TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 265.778 | Formula: C15H20ClNO
H donors: 0 H acceptors: 1 LogP: 3.38 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=C1C(CN2CCCCC2)Cc2c1cccc2.Cl
InChi: 1S/C15H19NO.ClH/c17-15-13(11-16-8-4-1-5-9-16)10-12-6-2-3-7-14(12)15;/h2-3,6-7,13H,1,4-5,8-11H2;1H
InChiKey: RAEAAEHPGNXREH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	methionine aminopeptidase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium berghei	methionine aminopeptidase 1b, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Candida albicans	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	Get druggable targets OG5_126721	All targets in OG5_126721
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma brucei	methionine aminopeptidase, type I, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium vivax	methionine aminopeptidase 1a, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Neospora caninum	methionine aminopeptidase, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium falciparum	methionine aminopeptidase 1b, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Toxoplasma gondii	methionine aminopeptidase, type i, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Leishmania mexicana	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Theileria parva	methionine aminopeptidase, type I, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Neospora caninum	methionine aminopeptidase, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Leishmania donovani	metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma congolense	metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Leishmania braziliensis	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Mycobacterium ulcerans	methionine aminopeptidase MapB	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma brucei gambiense	methionine aminopeptidase, putative,metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium yoelii	methionine aminopeptidase, type I, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Cryptosporidium hominis	methionine aminopeptidase 1 (MetAP 1) (MAP 1) (Peptidase M 1)	Get druggable targets OG5_126721	All targets in OG5_126721
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	Get druggable targets OG5_126721	All targets in OG5_126721
Babesia bovis	methionine aminopeptidase, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium berghei	methionine aminopeptidase 1a, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium falciparum	methionine aminopeptidase 1a, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma brucei	methionine aminopeptidase, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium knowlesi	methionine aminopeptidase 1a, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Neospora caninum	methionine aminopeptidase, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Leishmania infantum	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Babesia bovis	methionine aminopeptidase, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Cryptosporidium parvum	methionine aminopeptidase with MYND finger at N-terminus	Get druggable targets OG5_126721	All targets in OG5_126721
Chlamydia trachomatis	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Candida albicans	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	Get druggable targets OG5_126721	All targets in OG5_126721
Brugia malayi	Methionine aminopeptidase protein type I	Get druggable targets OG5_126721	All targets in OG5_126721
Mycobacterium ulcerans	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium knowlesi	methionine aminopeptidase 1b, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Schistosoma japonicum	ko:K01265 methionyl aminopeptidase [EC3.4.11.18], putative	Get druggable targets OG5_126721	All targets in OG5_126721
Treponema pallidum	methionine aminopeptidase (map)	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium yoelii	methionine aminopeptidase, type I	Get druggable targets OG5_126721	All targets in OG5_126721
Schistosoma japonicum	ko:K01265 methionyl aminopeptidase [EC3.4.11.18], putative	Get druggable targets OG5_126721	All targets in OG5_126721
Theileria parva	methionine aminopeptidase, type I, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium vivax	methionine aminopeptidase 1b, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	Get druggable targets OG5_126721	All targets in OG5_126721
