	0.0093	0.0093
Loa Loa (eye worm)	cytochrome P450 family protein	0.0061	0.004	0.003
Echinococcus multilocularis	Immunoglobulin	0.0104	0.0128	0.0128
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Schistosoma mansoni	protein kinase	0.0054	0.0026	0.0016
Entamoeba histolytica	protein kinase, putative	0.0054	0.0026	0.173
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0083	0.0085	0.0085
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0054	0.0026	0.0026
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0061	0.004	0.003
Schistosoma mansoni	tyrosine kinase	0.0054	0.0026	0.0016
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0054	0.0026	0.0016
Entamoeba histolytica	protein kinase domain containing protein	0.0059	0.0036	0.2814
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0119	0.0159	0.0159
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0026	0.0016
Brugia malayi	Protein kinase domain containing protein	0.09	0.177	0.1762
Schistosoma mansoni	cell adhesion molecule	0.0061	0.004	0.003
Echinococcus granulosus	microtubule associated protein 2	0.0758	0.1478	0.1478
Echinococcus granulosus	defective proboscis extension response	0.0104	0.0128	0.0128
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.0064	0.0045	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0128	0.0118
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	0.007	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Schistosoma mansoni	cell adhesion molecule	0.0059	0.0035	0.0026
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0059	0.0036	0.007
Trichomonas vaginalis	protein kinase atn1, putative	0.0054	0.0026	0.4606
Brugia malayi	SH2 domain containing protein	0.0076	0.007	0.0061
Schistosoma mansoni	tyrosine kinase	0.158	0.3174	0.3168
Entamoeba histolytica	hypothetical protein	0.0054	0.0026	0.173
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Echinococcus multilocularis	dual specificity protein kinase clk2	0.0064	0.0045	0.0045
Echinococcus multilocularis	protein kinase	0.0054	0.0026	0.0026
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Echinococcus granulosus	dual specificity	0.0092	0.0103	0.0103
Echinococcus multilocularis	roundabout 2	0.0061	0.004	0.004
Echinococcus granulosus	cyclin dependent kinase 5	0.0047	0.001	0.001
Entamoeba histolytica	tyrosin kinase, putative	0.0054	0.0026	0.173
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0054	0.0026	0.0016
Echinococcus multilocularis	tyrosine protein kinase csk	0.0054	0.0026	0.0026
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0038	0.8107
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0119	0.0159	0.0159
Loa Loa (eye worm)	TK/EPH protein kinase	0.0131	0.0183	0.0174
Echinococcus granulosus	hemicentin 1	0.0059	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0035	0.0026
Echinococcus multilocularis	tyrosine protein kinase otk	0.0059	0.0035	0.0035
Echinococcus multilocularis	insulin receptor	0.158	0.3174	0.3174
Brugia malayi	Fibronectin type III domain containing protein	0.0106	0.0132	0.0123
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0054	0.0026	0.0043
Echinococcus granulosus	tyrosine protein kinase Blk	0.0108	0.0136	0.0136
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.006	0.0038	0.0028
Echinococcus granulosus	hypothetical protein	0.0059	0.0034	0.0034
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0153	0.023	0.023
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.006	0.0038	0.0076
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0869	0.1707	0.1707
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0108	0.0136	0.0136
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0929	0.1829	0.1821
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0119	0.0159	0.0159
Leishmania major	protein kinase, putative	0.0064	0.0045	0.0093
Entamoeba histolytica	protein kinase, putative	0.0054	0.0026	0.173
Brugia malayi	hypothetical protein	0.0076	0.007	0.0061
Loa Loa (eye worm)	hypothetical protein	0.025	0.043	0.0421
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0106	0.0132	0.0123
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0026	0.173
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0026	0.0016
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0026	0.0016
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0087	0.0093	0.0093
Brugia malayi	SH2 domain containing protein	0.0076	0.007	0.0061
Onchocerca volvulus		0.0076	0.007	0.028
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0026	0.0016
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	0.007	0.0061
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0026	0.0016
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0059	0.0036	0.007
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0035	0.0026
Schistosoma mansoni	tyrosine kinase	0.0281	0.0493	0.0484
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Echinococcus granulosus	kinase suppressor of Ras 1	0.0054	0.0026	0.0026
Echinococcus granulosus	raf serine:threonine protein kinase	0.0054	0.0026	0.0026
