Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0726 | 0.0726 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0726 | 0.0726 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0726 | 0.0726 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0726 | 0.0726 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0726 | 0.0726 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0726 | 0.0726 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0726 | 0.0726 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0726 | 0.0726 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0726 | 0.0726 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0726 | 0.0726 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0726 | 0.0726 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0726 | 0.0726 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0726 | 0.0726 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0726 | 0.0726 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0726 | 0.0726 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0726 | 0.0726 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0726 | 0.0726 |
Brugia malayi | TAR-binding protein | 0.007 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0726 | 0.0726 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0726 | 0.0726 |
Onchocerca volvulus | 0.001 | 0.0726 | 0.5 | |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0726 | 0.0726 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0726 | 0.0726 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0726 | 0.0726 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0726 | 0.0726 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0726 | 0.0726 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0726 | 0.0726 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0726 | 0.0726 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0726 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0726 | 0.0726 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0726 | 0.0726 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0726 | 0.0726 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0726 | 0.0726 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0726 | 0.0726 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0726 | 0.0726 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0726 | 0.0726 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0726 | 0.0726 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0726 | 0.0726 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0726 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0726 | 0.0726 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0726 | 0.0726 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0726 | 0.0726 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0726 | 0.0726 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0726 | 0.0726 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0726 | 0.0726 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0726 | 0.0726 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0726 | 0.0726 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0726 | 0.0726 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0726 | 0.0726 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0726 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0726 | 0.0726 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0726 | 0.0726 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0726 | 0.0726 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0726 | 0.0726 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0726 | 0.0726 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0726 | 0.0726 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0726 | 0.0726 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.95 uM | Antimalarial activity against Plasmodium falciparum FCR3 after 48 hrs by parasite lactate dehydrogenase assay | ChEMBL. | 25255435 |
IC50 (functional) | > 100 uM | Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay | ChEMBL. | 25255435 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 25255435 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.