Toxoplasma gondii	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Loa Loa (eye worm)	methionine aminopeptidase type I	Get druggable targets OG5_126721	All targets in OG5_126721
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	Get druggable targets OG5_126721	All targets in OG5_126721
Schistosoma japonicum	Methionine aminopeptidase 1, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Toxoplasma gondii	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	Get druggable targets OG5_126721	All targets in OG5_126721

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0115	0.0084
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0361	0.4375	1
Leishmania major	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0074	0.0613	0.034
Echinococcus granulosus	NAD dependent deacetylase sirtuin 7	0.0192	0.2152	0.2127
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0049	0.0282	0.07
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.043	0.5281	0.5266
Plasmodium vivax	thioredoxin reductase, putative	0.0142	0.1504	0.4109
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0049	0.0282	0.0252
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0613	0.0808
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0038	0.0134	0.0103
Loa Loa (eye worm)	PXA domain-containing protein	0.0038	0.0134	0.0103
Giardia lamblia	Hypothetical protein	0.0789	1	1
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0464	0.0434
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0038	0.0134	0.0103
Brugia malayi	regulator of G-protein signaling egl-10	0.0038	0.0134	0.0103
Echinococcus granulosus	regulator of G protein signaling 3	0.0038	0.0134	0.0103
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.0115	0.0084
Schistosoma mansoni	regulator of G protein signaling	0.0038	0.0134	0.0103
Schistosoma mansoni	chromatin regulatory protein sir2	0.0192	0.2152	0.2127
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0789	1	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0049	0.0282	0.07
Loa Loa (eye worm)	hypothetical protein	0.043	0.5281	0.5266
Mycobacterium tuberculosis	Transcriptional regulatory protein	0.0303	0.3615	0.8144
Plasmodium vivax	hypothetical protein, conserved	0.0192	0.2152	0.5916
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0038	0.0134	0.0103
Toxoplasma gondii	methionine aminopeptidase, type i, putative	0.0052	0.0314	0.0787
Plasmodium vivax	NAD-dependent deacetylase, putative	0.0303	0.3615	1
Echinococcus multilocularis	regulator of G protein signaling	0.0038	0.0134	0.0103
Schistosoma mansoni	regulator of G protein signaling	0.0038	0.0134	0.0103
Toxoplasma gondii	methionine aminopeptidase	0.0052	0.0314	0.0787
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0287	0.3407	0.3215
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0038	0.0134	0.0103
Brugia malayi	NAD-dependent deacetylase SIRT1	0.043	0.5281	0.5266
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0789	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.0146	0.0115
Trypanosoma brucei	Silent information regulator 2 related protein 3	0.0303	0.3615	0.343
Echinococcus granulosus	Regulator of G protein signaling 20	0.0038	0.0134	0.0103
Toxoplasma gondii	histone deacetylase SIR2-like	0.0192	0.2152	0.5916
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0464	0.0434
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0325	0.3899	0.8837
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0038	0.0134	0.0103
Brugia malayi	hypothetical protein	0.0038	0.0134	0.0103
Echinococcus granulosus	chromobox protein 1	0.007	0.0556	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0315	0.0285
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0789	1	1
Giardia lamblia	Kinase, PLK	0.0287	0.3407	0.3386
Trypanosoma cruzi	hypothetical protein, conserved	0.0647	0.813	0.8075
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0287	0.3407	0.3386
Plasmodium falciparum	methionine aminopeptidase 1b, putative	0.0052	0.0314	0.0787
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.043	0.5281	0.5266
Trichomonas vaginalis	CAMK family protein kinase	0.0287	0.3407	0.3407
Mycobacterium ulcerans	methionine aminopeptidase	0.0052	0.0314	0.0048
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.019	0.019
Echinococcus granulosus	axis inhibition protein axin	0.0038	0.0134	0.0103
Echinococcus multilocularis	chromobox protein 1	0.007	0.0556	0.0526
Trypanosoma cruzi	trypanothione reductase, putative	0.0142	0.1504	0.1257