Entamoeba histolytica	protein kinase, putative	0.0054	0.0026	0.173
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0026	0.0016
Entamoeba histolytica	protein kinase, putative	0.0086	0.0092	0.8836
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0026	0.173
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0059	0.0035	0.0026
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0026	0.173
Echinococcus multilocularis	neuroglian	0.0061	0.004	0.004
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0026	0.0016
Brugia malayi	MAP kinase sur-1	0.006	0.0038	0.0028
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0073	0.0063	0.5744
Entamoeba histolytica	hypothetical protein	0.0054	0.0026	0.173
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0054	0.0026	0.0016
Brugia malayi	integrin-linked kinase	0.0054	0.0026	0.0016
Echinococcus multilocularis	protein kinase	0.0054	0.0026	0.0026
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0054	0.0026	0.0016
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0026	0.4606
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0026	0.173
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	0.007	0.0061
Schistosoma mansoni	fructose-16-bisphosphatase-related	0.1865	0.3761	0.3755
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Schistosoma mansoni	protein kinase	0.0054	0.0026	0.0016
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0026	0.173
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0054	0.0026	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0132	0.0123
Toxoplasma gondii	fructose-bisphospatase II	0.1865	0.3761	1
Entamoeba histolytica	cysteine surface protein, putative	0.0054	0.0026	0.173
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Schistosoma mansoni	nephrin	0.0061	0.004	0.003
Trypanosoma brucei	Pseudokinase, putative	0.0054	0.0026	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0026	0.4606
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0054	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0026	0.0016
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0119	0.0159	0.0159
Loa Loa (eye worm)	serine/threonine protein kinase	0.0054	0.0026	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0132	0.0123
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0054	0.0026	0.0043
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0073	0.0063	0.0063
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0419	0.0777	0.2046
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0054	0.0026	0.0016
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Echinococcus multilocularis	activin receptor type	0.0059	0.0036	0.0036
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.0064	0.0045	0.0093
Echinococcus multilocularis	tyrosine protein kinase csk	0.0054	0.0026	0.0026
Schistosoma mansoni	tyrosine kinase	0.0076	0.007	0.0061
Entamoeba histolytica	tyrosin kinase, putative	0.0054	0.0026	0.173
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0054	0.0026	0.0016
Echinococcus granulosus	Immunoglobulin	0.0104	0.0128	0.0128
Onchocerca volvulus		0.0076	0.007	0.028
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0073	0.0063	0.0063
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.006	0.0038	0.0076
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0061	0.004	0.004
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0103	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0059	0.0035	0.0026
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0064	0.0045	0.0093
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.1583	0.3179	0.3179
Schistosoma mansoni	tyrosine kinase	0.0054	0.0026	0.0016
Echinococcus multilocularis	hemicentin 1	0.0059	0.0035	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0054	0.0026	0.0016
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0059	0.0035	0.0026
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0026	0.173
Schistosoma mansoni	microtubule-associated protein tau	0.0758	0.1478	0.147
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0026	0.0016
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0034	0.0025
Leishmania major		0.1865	0.3761	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0026	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0128	0.0118
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Schistosoma mansoni	tyrosine kinase	0.0054	0.0026	0.0016
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0026	0.0016
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0026	0.173
Echinococcus multilocularis	peroxidasin	0.0059	0.0035	0.0035
Brugia malayi	hypothetical protein	0.0054	0.0026	0.0016
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0119	0.0159	0.0159
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Trypanosoma brucei	sedoheptulose-1,7-bisphosphatase	0.0693	0.1344	0.3558
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.006	0.0038	0.0076
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.006	0.0038	0.0076
Echinococcus granulosus	contactin	0.0061	0.004	0.004
Leishmania major	protein kinase, putative	0.0064	0.0045	0.0093
Loa Loa (eye worm)	hypothetical protein	0.012	0.0161	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0163	0.025	0.024
Brugia malayi	Protein kinase domain containing protein	0.0064	0.0045	0.0035
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0693	0.1344	0.3558
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0128	0.0118
Plasmodium vivax	protein kinase, putative	0.0059	0.0035	0.7386
Brugia malayi	Protein kinase domain containing protein	0.0076	0.007	0.0061
Echinococcus multilocularis	FL cytokine receptor	0.0054	0.0026	0.0026
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0054	0.0026	0.0026
Echinococcus granulosus	activin receptor type	0.0059	0.0036	0.0036
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0026	0.0016
Echinococcus granulosus	ephrin type A receptor 4 A	0.0129	0.0179	0.0179
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Schistosoma mansoni	ephrin receptor	0.0057	0.003	0.0021
Echinococcus granulosus	epidermal growth factor receptor	0.2639	0.5358	0.5358
Echinococcus granulosus	integrin linked protein kinase	0.0054	0.0026	0.0026
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0092	0.0103	0.0248
Echinococcus multilocularis	dual specificity	0.0092	0.0103	0.0103
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0059	0.0035	0.0026
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0054	0.0026	0.4606
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Schistosoma mansoni	cell adhesion molecule	0.0061	0.004	0.003
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0054	0.0026	0.0026
Entamoeba histolytica	hypothetical protein, conserved	0.0054	0.0026	0.173
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0104	0.0128	0.0128
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0059	0.0036	0.007
Schistosoma mansoni	tyrosine kinase	0.0119	0.0159	0.0149
Trypanosoma cruzi	protein kinase, putative	0.0054	0.0026	0.0043
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Echinococcus granulosus	mitogen activated protein kinase 11	0.0419	0.0777	0.0777
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0054	0.0026	0.0026
Echinococcus granulosus	tyrosine protein kinase	0.0054	0.0026	0.0026
Echinococcus granulosus	tyrosine protein kinase csk	0.0054	0.0026	0.0026
Schistosoma mansoni	tyrosine kinase	0.0054	0.0026	0.0016
Entamoeba histolytica	protein kinase, putative	0.0054	0.0026	0.173
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0054	0.0026	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Schistosoma mansoni	protein kinase	0.0054	0.0026	0.0016
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0073	0.0063	0.0142
Plasmodium falciparum	protein kinase, putative	0.0054	0.0026	0.4606
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0419	0.0777	0.0777
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0026	0.173
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0092	0.0103	0.0248
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Brugia malayi	SRC-1	0.0119	0.0159	0.0149
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Brugia malayi	Protein kinase domain containing protein	0.158	0.3174	0.3168
Onchocerca volvulus		0.0076	0.007	0.028
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0054	0.0026	0.0026
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0054	0.0026	0.0016
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0929	0.1829	0.1821
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0076	0.007	0.007
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0026	0.173
Loa Loa (eye worm)	hypothetical protein	0.0076	0.007	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0093	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0026	0.0016
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0061	0.004	0.003
Schistosoma mansoni	protein kinase	0.0059	0.0036	0.0026
Schistosoma mansoni	tyrosine kinase	0.0054	0.0026	0.0016
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0108	0.0136	0.0136
Echinococcus granulosus	roundabout 2	0.0061	0.004	0.004
Loa Loa (eye worm)	TK/ABL protein kinase	0.0303	0.0538	0.0529
Entamoeba histolytica	hypothetical protein	0.0054	0.0026	0.173
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0059	0.0035	0.0035
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0073	0.0063	0.0054
Schistosoma mansoni	tyrosine kinase	0.2639	0.5358	0.5354
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0093	0.0083
Onchocerca volvulus		0.0076	0.007	0.028
Toxoplasma gondii	fructose-bisphospatase I	0.0693	0.1344	0.3558
Giardia lamblia	Kinase, NEK	0.0054	0.0026	0.4606
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0054	0.0026	0.0026
Echinococcus multilocularis	hemicentin 1	0.0059	0.0035	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Echinococcus multilocularis	cyclin dependent kinase	0.0047	0.001	0.001
Entamoeba histolytica	ankyrin repeat protein	0.0054	0.0026	0.173
Entamoeba histolytica	protein kinase, putative	0.0054	0.0026	0.173