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0134	0.0103
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0325	0.3899	0.8837
Schistosoma mansoni	chromatin regulatory protein sir2	0.0789	1	1
Trichomonas vaginalis	glutaminase, putative	0.055	0.6864	0.6864
Brugia malayi	serine/threonine-protein kinase plk-2	0.0287	0.3407	0.3386
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0287	0.3407	0.3317
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0556	0.0556
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0134	0.0103
Leishmania major	sir2-family protein-like protein	0.0192	0.2152	0.1924
Echinococcus granulosus	axis inhibition protein axin	0.0038	0.0134	0.0103
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.0074	0.0613	0.0613
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0151	0.0151
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0303	0.3615	0.3615
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	0.0052	0.0314	0.0077
Giardia lamblia	Sirtuin type 2	0.0192	0.2152	0.2127
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	0.0052	0.0314	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0134	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0134	0.0103
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 7	0.0192	0.2152	0.2127
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0039	0.0146	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0313	0.0283
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0464	0.0434
Entamoeba histolytica	hypothetical protein, conserved	0.0192	0.2152	0.2045
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.043	0.5281	0.5281
Schistosoma mansoni	regulator of G protein signaling	0.0038	0.0134	0.0103
Echinococcus granulosus	regulator of G protein signaling 7	0.0038	0.0134	0.0103
Trypanosoma cruzi	hypothetical protein, conserved	0.0647	0.813	0.8075
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0052	0.0314	0.0283
Brugia malayi	jmjC domain containing protein	0.0099	0.0935	0.0906
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0049	0.0282	0.0252
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0036	0.011	0.0079
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0074	0.0613	0.0502
Echinococcus multilocularis	axis inhibition protein axin	0.0038	0.0134	0.0103
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0134	0.0134
Schistosoma mansoni	chromatin regulatory protein sir2	0.0789	1	1
Schistosoma mansoni	regulator of G protein signaling	0.0038	0.0134	0.0103
Trichomonas vaginalis	CAMK family protein kinase	0.0142	0.1502	0.1502
Schistosoma mansoni	regulator of G protein signaling	0.0038	0.0134	0.0103
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0303	0.3615	0.3615
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0039	0.0146	0.0115
Echinococcus multilocularis	citrate lyase subunit beta protein	0.0074	0.0613	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.0067
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0556	0.0556
Loa Loa (eye worm)	hypothetical protein	0.0238	0.2764	0.2741
Loa Loa (eye worm)	RGS-3 protein	0.0038	0.0134	0.0103
Giardia lamblia	Transcriptional regulator, Sir2 family	0.0303	0.3615	0.3595
Mycobacterium ulcerans	methionine aminopeptidase MapB	0.0052	0.0314	0.0048
Echinococcus multilocularis	regulator of G protein signaling 7	0.0038	0.0134	0.0103
Plasmodium vivax	methionine aminopeptidase 1b, putative	0.0052	0.0314	0.0787
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0464	0.0434
Echinococcus multilocularis	regulator of G protein signaling 3	0.0038	0.0134	0.0103
Leishmania major	hypothetical protein, conserved	0.0647	0.813	0.8075
Schistosoma mansoni	chromatin regulatory protein sir2	0.0192	0.2152	0.2127
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0151	0.012
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.019	0.047
Trypanosoma brucei	methionine aminopeptidase, putative	0.0052	0.0314	0.0032
Plasmodium falciparum	transcriptional regulatory protein sir2a	0.0303	0.3615	1
Mycobacterium ulcerans	glutaminase	0.055	0.6864	1
Brugia malayi	jmjC domain containing protein	0.0037	0.0115	0.0084
Brugia malayi	Heterochromatin protein 1	0.007	0.0556	0.0526
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0361	0.4375	1
Brugia malayi	Methionine aminopeptidase protein type I	0.0052	0.0314	0.0283
Plasmodium falciparum	glutathione reductase	0.0049	0.0282	0.07