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0419	0.0777	0.2046
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0026	0.4606
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0054	0.0026	0.4606
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0026	0.173
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0038	0.8107
Brugia malayi	Tyrosine-protein kinase PR2	0.0054	0.0026	0.0016
Giardia lamblia	Kinase, CMGC MAPK	0.006	0.0038	0.8107
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0054	0.0026	0.173
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Entamoeba histolytica	hypothetical protein	0.0054	0.0026	0.173
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0059	0.0035	0.0026
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0119	0.0159	0.0159
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0064	0.0045	0.0093
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0026	0.173
Onchocerca volvulus		0.006	0.0037	0.0072
Entamoeba histolytica	receptor protein kinase, putative	0.0054	0.0026	0.173
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0059	0.0036	0.0036
Echinococcus multilocularis	Immunoglobulin	0.0104	0.0128	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0132	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0026	0.0016
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0026	0.173
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Trypanosoma brucei	protein kinase, putative	0.0059	0.0036	0.007
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0054	0.0026	0.0016
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0064	0.0045	0.0093
Trichomonas vaginalis	STE family protein kinase	0.0054	0.0026	0.4606
Plasmodium falciparum	tyrosine kinase-like protein	0.0054	0.0026	0.4606
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.006	0.0038	0.0076
Schistosoma mansoni	protein tyrosine kinase	0.0054	0.0026	0.0016
Entamoeba histolytica	protein kinase, putative	0.0054	0.0026	0.173
Schistosoma mansoni	tyrosine kinase	0.0054	0.0026	0.0016
Plasmodium falciparum	protein kinase, putative	0.0059	0.0036	0.7489
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.0103	0.0093
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0026	0.173
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0045	0.0035
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0108	0.0136	0.0136
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0054	0.0026	0.0026
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0119	0.0159	0.0159
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0419	0.0777	0.0768
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.0045	1
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Brugia malayi	P38 map kinase family protein 2	0.0419	0.0777	0.0768
Entamoeba histolytica	protein kinase, putative	0.0092	0.0103	1
Schistosoma mansoni	tyrosine kinase	0.0087	0.0093	0.0083
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.006	0.0038	0.0076
Echinococcus granulosus	tyrosine kinase	0.0076	0.007	0.007
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0054	0.0026	0.0026
Echinococcus multilocularis	epidermal growth factor receptor	0.2639	0.5358	0.5358
Trypanosoma brucei	protein kinase, putative	0.006	0.0038	0.0076
Entamoeba histolytica	protein kinase, putative	0.0054	0.0026	0.173
Entamoeba histolytica	protein kinase, putative	0.0054	0.0026	0.173
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Echinococcus multilocularis	neuroglian	0.0133	0.0187	0.0187
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0038	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0026	0.0016
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	0.007	0.0061
Trypanosoma brucei	fructose-1,6-bisphosphatase	0.1865	0.3761	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0026	0.0016
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0119	0.0159	0.0159
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Entamoeba histolytica	protein kinase, putative	0.0054	0.0026	0.173
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0104	0.0128	0.0118
Schistosoma mansoni	protein kinase	0.0054	0.0026	0.0016
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0061	0.004	0.003
Toxoplasma gondii	sedoheptulose-1,7-bisphosphatase	0.0693	0.1344	0.3558
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0119	0.0159	0.0159
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	0.007	0.0061
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0026	0.0016
Toxoplasma gondii	protein kinase	0.0054	0.0026	0.0043
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0073	0.0063	0.0142
Schistosoma mansoni	tyrosine kinase	0.158	0.3174	0.3168
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0026	0.4606
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0026	0.173
Schistosoma mansoni	roundabout	0.0059	0.0035	0.0026
Entamoeba histolytica	hypothetical protein	0.0054	0.0026	0.173
Brugia malayi	Protein kinase domain containing protein	0.0076	0.007	0.0061
Brugia malayi	C-terminal src kinase protein 1	0.0054	0.0026	0.0016
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0054	0.0026	0.0026
Echinococcus multilocularis	roundabout 2	0.0165	0.0254	0.0254
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Brugia malayi	hypothetical protein	0.0054	0.0026	0.0016
Echinococcus granulosus	tyrosine protein kinase shark	0.0076	0.007	0.007
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0054	0.0026	0.0043
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0092	0.0103	0.0093
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0026	0.173
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0205	0.0195
Schistosoma mansoni	protein kinase	0.0059	0.0036	0.0026
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0073	0.0063	0.0142
Entamoeba histolytica	hypothetical protein	0.0054	0.0026	0.173
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0045	0.0035
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0134	0.019	0.019
Brugia malayi	Prion-like-	0.0059	0.0035	0.0026
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0054	0.0026	0.0026
Echinococcus multilocularis	tyrosine protein kinase	0.0054	0.0026	0.0026
Brugia malayi	hypothetical protein	0.012	0.0161	0.0151
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0061	0.004	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0693	0.1344	0.3558
Echinococcus granulosus	cyclin dependent kinase 5 activator 1	0.025	0.043	0.043
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0061	0.004	0.004
Brugia malayi	Tyrosine-protein kinase abl-1	0.014	0.0202	0.0193
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0.0026	0.173
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0026	0.173
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0026	0.0016
Schistosoma mansoni	tyrosine kinase	0.0054	0.0026	0.0016
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0061	0.004	0.004
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0054	0.0026	0.0026
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0059	0.0036	0.007
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0026	0.4606
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0059	0.0036	0.0036
Giardia lamblia	Kinase, NEK	0.0054	0.0026	0.4606
Loa Loa (eye worm)	TK protein kinase	0.0108	0.0136	0.0127
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0026	0.173
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0035	0.0026
Loa Loa (eye worm)	TK/ALK protein kinase	0.0284	0.05	0.0491
Schistosoma mansoni	tyrosine kinase	0.0054	0.0026	0.0016
Echinococcus granulosus	mitogen activated protein kinase 3	0.006	0.0038	0.0038
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0054	0.0026	0.4606
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Loa Loa (eye worm)	hypothetical protein	0.0163	0.025	0.024
Brugia malayi	Protein kinase domain containing protein	0.0076	0.007	0.0061
Entamoeba histolytica	hypothetical protein	0.0092	0.0103	1
Echinococcus granulosus	twitchin	0.0138	0.0198	0.0198
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0124	0.0169	0.0169
Leishmania major	protein kinase, putative	0.0059	0.0036	0.007
Schistosoma mansoni	tyrosine kinase	0.0054	0.0026	0.0016
Echinococcus granulosus	protein tyrosine kinase	0.0054	0.0026	0.0026
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0066	0.005	0.004
Echinococcus multilocularis	cyclin dependent kinase 1	0.0047	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase csk	0.0054	0.0026	0.0026
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Schistosoma mansoni	tyrosine kinase	0.2639	0.5358	0.5354
Brugia malayi	Tyrosine-protein kinase abl-1	0.0174	0.0271	0.0262
Onchocerca volvulus		0.0076	0.007	0.028
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0419	0.0777	0.0777
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0026	0.173
Echinococcus granulosus	fructose 16 bisphosphatase 1	0.1865	0.3761	0.3761
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	0.007	0.0061
Echinococcus granulosus	c src tyrosine kinase	0.0087	0.0093	0.0093
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Echinococcus granulosus	roundabout 2	0.0165	0.0254	0.0254
Entamoeba histolytica	protein kinase, putative	0.0054	0.0026	0.173
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0026	0.0016
Schistosoma mansoni	tyrosine kinase	0.2585	0.5246	0.5242
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.1583	0.3179	0.3179
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0103	0.0093
Schistosoma mansoni	tyrosine kinase	0.0054	0.0026	0.0016
Schistosoma mansoni	tyrosine kinase	0.0054	0.0026	0.0016
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0087	0.0093	0.0083
Loa Loa (eye worm)	TK/ACK protein kinase	0.0054	0.0026	0.0016
Giardia lamblia	Kinase	0.0054	0.0026	0.4606
Echinococcus multilocularis	transfer RNA-Thr	0.0054	0.0026	0.0026
Entamoeba histolytica	ankyrin repeat protein	0.0054	0.0026	0.173
Loa Loa (eye worm)	hypothetical protein	0.012	0.0161	0.0151
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0108	0.0136	0.0136
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0026	0.173