Echinococcus granulosus	NAD dependent deacetylase sirtuin 6	0.0192	0.2152	0.2127
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0287	0.3407	0.3386
Mycobacterium tuberculosis	Probable reductase	0.0325	0.3899	0.8837
Loa Loa (eye worm)	transcriptional regulator	0.0192	0.2152	0.2127
Trichomonas vaginalis	CAMK family protein kinase	0.0287	0.3407	0.3407
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.043	0.5281	0.5266
Schistosoma mansoni	hypothetical protein	0.0035	0.0098	0.0067
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0134	0.0134
Brugia malayi	PXA domain containing protein	0.0038	0.0134	0.0103
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0052	0.0314	0.0032
Loa Loa (eye worm)	jmjC domain-containing protein	0.0037	0.0115	0.0084
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0074	0.0613	0.0502
Trichomonas vaginalis	CAMK family protein kinase	0.0287	0.3407	0.3407
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0052	0.0314	0.0032
Echinococcus multilocularis	expressed protein	0.074	0.9358	0.9356
Trypanosoma brucei	polo-like protein kinase	0.0287	0.3407	0.3215
Trichomonas vaginalis	CAMK family protein kinase	0.0287	0.3407	0.3407
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0134	0.0134
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0074	0.0613	0.034
Trichomonas vaginalis	CAMK family protein kinase	0.0287	0.3407	0.3407
Loa Loa (eye worm)	jmjC domain-containing protein	0.0062	0.0454	0.0424
Schistosoma mansoni	chromatin regulatory protein sir2	0.043	0.5281	0.5266
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0036	0.011	0.0079
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0303	0.3615	0.3615
Onchocerca volvulus		0.0031	0.0039	0.0023
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.0146	0.0115
Chlamydia trachomatis	methionine aminopeptidase	0.0052	0.0314	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0115	0.0084
Brugia malayi	A-kinase anchor protein 10, precursor	0.0038	0.0134	0.0103
Echinococcus multilocularis	axis inhibition protein axin	0.0038	0.0134	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0039	0.0008
Echinococcus multilocularis	regulator of G protein signaling 7	0.0038	0.0134	0.0103
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.0146	0.0115
Plasmodium vivax	glutathione reductase, putative	0.0142	0.1504	0.4109
Plasmodium falciparum	thioredoxin reductase	0.0142	0.1504	0.4109
Schistosoma mansoni	chromatin regulatory protein sir2	0.0789	1	1
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0303	0.3615	0.3529
Loa Loa (eye worm)	thioredoxin reductase	0.0142	0.1504	0.1477
Mycobacterium ulcerans	hypothetical protein	0.0074	0.0613	0.0502
Brugia malayi	Thioredoxin reductase	0.0142	0.1504	0.1477
Echinococcus granulosus	jumonji domain containing protein	0.0042	0.0187	0.0156
Echinococcus multilocularis	jumonji domain containing protein	0.0042	0.0187	0.0156
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0192	0.2152	0.2152
Brugia malayi	RNA binding protein	0.0063	0.0464	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0134	0.0103
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0325	0.3899	0.8837
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0052	0.0314	0.0283
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0151	0.0354
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.019	0.019
Loa Loa (eye worm)	transcriptional regulator	0.0192	0.2152	0.2127
Mycobacterium ulcerans	NAD-dependent deacetylase	0.0303	0.3615	0.5064
Mycobacterium tuberculosis	Probable oxidoreductase	0.0361	0.4375	1
Schistosoma mansoni	jumonji domain containing protein	0.0079	0.0668	0.0638
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0052	0.0314	0.0283
Leishmania major	trypanothione reductase	0.0142	0.1504	0.1257
Schistosoma mansoni	serine/threonine protein kinase	0.0287	0.3407	0.3386
Schistosoma mansoni	glutaminase	0.055	0.6864	0.6854
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0038	0.0134	0.0103
Echinococcus multilocularis	regulator of G protein signaling 3	0.0038	0.0134	0.0103
Loa Loa (eye worm)	glutaminase 2	0.055	0.6864	0.6854
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0287	0.3407	1
Echinococcus granulosus	citrate lyase subunit beta protein	0.0074	0.0613	0.0583
Echinococcus granulosus	expressed protein	0.074	0.9358	0.9356
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0192	0.2152	0.2152
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0464	0.0434