Echinococcus multilocularis	mitogen activated protein kinase 3	0.006	0.0038	0.0038
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0153	0.023	0.023
Brugia malayi	Protein kinase domain containing protein	0.0285	0.0501	0.0491
Schistosoma mansoni	tyrosine kinase	0.0153	0.023	0.022
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0054	0.0026	0.0016
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0054	0.0026	0.0016
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0073	0.0063	0.0054
Echinococcus multilocularis	tyrosine protein kinase csk	0.0054	0.0026	0.0026
Schistosoma mansoni	protein kinase	0.0054	0.0026	0.0016
Echinococcus granulosus	tyrosine protein kinase HCK	0.0086	0.0092	0.0092
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0054	0.0026	0.0016
Schistosoma mansoni	septate junction protein	0.0059	0.0035	0.0026
Schistosoma mansoni	tyrosine kinase	0.0054	0.0026	0.0016
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0083	0.0085	0.0085
Echinococcus granulosus	epidermal growth factor receptor	0.4888	1	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0.0026	0.173
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0129	0.0179	0.0179
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0038	0.8107
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	0.007	0.0061
Echinococcus granulosus	natriuretic peptide receptor 1	0.0054	0.0026	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0054	0.0026	0.0016
Loa Loa (eye worm)	camk/mapkapk/mnk protein kinase	0.09	0.177	0.1762
Loa Loa (eye worm)	TK/ROR protein kinase	0.0083	0.0085	0.0076
Brugia malayi	Raf kinase	0.0054	0.0026	0.0016
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0119	0.0159	0.0159
Echinococcus granulosus	cyclin dependent kinase 1	0.0047	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase shark	0.0076	0.007	0.007
Schistosoma mansoni	hypothetical protein	0.0054	0.0026	0.0016
Schistosoma mansoni	tyrosine kinase	0.0054	0.0026	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0026	0.4606
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0061	0.004	0.004
Echinococcus granulosus	insulin receptor	0.158	0.3174	0.3174
Schistosoma mansoni	serine/threonine protein kinase	0.0065	0.0048	0.0039
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0061	0.004	0.003
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0174	0.0271	0.0271
Brugia malayi	hypothetical protein	0.0106	0.0132	0.0123
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Loa Loa (eye worm)	TK/Met protein kinase	0.0054	0.0026	0.0016
Schistosoma mansoni	tyrosine kinase	0.0119	0.0159	0.0149
Toxoplasma gondii	STE kinase	0.0054	0.0026	0.0043
Schistosoma mansoni	titin	0.0059	0.0035	0.0026
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Plasmodium falciparum	protein serine/threonine kinase-1	0.0064	0.0045	1
Echinococcus granulosus	peroxidasin	0.0059	0.0035	0.0035
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Schistosoma mansoni	ephrin receptor	0.0114	0.0149	0.014
Entamoeba histolytica	tyrosin kinase, putative	0.0054	0.0026	0.173
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0119	0.0159	0.0159
Echinococcus multilocularis		0.1505	0.3018	0.3018
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0054	0.0024	0.0024
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0054	0.0026	0.0016
Toxoplasma gondii	protein kinase domain-containing protein	0.0054	0.0026	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0035	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0061	0.004	0.003
Brugia malayi	Receptor family ligand binding region containing protein	0.0054	0.0026	0.0016
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0059	0.0035	0.006
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0064	0.0045	0.0035
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0119	0.0159	0.0159
Echinococcus multilocularis	epidermal growth factor receptor	0.4888	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	0.007	0.0061
Echinococcus multilocularis	tyrosine kinase	0.0054	0.0026	0.0026
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0104	0.0128	0.0118
Schistosoma mansoni	septate junction protein	0.0059	0.0035	0.0026
Echinococcus granulosus	roundabout 2	0.0061	0.004	0.004
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0059	0.0035	0.0026
Echinococcus granulosus	cyclin dependent kinase	0.0047	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0076	0.007	0.0061
Echinococcus granulosus	mitogen activated protein kinase	0.006	0.0038	0.0038
Entamoeba histolytica	protein kinase, putative	0.0054	0.0026	0.173
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0076	0.007	0.6508
Echinococcus granulosus	neuroglian	0.0133	0.0187	0.0187
Schistosoma mansoni	tyrosine protein kinase	0.0054	0.0026	0.0016
Loa Loa (eye worm)	TK/EGFR protein kinase	0.4888	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0054	0.0026	0.0026
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Echinococcus multilocularis	activated cdc42 kinase 1	0.0054	0.0026	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0054	0.0026	0.0026
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0054	0.0026	0.0026
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0054	0.0026	0.0016
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0054	0.0026	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0026	0.0016
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0153	0.023	0.023
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	0.1865	0.3761	0.3755
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0054	0.0026	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0026	0.4606
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0419	0.0777	0.0777
Trichomonas vaginalis	TK family protein kinase	0.0054	0.0026	0.4606
Schistosoma mansoni	cyclin-dependent kinase 5 activator	0.025	0.043	0.0421
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Echinococcus multilocularis	lachesin	0.0059	0.0035	0.0035
Echinococcus multilocularis	heat shock protein 70	0.0054	0.0026	0.0026
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0064	0.0045	0.0093
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0026	0.173
Echinococcus granulosus	tyrosine protein kinase csk	0.0054	0.0026	0.0026
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0026	0.0016
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0.0026	0.173
Leishmania major	hypothetical protein, conserved	0.0054	0.0026	0.0043
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Echinococcus multilocularis	cyclin dependent kinase 5	0.0047	0.001	0.001
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Echinococcus multilocularis	protein tyrosine kinase	0.0054	0.0026	0.0026
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0059	0.0035	0.0026
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0182	0.0289	0.028
Brugia malayi	Protein kinase domain containing protein	0.0076	0.007	0.0061
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.1865	0.3761	1
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0026	0.173
Schistosoma mansoni	tyrosine kinase	0.0113	0.0147	0.0138
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0026	0.173
Echinococcus granulosus	tyrosine protein kinase csk	0.0054	0.0026	0.0026
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0054	0.0026	0.0016
Schistosoma mansoni	tyrosine kinase	0.2585	0.5246	0.5242
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0054	0.0026	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0026	0.4606
Trypanosoma cruzi	protein kinase, putative	0.0054	0.0026	0.0043
Echinococcus multilocularis	cyclin dependent kinase 5 activator 1	0.025	0.043	0.043
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0026	0.173
Echinococcus multilocularis	mitogen activated protein kinase	0.006	0.0038	0.0038
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	0.007	0.0061
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0026	0.173
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0026	0.0016
Brugia malayi	Peroxidasin	0.0059	0.0035	0.0026
Onchocerca volvulus		0.0076	0.007	0.028
Loa Loa (eye worm)	TK/CSK protein kinase	0.0054	0.0026	0.0016
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.006	0.0038	0.0076
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0054	0.0026	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Schistosoma mansoni	nephrin	0.0135	0.0192	0.0183
Entamoeba histolytica	hypothetical protein	0.0054	0.0026	0.173
Entamoeba histolytica	protein kinase, putative	0.0054	0.0026	0.173
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0119	0.0159	0.0159
Schistosoma mansoni	tyrosine kinase	0.0054	0.0026	0.0016
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0073	0.0063	0.0054
Echinococcus granulosus	tyrosine kinase	0.0108	0.0136	0.0136
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0054	0.0026	0.173
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0073	0.0063	0.0142
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0119	0.0159	0.0159
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0419	0.0777	0.0777
Brugia malayi	ephrin receptor 1 precursor	0.0083	0.0084	0.0074
Brugia malayi	protein-tyrosine kinase	0.0108	0.0136	0.0127
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0038	0.8107
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0153	0.023	0.023
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0054	0.0026	0.0026
Loa Loa (eye worm)	TK/RYK protein kinase	0.0054	0.0026	0.0016
Schistosoma mansoni	cell adhesion molecule	0.0136	0.0194	0.0185
Echinococcus multilocularis	integrin linked protein kinase	0.0054	0.0026	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Echinococcus multilocularis	roundabout 2	0.0061	0.004	0.004
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0026	0.173
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0054	0.0026	0.0016
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0.0026	0.173
Entamoeba histolytica	protein kinase, putative	0.0054	0.0026	0.173
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0035	0.0026