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0134	0.0134
Echinococcus granulosus	chromobox protein 1	0.007	0.0556	0.0526
Trichomonas vaginalis	CAMK family protein kinase	0.0142	0.1502	0.1502
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0313	0.0283
Schistosoma mansoni	chromatin regulatory protein sir2	0.0303	0.3615	0.3595
Echinococcus multilocularis	chromobox protein 1	0.007	0.0556	0.0526
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.043	0.5281	0.5281
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0313	0.0283
Echinococcus granulosus	chromatin regulatory protein sir2	0.0789	1	1
Loa Loa (eye worm)	heterochromatin protein 1	0.007	0.0556	0.0526
Mycobacterium tuberculosis	Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase)	0.0074	0.0613	0.0808
Loa Loa (eye worm)	methionine aminopeptidase type I	0.0052	0.0314	0.0283
Trichomonas vaginalis	CAMK family protein kinase	0.0287	0.3407	0.3407
Echinococcus granulosus	regulator of G protein signaling 3	0.0038	0.0134	0.0103
Brugia malayi	TAR-binding protein	0.0063	0.0464	0.0434
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0325	0.3899	0.8837
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0039	0.0146	0.0115
Treponema pallidum	methionine aminopeptidase (map)	0.0052	0.0314	1
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0464	0.0434
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	0.0052	0.0314	1
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0287	0.3407	0.3386
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0464	0.0434
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0789	1	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0098	0.0067
Plasmodium falciparum	glutathione reductase	0.0142	0.1504	0.4109
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.043	0.5281	0.5281
Mycobacterium ulcerans	citrate lyase beta subunit, CitE_2	0.0074	0.0613	0.0502
Plasmodium vivax	methionine aminopeptidase 1a, putative	0.0052	0.0314	0.0787
Schistosoma mansoni	z-protein (S1r protein)	0.0038	0.0134	0.0103
Echinococcus multilocularis	lysine specific demethylase 5A	0.0037	0.0115	0.0084
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0134	0.0134
Brugia malayi	hypothetical protein	0.0038	0.0134	0.0103
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0038	0.0134	0.0103
Brugia malayi	glutathione reductase	0.0142	0.1504	0.1477
Mycobacterium ulcerans	Sir2-like regulatory protein	0.0192	0.2152	0.284
Trypanosoma cruzi	polo-like protein kinase, putative	0.0287	0.3407	0.3215
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0142	0.1504	0.2985
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0361	0.4375	1
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0325	0.3899	0.8828
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0303	0.3615	0.343
Brugia malayi	glutaminase DH11.1	0.055	0.6864	0.6854
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0099	0.0935	0.0906
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0303	0.3615	0.343
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0192	0.2152	0.2127
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0789	1	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0789	1	1
Echinococcus granulosus	regulator of G protein signaling 7	0.0038	0.0134	0.0103
Schistosoma mansoni	kinase	0.0146	0.1551	0.1525
Toxoplasma gondii	histone deacetylase SIR2	0.0303	0.3615	1
Toxoplasma gondii	methionine aminopeptidase	0.0052	0.0314	0.0787
Plasmodium falciparum	transcriptional regulatory protein sir2b	0.0192	0.2152	0.5916
Trypanosoma brucei	trypanothione reductase	0.0142	0.1504	0.1257
Leishmania major	silent information regulator 2, putative	0.0789	1	1
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0052	0.0314	0.0283
Entamoeba histolytica	NAD-dependent deacetylase 1, putative	0.0192	0.2152	0.2045
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0099	0.0935	0.0906
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0134	0.0134
Trypanosoma brucei	hypothetical protein, conserved	0.0647	0.813	0.8075
Plasmodium falciparum	methionine aminopeptidase 1a, putative	0.0052	0.0314	0.0787
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0789	1	1
Loa Loa (eye worm)	sirtuin 4	0.0192	0.2152	0.2127
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0192	0.2152	0.2127
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 6	0.0192	0.2152	0.2127
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0049	0.0282	0.07