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Echinococcus granulosus	dual specificity protein kinase clk2	0.0064	0.0045	0.0045
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0059	0.0035	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Leishmania major	protein kinase, putative	0.0054	0.0026	0.0043
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0054	0.0026	0.4606
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0054	0.0024	0.0024
Echinococcus granulosus	neuroglian	0.0061	0.004	0.004
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Brugia malayi	Cytochrome P450 family protein	0.0061	0.004	0.003
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0054	0.0026	0.173
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0026	0.0016
Giardia lamblia	Protein 21.1	0.0054	0.0026	0.4606
Schistosoma mansoni	vesicular amine transporter	0.0104	0.0128	0.0118
Entamoeba histolytica	protein kinase, putative	0.0054	0.0026	0.173
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0054	0.0026	0.0026
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0054	0.0026	0.0016
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.1865	0.3761	1
Schistosoma mansoni	tyrosine kinase	0.2585	0.5246	0.5242
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0076	0.007	0.007
Entamoeba histolytica	protein kinase, putative	0.0092	0.0103	1
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0026	0.173
Schistosoma mansoni	neuroglian	0.0061	0.004	0.003
Loa Loa (eye worm)	hypothetical protein	0.0203	0.0331	0.0322
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0054	0.0026	0.0016
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Loa Loa (eye worm)	SRC-1	0.0119	0.0159	0.0149
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0054	0.0026	0.0026
Entamoeba histolytica	protein kinase, putative	0.0054	0.0026	0.173
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	0.1865	0.3761	0.3761
Loa Loa (eye worm)	TK protein kinase	0.0086	0.0092	0.0082
Entamoeba histolytica	protein kinase, putative	0.0054	0.0026	0.173
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Onchocerca volvulus		0.074	0.1441	0.8916
Echinococcus granulosus	lachesin	0.0059	0.0035	0.0035
Entamoeba histolytica	hypothetical protein	0.0054	0.0026	0.173
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0054	0.0026	0.4606
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0026	0.0016
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0054	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0035	0.0026
Loa Loa (eye worm)	TK protein kinase	0.0182	0.0289	0.028
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Loa Loa (eye worm)	hypothetical protein	0.0134	0.019	0.018
Echinococcus multilocularis	tyrosine kinase	0.0076	0.007	0.007
Plasmodium falciparum	protein kinase, putative	0.0054	0.0026	0.4606
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0026	0.4606
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0303	0.0538	0.0538
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.0064	0.0045	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0054	0.0026	0.0016
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	0.007	0.0061
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0119	0.0159	0.0159
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0092	0.0103	0.0248
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0047	0.001	0.001
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0026	0.173
Schistosoma mansoni	tyrosine kinase	0.0054	0.0026	0.0016
Schistosoma mansoni	protein kinase	0.0054	0.0026	0.0016
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0026	0.173
Echinococcus granulosus	tyrosine protein kinase otk	0.0059	0.0035	0.0035
Giardia lamblia	Kinase, CMGC CLK	0.0064	0.0045	1
Schistosoma mansoni	protein kinase	0.0054	0.0026	0.0016
Brugia malayi	Protein kinase domain containing protein	0.0076	0.007	0.0061
Echinococcus multilocularis	microtubule associated protein 2	0.0758	0.1478	0.1478
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0026	0.0016
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0054	0.0026	0.0016
Onchocerca volvulus	Tyrosine kinase homolog	0.0824	0.1613	1
Echinococcus multilocularis		0.0059	0.0034	0.0034
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0059	0.0035	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0026	0.4606
Entamoeba histolytica	protein kinase, putative	0.0054	0.0026	0.173
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0026	0.0016
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0119	0.0159	0.0159

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 150 nM	Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgammaS binding assay	ChEMBL.	25437506
t1/2 (functional)		Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells assessed as dissociation half-life at 10 times IC50 after 1 hr preincubation by radio-labelled [35S]-GTPgammaS binding assay	ChEMBL.	25437506

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3338273

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 932240