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0074	0.0613	0.034
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0039	0.0146	0.0115
Toxoplasma gondii	NADPH-glutathione reductase	0.0049	0.0282	0.07
Mycobacterium ulcerans	hypothetical protein	0.0074	0.0613	0.0502
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0049	0.0282	0.07
Plasmodium falciparum	thioredoxin reductase	0.0049	0.0282	0.07
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0049	0.0282	0.07
Schistosoma mansoni	chromobox protein	0.007	0.0556	0.0526
Loa Loa (eye worm)	glutaminase	0.055	0.6864	0.6854
Loa Loa (eye worm)	transcriptional regulator	0.0789	1	1
Trichomonas vaginalis	glutathione reductase, putative	0.0049	0.0282	0.0282
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	0.0052	0.0314	0.0283
Mycobacterium leprae	Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog)	0.0111	0.1098	0.1932
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0464	0.0434
Echinococcus granulosus	thioredoxin glutathione reductase	0.0142	0.1504	0.1477
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0789	1	1
Trichomonas vaginalis	mercuric reductase, putative	0.0049	0.0282	0.0282
Trichomonas vaginalis	CAMK family protein kinase	0.0287	0.3407	0.3407
Trypanosoma brucei	methionine aminopeptidase, type I, putative	0.0052	0.0314	0.0032
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0049	0.0282	0.0252
Brugia malayi	regulator of G-protein signaling rgs-7	0.0038	0.0134	0.0103
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0151	0.0151
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0789	1	1
Schistosoma mansoni	axis inhibition protein axin	0.0038	0.0134	0.0103
Schistosoma mansoni	chromobox protein	0.007	0.0556	0.0526
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0038	0.0134	0.0103
Leishmania major	NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe	0.0303	0.3615	0.343
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0464	0.0434
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0142	0.1504	0.1477
Loa Loa (eye worm)	glutathione reductase	0.0142	0.1504	0.1477
Brugia malayi	PXA domain containing protein	0.0038	0.0134	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0134	0.0103
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0052	0.0314	0.0032
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0464	0.0434
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0038	0.0134	0.0103
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0049	0.0282	0.0252
Schistosoma mansoni	axis inhibition protein axin	0.0038	0.0134	0.0103
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.043	0.5281	0.5281
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0464	0.0434
Trypanosoma brucei	SIR2-like protein 4, putative	0.0192	0.2152	0.1924
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0049	0.0282	0.0252
Toxoplasma gondii	thioredoxin reductase	0.0142	0.1504	0.4109
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	0.0052	0.0314	0.0032
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0789	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0313	0.0283
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0038	0.0134	0.0134
Mycobacterium tuberculosis	Probable dehydrogenase	0.0325	0.3899	0.8837
Trypanosoma cruzi	polo-like protein kinase, putative	0.0287	0.3407	0.3215
Brugia malayi	chromobox protein homolog 3	0.0039	0.0151	0.012
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0039	0.0146	0.0115

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Inhibition of human MetAP-2 expressed in Sf9 cells incubated for 60 mins before MGMM substrate addition by fluorescence assay	ChEMBL.	25293447
IC50 (binding)	= 3.1 uM	Inhibition of C-terminal poly-His-tagged Escherichia coli MetAP expressed in Escherichia coli BL21(DE3) incubated for 30 mins before MGMM substrate addition by fluorescence assay	ChEMBL.	25293447
IC50 (binding)	= 25 uM	Inhibition of N-terminal poly-His-tagged Staphylococcus aureus COL MetAP expressed in Escherichia coli BL21(DE3) incubated for 30 mins before MGMM substrate addition by fluorescence assay	ChEMBL.	25293447
IC50 (binding)	= 27 uM	Inhibition of N-terminal poly-His-tagged human MetAP-1 expressed in Escherichia coli BL21(DE3) incubated for 30 mins before MGMM substrate addition by fluorescence assay	ChEMBL.	25293447

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3337736

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 932315